EP2709460A1 - Composition comprenant de la vitamine k2 - Google Patents

Composition comprenant de la vitamine k2

Info

Publication number
EP2709460A1
EP2709460A1 EP12724777.3A EP12724777A EP2709460A1 EP 2709460 A1 EP2709460 A1 EP 2709460A1 EP 12724777 A EP12724777 A EP 12724777A EP 2709460 A1 EP2709460 A1 EP 2709460A1
Authority
EP
European Patent Office
Prior art keywords
composition according
vitamin
blood
mammal
health
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP12724777.3A
Other languages
German (de)
English (en)
Inventor
Elisabeth Gertruda Hendrika Maria Van Den Heuvel
Renate Marie Louise Zwijsen
Ioannis MANIOS
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
FrieslandCampina Nederland BV
Original Assignee
Friesland Brands BV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Friesland Brands BV filed Critical Friesland Brands BV
Publication of EP2709460A1 publication Critical patent/EP2709460A1/fr
Withdrawn legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
    • A23C9/00—Milk preparations; Milk powder or milk powder preparations
    • A23C9/12—Fermented milk preparations; Treatment using microorganisms or enzymes
    • A23C9/13—Fermented milk preparations; Treatment using microorganisms or enzymes using additives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A61K31/202—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids having three or more double bonds, e.g. linolenic
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
    • A23C13/00—Cream; Cream preparations; Making thereof
    • A23C13/12—Cream preparations
    • A23C13/16—Cream preparations containing, or treated with, microorganisms, enzymes, or antibiotics; Sour cream
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
    • A23C17/00—Buttermilk; Buttermilk preparations
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
    • A23C19/00—Cheese; Cheese preparations; Making thereof
    • A23C19/06—Treating cheese curd after whey separation; Products obtained thereby
    • A23C19/09—Other cheese preparations; Mixtures of cheese with other foodstuffs
    • A23C19/0921—Addition, to cheese or curd, of minerals, including organic salts thereof, trace elements, amino acids, peptides, protein hydrolysates, nucleic acids, yeast extracts or autolysate, vitamins or derivatives of these compounds
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
    • A23C9/00—Milk preparations; Milk powder or milk powder preparations
    • A23C9/12—Fermented milk preparations; Treatment using microorganisms or enzymes
    • A23C9/13—Fermented milk preparations; Treatment using microorganisms or enzymes using additives
    • A23C9/1315—Non-milk proteins or fats; Seeds, pulses, cereals or soja; Fatty acids, phospholipids, mono- or diglycerides or derivatives therefrom; Egg products
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
    • A23C9/00—Milk preparations; Milk powder or milk powder preparations
    • A23C9/12—Fermented milk preparations; Treatment using microorganisms or enzymes
    • A23C9/13—Fermented milk preparations; Treatment using microorganisms or enzymes using additives
    • A23C9/1322—Inorganic compounds; Minerals, including organic salts thereof, oligo-elements; Amino-acids, peptides, protein-hydrolysates or derivatives; Nucleic acids or derivatives; Yeast extract or autolysate; Vitamins; Antibiotics; Bacteriocins
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
    • A23C9/00—Milk preparations; Milk powder or milk powder preparations
    • A23C9/152—Milk preparations; Milk powder or milk powder preparations containing additives
    • A23C9/1522—Inorganic additives, e.g. minerals, trace elements; Chlorination or fluoridation of milk; Organic salts or complexes of metals other than natrium or kalium; Calcium enrichment of milk
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
    • A23C9/00—Milk preparations; Milk powder or milk powder preparations
    • A23C9/152—Milk preparations; Milk powder or milk powder preparations containing additives
    • A23C9/1528—Fatty acids; Mono- or diglycerides; Petroleum jelly; Paraffine; Phospholipids; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
    • A23C9/00—Milk preparations; Milk powder or milk powder preparations
    • A23C9/152—Milk preparations; Milk powder or milk powder preparations containing additives
    • A23C9/158—Milk preparations; Milk powder or milk powder preparations containing additives containing vitamins or antibiotics
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23D—EDIBLE OILS OR FATS, e.g. MARGARINES, SHORTENINGS, COOKING OILS
    • A23D7/00—Edible oil or fat compositions containing an aqueous phase, e.g. margarines
    • A23D7/001—Spread compositions
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23D—EDIBLE OILS OR FATS, e.g. MARGARINES, SHORTENINGS, COOKING OILS
    • A23D7/00—Edible oil or fat compositions containing an aqueous phase, e.g. margarines
    • A23D7/005—Edible oil or fat compositions containing an aqueous phase, e.g. margarines characterised by ingredients other than fatty acid triglycerides
    • A23D7/0056—Spread compositions
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/115—Fatty acids or derivatives thereof; Fats or oils
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/15—Vitamins
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/16—Inorganic salts, minerals or trace elements
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/17—Amino acids, peptides or proteins
    • A23L33/19—Dairy proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2200/00—Function of food ingredients
    • A23V2200/30—Foods, ingredients or supplements having a functional effect on health
