EP2738559B1 - Verfahren zum vorübergehenden Betrieb eines automatischen Analysegeräts in einem Bereitschaftsmodus - Google Patents

Verfahren zum vorübergehenden Betrieb eines automatischen Analysegeräts in einem Bereitschaftsmodus Download PDF

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Publication number
EP2738559B1
EP2738559B1 EP12194558.8A EP12194558A EP2738559B1 EP 2738559 B1 EP2738559 B1 EP 2738559B1 EP 12194558 A EP12194558 A EP 12194558A EP 2738559 B1 EP2738559 B1 EP 2738559B1
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EP
European Patent Office
Prior art keywords
control unit
analysis device
central control
standby
automated analysis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
EP12194558.8A
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German (de)
English (en)
French (fr)
Other versions
EP2738559A1 (de
Inventor
Dirk Bugner
Markus Preidel
Klaus Proch
Holger Pufahl
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Siemens Healthcare Diagnostics Products GmbH
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Siemens Healthcare Diagnostics Products GmbH
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Filing date
Publication date
Application filed by Siemens Healthcare Diagnostics Products GmbH filed Critical Siemens Healthcare Diagnostics Products GmbH
Priority to ES12194558T priority Critical patent/ES2777893T3/es
Priority to EP12194558.8A priority patent/EP2738559B1/de
Priority to JP2013245014A priority patent/JP6214360B2/ja
Priority to US14/092,878 priority patent/US9430025B2/en
Publication of EP2738559A1 publication Critical patent/EP2738559A1/de
Application granted granted Critical
Publication of EP2738559B1 publication Critical patent/EP2738559B1/de
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    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06F—ELECTRIC DIGITAL DATA PROCESSING
    • G06F1/00—Details not covered by groups G06F3/00 - G06F13/00 and G06F21/00
    • G06F1/26—Power supply means, e.g. regulation thereof
    • G06F1/32—Means for saving power
    • G06F1/3203—Power management, i.e. event-based initiation of a power-saving mode
    • G06F1/3234—Power saving characterised by the action undertaken
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/00584—Control arrangements for automatic analysers
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06F—ELECTRIC DIGITAL DATA PROCESSING
    • G06F1/00—Details not covered by groups G06F3/00 - G06F13/00 and G06F21/00
    • G06F1/26—Power supply means, e.g. regulation thereof
    • G06F1/32—Means for saving power
    • G06F1/3203—Power management, i.e. event-based initiation of a power-saving mode
    • G06F1/3206—Monitoring of events, devices or parameters that trigger a change in power modality
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06F—ELECTRIC DIGITAL DATA PROCESSING
    • G06F1/00—Details not covered by groups G06F3/00 - G06F13/00 and G06F21/00
    • G06F1/26—Power supply means, e.g. regulation thereof
    • G06F1/32—Means for saving power
    • G06F1/3203—Power management, i.e. event-based initiation of a power-saving mode
    • G06F1/3234—Power saving characterised by the action undertaken
    • G06F1/3293—Power saving characterised by the action undertaken by switching to a less power-consuming processor, e.g. sub-CPU
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02D—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN INFORMATION AND COMMUNICATION TECHNOLOGIES [ICT], I.E. INFORMATION AND COMMUNICATION TECHNOLOGIES AIMING AT THE REDUCTION OF THEIR OWN ENERGY USE
    • Y02D10/00—Energy efficient computing, e.g. low power processors, power management or thermal management

