Classifications

• • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
  • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
  • F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
  • F16K11/00—Multiple-way valves, e.g. mixing valves; Pipe fittings incorporating such valves
• • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
  • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
  • F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
  • F16K11/00—Multiple-way valves, e.g. mixing valves; Pipe fittings incorporating such valves
  • F16K11/02—Multiple-way valves, e.g. mixing valves; Pipe fittings incorporating such valves with all movable sealing faces moving as one unit
  • F16K11/06—Multiple-way valves, e.g. mixing valves; Pipe fittings incorporating such valves with all movable sealing faces moving as one unit comprising only sliding valves, i.e. sliding closure elements
  • F16K11/072—Multiple-way valves, e.g. mixing valves; Pipe fittings incorporating such valves with all movable sealing faces moving as one unit comprising only sliding valves, i.e. sliding closure elements with pivoted closure members
  • F16K11/074—Multiple-way valves, e.g. mixing valves; Pipe fittings incorporating such valves with all movable sealing faces moving as one unit comprising only sliding valves, i.e. sliding closure elements with pivoted closure members with flat sealing faces
  • F16K11/0743—Multiple-way valves, e.g. mixing valves; Pipe fittings incorporating such valves with all movable sealing faces moving as one unit comprising only sliding valves, i.e. sliding closure elements with pivoted closure members with flat sealing faces with both the supply and the discharge passages being on one side of the closure plates
• • G—PHYSICS
  • G01—MEASURING; TESTING
  • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
  • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
  • G01N30/02—Column chromatography
  • G01N30/04—Preparation or injection of sample to be analysed
  • G01N30/16—Injection
  • G01N30/20—Injection using a sampling valve
• • G—PHYSICS
  • G01—MEASURING; TESTING
  • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
  • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
  • G01N30/02—Column chromatography
  • G01N30/26—Conditioning of the fluid carrier; Flow patterns
• • G—PHYSICS
  • G01—MEASURING; TESTING
  • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
  • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
  • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
  • G01N35/1095—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices for supplying the samples to flow-through analysers
  • G01N35/1097—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices for supplying the samples to flow-through analysers characterised by the valves
• • G—PHYSICS
  • G01—MEASURING; TESTING
  • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
  • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
  • G01N30/02—Column chromatography
  • G01N30/04—Preparation or injection of sample to be analysed
  • G01N30/16—Injection
  • G01N30/20—Injection using a sampling valve
  • G01N2030/201—Injection using a sampling valve multiport valves, i.e. having more than two ports
• • G—PHYSICS
  • G01—MEASURING; TESTING
  • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
  • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
  • G01N30/02—Column chromatography
  • G01N30/04—Preparation or injection of sample to be analysed
  • G01N30/16—Injection
  • G01N30/20—Injection using a sampling valve
  • G01N2030/202—Injection using a sampling valve rotary valves
• • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
  • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
  • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
  • Y10T137/00—Fluid handling
  • Y10T137/8593—Systems
  • Y10T137/86493—Multi-way valve unit