    • A23V2200/306—Foods, ingredients or supplements having a functional effect on health having an effect on bone mass, e.g. osteoporosis prevention
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2200/00—Function of food ingredients
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    • A23V2200/322—Foods, ingredients or supplements having a functional effect on health having an effect on the health of the nervous system or on mental function
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2200/00—Function of food ingredients
    • A23V2200/30—Foods, ingredients or supplements having a functional effect on health
    • A23V2200/324—Foods, ingredients or supplements having a functional effect on health having an effect on the immune system
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2200/00—Function of food ingredients
    • A23V2200/30—Foods, ingredients or supplements having a functional effect on health
    • A23V2200/326—Foods, ingredients or supplements having a functional effect on health having effect on cardiovascular health
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2200/00—Function of food ingredients
    • A23V2200/30—Foods, ingredients or supplements having a functional effect on health
    • A23V2200/3262—Foods, ingredients or supplements having a functional effect on health having an effect on blood cholesterol
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
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    • A23V2200/328—Foods, ingredients or supplements having a functional effect on health having effect on glycaemic control and diabetes
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
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    • A23V2200/332—Promoters of weight control and weight loss
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    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2250/00—Food ingredients
    • A23V2250/15—Inorganic Compounds
    • A23V2250/156—Mineral combination
    • A23V2250/1578—Calcium
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2250/00—Food ingredients
    • A23V2250/15—Inorganic Compounds
    • A23V2250/156—Mineral combination
    • A23V2250/161—Magnesium
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2250/00—Food ingredients
    • A23V2250/70—Vitamins
    • A23V2250/714—Vitamin K
    • A23V2250/7144—Vitamin K2

Definitions

  • the present invention relates to the field of nutrition, and in particular to products comprising and/or supplemented with micronutrients.
  • the invention relates to food products comprising vitamins, minerals or other micronutrients and the use of these products for promoting cardiovascular health of mammals and, in particular, for supporting and/or improving vascular elasticity.
  • Functional foods are an emerging field in food science due to their increasing popularity with health-conscious consumers.
  • Functional food is any food or food ingredient that may provide a health benefit beyond the traditional nutrients comprised in it.
  • the general category of functional foods includes processed food or foods fortified with health-promoting additives, e.g., vitamin enriched products.
  • the invention provides, in a first aspect, a composition comprising vitamin K2, calcium and magnesium, wherein the weight ratio calcium/magnesium is less than 8.
  • composition according to the present invention can effectively be used against vascular stiffness and/or to improve, support and/or maintain the flexibility and/or the strength of blood vessels. In this manner, a healthy blood circulation and/or blood flow can be improved, supported and/or maintained.
  • the present invention concerns a food composition of the type generally intended for daily consumption and particularly intended to have a positive effect on human or animal health, and/or to improve, support and/or maintain human or animal inconvenience.
  • vitamin K2 is a member of the vitamin K group which is a group of fat soluble vitamins. All members of the vitamin K group share a methylated naphthoquinone ring structure, and vary in the aliphatic side chain attached at the 3-position.
  • Phylloquinone also known as vitamin Kl
  • Menaquinones have side chains composed of a variable number of unsaturated isoprenoid residues; generally they are designated as MK-n, where n specifies the number of isoprenoids.
  • Vitamin K is essential for the carboxylation of glutamate residues in certain proteins. These vitamin K-dependent proteins require carboxylation to become biologically active. Although the coagulant factors are the most well- known vitamin K dependent proteins, there are many others with important physiologic roles. Matrix Gla Protein (MGP), osteocalcin and Growth Arrest Specific Gene 6 (Gas-6) are the three particularly important vitamin K dependent proteins. Vitamin K is commonly found in multiple vitamin supplements and in infant formula. However, it is mostly present in the form of vitamin Kl and therefore a general designation to vitamin K refers in fact to vitamin Kl, since this form is considerably less expensive to obtain and it has been generally recognised as safe in food since a long time.
  • MGP Matrix Gla Protein
  • Gas-6 Growth Arrest Specific Gene 6
  • Vitamin K2 in the present invention may be obtained from any suitable source, e.g., fermented soy product such as natto. Also synthetically prepared vitamin K2 is suitable having an advantage that the quality of such obtained vitamin K2 can easily be controlled. However, vitamin K2 obtained from a natural source, e.g., by microbial production, is preferred.
