EP2659881B1 - Formulation de médicament à libération retardée - Google Patents

Formulation de médicament à libération retardée Download PDF

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Publication number
EP2659881B1
EP2659881B1 EP12166110.2A EP12166110A EP2659881B1 EP 2659881 B1 EP2659881 B1 EP 2659881B1 EP 12166110 A EP12166110 A EP 12166110A EP 2659881 B1 EP2659881 B1 EP 2659881B1
Authority
EP
European Patent Office
Prior art keywords
polymeric material
coating
polymer
delayed release
core
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
EP12166110.2A
Other languages
German (de)
English (en)
Other versions
EP2659881A1 (fr
Inventor
Roberto Carlos Bravo Gonzàles
Thomas Buser
Frédéric Jean-Claude Goutte
Abdul Waseh Basit
Felipe José Oliveira VARUM
Ana Cristina Freire
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Tillotts Pharma AG
Original Assignee
Tillotts Pharma AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
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Application filed by Tillotts Pharma AG filed Critical Tillotts Pharma AG
Priority to RS20180067A priority Critical patent/RS56839B1/sr
Priority to SI201231190T priority patent/SI2659881T1/en
Priority to EP12166110.2A priority patent/EP2659881B1/fr
Priority to HUE12166110A priority patent/HUE036187T2/hu
Priority to EP17157257.1A priority patent/EP3187171A1/fr
Priority to DK12166110.2T priority patent/DK2659881T3/en
Priority to JOP/2020/0144A priority patent/JOP20200144A1/ar
Priority to PL12166110T priority patent/PL2659881T3/pl
Priority to ES12166110.2T priority patent/ES2655622T3/es
Priority to LTEP12166110.2T priority patent/LT2659881T/lt
Priority to PT121661102T priority patent/PT2659881T/pt
Priority to NO12166110A priority patent/NO2659881T3/no
Priority to JOP/2013/0111A priority patent/JO3574B1/ar
Priority to TW109117718A priority patent/TWI705833B/zh
Priority to TW102114911A priority patent/TWI618547B/zh
Priority to TW106104627A priority patent/TWI700102B/zh
Priority to SA113340508A priority patent/SA113340508B1/ar
Priority to SA115370043A priority patent/SA115370043B1/ar
Priority to TR2018/09416T priority patent/TR201809416T4/tr
Priority to LTEP13723033.0T priority patent/LT2844222T/lt
Priority to SI201331070T priority patent/SI3189830T1/en
Priority to TR2019/03569T priority patent/TR201903569T4/tr
Priority to PL13723033T priority patent/PL2844222T3/pl
Priority to DK13723033T priority patent/DK2844222T3/da
Priority to GEAP201313617A priority patent/GEP201706736B/en
Priority to EA201491781A priority patent/EA032811B1/ru
Priority to KR1020147033588A priority patent/KR102104070B1/ko
Priority to CR20190246A priority patent/CR20190246A/es
Priority to ES17156227.5T priority patent/ES2673931T3/es
Priority to JP2015509406A priority patent/JP6621661B2/ja
Priority to PT17188821T priority patent/PT3278792T/pt
Priority to KR1020197032680A priority patent/KR20190127986A/ko
Priority to CA3052460A priority patent/CA3052460C/fr
Priority to PT17156227T priority patent/PT3189830T/pt
Priority to CUP2014000124A priority patent/CU24302B1/xx
Priority to CN201380022729.2A priority patent/CN104302274A/zh
Priority to SG11201406798WA priority patent/SG11201406798WA/en
Priority to SI201331380T priority patent/SI2844220T1/sl
Priority to KR1020197032656A priority patent/KR102177773B1/ko
Priority to EA201491783A priority patent/EA032514B1/ru
Priority to CA2871016A priority patent/CA2871016C/fr
Priority to MX2018010475A priority patent/MX367127B/es
Priority to RS20180739A priority patent/RS57431B1/sr
Priority to DK17156227.5T priority patent/DK3189830T3/en
Priority to DK17188821.7T priority patent/DK3278792T3/da
