EP3349910B1 - Dispositif de séparation magnétique à activation et désactivation mécanique - Google Patents

Dispositif de séparation magnétique à activation et désactivation mécanique Download PDF

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Publication number
EP3349910B1
EP3349910B1 EP16766295.6A EP16766295A EP3349910B1 EP 3349910 B1 EP3349910 B1 EP 3349910B1 EP 16766295 A EP16766295 A EP 16766295A EP 3349910 B1 EP3349910 B1 EP 3349910B1
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EP
European Patent Office
Prior art keywords
tip
magnet arrangement
separation device
magnetic
magnetic separation
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Active
Application number
EP16766295.6A
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German (de)
English (en)
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EP3349910A1 (fr
Inventor
Martin Gajewski
Hanspeter Romer
Mario Arangio
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Hamilton Bonaduz AG
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Hamilton Bonaduz AG
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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C1/00—Magnetic separation
    • B03C1/02—Magnetic separation acting directly on the substance being separated
    • B03C1/025—High gradient magnetic separators
    • B03C1/031—Component parts; Auxiliary operations
    • B03C1/033—Component parts; Auxiliary operations characterised by the magnetic circuit
    • B03C1/034—Component parts; Auxiliary operations characterised by the magnetic circuit characterised by the matrix elements
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C1/00—Magnetic separation
    • B03C1/02—Magnetic separation acting directly on the substance being separated
    • B03C1/28—Magnetic plugs and dipsticks
    • B03C1/284—Magnetic plugs and dipsticks with associated cleaning means, e.g. retractable non-magnetic sleeve
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C1/00—Magnetic separation
    • B03C1/02—Magnetic separation acting directly on the substance being separated
    • B03C1/28—Magnetic plugs and dipsticks
    • B03C1/286—Magnetic plugs and dipsticks disposed at the inner circumference of a recipient, e.g. magnetic drain bolt
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C2201/00—Details of magnetic or electrostatic separation
    • B03C2201/18—Magnetic separation whereby the particles are suspended in a liquid
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C2201/00—Details of magnetic or electrostatic separation
    • B03C2201/26—Details of magnetic or electrostatic separation for use in medical applications

Definitions

  • the present invention relates to a magnetic separation device for separating magnetic particles from a suspension with a soft magnetic tip extending along a tip axis, the magnetization state of which can optionally be changed between a more strongly magnetized state and a weaker magnetized state, the tip having an immersion end for insertion into has the suspension and a magnetization section for changing the magnetization state of the tip, the separating device having a movement drive and a magnet arrangement which is in motion transmission connection and which comprises at least one permanent magnet or is formed from at least one permanent magnet and which can be brought closer to the magnetization section by the movement drive is removable from this, so that the magnetic field of the magnet arrangement in the magnetization section of the tip to change the magnetization state of the Sp itze is variable over time.
  • Such separation devices are used, for example, in chemical, biochemical and / and pharmaceutical laboratories in order to remove magnetic particles contained in a suspension from the suspension.
  • Such suspensions with magnetic particles can be used, for example, to purify DNA.
  • the magnetic particles serve only as a means of transport and are usually coated in such a way that only a certain component of the suspension can and will attach to the outer surface of the coating facing away from the particle, which component can then be removed from the suspension together with the particle.
  • the magnetic particles are therefore usually magnetic only for the purpose of the planned removal of chemical or biological material from the suspension liquid.
  • magnetic refers to a material which is either magnetizable or is magnetized. In most of the applications of the magnetic separation device discussed here, the magnetic particles will comprise ferromagnetic material or consist of ferromagnetic material.
  • a generic magnetic separator is from the US 7799281 B2 known. This document discloses a magnetic separating device with a soft magnetic tip which is rigidly coupled to a guide tube at its longitudinal end remote from the immersion end, in which a permanent magnet can be approached and removed from the soft magnetic tip along the tube axis up to the touch contact.
  • the movable permanent magnet is polarized along its axis of movement so that one of its magnetic poles can be brought into physical contact with the soft magnetic tip.
  • the soft magnetic tip is magnetized for the duration of the touch contact, while it is essentially unmagnetized when the permanent magnet is arranged at a distance from the soft magnetic tip. That area of the soft magnetic tip which comes into physical contact with the movable permanent magnet is the magnetization section of the known soft magnetic tip.
  • the known generic magnetic separating device thus manages in the area of its soft magnetic tip without electrically energized components, in particular without an electromagnet, which often represents an undesirable heat source for magnetic separating devices.
  • the relative direction of movement of the permanent magnet which coincides with the axis of the guide tube, is collinear with the tip axis in order to provide a magnetic separating device that is as slender as possible radially with respect to the tip axis.
  • the permanent magnet is coupled with its movement drive via a rod accommodated in the guide tube and extending coaxially with the guide tube or via a cable accommodated in the guide tube and running coaxially with the guide tube and can thus be driven to move within the guide tube.
  • a further mobility of the permanent magnet and the soft magnetic tip is not provided.