Definitions

  • the invention is in the field of in-vitro diagnostics and relates to an automatic analysis device and a method for the temporary, energy-saving operation of the analysis device in a standby mode, the analysis device comprising a central control unit and a standby control unit.
  • Today's analyzers are able to perform a variety of different detection reactions and analyzes on a variety of samples.
  • Current analysis devices such as those used in the clinical laboratory or in blood banks, usually comprise an area for the supply of sample vessels which contain the primary samples to be analyzed.
  • a transport system is usually provided, which first transports the sample vessels to a sample identification device, which records sample-specific information that is attached to a sample vessel and forwards it to a storage unit.
  • the sample vessels are then transported to a sampling station. With the aid of a sample pipetting device, at least one aliquot of the sample liquid is removed from a sample vessel and transferred to a reaction vessel.
  • the reaction vessels are usually disposable cuvettes that are kept in stock in a cuvette container in the analysis device and that are automatically transferred from the storage container to defined receiving positions. However, there are also devices in which the cuvettes are used several times by washing them before the next use.
  • the reagents which are required for the provision of various types of test-specific reaction batches, are located in reagent containers which are stored in a reagent station. The reagent containers are fed to the analyzer either automatically or manually.
  • the reagent station usually has a cooling unit to ensure the longest possible shelf life of the reagents.
  • An aliquot of one or more reagents is transferred into a reaction vessel, in which the sample to be examined is already located, with the aid of a reagent pipetting device, which moreover often has a heating device.
  • a reagent pipetting device which moreover often has a heating device.
  • a differently long incubation time of the reaction mixture may be necessary.
  • the reaction vessel with the reaction mixture is finally fed to a measuring system that measures a physical property of the reaction mixture.
  • Measuring systems based on photometric (eg turbidimetric, nephelometric, fluorometric or luminometric) or radiometric measuring principles are particularly widespread. These methods enable the qualitative and quantitative detection of analytes in liquid samples without having to provide additional separation steps.
  • the determination of clinically relevant parameters, such as the concentration or the activity of an analyte is often carried out by mixing an aliquot of a patient's body fluid simultaneously or in succession with one or more test reagents in the reaction vessel, which triggers a biochemical reaction which causes a measurable change in an optical property of the test mixture.
  • the measurement result is in turn forwarded by the measurement system to a storage unit and evaluated.
  • the analyzer then delivers to a user via an output medium, such as a monitor, a printer or a network connection sample-specific measured values.
  • an automatic analyzer has a variety of other components, such as stepper motors for driving pipetting devices, cuvette grippers or other moving devices, temperature sensors, pressure sensors, motion sensors, liquid level detectors, heating elements, fans, light sources and many more.
  • a central control unit usually in the form of a personal computer with storage medium, computing unit, screen and keyboard.
  • the analyzer To operate all of these functions and components, electrical energy must be supplied to the automatic analyzer.
  • the power consumption of the analyzer is particularly problematic if it does not carry out any tests but is kept ready for use. If the analyzer is not in use, ie if no analyzes are requested, it is customary to put the analyzers in a standby mode. For this purpose, various functions of the device, such as moving devices, heaters or light sources, are switched off, and the central control unit is put into an internal sleep mode in order to reduce the power consumption.
  • the restoration of the operating mode takes longer the more components of the analysis device are switched off.
  • the restoration of the operating mode can take as little time as possible, especially in clinical laboratories, which must be prepared for the processing of emergency samples at all times, the entire electronics of the device are typically kept live so that the device can be put back into operation very quickly can be taken.
  • the central control unit which is typically designed as a personal computer, remains live. This results in considerable power consumption of the device even during periods of non-use.
  • WO 2012/070577 A1 describes an automatic analysis device which saves at least one parameter of the system status of the analysis device when changing to the standby mode.
  • the standby control unit monitors a number of operating parameters for a deviation from a predetermined target value during the standby mode.
  • the invention is based on the consideration that a reduction in power consumption during a period of non-use could be achieved in particular if the central control unit could be put out of operation completely.
  • a dedicated standby control unit is provided for this purpose, which is independent of the central control unit. Since the standby control unit does not have to control analyzes, it can be designed to be much simpler and more energy-efficient than the central control unit.
  • this has the disadvantage that when the central control unit is switched off, the system states are also lost, i.e. the status of the individual components or functional units of the system. These have to be determined again in a complex procedure when the system is restarted, which considerably increases the time for restarting. Therefore, the system states are saved before the central control unit is deactivated, the standby control unit is put into operation, and the central control unit is put out of operation.
