EP2688670B1 - Système fluidique de remplissage sans bulles d'une chambre de filtration microfluidique - Google Patents

Système fluidique de remplissage sans bulles d'une chambre de filtration microfluidique Download PDF

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Publication number
EP2688670B1
EP2688670B1 EP12703472.6A EP12703472A EP2688670B1 EP 2688670 B1 EP2688670 B1 EP 2688670B1 EP 12703472 A EP12703472 A EP 12703472A EP 2688670 B1 EP2688670 B1 EP 2688670B1
Authority
EP
European Patent Office
Prior art keywords
channel
filter
microfluidic
venting
valve
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
EP12703472.6A
Other languages
German (de)
English (en)
Other versions
EP2688670A1 (fr
Inventor
Peter Rothacher
Jochen Rupp
Christian Dorrer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Robert Bosch GmbH
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Robert Bosch GmbH
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Publication date
Application filed by Robert Bosch GmbH filed Critical Robert Bosch GmbH
Publication of EP2688670A1 publication Critical patent/EP2688670A1/fr
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Publication of EP2688670B1 publication Critical patent/EP2688670B1/fr
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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502753—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by bulk separation arrangements on lab-on-a-chip devices, e.g. for filtration or centrifugation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502723—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by venting arrangements
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0684—Venting, avoiding backpressure, avoid gas bubbles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0681—Filter
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0874—Three dimensional network
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0887—Laminated structure
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0406—Moving fluids with specific forces or mechanical means specific forces capillary forces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • B01L2400/0633—Valves, specific forms thereof with moving parts
    • B01L2400/0655—Valves, specific forms thereof with moving parts pinch valves

Claims (5)

  1. Chambre de filtration microfluidique (10), comprenant un filtre (3), un canal de désaération (4), un canal d'entrée (1) et un canal de sortie (6),
    dans laquelle le filtre (3) est inséré entre le canal d'entrée (1) et le canal de sortie (6),
    dans laquelle le canal de désaération (4) est dérivé du canal d'entrée (1),
    dans laquelle le débit à travers la chambre de filtration microfluidique (10) peut être réglé au moyen d'une soupape (5) dans le canal de désaération (4),
    dans laquelle le canal de désaération (4) débouche dans le canal de sortie (6) et le canal d'entrée (1) et le canal de sortie (6) présentent un élargissement de canal (2) sous la forme d'une surface de section transversale variable en forme d'entonnoir avec une section transversale plus grande en direction du filtre et
    dans laquelle l'élargissement de canal (2) présente avant le filtre (3) un canal de désaération (4), qui débouche dans le canal de sortie (6).
  2. Système fluidique doté d'une chambre de filtration microfluidique (10) selon la revendication 1, caractérisé par une structure multicouche en au moins deux couches (9, 11, 14).
  3. Système fluidique selon la revendication 2, caractérisé en ce qu'il se trouve entre deux couches (11, 14.) une feuille élastique (12), qui fait office de soupape (5).
  4. Procédé pour le remplissage sans bulles d'une chambre de filtration microfluidique (10), qui comprend un filtre (3), un canal de désaération (4) et une soupape (5) disposée dans le canal de désaération (4), dans lequel le canal de désaération (4) débouche dans le canal de sortie (6) et le canal d'entrée (1) et le canal de sortie (6) présentent un élargissement de canal sous la forme d'une surface de section transversale variable en forme d'entonnoir avec une section transversale plus grande en direction du filtre et dans lequel l'élargissement de canal (2) présente avant le filtre (3) un canal de désaération (4), qui débouche dans le canal de sortie (6), dans lequel on pompe un liquide à travers le canal d'entrée (1) vers le filtre (3), tandis qu'une soupape (5) dans le canal de désaération (4) est ouverte, grâce à quoi on remplit le filtre (3) capillarité et on remplit la région de canal (2) avant le filtre (3) et une partie du canal de désaération (4), dans lequel on remplit ensuite la région de canal (13) après le filtre (3) par le canal de désaération (4), et dans lequel on ferme ensuite la soupape (5).
  5. Procédé pour la filtration d'un liquide avec une chambre de filtration microfluidique (10), dans lequel on remplit d'abord la chambre de filtration microfluidique (10) sans bulles par le procédé selon la revendication 4, puis le liquide à filtrer pénètre à travers le canal d'entrée (1) et s'écoule ensuite à travers le filtre (3) dans le canal de sortie (6).
EP12703472.6A 2011-03-23 2012-01-23 Système fluidique de remplissage sans bulles d'une chambre de filtration microfluidique Active EP2688670B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102011005932.6A DE102011005932B4 (de) 2011-03-23 2011-03-23 Fluidisches System zur blasenfreien Befüllung einer mikrofluidischen Filterkammer sowie Verfahren zur blasenfreien Befüllung und Verfahren zum Filtern einer Flüssigkeit mit einem solchen System
PCT/EP2012/050948 WO2012126647A1 (fr) 2011-03-23 2012-01-23 Système fluidique de remplissage sans bulles d'une chambre de filtration microfluidique