  • FIG WO 02/40173 A1 Another magnetic separating device, which for the temporary magnetization of the soft magnetic tip, however, uses an electromagnet to be energized for the duration of the magnetization, is, for example, from FIG WO 02/40173 A1 known.
  • a strong and correspondingly space-demanding electric ring magnet surrounds the soft magnetic tip, which penetrates the plane of extension of the electric ring magnet along the ring axis.
  • the soft magnetic tip penetrating it acts like an armature or iron core and is magnetized for the duration of the energization of the electric ring magnet, so that the immersion end of the soft magnetic tip is introduced into the respective suspension and then based on it
  • magnetic particles contained in the suspension can be attracted until they come into contact with an outer surface of the soft magnetic tip and can then remove them frictionally or non-positively from the remaining suspension liquid.
  • the outer surface of the soft magnetic tip can be formed by the soft magnetic material itself or - depending on the requirements of the respective cleaning process - by a protective cover surrounding the immersion end of the soft magnetic tip.
  • the soft magnetic tip At its longitudinal end opposite the dipping end is that of the WO 02/40173 A1 known magnetic separating device coupled with an electromotive rotary drive, by means of which the soft magnetic tip can be rotated about its longitudinal axis.
  • the coupling of the soft magnetic tip with a rotary drive is for those from the WO 02/40173 A1 known magnetic separating device easily possible, since the state of magnetization of the tip changing electric ring magnet can interact without contact with the tip and so does not interfere with the rotary drive coupling.
  • the WO 02/40173 A1 By rotating the soft magnetic tip, the WO 02/40173 A1 the separation of the particles with the magnetized immersion end of the soft magnetic tip are supported.
  • the rotation can also be used to remove magnetic particles from the immersion end that have accumulated on the immersion end of the soft magnetic tip and removed from the suspension liquid together with the soft magnetic tip.
  • A1 known magnetic separating device Disadvantageous from the WO 02/40173 A1 known magnetic separating device is, on the one hand, its expansive construction space-demanding design, in which the soft magnetic tip and the electric ring magnet as the above-mentioned magnet arrangement are arranged coaxially and axially overlapping.
  • a further device in particular a further magnetic separating device, cannot therefore be brought closer to the known separating device than the radius of the electric ring magnet surrounding the soft magnetic tip.
  • the use of an electromagnet for the temporary magnetization of the soft magnetic tip can be questionable, especially if the electromagnet for magnetizing the soft magnetic tip is to be arranged axially overlapping with it in the direction of its longitudinal axis.
  • the electromagnet is thus arranged comparatively close to the suspension to be processed with the separating device. Since the electromagnet only provides its magnetic field when it is energized, the electromagnet heats up during operation of the magnetic separating device and thus at least the risk of thermal stress on the suspension to be processed, which can be disadvantageous for thermally sensitive ingredients in the suspension.
  • a magnetic separating device is known with a magnetic device that can be raised and lowered as well as rotatable.
  • a magnetic separation device which has a permanent magnet and a protective cover surrounding it.
  • the permanent magnet and the protective cover can be rotatable together about their longitudinal axis.
  • the effect of the magnetic field emanating from the permanent magnet can optionally be weakened by a screen arranged between the permanent magnet and the protective cover. For this purpose, the screen can be moved relative to the permanent magnet and the protective cover.
  • a magnetic separating device with a protective cover and a protective cover which can be inserted into the protective cover and pulled out of it is known.
  • the protective cover can be rotated around its longitudinal axis relative to the permanent magnet.
  • a magnetic separator called a "mixer bar” is known. This can be raised and lowered in combination and rotated around its lifting and lowering movement axis.
  • the object of the present invention is to further improve the functionality of the magnetic separation device mentioned at the beginning.
  • the magnetically soft tip can be rotated around the tip axis, centrifugal forces acting radially to the tip axis can be generated on the magnetically soft tip. By means of these centrifugal forces, magnetic particles adhering to the soft magnetic tip can be removed therefrom again and / or residual suspension liquid present on the magnetic particles adhering to the tip can be removed from the magnetic particles.
  • the speed at which the tip axis can be rotated is preferably adjustable or changeable.
  • the soft magnetic tip can then be rotatable when it is in its more strongly magnetized magnetization state, in which a higher magnetic force acts between the soft magnetic tip and magnetic particles adhering to it, so that by rotation of the soft magnetic tip suspension liquid from the magnetic particles adhering to the tip can be deposited.
  • a higher magnetic force acts between the soft magnetic tip and magnetic particles adhering to it, so that by rotation of the soft magnetic tip suspension liquid from the magnetic particles adhering to the tip can be deposited.
  • the soft magnetic tip can be rotatable in its weaker magnetized state of magnetization, wherein the weaker magnetized state of magnetization can in particular be a state of missing magnetization, that is to say a non-magnetized or demagnetized state.
  • the centrifugal forces caused by the rotation of the tip can outweigh those forces with which magnetic particles previously removed from a suspension adhere to the soft magnetic tip. If the weakly magnetized state of the soft magnetic tip is present, these can be weak magnetic forces and / or adhesive forces due to residual suspension fluid that is still present.