  • the content of vitamin K2 and other ingredients in the composition according to the invention is characterised in this description in amounts per daily intake, or in amounts per serving.
  • a serving is about 125 g for a viscous (spoonable) product, or about 200-250 ml for a pourable product such as milk or a yogurt drink.
  • a serving means one slice of about 30-40 g, and for a spread or butter a serving is about 3.5-7 g normally used with a one slice of bread.
  • Daily intake means the total amount of an ingredient as consumed within the product or products of the invention per day.
  • a daily intake may be consumed in one serving, but can also be divided over 2, 3, 4 or even more servings per day.
  • the daily intake can also be spread over several products, such as milk and yogurt, milk and cheese, etc.
  • a skilled person is able to find an appropriate amount of servings, or an appropriate combination of products, based on the provided information.
  • spoonable and drink yogurts are usually consumed once or twice per day, therefore the daily intake is generally one to two servings per day.
  • a daily intake usually means one slice per day, but can also be more.
  • a daily intake usually means about 4 servings, assuming that on average 4 slices of bread are consumed per day.
  • the composition according to the present invention preferably comprises at least 5 meg vitamin K2 per daily intake.
  • the upper limit for vitamin K2 in the composition is preferably less than 200 meg per daily intake. More preferably, the composition contains from 5 to 150 meg, and even more preferably from 7 to 100 meg of vitamin K2 per daily intake. Yet more preferably, the composition contains from 10 to 90 meg vitamin K2 per daily intake. More preferably the amount of vitamin K2 per day from 15 to 75 meg even more preferably from 25 to 60 meg, even more preferably from 35 to 50 meg and most preferably from 40 to 45 meg of vitamin K2 per day.
  • “meg” is meant to mean microgram.
  • vitamin K2 contains from 4 to 13 isoprenoid residues, especially 6-13 isoprenoid residues. Yet more preferably, vitamin K2 contains from 6 to 10 isoprenoid residues, in particular 6, 7, 8, 9 or 10 residues. These forms of vitamin K2, especially MK-6 and higher, have a considerably higher bioavailability than menaquinones having less isoprenoid residues.
  • composition according to the invention further contains minerals calcium and magnesium.
  • minerals calcium and magnesium any form of food grade sources of calcium and magnesium may be used. These include organic and inorganic compounds, salts, molecular complexes, chelates, such as calcium citrate, calcium carbonate, calcium gluconate, calcium lactate, calcium phosphate, magnesium oxide, magnesium citrate, etc.
  • a preferred source is magnesium citrate.
  • dairy products or dairy components, especially milk and milk parts are examples of suitable sources of calcium.
  • Calcium (Ca) is preferably present in the composition of the invention in an amount from 20 to 1600 mg, and preferably from 70 to 1000 mg, more preferably, from 80 to 800 mg per daily intake.
  • a preferred amount of calcium in the present composition is in the range of 100-600 mg per daily intake, more preferably from 150-500 mg per daily intake, more preferably from 200 to 450 mg per daily intake, even more preferably from 250-400 mg per daily intake and most preferably from 300-350 mg calcium per daily intake.
  • “mg” is mean to mean milligram.
  • the content of magnesium (Mg) is preferably from 20 to 800 mg, more preferably, from 30 to 600 mg, and even more preferably from 50 to 500 mg per daily intake, more preferably from 75 to 400 mg, even more preferably from 100 to 300 mg, even more preferably from 150 to 250 mg and most preferably from 160 to 200 mg magnesium per daily intake.
  • the composition comprises 80-800 mg calcium and 50-300 mg magnesium per daily intake or 100-600 mg calcium and 75 to 400 mg magnesium, or 150-500 mg calcium and 100 to 300 mg magnesium. If the composition according to the invention is a dairy composition, in one preferred embodiment, the dairy component is the sole source of calcium, that is, the composition is not supplemented with additional calcium.
  • the level of calcium corresponds to the level of calcium in milk, that is, from 50 to 200 mg per 100 g, or from 60 to 400 mg per serving.
  • the calcium daily intake in this case is preferably from 80 to 800 mg, more preferably, from 100 to 700 mg, even more preferably from 120 to 600 mg, and particularly preferably from 240 to 500 mg and even more preferably from 300 to 450 mg, and most preferably from 350 to 400 mg calcium.
  • the dairy composition may be supplemented with additional calcium so that the total amount of calcium present is, e.g., from 100 to 1200 mg, and preferably from 120 to 1000 mg and even more preferably from 240 to 800 mg, more preferably from 300 to 700 mg, even more preferably between 400 and 600 mg and most preferably between 450 and 550 mg per daily intake.