Definitions

• the invention relates to a valve, in particular sample introduction valve, for a device for synthesis, analysis and / or separation purposes with at least three fluid connections, with a housing as a valve member and with a valve body as another valve member for selectively connecting the fluid connections via at least one at least partially by sealing surfaces between the housing and the valve body limited flow channel, said housing and / or valve body are mounted to be movable relative to each other.
• sample separation devices for example in a HPLC (High Performance Liquid Chromatography) device
• a valve in particular a sample introduction valve (DE102008042252A1).
• pumps for moving the mobile phase can generate a pressure of up to 1000 bar, so that the sample feeding valve must meet considerable material and leakage requirements. Therefore, complex and relatively expensive valve designs are known from the prior art, whereby these valves are denied use as a one-way valve.
• a repeated use of the valves disadvantageously requires a considerable cleaning effort. Especially the latter is of crucial importance for the result of the sample separation device, so that the sample loading valve for device for synthesis, analysis and / or separation purposes plays a special role.
• Other valves are known from US3707991A and SU773359A1. Presentation of the invention
• the invention solves this problem in that depending on a relative position, in particular of the valve body at least one adjacent to the sealing surface and a plastic material exhibiting valve member is formed plastically deformable to withstand liquid pressure in this relative position, in particular the valve body increased pressure loads in the flow channel can.
• a particularly pressure-resistant valve can be created in a structurally simple manner.
• This irreversible deformation of the plastic can namely be used to withstand liquid pressure in this relative position (relative to other relative positions, in particular of the valve body relative to the housing) increased pressure loads in the flow channel, so that even tolerances related to craft can be compensated.
• Such a valve can therefore ensure transmission of high pressures at least in a relative position, in particular of its valve body, so that a stable flow channel can be made available in order, for example, to transfer a mobile phase into a column.
• valve member the housing or even a provided between the valve member and / or the housing seal the plastic deformation of the plastic material passes through in order to create a pressure-resistant and dense flow channel or a sturdy valve to be ensured -
• the fact of the possible loss of function of the valve due to its irreversible deformation plays a minor role in the invention - after the high-pressure transfer of the mobile phase, the valve has fulfilled its function for synthesis, analysis and / or separation purposes.
• the valve according to the invention can be kept particularly structurally simple and thus cost-effective with respect to known valves, so that the possibility of a one-way valve can also open up.
• the valve according to the invention is characterized not only by its constructive simplicity and cost-effectiveness, but can also significantly simplify the handling of a device for synthesis, analysis and / or separation purposes when used as a one-way valve.
• valve body is rotatably mounted in the housing via a screw connection.
• degree of plastic deformation can be adjusted by the pitch of the screw in a simple manner, which ensures a reproducible same relative position of the valve body at its high pressure position.
• a rotary valve also opens up a constructive simplicity, because the end face of the valve body or its shell sides can be used for this purpose.
• valve body is formed at least partially plastically deformable, then the design effort can be further reduced by the guide is used to provide precisely that sealing surface for a plastic deformation, which is to limit the flow channel with increased pressure resistance.
• the valve body is relatively easy to manufacture and is usually not particularly dependent on other valve parts when assembling the valve. The associated reduced production costs can further ensure a reduction in manufacturing costs, so that the valve according to the invention can also be suitable as a one-way valve.
• valve body rotatably mounted in the housing has at least one end-side recess for at least one flow channel, a stable flow channel can be provided despite plastic deformations in the region of the sealing surface.
• Dimensional changes at the interfaces of the valve parts can namely be absorbed in a simple manner from the flow channel, without disadvantageous to be expected with a closure of this channel.
• a particularly tight connection between the housing and the valve body can be created if the valve body forms at least one plastically deformable sealing lip, which adjoins at least one sealing surface.
• the design effort and thus the cost of the one-way valve can be reduced.
• it can be ensured in this way for a sufficient plastic deformability in the region of the sealing surface, without having to expect an interruption of the flow channel. The stability of the valve can thus be significantly increased.
• the valve may have a second divided, the housing at least in the area of the liquid connections comprising bushing, in particular with in alignment the insertion guides of the liquid connections form directed receptacles for the connection of elastic hose lines.
• the hose lines can be picked up and held by the ring, whereby with the help of the elastic expansion of the hose lines under pressure loading a liquid-tight assembly of the hose lines on the valve is possible.
• a particularly inexpensive valve can thus be created.
• Assign the recordings surface structures for holding the recorded hose lines then can be ensured in a simple constructive and cost-effective manner holding the hose lines even at high pressure loads. In addition, it can be used to further improve the resistance of the valve to high pressure loads. Simplified design conditions arise when a holding thread forms such surface structures that can be pressed into the elastic hose lines, for example.
• the invention has been particularly distinguished when this valve is used as a one-way valve in a high performance liquid chromatography (HPLC) apparatus. Elaborate cleaning of the valve can thus be omitted, whereby such methods can be particularly easy to handle and reliable in their results.
• HPLC liquid chromatography
• FIG. 1 shows a device for synthesis, analysis and / or separation purposes with the valve according to the invention in its "Inject" position
• FIG. 3 is a sectional view of the valve of FIG. 1 in its "Inject" position with a plastic deformation of a valve member
• Fig. 4 is an end view of the valve body
• Fig. 5 is an enlarged view of a detail section through the valve body of Fig. 4 and
• Fig. 6 is a partially torn plan view of the valve without valve body. Way to carry out the invention
• the valve 2 has a plurality of fluid ports 3 ', 4', 5 ', 6', 7 'and 7 ", which are provided on the housing 8.
• a valve body 9 movably mounted relative to the housing 8 is provided, as can be seen in Fig. 2.
• a hose 5 is provided, which is connected to a waste container 5 ". Based on its relative position 9 ', 9 ", the liquid connections 3', 4 ', 5', 6 ', 7' and 7" can be selectively connected, with a relative position 9 'in FIG.
• a low surface pressure between the valve parts or between the housing 8 and valve body 9 at the sealing surfaces 10 ', 1 1', 12 ' has been found to be sufficient. It is conceivable to create such a low surface pressure and elastic deformation of the valve parts 8 and / or 9 conceivable. For example, such a low surface pressure is sufficient when the valve in the "load" starting position (relative position 9 ") is brought, because here only low pressures must be withstood. However, if increased pressure requirements are to be withstood by the flow channels 10, 11, 12, what is needed to control a 200 bar HPLC purification pressure, for example, is known to require considerable design effort.
• valves are therefore not suitable as a one-way valve, especially when in the direction of a plastic material for the valve parts 8 and 9 is thought, so as to provide a cost-effective valve 2.
• these disadvantages are overcome by at least one of the sealing surface 10 ', 1 1', 12 'adjacent and a plastic material exhibiting valve member 8 and / or 9 is formed plastically deformable in response to a relative position.
• FIG. 3 it can be seen that the valve body 9 as a valve part is subject to a plastic deformation 13.
• the valve body 9 is rotatably mounted in the housing 8 via a screw connection 16, in order to enable different relative positions 9 ', 9 "of the valve body 9 with respect to the housing 8 in a structurally simple manner, but in particular via the screw connection 16 a reproducibly increasing surface pressure can occur.
• a reproducibly increasing surface pressure can occur, among other things, in the fact that a reproducible plastic deformation for a dense flow channel can be ensured, so that the valve 2 can be characterized by cost-effectiveness and precision as well as by stability.
• the valve body 9 has end-side recesses 17, 18, 19 for the flow channels 10, 11 and 12, as shown in FIG. 4. Thus, despite plastic deformations in the region of the sealing surfaces 10 ', 1 1' and 12 'stable flow channels 10, 1 1 and 12 can be ensured.
• valve body 9 forms a plastically deformable sealing lip 20, the Sealing surface 10 'connects, as can be seen in particular in FIG. 5.
• this sealing lip 20 is also provided in the other flow channels 1 1 and 12.
• the possibilities for plastic deformability of the valve body 9 can be adjusted in a simple manner via the configuration of the sealing lip 20.
• the valve body 9 and the sealing lip 20 are integrally formed, so that constructive simplicity exists, especially if the entire valve body 9 (with its sealing lip) consists of a plastic material and can be produced for example by an injection molding process in one process step.
• Polyetheretherketone has been distinguished as a plastic material for the housing 8 and the valve body 9, in order to create a suitable and inexpensive sample introduction valve 2 for a device 1 for high-performance liquid chromatography (HPLC).
• a sleeve 22 is provided around the housing 8, wherein for simplicity, only one hose line 6 has been shown in FIG.
• the bushing 22 is divided into two parts, indicated by the separating surface 22 'and / or separating surface 22 ", so that it can be easily removed from the housing 8.
• the separating surface 22" can be seen that the elevation runs along this separating surface 22 "and so no In particular, the separating surface 22 "allows a simple connection of the hose lines 3, 4, 5, 6 and at the valve 2.
• the sleeve 22 is in alignment with the plug-in guides 23 of the liquid connections 3 ', 4', 5 ', 6', 7 ', 7 "directed receptacles 24 for connection of the elastic hose lines 3, 4, 5, 6, 7
• the separation 22 "of the bushing 22 in the plane of the receptacle 24 is advantageous for the simple connection possibility of the hose lines 3, 4, 5, 6, 7.