  • only one movement drive is provided for both movements, which is coupled to the magnet arrangement in a movement-transmitting manner in order to drive it to move towards the magnetization section and to move it away from it, as well as being coupled to the soft magnetic tip in a movement-transmitting manner in order to make it rotate to drive the top axis.
  • the magnetic separating device needs a single movement drive.
  • the transmission can be suitable for converting one type of movement of an output member of the movement drive into another type of movement of the movement desired by the magnet arrangement, for example converting a rotary movement of the output member into a translational movement of the magnet arrangement.
  • a preferred gear which fulfills the above requirements and additionally enables a radially slim design of the magnetic separating device with respect to the tip axis, is a screw drive.
  • a screw drive enables the implementation of rotary movement of an output element of a movement drive, such as an output shaft, and thus enables the use of spatially compact movement drives.
  • the screw drive can also be advantageous be designed to be self-locking, so that movement and force can only be introduced into the device from one side, in this case from the side of the movement drive.
  • a thread axis of a threaded component carrying a thread of the screw drive is collinear with the tip axis.
  • the screw drive can be designed in such a way to achieve the desired radially slim design already mentioned above and to reduce the components required to form the magnetic separating device that it has a threaded rod connected to the soft magnetic tip for common rotation, which penetrates the magnet arrangement
  • the Magnet arrangement can be coupled for common movement with a threaded nut of the screw drive or - preferably - is part of the threaded nut of the screw drive.
  • the magnet arrangement can, for example, have one or more ring-shaped permanent magnets, which are coupled radially on the inside for joint movement with a sleeve, on the inside of which an internal thread is formed.
  • the internal thread can be screw-engaged with the threaded rod.
  • the magnetic separating device can have a frame which is intended to serve as the origin of a coordinate system at rest for further discussion.
  • the movement drive usually rests relative to the frame.
  • the frame as a whole can, however, in turn be movable relative to a higher-level structure, for example to a machine carrying the magnetic separating device, for example in order to be able to lower the magnetic separating device into a suspension and to be able to lift it out of it.
  • a rotation prevention for example in the form of a link guide, which prevents relative rotation of the threaded nut about the threaded axis of the threaded rod, so that a rotation of the threaded rod reliably leads to a translational displacement of the threaded nut along the threaded axis.
  • the magnet arrangement is provided separately from the threaded nut and is coupled to it for common translational movement, although this is not preferred.
  • the soft magnetic tip can be coupled to the threaded rod for common rotation with the interposition of a further gear, "together” then being understood in a broad sense, according to which the soft magnetic tip rotates at least when the threaded rod rotates, is simple for the sake of simplicity , slim design preferred if the threaded rod is rigidly coupled to the soft magnetic tip for common rotation, so that the rotation of the tip and the rotation of the threaded rod coincide in terms of speed and direction and the tip only rotates when the threaded rod is set in rotation.
  • the tip axis runs in the direction of the action of gravity, to which the surface of the suspension into which the tip is lowered is naturally orthogonal. Then the movement of the magnet arrangement closer to the magnetically soft tip is usually supported by gravity, while the movement of the magnet assembly away from the magnet assembly must take place against the force of gravity in order to remove it from the magnetically soft tip.
  • the location of the maximum distance between the magnet arrangement and the tip can be determined by a mechanical stop against which the magnet arrangement is moved.
  • a stop to define this location can, however, mean a blockage of the rotatability of the threaded rod and thus usually also of the soft magnetic tip, if the magnet arrangement has reached the stop at the location of the maximum distance and the magnet arrangement should not be brought closer to the soft magnetic tip again.
  • the location of the maximum distance of the magnet arrangement can be defined in a simple manner by the threaded end of the threaded rod itself.
  • a mechanical end stop is therefore not required at the location of the maximum distance between the magnet arrangement and the tip.
  • the magnetic separating device is preferably designed such that the maximum distance of the magnet arrangement from the tip is defined by a threaded end of the threaded rod, with between the Threaded end and the movement drive a rod intermediate section is arranged on which the magnet arrangement is out of engagement with a threaded section of the threaded rod and remains at substantially the same distance from the soft magnetic tip even with continued rotation of the threaded rod in the distance sense.
  • the threaded nut of the screw drive and with it the magnet assembly are simply screwed out of the threaded area of the threaded rod, so that a further rotation of the threaded rod in the sense of removing the magnet assembly from the tip does not lead to any further removal movement of the threaded nut due to the lack of engagement between the threaded rod and the threaded nut .
  • the threaded rod can be made in one or more parts, for example comprising a threaded component with an external thread and an idle component with the above-mentioned intermediate rod section.
  • the threaded nut rests on the threaded end of the threaded rod remote from the tip, when the direction of rotation of the threaded rod changes, the screw engagement between the threaded rod and threaded nut can be restored and the threaded nut and with it the magnet arrangement can be brought closer to the soft magnetic tip again.
  • the thread axis of the threaded rod has a component in the direction of the action of gravity, preferably runs in the direction of the action of gravity.