  • the weight ratio calcium/magnesium (Ca/Mg) is less than in cow's milk. In normal cow's milk the calcium/magnesium ratio is by nature about 10.
  • the Ca/Mg ratio is not greater than 8 and more preferably not greater than 6, such as 5 or less.
  • the Ca/Mg ratio is not greater than 3.5 and even more preferably, not greater than 3.
  • a preferred range for the Ca/Mg ratio is 0.5-2.7.
  • a low Ca/Mg ratio relates to each product or serving separately. Where the daily intake of vitamin K2 can be spread over several servings or products, the Ca/Mg ratio must be in the described range for each serving or each product.
  • the optimal Ca/Mg ratio allows lower amounts of vitamin K2 to needed in order to achieve the same health effect. In this way, less vitamin K2 is needed per serving or per daily intake. This has the advantage of a lower risk of blood clotting associated with high dosages of vitamin K2, and also allows costs be reduced, since vitamin K2 is considerably more expensive than, e.g., vitamin Kl.
  • the calcium/phosphate ratio of the composition according to the present invention is from 0.5 to 5, more preferably from 1 to 4, more preferably from 1.5 to 3.5, and most preferably from 2 to 2.5.
  • this ratio is preferably in the range 1-2.
  • the composition further comprises at least one polyunsaturated fatty acid (PUFA).
  • PUFA's are fatty acids that contain more than one double bond in the backbone. This class includes many important compounds, such as essential fatty acids, e.g., omega-3 and omega-6 fatty acids.
  • long chain polyunsaturated fatty acids are suitable, and preferably those having at least 20 carbon atoms in the molecule.
  • Such long chain omega-3 fatty acids include cis- 11, 14, 17-eicosatrienoic acid (ETE) C20:3, cis-8, 11, 14, 17-eicosatetraenoic acid (ETA) C20:4, cis-5,8, l l, 14, 17-eicosapentaenoic acid (EPA) C20:5, cis- 7, 10, 13, 16, 19-docosapentaenoic acid (DPA, Clupanodonic acid) C22:5, cis- 4, 7, 10, 13, 16, 19-docosahexaenoic acid (DHA) C22:6, cis-9, 12, 15, 18,21- tetracosapentaenoic acid C24:5; cis-6,9, 12, 15, 18,21-tetracosahexaenoic acid (N
  • Long chain omega-6 fatty acids having at least 20 carbon atoms include cis-11, 14-eicosadienoic acid C20:2, cis-8, 11, 14-eicosatrienoic acid (Dihomo-gamma-linolenic acid) (DGLA) C20:3, cis-5,8, 11, 14-eicosatetraenoic acid (Arachidonic acid) (AA) C20:4, cis-13, 16-docosadienoic acid C22:2, cis- 7, 10, 13, 16-docosatetraenoic acid (Adrenic acid) C22:4, cis-4, 7, 10, 13, 16- docosapentaenoic acid (Osbond acid) C22:5.
  • the LC-PUFAs are preferably present in the product according to the invention in an amount from 20 to 1000 mg, and preferably from 30 to 500 mg per daily intake.
  • LC-PUFAs are EPA C20:5, DHA C22:6 and a combination of these.
  • the animal sources are preferably used, in particular fish and marine oil, or algae oil.
  • the fish oil obtained from cod liver, herring, mackerel, salmon, menhaden and sardine is used as a source of LC- PUFAs.
  • the composition according to the invention preferably contains EPA, DHA or a combination of these in an amount from 10 to 500 mg per daily intake, and preferably from 30 to 350 mg.
  • Particularly preferred is a combination of EPA with DHA in an amount from 40 to 250 mg per daily intake.
  • composition according to the invention and embodiments thereof may further contain other vitamins and/or minerals, emulsifiers, colorants, preservatives, gums, thickeners.
  • PUFAs emulsifiers
  • antioxidants like vitamin C, vitamin E, selenium, polyphenols, bioflavonoids to prevent the oxidation of long chain fatty acids, which can lead to unwanted taste changes and a short shelf life of the product.
  • the composition contains further vitamin D and, preferably, vitamin D3.
  • the amount of vitamin D can range from 0.25 to 6 meg and preferably from 1 to 5 meg, more preferably from 2 to 4 meg and most preferably from 2.5 to 3.5 meg per daily intake.
  • vitamin D refers, to any of known form of vitamin D, and specifically includes vitamin D2 (ergocalciferol), vitamin D3 (cholecalciferol), vitamin D precursors, metabolites and another analogues, and combinations thereof, as well as the various active and inactive forms of vitamin D.
  • vitamin D3 may be provided in its unhydroxylated inactive form as cholecalciferol, or may be provided in its hydroxylated active form as calcitriol.
