EP2825218A1 - Structure plane antibactérienne destinée à être utilisée comme pansement et procédé de fabrication de ladite structure plane - Google Patents

Structure plane antibactérienne destinée à être utilisée comme pansement et procédé de fabrication de ladite structure plane

Info

Publication number
EP2825218A1
EP2825218A1 EP13706010.9A EP13706010A EP2825218A1 EP 2825218 A1 EP2825218 A1 EP 2825218A1 EP 13706010 A EP13706010 A EP 13706010A EP 2825218 A1 EP2825218 A1 EP 2825218A1
Authority
EP
European Patent Office
Prior art keywords
wound dressing
fabric
suspension
sheet
usable
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP13706010.9A
Other languages
German (de)
English (en)
Inventor
Marco WOLFSTÄDTER
Birgit Schäfer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aap Implantate AG
Original Assignee
Aap Biomaterials GmbH and Co KG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aap Biomaterials GmbH and Co KG filed Critical Aap Biomaterials GmbH and Co KG
Publication of EP2825218A1 publication Critical patent/EP2825218A1/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/04—Macromolecular materials
    • A61L31/043—Proteins; Polypeptides; Degradation products thereof
    • A61L31/044—Collagen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
    • A61L26/0028—Polypeptides; Proteins; Degradation products thereof
    • A61L26/0033—Collagen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/38—Silver; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
    • A61L15/32—Proteins, polypeptides; Degradation products or derivatives thereof, e.g. albumin, collagen, fibrin, gelatin
    • A61L15/325—Collagen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42—Use of materials characterised by their function or physical properties
    • A61L15/46—Deodorants or malodour counteractants, e.g. to inhibit the formation of ammonia or bacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/16—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/10—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing inorganic materials
    • A61L2300/102—Metals or metal compounds, e.g. salts such as bicarbonates, carbonates, oxides, zeolites, silicates
    • A61L2300/104—Silver, e.g. silver sulfadiazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/70—Nanostructure
    • Y10S977/773—Nanoparticle, i.e. structure having three dimensions of 100 nm or less