  • a rod axis along which the threaded rod extends is collinear with the tip axis in order to achieve a separating device that is as slender as possible radially.
  • the rod axis coincides with the aforementioned threaded axis.
  • the point of maximum approach of the magnet arrangement to the tip can be formed by a stop against which the magnet arrangement rests in the more strongly magnetized state of the tip.
  • This stop can also be formed by a section, in particular the magnetization section, of the tip itself.
  • it can also be formed by an intermediate component which is arranged between the magnet arrangement and the soft magnetic tip.
  • an intermediate component is preferably at least partially made of soft magnetic material, preferably completely made of soft magnetic material.
  • a force- or torque-dependent coupling can be arranged in the torque transmission path between the movement drive and the magnet arrangement, which, for example, then prevents further torque transmission from the movement drive to the magnet arrangement in the approximation direction when the soft magnetic tip is maximally approximated to the magnet arrangement and the motion drive is operated in the direction of approach.
  • the clutch can be designed in such a way that it transmits force and / or torque to the threaded nut of the screw drive and / or to the magnet arrangement when the torque falls below a predetermined release torque and that it transfers no force and / or torque to the threaded nut or when the release torque is exceeded / and transfers to the magnet assembly.
  • the threaded rod and with it the tip can continue to rotate in the direction of approach when the end stop is reached at the site, when the magnet arrangement is as close as possible to the soft magnetic tip, without this causing a displacement of the threaded nut and, with it, the magnet arrangement in the approaching direction.
  • Such a coupling can, for example, be provided radially between the above-mentioned sleeve bearing an internal thread and the at least one annular permanent magnet of the magnet arrangement which surrounds this sleeve radially on the outside.
  • the clutch can be a slip clutch or the like.
  • the magnet arrangement is designed to be rotationally symmetrical at least in sections, preferably completely.
  • the magnet arrangement can bring about maximum magnetization when the soft magnetic tip is approached as closely as possible, so that the magnetic field of the magnet arrangement is the magnetic field that magnetizes the soft magnetic tip.
  • the magnetic field of the above-mentioned magnet arrangement is only a control magnetic field which weakens a magnetizing magnetic field of a further magnet arrangement to different degrees depending on the relative position of the first-mentioned movable magnet arrangement relative to the soft magnetic tip.
  • the magnetization of the soft magnetic tip is caused by the magnetic field of the further magnet arrangement, whose magnetic field can be influenced by the magnetic field of the first-mentioned movable magnet arrangement.
  • the magnetic separating device can comprise a second magnet arrangement which is permanently connected to the soft magnetic tip, wherein the magnet arrangement which can be approached and removed from the tip weakens the magnetic field of the second magnet arrangement more strongly in the state approached to the magnetization section than in the further from the tip distant state.
  • the second magnet arrangement is the above-mentioned further magnet arrangement.
  • the magnet arrangement which has been described so far alone and which can be approached and removed from the tip is referred to as the first magnet arrangement.
  • the permanent connection of the second magnet arrangement to the soft magnetic tip can then be advantageously designed for the intended magnetization of the soft magnetic tip, for example by the magnetization section of the soft magnetic tip surrounding the second magnet arrangement at its end section closest to the soft magnetic tip, preferably surrounding it in a pot-like manner.
  • the second magnet arrangement is also preferably configured to be rotationally symmetrical at least in sections, particularly preferably completely.
  • the second magnet arrangement also preferably extends along an arrangement axis, which is preferably its axis of rotational symmetry and which is collinear with the tip axis.
  • a desired radially slim configuration of the magnetic separating device can be achieved in that the second magnet arrangement penetrates the movable, that is to say the approachable and removable first magnet arrangement.
  • the second magnet arrangement is part of the threaded rod.
  • the second magnet arrangement as a cylinder bar magnet, can be surrounded by a radially outer cylindrical sleeve which has an external thread.
  • the external thread of the threaded rod directly on the second magnet arrangement, there are numerous for permanent magnets preferred materials are very brittle, so that a thread formation on the outside of a magnet arrangement should be associated with difficulties.
  • a possible weakening of the magnetic field of the second magnet arrangement depending on the relative position of the first magnet arrangement relative to the soft magnetic tip and thus also relative to the second magnet arrangement can be brought about that the first magnet arrangement and the second magnet arrangement are arranged coaxially with opposite polarization, with their respective magnetic Poles follow one another along the common axis of extension.
  • unlike poles of the first and second magnet arrangement are very close to each other in the position of closest approach of the first magnet arrangement to the soft magnetic tip, so that a magnetic return can be caused by the first magnet arrangement and thus only a small part of the magnetic field of the second magnet arrangement actually penetrates the soft magnetic tip.
  • the soft magnetic tip can have its magnetization state of greatest magnetization.
  • the magnetic separating device preferably has a separating device head with a plurality of soft magnetic tips, which all extend along a tip axis, the tip axes of the individual soft magnetic tips being arranged parallel to one another.
  • the soft magnetic tips are preferably arranged in the manner of a matrix in rows and columns, an orthogonal row and column system being preferred.