  • the composition contains vitamin B12 (various cobalamins).
  • vitamin B12 variable cobalamins
  • This vitamin contributes to energy metabolism, red blood cell formation, function of the immune system and mental health.
  • Suboptimal blood levels are quite common in human and particularly in elderly, as absorption through the gut declines with age.
  • Low vitamin B12 blood levels results in a macrocytic anemia, elevated homocysteine which increases the risk for cardiovascular diseases, peripheral neuropathy, memory loss and other cognitive deficits.
  • a preferred amount for vitamin B12 is from 0.25 to 3 meg, and preferably from 0.375 to 2 meg, more preferably from 0.45 to 1.75 meg, more preferably from 0.5 to 1.5 meg, even more preferably from 0.75 to 1.3 meg and most preferably from 0.9 to 1.2 meg per daily intake.
  • the composition according to the invention and embodiments thereof is a dairy composition, which is understood as a composition containing further at least one of the following components: milk fat, milk protein, skim milk or other milk constituents.
  • milk and products based on milk or obtained by processing of milk such as dairy cream, cheese, milk powder, sauces, yogurt, other fermented milk products are encompassed by the term dairy composition.
  • the low Ca/Mg ratio as described in this invention has a further positive effect on the taste of the product, especially on the yogurts such as fruit yogurts. The taste of a yogurt can become
  • the low Ca/Mg ratio such as lower than 8 and preferably lower than 5, however, surprisingly provides for a better taste and is capable of masking the PUFA taste in a yogurt, without the necessity to add taste improving agents. The effect is especially advantageous in fruit yogurt compositions.
  • the composition according to the present invention is a food or beverage product, or a dietary supplement. Most preferably, it is a dairy food product.
  • the composition according to the invention and embodiments thereof is a yogurt or other fermented milk product such as cheese, processed cheeses, butter milk, creme fraiche, sour cream.
  • the yogurt can be of a thick consistency (spoonable yogurt), or have a pourable consistency (drink yogurt).
  • the product is a fruit yogurt, or a milk product containing fruit juices.
  • the product is based on non-fermented milk, e.g. milk drink, milkshakes, fruit-milk drinks, chocolate milk.
  • the product is a dairy cream, whippable cream, dairy based spread, ice cream, butter, margarine, melange, cream sauce, bakery cream and the like.
  • the product according to the invention may be prepared in any convenient way, known to a person skilled in the art.
  • a preferred method known to a person skilled in the art.
  • the composition according to the invention is prepared by adding a suitable source of vitamin K2, a suitable source of magnesium and, optionally, a suitable source of calcium to a food product.
  • a suitable source such as a compound or a composition comprising the desired vitamin or element, which source is suitable for use in food products (food grade).
  • the suitable source contains the vitamin or mineral in a bioavailable form, such as in a chelated form or as an organic acid salt. Minerals from animal sources are preferred over those from plant sources.
  • the ingredients can be mixed in any conventional way known to a person skilled in the art.
  • vitamin K2 can be first dissolved in a fat phase while calcium and/or magnesium - in an aqueous phase, followed by emulsification and addition to a food product to be fortified.
  • Vitamin K2 can also be used in powder form and be added to the remaining ingredients in an aqueous phase, or directly to the product.
  • some additional amount of calcium is added to reach the needed levels, for example, when the product contains fruit juices.
  • the product according to the invention may advantageously be used for maintaining, supporting and/or promoting cardiovascular health of mammals, and particularly humans.
  • the described composition can be used for maintaining, supporting and/or promoting vascular elasticity and/or for the prevention of vascular hardening.
  • it can effectively be used for maintaining, supporting and/or improving of blood circulation and/or blood flow of micro- and/or macrovascular system; and/or for maintaining, supporting and/or improving of the transport of oxygen and nutrients to the tissues and/or of removal of waste and carbon dioxide from the tissues; and/or for maintaining, supporting and/or promoting an adequate energy level, particularly for high oxygen consuming tissues, including heart, brain, skeletal muscles, liver and kidney and/or keeping physically and mentally fit.
  • Another aspect of the invention relates to a composition according to the invention or embodiments thereof to support and/or maintain and/or improve vascular health, in particular cardiovascular health.
  • the invention further relates to a composition according to the invention or embodiments thereof to support and/or maintain and/or improve vessel flexibility.
  • the invention further relates to a composition according to the invention or embodiments thereof to prevent and/or maintain and/or reduce arterial stiffness.
  • the invention further relates to a composition according to the invention or embodiments thereof to support and/or maintain and/or improve bone health.
  • the invention further relates to a composition according to the invention or embodiments thereof to support and/or maintain and/or improve normal clotting capability and/or to maintain normal platelet aggregation and/or to prevent adherence of platelets to blood vessel walls and/or fatty plaques.