  • central control unit is to be understood as a control unit that is configured such that it controls all functional units of the automatic analysis device when the device is in the so-called operating mode located. In the operating mode, all functional units of the device are active or at least immediately ready for use.
  • the central control unit is preferably designed as a personal computer.
  • standby control unit is to be understood as a control unit which is configured such that it controls only a subset of all functional units of the automatic analysis device when the device is in a so-called standby mode. In the standby mode, only a subset of all functional units of the automatic analysis device is active, and the device as a whole is not immediately ready for use, i.e. it is not possible to carry out analyzes directly.
  • the standby control unit is preferably designed as a programmable microcontroller or digital control module, which is arranged on a circuit board and is only connected to a subset of the functional units of the automatic analysis device.
  • the automatic analysis device which has a central control unit, is equipped with a standby control unit that is configured such that it monitors a number of operating parameters for a deviation from a predetermined target value after the central control unit has been shut down.
  • the temperature in the cooling unit can be checked for remaining in a predetermined temperature interval during the standby mode.
  • Appropriate sensors can also be used to check whether housing parts have been opened during the standby mode. Any deviations from the target value are stored in the standby control unit and transferred to the central control unit when it is put back into operation. Here they can be processed further and the validity The stored system status can be checked based on the detected deviations.
  • the standby control unit advantageously controls an electrical switch that separates the central control unit from the voltage supply. This separation takes place in the course of the decommissioning of the central control unit during the transition to the standby mode.
  • Modern automatic analyzers often include a cooling unit for reagents that are used for analysis.
  • the standby control unit also operates the cooling unit. This means that the reagents have to be used at times when no analyzes are being carried out, e.g. overnight, can no longer be removed. The reagents remain in the device and are further cooled during the standby mode. They are immediately available when restarting.
  • the system state stored in the central control unit is therefore a loading state of the sample or reagent supply. Deviating loading conditions can be loaded from the standby control unit into the central control unit when it is put back into operation, ie during the transition from standby to operating mode. Otherwise, a cumbersome determination would be necessary by automatically removing each individual reagent container and reading out, for example, a printed bar code, which would considerably slow down the restarting process.
  • the automatic analysis device often includes a supply of consumables and / or waste.
  • Reaction tubes and pipette tips are typical consumables that are kept in large quantities in appropriate storage containers in the device and disposed of in a waste container after a single use.
  • the system state stored in the central control unit is therefore advantageously a loading state of a storage container for a consumable, such as e.g. Reaction tubes or pipette tips, and / or a waste container.
  • Deviating loading conditions can be re-started, i.e. be loaded from the standby control unit into the central control unit during the transition from standby to operating mode. This avoids the need to check the status of consumables and waste when it is restarted.
  • the commissioning of the standby control unit and thus the initiation of the standby mode can take place actively by the command of a user or after a predetermined period of inactivity of the automatic analysis device.
  • the latter variant also reduces power consumption, since the standby mode is activated even if the user is forgotten.
  • the readiness control unit monitors a number of operating parameters for a deviation from a predetermined target value.
  • deviations detected by the standby control unit are advantageously displayed to a user.
  • the user can then assess whether, for example, an opening in the housing was critical for the loading condition, since reagents were removed, or whether only an optical check was carried out.
  • the user can also decide that a temperature deviation, for example, was so minimal that an exchange of the reagents is not necessary.
  • the system status can be determined anew on user input. If the deviations were such that the information stored in the standby control unit can no longer be trusted, the corresponding information is determined anew. However, this is not absolutely necessary.
  • a separate standby control unit can be used to deactivate the central control unit and further assemblies and functional units such as motors, valves and heaters of the automatic analysis device in standby mode, thus achieving considerable energy savings.
  • the consumption can be reduced by up to 300 W compared to systems known in the prior art.
  • FIG. 1 shows schematically the structure of an automatic analyzer 1. Electrical supply lines are with simple lines in the left area of the FIG. 1 shown, data connection lines with double lines in the right area.
  • the automatic analyzer 1 has a connector 2 for the power supply from a socket of a 220 V or 110 V AC network.
  • the connector 2 is connected to an AC distributor 4.
  • the AC distributor 4 is connected to those systems of the automatic analysis device 1 which are designed for a supply with AC voltage.
  • These systems include the central control unit 6, which is designed as a personal computer, a screen 8, which is connected to the central control unit via a graphic data connection 7 designed as a DVI or VGA cable, a vacuum pump 10 and a cooling unit 12, which in particular comprises a refrigeration compressor.