Definitions

  • the invention relates to a usable as a wound dressing sheet with antibacterial properties.
  • the invention relates to a metal-containing collagen material.
  • the silver salts used have the disadvantage that in many cases immediately after the application of the fabric to the wound, rapid release of almost all the silver occurs, resulting in undesirably high toxic concentrations in the vicinity of the wound dressing and, secondly, the Effect does not last long.
  • the object of the invention is to produce a fabric which can be used as a wound dressing, in which the aforementioned disadvantages of the prior art are reduced. In particular, the release of the metal atoms should be improved.
  • the object of the invention is already achieved by a method for producing a wound dressing
  • the invention relates to a method for producing a fabric usable as a wound dressing.
  • Such material is characterized in that it is applied to a wound and has a hemostatic effect.
  • films, sponges or fleece-like materials can be used.
  • the fabric is made of a liquid
  • Starting material which means that in the manufacture of the fabric in at least one
  • the starting material or precursor is liquid. It can be a suspension or a solution.
  • EP 2 089 255 A2 (AAP Biomaterials GmbH) describes a process for producing a porous collagen material.
  • a suspension is prepared from the wet-chemically processed and mechanically comminuted skin of mammals.
  • This suspension forms the liquid starting material in the context of the invention.
  • collagen materials from atelocollagen which are first dissolved in water. By drying the solution, a collagen-containing sheet can be produced.
  • the invention also relates, however, also to alternative materials produced by polymerization.
  • a suspension containing elemental metal particles ie metal particles in non-ionic form, is added to the liquid outer material.
  • these metal particles are incorporated into the fabric in elemental form.
  • the metals are present as ions. Due to a small particle size can be a big effective
  • Particularly suitable metals are silver, gold, zinc and / or copper.
  • silver is used.
  • suspension with metal particles having an average particle size between 10 nm and 10 microns is used.
  • nanoparticles having an average particle size of less than 50 nm are used.
  • the metal particle-containing suspension is preferably stabilized with a stabilizer such that the metal particles remain suspended over a sufficiently long period of time.
  • these particles can at least partially be present as agglomerates.
  • the sheet is dried by drying the starting material at a temperature above the freezing point of the
  • a material with a closed porosity of less than 50%, preferably less than 20%, has the advantage of that the metal particles are kept better in this, which slows down the delivery.
  • Collagen material can be used. This material is highly porous and very flexible and is preferable to a low porosity material, depending on the application. In one embodiment of the invention that is
  • the sheet may have a thickness between 0.05 and 2.00 mm, preferably between 0.1 and 1.00 mm.
  • the metal particle-containing suspension is metered in such a way that a sheet with a proportion of metal particles between 10 and 100,000 ppm, preferably between 100 and 10,000 ppm is provided.
  • Fig. 1 shows a flowchart of a method for
  • pork skin becomes alkaline and oxidative
  • the starting material is alternately immersed and then washed out.
  • the wet-chemical purified pig skin is acidified.
  • phosphoric acid is preferably used, or another acid such as e.g. Hydrochloric or acetic acid.
  • the pig skin is first mechanically comminuted by means of grinding and then an aqueous suspension is prepared from the slurry formed by further comminution steps.
  • this suspension has a solids content of between 0.5 and 5%.
  • the aqueous suspension is then adjusted to a neutral to slightly basic pH of 6.5 to 8.5 by addition of a phosphate buffer.
  • a nanosilver-containing aqueous suspension is added.
  • a suspension should be used which is stable over a longer period of time.
  • the metal is not called salt, but as
  • the addition of the suspension containing nanosilver can be carried out with the aid of suitable dispersing aids, for example in an ultrasonic bath or a mill according to the rotor-stator principle.
  • the suspension is dried in trays at a temperature of over 20 ° Celsius under vacuum.
  • the collagen settles predominantly as a foil-like structure on the shell bottom, wherein a large part of the silver particles are fixed in the resulting material.
  • the dried fabric can be packaged and sterilized.
  • the sterilization can be carried out, for example, with ethylene oxide, in addition cross-linking can be brought about that increase the stability of the resulting material.
  • the produced material rehydrates very quickly, has a good hemostatic effect and is also foldable in the dry state, rollable and easy to cut.
  • the material is at least so translucent that the applied material, the underlying tissue lets recognize. Under the fabric forming complications such as inflammation can be well recognized.
  • the material is less prone to sticking and can be removed more easily.
  • Fig. 2 shows a scanning electron micrograph of a usable as a wound dressing sheet containing about 1000 ppm of nanosilver.
  • Emulsifier is stabilized, so that the silver particles in the liquid precursor evenly distributed.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Materials Engineering (AREA)
  • Medicinal Chemistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Hematology (AREA)
  • Surgery (AREA)
  • Inorganic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Materials For Medical Uses (AREA)

Abstract

L'invention concerne une structure plane destinée à être utilisée comme un pansement et contenant des particules métalliques élémentaires.
EP13706010.9A 2012-03-13 2013-02-26 Structure plane antibactérienne destinée à être utilisée comme pansement et procédé de fabrication de ladite structure plane Withdrawn EP2825218A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE201210004841 DE102012004841A1 (de) 2012-03-13 2012-03-13 Antibakterielles, als Wundauflage verwendbares Flächengebilde und Verfahren zu dessen Herstellung
PCT/EP2013/053764 WO2013135478A1 (fr) 2012-03-13 2013-02-26 Structure plane antibactérienne destinée à être utilisée comme pansement et procédé de fabrication de ladite structure plane

Publications (1)

Publication Number Publication Date
EP2825218A1 true EP2825218A1 (fr) 2015-01-21

Family

ID=47749842

Family Applications (1)