  • the invention further relates to a composition according to the invention or embodiments thereof to support and/or maintain and/or improve glucose control and/or insulin secretion and/or insulin sensitivity.
  • the invention further relates to a composition according to the invention or embodiments thereof to prevent and/or maintain and/or reduce chronic inflammation and/or low grade inflammation.
  • the invention further relates to a composition according to the invention or embodiments thereof to support and/or maintain and/or improve mental health and/or cognitive performance and/or alertness, and/or mental sharpness and/or memory.
  • the invention further relates to a composition according to the invention or embodiments thereof to support and/or maintain and/or improve a healthy bodyweight, and/or a healthy body mass index (BMI), and/or a healthy triglyceride blood levels, and/or a healthy waist circumference.
  • the health status of all health parameters mentioned in this invention is preferably according to the World Health Organization guidelines (WHO guidelines for the prevention, management and care of diabetes mellitus, 2006; Global strategy on diet, physical activity and health, WHO report 2004).
  • the invention further relates to a composition according to the invention or embodiments thereof to maintain a healthy blood pressure and/or to prevent and/or reduce high blood pressure (according to WHO guidelines).
  • the invention further relates to a composition according to the invention or embodiments thereof to support and/or maintain and/or improve blood flow.
  • the invention further relates to a composition according to the invention or embodiments thereof to support and/or maintain and/or improve blood circulation, including the macrocirculation and/or the microcirculation.
  • the invention further relates to a composition according to the invention or embodiments thereof to support and/or maintain and/or improve blood perfusion.
  • This is the process of delivery of blood to a capillary bed to tissues of a mammal, such as to the brain, kidney, heart, lung, liver, limbs and to the gastrointestinal tract tissue.
  • the invention further relates to a composition according to the invention or embodiments thereof to prevent and/or maintain and/or reduce metabolic syndrome.
  • the invention further relates to a composition according to the invention or embodiments thereof for use in the treatment of vascular disease, and/or cardiovascular disease, and/or atherosclerosis, and/or arteriosclerosis, and/or arterial stiffness and/or hypertension and/or clogged arteries and/or varicose veins and/or transient ischemic attack (TIA) and/or stroke and/or cold limbs.
  • the invention further relates to a composition according to the invention or embodiments thereof for use in the treatment of vessel
  • the invention further relates to a composition according to the invention or embodiments thereof for use in the treatment of thrombosis and/or stroke.
  • the invention further relates to a composition according to the invention or embodiments thereof for use in the treatment of diabetes and/or insulin resistancy.
  • the invention further relates to a composition according to the invention or embodiments thereof for use in the treatment of chronic inflammation and/or low grade inflammation.
  • the invention further relates to a composition according to the invention or embodiments thereof for use in the treatment of mental decline and/or mental disease, such as dementia and/or Alzheimer disease.
  • the invention further relates to a composition according to the invention or embodiments thereof for use in the treatment of obesity, and/or metabolic syndrome, and/or high BMI, and/or high triglyceride in blood, and/or high body weight, and/or high waist circumference.
  • the invention further relates to the use of a composition according to the invention or embodiments thereof to support and/or maintain and/or improve vascular health, and/or cardiovascular health.
  • the invention further relates to the use of a composition according to the invention or embodiments thereof to support and/or maintain and/or improve vessel flexibility
  • the invention further relates to the use of a composition according to the invention or embodiments thereof to prevent and/or maintain and/or reduce arterial stiffness.
  • the invention further relates to the use of a composition according to the invention or embodiments thereof to maintain a healthy blood pressure and/or to prevent and/or reduce high blood pressure (according to WHO guidelines).
  • the invention further relates to the use of a composition according to the invention or embodiments thereof to support and/or maintain and/or improve blood flow.
  • the invention further relates to the use of a composition according to the invention or embodiments thereof to support and/or maintain and/or improve blood circulation, including the macrocirculation and/or the
  • the invention further relates to the use of a composition according to the invention or embodiments thereof to support, maintain and/or improve blood perfusion.
  • This is the process of delivery of blood to a capillary bed to tissues of a mammal, such as to the brain, kidney, heart, lung, liver, limbs and to the gastrointestinal tract tissue.
  • the invention further relates to the use of a composition according to the invention or embodiments thereof to support and/or maintain and/or improve bone health.
  • the invention further relates to the use of a composition according to the invention or embodiments thereof to support and/or maintain and/or improve normal clotting capability and/or to maintain normal platelet aggregation and/or to prevent adherence of platelets to blood vessel walls and/or fatty plaques.