  • the magnetization state of at least some of the soft magnetic tips of the separator head can preferably be changed independently of another part of the soft magnetic tips.
  • This independent changeability of the magnetization state of soft magnetic tips in a separating device head can take place by individual movement of the magnet arrangement which can be approached and removed from the soft magnetic tip.
  • the magnetization state of each individual soft magnetic tip of the separating device head can preferably be changed independently of the magnetization state of each other soft magnetic tip.
  • the energization of individual movement drives can be effected in a simple and reliable manner by a corresponding control device, whereby the control device can also be designed to line or / or line soft magnetic tips of the separating device head. and to summarize column by column for a common change of the magnetization state.
  • the control device can change all soft magnetic tips of a row and / or a column by jointly controlling the respective movement drives of the movable magnet arrangements in the same sense and at the same time.
  • Such magnetic separating devices can advantageously be provided on a pipetting device, in which case at least one pipetting channel of the pipetting device is replaced by a separating device as described above.
  • a separating device that is as slender as possible in the radial direction allow the magnetic separating device of the present invention to be designed with a radial installation space requirement which does not exceed that of a pipetting channel in a pipetting device.
  • Preferred has a like Separating device formed as described above has a radial extension of less than 20 mm, preferably of not more than 18 mm.
  • the soft magnetic tip can be bare metal or can have a coating.
  • the coating can be permanently connected to the magnetic tip or can be detachably provided on the latter.
  • the movement drive of the movable magnet arrangement is preferably provided at the greatest possible distance from the soft magnetic tip, and in particular from its immersion end, of the respective separating device.
  • the first and / or the second magnet arrangement is therefore preferably arranged between the movement drive and the soft magnetic tip.
  • the effect of the heat source provided by the preferred electromagnetic movement drive on the suspension to be processed is negligible not only because the movement drive is as far away as possible from the immersion end of the soft magnetic tip, but also because the movement drive only lasts for the duration of the change in the state of magnetization the soft magnetic tip needs to be energized, but not for the duration of the magnetization state itself.
  • FIG. 1 and 2 an embodiment according to the invention of a magnetic separating device with a mechanical drive is generally designated by 10.
  • the separating device 10 extends along a device axis V, which is preferably oriented parallel to the direction of the action of the force of gravity when it is arranged in accordance with its intended use and operation.
  • a container 12 in which a suspension 14 (see Figures 1b and 2 B ) is added, in which magnetic particles are suspended in a suspension liquid for the purpose of biochemical analysis.
  • the magnetic separating device 10 comprises, in a manner known per se, a soft magnetic tip 16 which extends along a tip axis S which runs collinear with the device axis V.
  • the soft magnetic tip has a longitudinal end 16a which is closer to the container 12 during normal operation and which is an immersion end 16a of the tip 16, since the tip 16 is immersed with this immersion end 16a in the suspension 14, and then with sufficient magnetization the tip 16 to remove magnetic particles from the suspension 14.
  • the magnetic particles of the suspension 14 are thereby attracted by the increased magnetization of the soft magnetic tip 16 and can be removed from the suspension 14 with the tip 16 adhering to the magnetic forces acting on the magnetic particles.
  • the soft magnetic tip 16 can be encased in a protective sheath 18 detachably surrounding the tip 16.
  • the protective cover 18 can be formed from plastic or from a generally non-magnetic metal.
  • the longitudinal end 16b of the tip 16 opposite the immersion end 16a forms a magnetization section 16b of the soft magnetic tip, since - as will be described in detail below - the temporary magnetization of the tip 16 is effected via this section 16b or this longitudinal end.
  • the magnetization section 16b is surrounded by a coupling component 20 which projects beyond the longitudinal end 16b axially with respect to the device axis V away from the immersion end 16a.
  • the coupling component 20 couples the soft magnetic tip 16 for common rotation with a drive component 24, the longitudinal end 14a of which, which is closer to the tip, is also surrounded by the coupling component 20.
  • the drive component 24 has a stub shaft section 24b, which is used for coupling to an in the Figures 1 and 2 drive motor, not shown, is formed.
  • the stub shaft section 24b has an axial recess 26 into which a feather key for torque transmission from a hub to a Figures 1 and 2 Drive motor, not shown, can be inserted in order to transmit torque in a form-fitting manner to the stub shaft section 24b and thus to the drive component 24.
  • the drive component 24 is formed in one piece in the example shown, but this does not have to be the case.
  • a section 24c of the drive component 24 is provided with an external thread 28 and forms a threaded rod section.
  • the threaded rod section 24c axially directly adjoining it, there is an intermediate rod section 24d free of external threads.
  • the threaded rod section 24c and the intermediate rod section 24d preferably have a smaller diameter than the shaft stub section 24b.
  • the drive component 24 extends along a component axis B, which is also collinear with the device axis V. With the exception of the feather key recess 26 and the external thread 28, the drive component 24 is preferably designed to be rotationally symmetrical with respect to the device axis V.
  • the coupling component 20 is preferably also designed to be rotationally symmetrical to the device axis V.