Priority to MEP-2019-111A priority patent/ME03641B/fr
Priority to MYPI2014703154A priority patent/MY169088A/en
Priority to PL17156227T priority patent/PL3189830T3/pl
Priority to LTEP17188821.7T priority patent/LT3278792T/lt
Priority to MYPI2018702635A priority patent/MY190392A/en
Priority to HUE17188821A priority patent/HUE043238T2/hu
Priority to GEAP201313924A priority patent/GEP201706759B/en
Priority to BR112014026935A priority patent/BR112014026935A2/pt
Priority to US14/398,005 priority patent/US9364440B2/en
Priority to MYPI2014703153A priority patent/MY169161A/en
Priority to EP17188821.7A priority patent/EP3278792B1/fr
Priority to CN201710241732.3A priority patent/CN106983735A/zh
Priority to CUP2014000123A priority patent/CU24304B1/xx
Priority to EP17156227.5A priority patent/EP3189830B1/fr
Priority to KR1020207017103A priority patent/KR102198621B1/ko
Priority to PCT/EP2013/058921 priority patent/WO2013164315A1/fr
Priority to MX2014012888A priority patent/MX366677B/es
Priority to CN201380022727.3A priority patent/CN104271113B/zh
Priority to CN201910669166.5A priority patent/CN110237056B/zh
Priority to GEAP201313618A priority patent/GEP201706753B/en
Priority to PE2014001779A priority patent/PE20142442A1/es
Priority to CA2871017A priority patent/CA2871017A1/fr
Priority to EP13719543.4A priority patent/EP2844220B1/fr
Priority to PT13719543T priority patent/PT2844220T/pt
Priority to ES13719543T priority patent/ES2714448T3/es
Priority to BR122019022551-6A priority patent/BR122019022551B1/pt
Priority to GEAP201313923A priority patent/GEP201706758B/en
Priority to NZ629262A priority patent/NZ629262A/en
Priority to RS20190330A priority patent/RS58625B1/sr
Priority to KR1020147033589A priority patent/KR102102198B1/ko
Priority to LTEP17156227.5T priority patent/LT3189830T/lt
Priority to ES13723033T priority patent/ES2761341T3/es
Priority to MEP-2019-72A priority patent/ME03364B/fr
Priority to LTEP13719543.4T priority patent/LT2844220T/lt
Priority to PCT/EP2013/058923 priority patent/WO2013164316A1/fr
Priority to PT137230330T priority patent/PT2844222T/pt
Priority to PE2014001778A priority patent/PE20150129A1/es
Priority to EP13723033.0A priority patent/EP2844222B1/fr
Priority to CN201910669128.XA priority patent/CN110200949B/zh
Priority to SI201331409T priority patent/SI3278792T1/sl
Priority to JP2015509407A priority patent/JP6621662B2/ja
Priority to KR1020207017101A priority patent/KR20200075024A/ko
Priority to US14/397,977 priority patent/US10226430B2/en
Priority to DK13719543.4T priority patent/DK2844220T3/en
Priority to PE2019000231A priority patent/PE20190625A1/es
Priority to CUP2016000026A priority patent/CU24343B1/xx
Priority to HUE13723033A priority patent/HUE046628T2/hu
Priority to NZ629260A priority patent/NZ629260A/en
Priority to ES17188821T priority patent/ES2720258T3/es
Priority to RS20190466A priority patent/RS58735B1/sr
Priority to BR112014026933-5A priority patent/BR112014026933B1/pt
Priority to TR2019/05226T priority patent/TR201905226T4/tr
Priority to AU2013255913A priority patent/AU2013255913B2/en
Priority to SG11201406799XA priority patent/SG11201406799XA/en
Priority to PL13719543T priority patent/PL2844220T3/pl
Priority to CR20190245A priority patent/CR20190245A/es
Priority to SI201331640T priority patent/SI2844222T1/sl
Priority to CA3080035A priority patent/CA3080035A1/fr
Priority to CUP2016000014A priority patent/CU24342B1/xx
Priority to NZ725409A priority patent/NZ725409A/en
Priority to HUE17156227A priority patent/HUE037702T2/hu
Priority to HUE13719543A priority patent/HUE042833T2/hu
Priority to RS20191589A priority patent/RS59697B1/sr
Priority to AU2013255914A priority patent/AU2013255914B2/en