  • the invention further relates to the use of a composition according to the invention or embodiments thereof to support and/or maintain and/or improve glucose control mechanism, and/or insulin secretion and/or insulin sensitivity, and/or to prevent diabetes and/or hyperglycemia.
  • the invention further relates to the use of a composition according to the invention or embodiments thereof to prevent and/or maintain and/or reduce to chronic inflammation and/or low grade inflammation.
  • the invention further relates to the use of a composition according to the invention or embodiments thereof to support and/or maintain and/or improve mental health and/or cognitive performance and/or alertness and/or memory and/or mental sharpness.
  • the invention further relates to the use of a composition according to the invention or embodiments thereof to support and/or maintain and/or improve healthy weight management and/or a healthy body mass index and/or a healthy triglyceride blood levels and/or to prevent the increase of body fat mass.
  • the invention further relates to the use of a composition according to the invention or embodiments thereof to support and/or maintain a healthy waist circumference and/or to reduce a high waist circumference.
  • the invention further relates to the use of a composition according to the invention or embodiments thereof to prevent and/or maintain and/or reduce metabolic syndrome.
  • the invention further relates to the use of a composition according to the invention or embodiments thereof to enhance bioavailability of vitamin K and/or vitamin K2.
  • the invention further relates to the use of a composition according to the invention or embodiments thereof to increase the biological activity of vitamin K and/or vitamin K2.
  • the invention further relates to the use of a composition according to the invention or embodiments thereof to increase the level of vitamin K and/or vitamin K2 in blood of a mammal.
  • the invention further relates to the use of a composition according to the invention or embodiments thereof to reduce the level of circulating uncarboxylated MGP and/or uncarboxylated osteocalcin in blood in a mammal.
  • the invention further relates to the use of a composition according to the invention or embodiments thereof to increase the level of circulating carboxylated MGP and/or carboxylated osteocalcin in blood in a mammal.
  • the reduction of the level of circulating uncarboxylated MGP and/or uncarboxylated osteocalcin, and/or the increase of the level of circulating carboxylated MGP and/or carboxylated osteocalcin in blood in a mammal and/or the increase of the level of vitamin K and/or vitamin K2 in blood of a mammal is obtained within 12 weeks, preferably within 8 weeks, more preferably within 4 weeks.
  • the invention further relates to a method to reduce the level of circulating uncarboxylated MGP and/or uncarboxylated osteocalcin in blood of a mammal by administering to a mammal a composition according to the invention or embodiments thereof.
  • the invention further relates to a method to increase the level of circulating carboxylated MGP and/or carboxylated osteocalcin in blood of a mammal by administering to a mammal a composition according to the invention or embodiments thereof.
  • the invention further relates to a method to increase the level of vitamin K2 in blood of a mammal by administering to a mammal a
  • composition according to the invention or embodiments thereof.
  • composition according to the invention or
  • embodiments thereof in a method according to the invention or embodiments thereof is administered for a period of at least 4 weeks, preferably at least 8 weeks and most preferably at least 12 weeks.
  • the composition of the present invention and embodiments thereof is administered life-long, suitably 3, 5, 7, 10, 12, 15, 18, 20, 23, 25, 27, 30, 32, 35, 38, 40, 45, 50, 55, 60, 65, 70, 75, 80, 85, 90, or even up to 95years.
  • the intake of vitamin K and/or vitamin K2 and/or MK-7 is preferably daily, each day, so as to maintain a steady level of vitamin K, vitamin K2 in the blood.
  • the products of the present invention may easily be incorporated in a normal healthy diet, so that each day, a life long, the vitamin K, vitamin K2 level is improved.
  • Control group 2 servings of dairy (choice of milk or yogurt) containing a daily intake of 10 meg vitamin D and 800 mg calcium.
  • the Ca/Mg ratio of the daily intake varies between about 10 (only milk) and about 15 (only yogurt).
  • Vitamin Kl group 2 servings of dairy (choice of milk or yogurt) containing a daily intake of 100 meg vitamin Kl, 10 meg vitamin D and 800 mg calcium.
  • the Ca/Mg ratio of the daily intake varies between about 10 (only milk) and about 15 (only yogurt).
  • Vitamin K2 group 2 servings of dairy (choice of milk or yogurt) containing a daily intake of 100 meg vitamin K2, 10 meg vitamin D and 800 mg calcium.
  • the Ca/Mg ratio of the daily intake varies between about 10 (only milk) and about 15 (only yogurt).
  • a vitamin K enriched product has a beneficial effect on vascular elasticity.
  • a vitamin Kl enriched dairy product has only a small nonsignificant effect on the vascular health parameter. This effect is comparable with the control group which had a dairy product with added vitamin D and calcium.