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• Engineering & Computer Science (AREA)
• General Engineering & Computer Science (AREA)
• Immunology (AREA)
• Pathology (AREA)
• Analytical Chemistry (AREA)
• Biochemistry (AREA)
• General Health & Medical Sciences (AREA)
• General Physics & Mathematics (AREA)
• Physics & Mathematics (AREA)
• Chemical & Material Sciences (AREA)
• Life Sciences & Earth Sciences (AREA)
• Health & Medical Sciences (AREA)
• Mechanical Engineering (AREA)
• Lift Valve (AREA)
• Multiple-Way Valves (AREA)
• Valve Housings (AREA)

Applications Claiming Priority (2)

Publications (1)

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ID=46026569

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Citations (1)

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• 2011
  • 2011-03-02 AT ATA278/2011A patent/AT511185B1/de not_active IP Right Cessation
• 2012
  • 2012-03-01 US US14/002,401 patent/US9611942B2/en active Active
  • 2012-03-01 CN CN2012800114105A patent/CN103403540A/zh active Pending
  • 2012-03-01 WO PCT/AT2012/050027 patent/WO2012116390A1/de active Application Filing
  • 2012-03-01 EP EP12718557.7A patent/EP2681547A1/de not_active Withdrawn
  • 2012-03-01 JP JP2013555703A patent/JP2014508934A/ja active Pending

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