Priority to MX2014012887A priority patent/MX362529B/es
Priority to PL17188821T priority patent/PL3278792T3/pl
Priority to UY34772A priority patent/UY34772A/es
Priority to ARP130101470 priority patent/AR090898A1/es
Priority to US14/066,054 priority patent/US9814681B2/en
Publication of EP2659881A1 publication Critical patent/EP2659881A1/fr
Priority to CL2014002795A priority patent/CL2014002795A1/es
Priority to CL2014002796A priority patent/CL2014002796A1/es
Priority to PH12014502339A priority patent/PH12014502339A1/en
Priority to TN2014000442A priority patent/TN2014000442A1/fr
Priority to TN2014000441A priority patent/TN2014000441A1/fr
Priority to PH12014502340A priority patent/PH12014502340A1/en
Priority to CR20140486A priority patent/CR20140486A/es
Priority to CR20140485A priority patent/CR20140485A/es
Priority to IL235283A priority patent/IL235283A/en
Priority to ZA2014/07675A priority patent/ZA201407675B/en
Priority to IL235282A priority patent/IL235282A/en
Priority to ECIEPI201428077A priority patent/ECSP14028077A/es
Priority to ECIEPI201428079A priority patent/ECSP14028079A/es
Priority to CO14260653A priority patent/CO7141433A2/es
Priority to CO14260651A priority patent/CO7151506A2/es
Priority to HK18103919.2A priority patent/HK1244435B/zh
Priority to HK15102823.2A priority patent/HK1202266A1/xx
Priority to HK15102824.1A priority patent/HK1202267A1/xx
Priority to US15/267,156 priority patent/US10272048B2/en
Priority to US15/612,065 priority patent/US11517534B2/en
Priority to JP2017112035A priority patent/JP6626470B2/ja
Priority to JP2017112044A priority patent/JP6700220B2/ja
Priority to CL2017001989A priority patent/CL2017001989A1/es
Priority to CL2017001990A priority patent/CL2017001990A1/es
Priority to AU2017210571A priority patent/AU2017210571B2/en
Priority to AU2017210577A priority patent/AU2017210577B2/en
Application granted granted Critical
Publication of EP2659881B1 publication Critical patent/EP2659881B1/fr
Priority to PH12017502369A priority patent/PH12017502369A1/en
Priority to HRP20180068TT priority patent/HRP20180068T1/hr
Priority to PH12018500304A priority patent/PH12018500304B1/en
Priority to CY20181100237T priority patent/CY1120215T1/el
Priority to PH12018501311A priority patent/PH12018501311A1/en
Priority to HRP20180965TT priority patent/HRP20180965T1/hr
Priority to CY20181100815T priority patent/CY1120492T1/el
Priority to HRP20190470TT priority patent/HRP20190470T1/hr
Priority to CY20191100312T priority patent/CY1121470T1/el
Priority to CY20191100417T priority patent/CY1121609T1/el
Priority to HRP20190727TT priority patent/HRP20190727T1/hr
Priority to HRP20192210TT priority patent/HRP20192210T1/hr
Priority to CY20191101316T priority patent/CY1122475T1/el
Priority to US16/823,094 priority patent/US11534406B2/en
Priority to JOP/2020/0147A priority patent/JOP20200147B1/ar
Priority to JOP/2020/0146A priority patent/JOP20200146B1/ar
Priority to JOP/2020/0145A priority patent/JOP20200145B1/ar
Priority to JOP/2020/0148A priority patent/JOP20200148B1/ar
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2893—Tablet coating processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5084—Mixtures of one or more drugs in different galenical forms, at least one of which being granules, microcapsules or (coated) microparticles according to A61K9/16 or A61K9/50, e.g. for obtaining a specific release pattern or for combining different drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/10—Laxatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Definitions

  • the present invention relates to a delayed release formulation with a core comprising a drug and a delayed release coating.