  • vitamin K2 is more effective as to vascular elasticity, whereas vitamin Kl is not.
  • the use of dairy with added vitamin D and calcium has a small, non significant effect on the vascular health parameter.
  • the two treatments arms are:
  • Control group daily 2 servings of yogurt of 250 ml each. These contain no DHA or EPA, 0 meg vitamin D and have a Ca/Mg ratio of about 10.
  • Treatment group daily 2 servings of yogurt of 250 ml each, containing a daily intake of 56.5 meg vitamin K2, 3.75 meg vitamin D3, 600 mg calcium, 280 mg magnesium and fish oil containing 200 mg of DHA and EPA.
  • the Ca/Mg ratio is 2.1.
  • the LC-PUFA's (particularly EPA and DHA) have been included in the composition for safety/antithrombotic reasons to reverse the thrombotic effects of vitamin K. It is believed that the LC-PUFAs do not contribute to the vascular elasticity marker MGP. The observed effect is, hence, due to the low Ca/Mg ratio in combination with vitamin K2.

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Abstract

La présente invention concerne des produits alimentaires supplémentés avec des micronutriments et, en particulier, une composition comprenant de la vitamine K2. La composition comprend en outre du calcium et du magnésium, le rapport Ca/Mg étant inférieur à 8. Facultativement, la composition comprend des acides gras polyinsaturés et/ou de la vitamine D. De préférence, la composition est une composition laitière et, plus préférablement, un yogourt. La composition selon l'invention offre des bénéfices pour la santé et peut être utilisée, en particulier, pour soutenir, maintenir et/ou améliorer l'élasticité vasculaire et pour la prévention du durcissement vasculaire. Elle est en outre efficace pour soutenir, maintenir et/ou améliorer la circulation sanguine et/ou le flux sanguin du système micro- et/ou macrovasculaire ; et/ou pour améliorer la transfusion sanguine et la transfusion d'oxygène et de nutriments vers les tissus et pour l'élimination de déchets et de dioxyde de carbone des tissus ; et/ou pour maintenir un niveau d'énergie adéquat.
EP12724777.3A 2011-05-20 2012-05-18 Composition comprenant de la vitamine k2 Withdrawn EP2709460A1 (fr)

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GB201314245D0 (en) * 2013-08-08 2013-09-25 Kappa Bioscience As Provitamins
EP2886129A1 (fr) * 2013-12-20 2015-06-24 VitaK B.V. Prévention et action contraire de risque de thrombose induite par le régime alimentaire
EP3258924A2 (fr) 2015-02-20 2017-12-27 VitaK B.V. Statut en vitamine k et fonction capillaire
US10563270B2 (en) * 2015-03-20 2020-02-18 Gnosis S.P.A. Solid forms of menaquinols
IT201700085412A1 (it) * 2017-07-26 2019-01-26 Pharmanutra S P A Composizione per uso nella prevenzione e nel trattamento di patologie dell'apparato cardiovascolare
US20220175888A1 (en) * 2018-04-30 2022-06-09 National Institute Of Immunology Carboxylated osteocalcin for treatment of amyloidosis or diseases associated with abnormal protein folding
CN108813262A (zh) * 2018-07-02 2018-11-16 杭州相生相成科技有限公司 一种含dha藻油的复合益生菌固体饮料
CN110122866A (zh) * 2019-05-31 2019-08-16 广东双骏生物科技有限公司 一种慢性肾脏病血管钙化的特殊医学用途食品及制备方法
CN110200086A (zh) * 2019-07-03 2019-09-06 江南大学 一种油脂组合物
CN111418653A (zh) * 2020-03-12 2020-07-17 广东双骏生物科技有限公司 一种发酵乳及其制备方法和应用
CN111345352A (zh) * 2020-04-21 2020-06-30 临夏州燎原乳业有限公司 含维生素k2和唾液酸的牦牛奶儿童配方奶粉以及制备方法
CN114451563A (zh) * 2022-02-25 2022-05-10 内蒙古伊利实业集团股份有限公司 一种组合物及其应用与食品
CN114748486A (zh) * 2022-03-25 2022-07-15 南京盛德生物科技研究院有限公司 一种含有维生素k2改善心血管钙化的药物组合物及其制备方法与应用

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US20100278940A1 (en) * 2005-04-04 2010-11-04 Hl Distribution Company Calcium supplements
AU2007271900B2 (en) * 2006-07-14 2013-05-23 Nattopharma As Pharmaceutical and nutraceutical products comprising vitamin K2
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RU2008128511A (ru) * 2008-07-15 2010-01-20 Закрытое акционерное общество "Академия-Т" (RU) Сбалансированная питательная композиция для функциональных напитков

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