Application Number Title Priority Date Filing Date
EP13706010.9A Withdrawn EP2825218A1 (fr) 2012-03-13 2013-02-26 Structure plane antibactérienne destinée à être utilisée comme pansement et procédé de fabrication de ladite structure plane

Country Status (4)

Country Link
US (1) US10478521B2 (fr)
EP (1) EP2825218A1 (fr)
DE (1) DE102012004841A1 (fr)
WO (1) WO2013135478A1 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101804953B1 (ko) * 2015-12-29 2017-12-06 영남대학교 산학협력단 바이오 패치 및 그 제조방법

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3800792A (en) * 1972-04-17 1974-04-02 Johnson & Johnson Laminated collagen film dressing
US4294241A (en) * 1977-06-09 1981-10-13 Teruo Miyata Collagen skin dressing
US5110604A (en) * 1988-06-30 1992-05-05 Collagen Corporation Processes for producing collagen matrixes and methods of using same
US5785983A (en) * 1991-05-23 1998-07-28 Euroresearch Srl Non-porous collagen sheet for therapeutic use, and the method and apparatus for preparing it
US5331092A (en) 1992-11-06 1994-07-19 Coletica Process of preparation of collagen containing in major proportion insoluble collagen and collagen having high mechanical resistance and thermal stability obtained thereby
US20030035786A1 (en) * 1999-11-04 2003-02-20 Medtronic, Inc. Biological tissue adhesives, articles, and methods
EP1313372B1 (fr) * 2000-08-22 2005-06-01 Chitoproducts Limited Preparation d'articles a propriete de contact biocide
ES2313031T3 (es) * 2003-06-20 2009-03-01 JOHNSON & JOHNSON MEDICAL LTD. Antimicrobianos que comprenden plata.
DE102004031955A1 (de) * 2004-06-24 2006-01-12 Paul Hartmann Ag Wundauflage
DE102005044360A1 (de) * 2005-09-09 2007-03-15 Aesculap Ag & Co. Kg Antimikrobielles medizintechnisches Produkt, Verfahren zu seiner Herstellung und Verwendung
GB0712287D0 (en) * 2007-06-22 2007-08-01 Ucl Business Plc Antimicrobial Conjugates
ATE464916T1 (de) * 2006-11-06 2010-05-15 Lohmann & Rauscher Gmbh & Co Kg Produkt zur versorgung von entzündungen, druckstellen und/oder aphten im oralbereich sowie verwendung eines solchen produkts
DE102006053563B4 (de) 2006-11-14 2022-05-12 Mercedes-Benz Group AG Gurtstraffer für ein Sicherheitsgurtsystem
DE202008008627U1 (de) * 2008-03-07 2009-07-23 Aap Biomaterials Gmbh & Co. Kg Implantat zur Wundabdeckung
DE102008062824A1 (de) * 2008-12-23 2010-07-01 Paul Hartmann Ag Wundauflage
DE102009053305A1 (de) * 2009-11-12 2011-08-18 medichema GmbH, 09112 Verfahren zur Herstellung einer schichtförmigen Wundauflage
DE102009059276A1 (de) * 2009-12-22 2011-06-30 Rent-a-Scientist GmbH, 93059 Formulierung mit Metallnanopartikel
PL2654429T3 (pl) * 2010-12-21 2018-12-31 Aap Implantate Ag Sposób wytwarzania zawiesiny zawierającej nanocząstki srebra oraz zastosowanie mieszaniny zawierającej nanocząstki srebra jako środka powlekającego
DE102012004842A1 (de) * 2012-03-13 2013-09-19 Aap Biomaterials Gmbh Kollagenhaltiges Flächengebilde

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
None *
See also references of WO2013135478A1 *

Also Published As

Publication number Publication date
US20150125512A1 (en) 2015-05-07
DE102012004841A1 (de) 2013-09-19
US10478521B2 (en) 2019-11-19
WO2013135478A1 (fr) 2013-09-19

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