  • the cooling unit 12 is used in particular to cool a reagent supply (not shown in more detail) in which a large number of reagents for various diagnostic tests are kept. If necessary, these are automatically removed from a removal system, also not shown in detail.
  • a DC distributor 14 is connected to the AC distributor 4. This comprises a power supply unit 16 with a rectifier for converting the alternating current from the alternating current distributor 4 into a 24 V direct voltage. Furthermore, the DC distributor 14 comprises an output unit 18, which applies the 24 V DC voltage outputs various DC-operated modules 20 of the automatic analysis device 1.
  • the DC-operated modules 20 include, among other things, a photometer used in the analysis, which is rotatably mounted and is therefore supplied via a slip ring 22. Furthermore, the DC-operated modules 20 include electric motors of the transfer systems for samples, aliquots and reagents and other components. Furthermore, the modules 20 comprise sensors which monitor the operating states of the automatic analysis device, for example the opening of the housing. If the entire automatic analyzer 1 is in operation, the power consumption in the exemplary embodiment is approximately 1500 W. In the FIG. 1 only three modules 20 are shown for reasons of clarity.
  • the data bus 13 On the data side, the various components of the automatic analysis device 1 are connected via a data bus 13.
  • the data bus 13 on the one hand routes control data from the central control unit 6 to the modules 20, the vacuum pump 10 and the cooling unit 12.
  • data from these components are passed to the central control unit 6.
  • These also include sensor data that are recorded by the sensors assigned to these components.
  • the central control unit 6 can be put into an idle state.
  • the power supply for all of the in FIG. 1 shown components remains however. Even if none of the modules 20 is active, the current consumption in the exemplary embodiment remains at approximately 500 to 600 W.
  • the automatic analysis device 1 has a standby control unit 24.
  • the standby control unit 24 is designed to be comparatively simple and has a low power consumption. It is not like the central control unit 1 as a personal computer designed, but only comprises a circuit board with a microcontroller with associated memory and corresponding connections to data bus 13 and to the power supply.
  • the standby control unit 24 is integrated in the housing of the DC distributor 14 and can interrupt the power supply to the individual components (for example 6, 8, 10 and 12) of the automatic analysis device 1 via electrical switches (not shown in more detail).
  • the standby mode is activated by user input on the central control unit 6 or after a period of inactivity of the automatic analysis device 1 which can be set on the central control unit 6.
  • the standby control unit 24 is first put into operation.
  • the central control unit 6 then stores a multiplicity of system states, in particular the loading and filling state of the reagent supply, the loading state of the waste supply and the supplies of various consumables such as e.g. Cuvettes, pipette tips etc. Any other system states, the knowledge of which is necessary for the operation of the system, are conceivable.
  • the central control unit 6 is then put out of operation.
  • the decommissioning does not only include an idle state, but the central control unit 6 is separated from the voltage supply by the AC distributor 4 by an electrical switch which can be controlled by the standby control unit 24.
  • all but a few of the modules 20 are separated from the voltage supply by the DC distributor 18 by an electrical switch which can be controlled by the standby control unit 24.
  • the standby mode is in the FIG 2 shown, which essentially all components from the FIG. 1 shows; however, the components are separate from the electrical supply hatched. Only a few modules 20, in particular sensors that monitor access to the housing of the automatic analysis device 1, are still active, as are the AC distributor 4, the DC distributor 14, the cooling unit 12 and, of course, the standby control unit 24.
  • the standby control unit 24 is designed such that the still active components can be operated in the standby mode via the data bus 13.
  • the standby control unit 24 monitors the active modules 20, in particular the sensors, and the cooling unit 12 with regard to certain operating parameters for deviations from a predetermined target value, e.g. the housing to open or the temperature in the reagent supply.
  • the data bus 13 is also used for the data transmission in the standby mode. Each deviation is logged in the memory of the standby control unit 24. The time and type of deviation are recorded.
  • the power consumption in the exemplary embodiment is limited to 200 to 250 W.
  • the automatic analysis device 1 can again be reactivated in the operating state either by user input via a switch which is assigned to the standby control unit 24, or after a period which can be set in the standby control unit 24 or after a fixed time.
  • the components separated from the power supply are again supplied with power, and the central control unit 6 is activated.
  • the stored system states are then loaded into the central control unit 6 and are therefore directly available and do not have to be determined again in a time-consuming manner.
  • the deviations logged by the standby control unit 24 during the standby mode are transferred to the central control unit 6. If there are deviations the user is informed of the target state. The user can thus decide whether to keep the information about the system states.
  • the automatic analysis device 1 If no deviations occur or if the user recognizes deviations as uncritical, the automatic analysis device 1 is ready for operation after activation. All relevant system states, i.e. In particular, status and loading conditions are correctly restored using the data stored in the standby control unit 24. This is done much faster than the complete rediscovery.
  • the affected units are initialized depending on the condition or the load is determined again. For example, reagents can be newly identified or, if the permissible storage temperature is exceeded or fallen short of, can be disposed of.