  • a delayed release formulation for delivering a drug to the colon is a delayed release formulation for delivering a drug to the colon.
  • the targeting of drugs to the intestine is well known and has been known for over one hundred years.
  • the target of the drugs is the small intestine although the colon can be utilised as a means of achieving local therapy or systemic treatment.
  • the requirements for the coatings on the drugs are different depending on the target site. In order to reach the colon, it is necessary for the drugs to pass through the small intestine, and therefore it is a requirement that a delayed release coating intended to release the drug in the colon does not release the drug in the small intestine.
  • Coated products for release in the small intestine commonly use polymer coatings which dissolve or disintegrate in a pH dependent manner. In the low pH environment of the stomach, the polymer coating is insoluble. However, on reaching the small intestine, the pH rises to 5 and above and the polymeric coating dissolves or disintegrates.
  • a commonly used coating is one containing ionizable carboxylic groups. At higher pH levels, the carboxylic groups ionize, allowing the polymer coatings to disintegrate or dissolve.
  • Common polymers of this type which are used include Eudragit® L and Eudragit® S.
  • Various methods of improving the release in the small intestine by ensuring an earlier release of the drug are known.
  • US-A-2008/0200482 is one of a number of references which discloses partially neutralizing the carboxylic groups in order to reduce the pH at which disintegration occurs.
  • WO-A-2008/135090 discloses a tablet with an inner coat of partially neutralized material and an outer coat with less or no neutralization. This is said to result in disintegration at an earlier time point when transferred from the stomach.
  • the colon is susceptible to a number of disease states, including inflammatory bowel disease, irritable bowel syndrome, constipation, diarrhoea, infection and carcinoma. In such conditions, drug targeting to the colon would maximise the therapeutic effectiveness of the treatment.
  • the colon can also be utilised as a portal for the entry of drugs into the systemic circulation.
  • Various formulations have been developed for colonic drug delivery, including pro-drugs as well as formulated dosage forms, with the latter being more popular since the concept once proved can be applied to other drugs.
  • Amorphous amylose is resistant to digestion by the enzymes of the upper gastrointestinal tract. It is, however, fermented in the colon by ⁇ -amylase enzymes produced by over half of the 400 bacteria species resident in the colon.
  • EP 0 502 032 A (British Technology Group Ltd) teaches the use of an outer coating comprising a film forming cellulose or acrylate polymer material and amorphous amylose for a tablet comprising an active compound.
  • the polymer material used is a pH independent release polymer material.
  • a further amylose-based coating composition is disclosed in WO 99/21536 A (BTG International Limited).
  • the coating composition comprises a mixture of amylose and a water insoluble pH independent film-forming polymer which is formed from a water-insoluble cellulosic or acrylate polymer material.
  • WO 99/25325 A also discloses a delayed release coating comprising amylose and (preferably) ethyl cellulose or alternatively an acrylate polymer, the degradation of which is independent of pH.
  • the coating composition also includes a plasticiser and the method finds particular application in the preparation of dosage forms comprising active materials that are unstable at temperatures in excess of 60°C, as the composition is formed at lower temperatures than this.
  • WO 03/068196 A (Alizyme Therapeutics Ltd) discloses a specific delayed release coating for the bioactive prednisolone sodium metasulphobenzoate comprising glassy amylose, ethyl cellulose and dibutyl sebacate.
  • polysaccharides other than amorphous amylose in a delayed release coating is disclosed in GB 2367002 (British Sugar PLC).
  • examples include guar gum, karaya gum, gum tragacanth and xanthan gum.
  • Microparticles of these polysaccharides are dispersed in a water-insoluble film-forming polymer matrix formed for example from a cellulose derivative, an acrylic polymer or a lignin.
  • WO 01/76562 A discloses a peroral pharmaceutical formulation containing a drug and a chitosan (a polysaccharide obtained from chitin) for controlling its release.
  • the drug and the chitosan are mixed into a homogeneous mechanical powder mixture which is granulated and then optionally tabletised.
  • the granulation may be performed with an enteric polymer (such as a copolymer of methacrylic acid) or the granules may be provided with a porous enteric coating.