Publications (2)

Publication Number Publication Date
EP2688670A1 EP2688670A1 (fr) 2014-01-29
EP2688670B1 true EP2688670B1 (fr) 2019-08-07

Family

ID=45581838

Family Applications (1)

Application Number Title Priority Date Filing Date
EP12703472.6A Active EP2688670B1 (fr) 2011-03-23 2012-01-23 Système fluidique de remplissage sans bulles d'une chambre de filtration microfluidique

Country Status (4)

Country Link
EP (1) EP2688670B1 (fr)
DE (1) DE102011005932B4 (fr)
ES (1) ES2753534T3 (fr)
WO (1) WO2012126647A1 (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102018220898B4 (de) 2018-12-04 2022-10-13 Robert Bosch Gmbh Mikrofluidische Vorrichtung und Verfahren zur Filterung eines Fluids
DE102021212645A1 (de) 2021-11-10 2023-05-11 Robert Bosch Gesellschaft mit beschränkter Haftung Vorrichtung und Verfahren zur Durchführung mikrofluidischer Prozessschritte
DE102022203627A1 (de) 2022-04-11 2023-10-12 Robert Bosch Gesellschaft mit beschränkter Haftung Mikrofluidische Vorrichtung

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6416293B1 (en) * 1999-07-20 2002-07-09 Deka Products Limited Partnership Pumping cartridge including a bypass valve and method for directing flow in a pumping cartridge

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6867049B1 (en) * 2000-09-27 2005-03-15 Becton, Dickinson And Company Method for obtaining increased particle concentration for optical examination
US6811695B2 (en) 2001-06-07 2004-11-02 Nanostream, Inc. Microfluidic filter
US7081201B2 (en) * 2002-04-19 2006-07-25 3M Innovative Properties Company Encapsulated filter cartridge
DE10218554A1 (de) 2002-04-25 2003-11-06 Qiagen Gmbh Aufreinigung von Flüssigkeiten
DE10345818A1 (de) 2003-09-30 2005-04-28 Boehringer Ingelheim Micropart Verfahren und Vorrichtung zum Separieren und Abführen von Gasblasen aus Flüssigkeiten
WO2007002579A2 (fr) * 2005-06-23 2007-01-04 Bioveris Corporation Cartouches et methodes d'analyse pour instruments d'analyse delocalisee
CA2614180A1 (fr) 2005-07-06 2007-01-11 The Regents Of The University Of California Dispositifs, systemes et procedes pour isoler et separer des substances biologiques
US20090188856A1 (en) * 2007-10-20 2009-07-30 Robb Benson Externally Centering Filter Element or Cartridge and Housing and System Utilizing the Same
CN102215967A (zh) * 2008-11-13 2011-10-12 皇家飞利浦电子股份有限公司 微流体系统的入口与毛细管通道的连接

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6416293B1 (en) * 1999-07-20 2002-07-09 Deka Products Limited Partnership Pumping cartridge including a bypass valve and method for directing flow in a pumping cartridge

Also Published As

Publication number Publication date
DE102011005932A1 (de) 2012-09-27
DE102011005932B4 (de) 2022-07-14
EP2688670A1 (fr) 2014-01-29
WO2012126647A1 (fr) 2012-09-27
ES2753534T3 (es) 2020-04-13

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