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EP12194558.8A 2012-11-28 2012-11-28 Verfahren zum vorübergehenden Betrieb eines automatischen Analysegeräts in einem Bereitschaftsmodus Active EP2738559B1 (de)

Priority Applications (4)

Application Number Priority Date Filing Date Title
ES12194558T ES2777893T3 (es) 2012-11-28 2012-11-28 Procedimiento para el funcionamiento temporal de un dispositivo de análisis automático en un modo de espera
EP12194558.8A EP2738559B1 (de) 2012-11-28 2012-11-28 Verfahren zum vorübergehenden Betrieb eines automatischen Analysegeräts in einem Bereitschaftsmodus
JP2013245014A JP6214360B2 (ja) 2012-11-28 2013-11-27 待機モードにおける自動分析装置の運転方法
US14/092,878 US9430025B2 (en) 2012-11-28 2013-11-27 Method for temporary operation of an automated analysis device in a standby mode

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP12194558.8A EP2738559B1 (de) 2012-11-28 2012-11-28 Verfahren zum vorübergehenden Betrieb eines automatischen Analysegeräts in einem Bereitschaftsmodus

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EP2738559A1 EP2738559A1 (de) 2014-06-04
EP2738559B1 true EP2738559B1 (de) 2020-01-08

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US (1) US9430025B2 (ja)
EP (1) EP2738559B1 (ja)
JP (1) JP6214360B2 (ja)
ES (1) ES2777893T3 (ja)

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CN106461687B (zh) * 2014-06-24 2018-10-12 株式会社岛津制作所 控制装置
EP3115787A1 (de) 2015-07-09 2017-01-11 Siemens Healthcare Diagnostics Products GmbH Verfahren zum ausserbetriebsetzen eines automatischen analysegeräts
CN112513646B (zh) * 2018-08-22 2024-04-16 深圳迈瑞生物医疗电子股份有限公司 一种流水线上的仪器状态控制方法及系统、分析装置

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JP4439711B2 (ja) * 2000-10-19 2010-03-24 Ｎｅｃエレクトロニクス株式会社 データ処理装置およびシステム
JPWO2002095556A1 (ja) * 2001-05-18 2004-09-09 富士通株式会社 待機モードを有する装置、プログラム、及び待機モードを有する装置の制御方法
JP2005011166A (ja) * 2003-06-20 2005-01-13 Renesas Technology Corp 情報処理装置
JP4241434B2 (ja) * 2004-03-01 2009-03-18 株式会社日立ハイテクノロジーズ 自動分析システム
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JP5480399B2 (ja) * 2010-11-26 2014-04-23 株式会社日立ハイテクノロジーズ 自動分析装置
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Publication number Publication date
JP2014106236A (ja) 2014-06-09
EP2738559A1 (de) 2014-06-04
ES2777893T3 (es) 2020-08-06
JP6214360B2 (ja) 2017-10-18
US20140149778A1 (en) 2014-05-29
US9430025B2 (en) 2016-08-30

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