  • the coupling component 20 can connect the tip 16 and the drive component 24, for example, by a press fit of the two components in the central recess of the coupling component 20 for common rotation about the device axis V.
  • the drive component 24 passes through a threaded nut 30, which is coupled to a permanent magnet arrangement 32 for joint movement, for example by gluing.
  • This positive engagement of the nose 30a in the elongated hole recess 34 prevents the threaded nut 30 from rotating about the device axis V, so that when the drive component 24 rotates, the threaded nut 30 and with it the permanent magnet arrangement 32 connected to it for joint movement safely translationally along the device axis V over the area of the threaded rod portion 24c are displaceable away.
  • the threaded nut 30 and the coupling component 20, like the soft magnetic tip 16 in the example shown, are made of soft magnetic material.
  • the drive component is preferably non-magnetic.
  • the threaded nut 30 and with it the permanent magnet arrangement 32 is arranged at its location closest to the tip 16, the threaded nut 30, which is permanently in touch contact with the permanent magnet arrangement 32, is in touch contact with the coupling component 20, which in turn is due to the above-mentioned press fit is in physical contact with the magnetization section 16b of the soft magnetic tip 16.
  • the soft magnetic tip 16 is therefore magnetized by the permanent magnet arrangement 32 or by the magnetic field emanating from it. It is at least more magnetized than the one in the Figures 2a and 2b shown state of the device 10, in which the permanent magnet arrangement 32 is located at its location furthest away from the tip 16.
  • the coupling component 20 can form a mechanical end stop for the threaded nut 30 or for a jointly movable arrangement of threaded nut 30 and permanent magnet arrangement 32. Then when the threaded nut 30 on the coupling component 20, as in Figure 1b shown, is applied, a further rotation of the drive component 24 in a direction of approach of the threaded nut 30 to the soft magnetic tip 16 is impossible, since the threaded nut 30 is already as close as possible to the tip 16.
  • the soft magnetic tip 16 can only be rotated if the drive component 24 is rotated in a removal direction in which the threaded nut 30 is removed from the tip 16 along the device axis V.
  • the threaded nut 30 can have a torque-dependent clutch, for example a slip clutch or the like, which allows the drive component 24 to continue turning in the direction of approach even when the threaded nut 30 is in contact with the end stop formed by the coupling component 20 and is as close as possible to the tip 16.
  • a torque-dependent clutch for example a slip clutch or the like
  • the magnetic separating device 10 is shown with a demagnetized tip 16 or with a weaker magnetized tip 16.
  • the drive component 24 is rotated about the device axis V in the distance direction until the gear nut 30 has been moved axially out of the threaded rod section 24c and is therefore no longer in screw engagement with the threaded rod section 24c.
  • the drive component 24 can be rotated further in the distance sense without the threaded nut 30 and, with it, the permanent magnet arrangement 32 being displaced further away from the soft magnetic tip 16.
  • the magnetic separating device 10 thus allows a radially extremely slim design which is suitable for an arrangement of several separating devices 10 in a matrix structure with parallel device axes V. Furthermore, the magnetic separating device 10 not only allows the targeted change of the magnetization state of the soft magnetic tip 16 between a more strongly magnetized state and a less strongly or not at all magnetized state, but also allows a rotation of the soft magnetic tip 16 about its tip axis S, which coincides with the device axis V coincides.
  • a further permanent magnet arrangement 40 ′ can be accommodated in this coaxially with the threaded rod section 24c.
  • the coupling section 24a of the drive component 24 is preferably made of soft magnetic material in order to achieve a magnetic closure of the second permanent magnet arrangement 40 'via the coupling longitudinal end 24a and the coupling component 20 with the magnetization section 16b.
  • the coupling portion 24a touches preferably the magnetization section 16b at the end face, so that there is also a direct magnetic connection between these components.
  • the coupling section 24a made of soft magnetic material therefore extends as far as the second permanent magnet arrangement 40 'and is in physical contact with it.
  • the entire threaded rod section 24c or even the entire drive component 24 is preferably formed from soft magnetic material.
  • both the permanent magnet arrangement 32 which is then to be referred to as the first permanent magnet arrangement
  • the second permanent magnet arrangement 40 ′ are magnetized in such a way that their magnetic poles follow one another along the device axis V.
  • the polarization directions of the two permanent magnet arrangements 32 and 40 ' are directed exactly in opposite directions.
  • the first permanent magnet arrangement 32 weakens in the in Figure 1b The position shown maximally approximating the tip 16, the magnetic field of the second permanent magnet arrangement 40 'in the area of its pole end closest to the tip 16 by field closure.
  • the unlike pole of the first permanent arrangement 32 which then lies close to the pole of the second permanent arrangement 40 'in the magnetization section 16b, provides a magnetic return path for the magnetic field emanating from the pole of the second permanent arrangement 40'.
  • the magnetization section 16b of the tip 16 is thus penetrated to a lesser extent by the magnetic field of the second permanent arrangement 40 'than when the first permanent magnet arrangement 32 is arranged further away from the magnetization section 16b.
  • the soft magnetic tip is then less strongly magnetized than if the permanent magnet arrangement 32 is arranged further away from the soft magnetic tip 16, in particular is arranged at a maximum distance, as shown in FIG Figure 2b is shown.
  • both a rotation of the soft magnetic tip 16 about the device axis V and a displacement movement of the permanent magnet arrangement 32 for the purpose of changing the magnetization state are possible the soft magnetic tip 16 possible by a single movement drive.

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  • Transmission Devices (AREA)
  • Finish Polishing, Edge Sharpening, And Grinding By Specific Grinding Devices (AREA)

Claims (16)

  1. Dispositif de séparation magnétique (10) pour séparer des particules magnétiques d'une suspension (14), comprenant une pointe magnétique douce (16) s'étendant le long d'un axe de pointe (S), l'état de magnétisation de la pointe (16) pouvant être changé sélectivement entre un état plus fortement magnétisé et un état moins fortement magnétisé, la pointe (16) ayant une extrémité d'immersion (16a) pour l'insertion dans la suspension (14) et une section de magnétisation (16b) pour changer l'état de magnétisation de la pointe (16) dans lequel le dispositif de séparation (10) comprend un entraînement de mouvement et un ensemble d'aimants (32) en connexion de transmission de mouvement avec celui-ci, qui comprend au moins un aimant permanent ou est formé d'au moins un aimant permanent et qui peut être approché et retiré de la section de magnétisation (16b) par l'entraînement de mouvement de sorte que le champ magnétique de l'ensemble d'aimants (32) dans la section de magnétisation (16b) de la pointe (16) est variable dans le temps pour changer l'état de magnétisation de la pointe (16), dans lequel la pointe magnétique douce (16) est rotative autour de l'axe de la pointe (S), dans lequel l'entraînement de mouvement est à la fois couplé par transmission de mouvement à l'ensemble d'aimants (32) pour l'entraîner à se rapprocher et à s'éloigner de la section de magnétisation (16) et couplé par transmission de mouvement à la pointe magnétique douce (16) pour l'entraîner à tourner autour de l'axe de pointe (S).
  2. Dispositif de séparation magnétique (10) selon la revendication 1,
    caractérisé en ce que ladite pointe magnétique douce (16) est rotative dans son état moins magnétisé.
  3. Dispositif de séparation magnétique (10) selon l'une des revendications précédentes,
    caractérisé en ce que l'ensemble d'aimants (32) est couplé de manière à transmettre le mouvement à l'entraînement de mouvement au moyen d'un engrenage (24c, 30), dont une partie d'engrenage (24c) est couplée de manière à transmettre le mouvement à la pointe (16).
  4. Dispositif de séparation magnétique (10) selon la revendication 3,
    caractérisé en ce que l'engrenage (24c, 30) est un engrenage fileté (24c, 30).
  5. Dispositif de séparation magnétique (10) selon la revendication 4,
    caractérisé en ce que l'engrenage fileté (24c, 30) comprend une tige filetée (24c) connectée pour une rotation commune avec la pointe magnétique douce (16) passant à travers l'ensemble d'aimants (32), l'ensemble d'aimants (32) étant connecté pour un mouvement commun avec un écrou fileté (30) de l'engrenage fileté (24c, 30), faisant de préférence partie de l'écrou fileté (30) de l'engrenage fileté (24c, 30).
  6. Dispositif de séparation magnétique (10) selon la revendication 5,
    caractérisé en ce que la distance maximale de l'ensemble d'aimants (32) par rapport à la pointe (16) est définie par une extrémité filetée de la tige filetée (24c), dans lequel une partie de tige intermédiaire (24d) est disposée entre l'extrémité filetée et l'entraînement de mouvement, à laquelle l'ensemble d'aimants (32) est désengagé d'une partie filetée (24c) de la tige filetée (24c) et reste sensiblement à la même distance de la pointe magnétique douce (16) même avec une rotation continue de la tige filetée (24c) dans la direction de retrait.
  7. Dispositif de séparation magnétique (10) selon l'une quelconque des revendications 4 à 6,
    caractérisé en ce que ladite tige filetée (24c) s'étend selon un axe de tige (V) qui est colinéaire avec ledit axe de pointe (S).
  8. Dispositif de séparation magnétique (10) selon l'une quelconque des revendications précédentes,
    caractérisé en ce que l'approche maximale de l'ensemble d'aimants (32) de la pointe (16) est formée par une butée (20) contre laquelle l'ensemble d'aimants (32) vient en butée dans l'état plus magnétisé de la pointe (16).
  9. Dispositif de séparation magnétique (10) selon la revendication 8,
    caractérisé en ce que, lorsque l'ensemble d'aimants (32) est empêché de poursuivre son mouvement d'approche en s'appuyant sur la butée (20), l'entraînement de mouvement est bloqué pour la poursuite du fonctionnement dans le sens de l'approche ou un couplage dépendant de la force ou du couple dans la voie de transmission de la force ou du couple entre l'entraînement de mouvement et l'ensemble d'aimants (32) empêche la poursuite de la transmission du couple dans le sens de l'approche.
  10. Dispositif de séparation magnétique (10) selon l'une des revendications précédentes,
    caractérisé en ce que l'ensemble d'aimants (32) est symétrique en rotation au moins par sections, de préférence complètement.
  11. Dispositif de séparation magnétique (10) selon l'une des revendications précédentes,
    caractérisé en ce qu'il comprend un deuxième ensemble d'aimants (40') qui est relié en permanence à la pointe magnétique douce (16), dans lequel l'ensemble d'aimants (32), qui peut être rapproché de la pointe (16) et retiré de la pointe (16), affaiblisse le champ magnétique du deuxième ensemble d'aimants (40') plus fortement dans l'état rapproché de la section de magnétisation (16b) que dans l'état plus éloigné de la pointe (16).
  12. Dispositif de séparation magnétique (10) selon la revendication 11,
    caractérisé en ce que le deuxième ensemble d'aimants (40') passe à travers l'ensemble d'aimants approchable et amovible (32).
  13. Dispositif de séparation magnétique (10) selon la revendication 11 ou 12, caractérisé en ce que le deuxième dispositif magnétique (40') est formé avec l'axe de pointe (S) comme axe de symétrie de rotation au moins dans des sections à symétrie de rotation, dans lequel de préférence le deuxième dispositif magnétique (40') fait partie de la tige filetée (24c).
  14. Dispositif de séparation magnétique (10) selon l'une quelconque des revendications 11 à 13,
    caractérisé en ce que l'ensemble d'aimants approchable et amovible (32) et le deuxième ensemble d'aimants (40') sont disposés coaxialement avec une polarisation opposée, leurs pôles magnétiques respectifs se suivant le long de l'axe d'extension commun (V).
  15. Dispositif de pipetage comprenant au moins un dispositif de séparation magnétique (10) selon l'une quelconque des revendications 1 à 14 à la place d'un canal de pipetage.
  16. Dispositif de traitement de liquide comprenant une pluralité de dispositifs de séparation magnétiques (10) selon les revendications 1 à 14, dans lequel la pluralité de dispositifs de séparation (10) sont pourvus d'axes de pointe parallèles (S) disposés à la manière d'une grille, chaque dispositif de séparation (10) ayant son propre entraînement de mouvement qui peut être actionné séparément des entraînements de mouvement des autres dispositifs de séparation.
EP16766295.6A 2015-09-18 2016-09-15 Dispositif de séparation magnétique à activation et désactivation mécanique Active EP3349910B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102015218008.5A DE102015218008A1 (de) 2015-09-18 2015-09-18 Magnetische Trennvorrichtung mit mechanischer Aktivierung und Deaktivierung
PCT/EP2016/071805 WO2017046235A1 (fr) 2015-09-18 2016-09-15 Dispositif de séparation magnétique à activation et désactivation mécanique

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EP3349910B1 true EP3349910B1 (fr) 2021-11-17

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Publication number Priority date Publication date Assignee Title
US20190022667A1 (en) * 2016-01-19 2019-01-24 Shanxi Zdgsy Bio-Scientific Co., Ltd. Multifunctional biological substance separation device
CN114534911B (zh) * 2022-02-25 2024-04-09 奥星制药设备（石家庄）有限公司 一种磁性分离器及清洗方法

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EP2033715B1 (fr) * 2007-08-14 2010-06-23 Qiagen GmbH Procédé destiné à suspendre ou resuspendre des particules dans une solution et dispositif adapté
US20150225714A1 (en) * 2012-06-07 2015-08-13 Hitachi High-Technologies Corporation Kit for nucleic acid extraction and a nucleic acid extractor

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FR2554016B1 (fr) * 1983-10-27 1986-08-08 Pasteur Institut Perfectionnements apportes aux moyens magnetiques destines a retirer des billes de gel magnetique d'un fluide de dosage
SE8601143L (sv) * 1986-03-12 1987-09-13 Carbematrix Ab Sett och anordning for samling och spridning av ferromagnetiska partiklar i ett fluidformigt medium
DE4421058A1 (de) * 1994-06-16 1995-12-21 Boehringer Mannheim Gmbh Verfahren zur magnetischen Abtrennung von Flüssigkeitskomponenten
DE10057396C1 (de) 2000-11-18 2002-04-04 Karlsruhe Forschzent Verfahren zum Abtrennen eines dispergierten oder gelösten Stoffes und Magnetseparator
FI120863B (fi) * 2002-10-18 2010-04-15 Biocontrol Systems Inc Magneettinen siirtomenetelmä ja mikropartikkelien siirtolaite
US7799281B2 (en) 2007-01-16 2010-09-21 Festo Corporation Flux concentrator for biomagnetic particle transfer device

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EP2033715B1 (fr) * 2007-08-14 2010-06-23 Qiagen GmbH Procédé destiné à suspendre ou resuspendre des particules dans une solution et dispositif adapté
US20150225714A1 (en) * 2012-06-07 2015-08-13 Hitachi High-Technologies Corporation Kit for nucleic acid extraction and a nucleic acid extractor

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DE102015218008A1 (de) 2017-03-23
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