  • WO 2004/052339 A discloses a pH dependent drug release system which is a free-flowing powder of solid hydrophobic nano-spheres comprising a drug encapsulated in a pH-sensitive micro-sphere.
  • the nano-spheres are formed from the drug in combination with a wax material, and the pH-sensitive micro-sphere formed from a pH-sensitive polymer (such as a Eudragit® polymer) in combination with a water-sensitive material such as a polysaccharide.
  • US 5,422,121 discloses an oral dosage form containing at least one active ingredient enclosed within a shell material which comprises a polysaccharide that decomposes in the colon.
  • the shell material contains a film-forming polymer in admixture with the polysaccharide.
  • the ratio by weight of polysaccharide to film forming polymer is from 1:2 to 5:1, preferably from 1:1 to 4:1.
  • the reference exemplifies the use of mixtures of guar gum (or tragacanth) with a film-forming polymer selected from Eudragit RL 30 D, Eudragit RL 30 D, Eudragit® L 30 D or Eudragit® S 100 as a tablet coating.
  • WO96/36321A discloses an oral dosage form comprising a core containing bisacodyl, and an enteric polymer coating for the core, the coating comprising at least one inner coating layer and an outer coating layer.
  • the or each the inner coating layer is an enteric polymer that begins to dissolve in an aqueous medium at a pH from about 5 to about 6.3
  • the outer coating layer is an enteric polymer that begins to dissolve in an aqueous medium at a pH from about 6.8 to about 7.2.
  • the enteric polymer coating materials for the inner layer(s) are selected from the group consisting of cellulose acetate phthalate; cellulose acetate trimellitate; hydroxypropyl methylcellulose phthalate; hydroxypropyl methylcellulose acetate succinate; polyvinyl acetate phthalate; poly(methacrylic acid, methyl methacrylate) 1:1; poly(methacrylic acid, ethyl acrylate) 1:1; and compatible mixtures thereof.
  • WO 2007/122374 A discloses a colonic drug delivery formulation in which a mixture of a pH dependent film forming polymeric material and a polysaccharide such as starch is used. Although it is known that this formulation shows delayed release followed by a relatively quick release of the drug, it would be preferred if the drug release was quicker in the colon.
  • US2004/028737A discloses an enteric coated oral dosage form.
  • the enteric coating is a bilayer comprising an inner layer of neutral or near neutral pH 7 to 7.5, and an outer layer of acidic pH 2 to 6.
  • a delayed release drug formulation for oral administration to deliver a drug to the colon of a subject comprising a core and a coating for the core, the core comprising a drug and the coating comprising an outer layer and an inner layer, wherein the outer layer comprises a mixture of a first polymeric material which is susceptible to attack by colonic bacteria and a second polymeric material which has a pH threshold at about pH 6.5 or above, and wherein the inner layer comprises a third polymeric material that is soluble in intestinal fluid, said third polymeric material being a polycarboxylic acid polymer that is at least partially neutralised, wherein at least 10% of the carboxylic acid groups of the polycarboxylic acid polymer are in the form of carboxylate anions.
  • a first polymeric material susceptible to attack by colonic bacteria e.g. a polysaccharide
  • a second polymeric material which has a pH threshold at about pH 6.5 or above e.g. a polycarboxylic acid polymer of the same type as the polymer of the inner layer but either non-neutralised or partially neutralised to a lower extent than the third
  • the first polymeric material comprises at least one polysaccharide selected from the group consisting of starch; amylose; amylopectin; chitosan; chondroitin sulfate; cyclodextrin; dextran; pullulan; carrageenan; scleroglucan; chitin; curdulan and levan. It is particularly preferred that the first polymeric material is starch.
  • the second polymeric material is an anionic polymeric material, and more preferably an anionic copolymer of a (meth)acrylic acid and a (meth)acrylic acid alkyl ester.
  • the third polymeric material is an anionic polymeric material and more preferably an at least partially neutralised, preferably fully neutralised, copolymer of a (meth)acrylic acid and a (meth)acrylic acid alkyl ester.
  • the second polymeric material is the same type of copolymer of a (meth)acrylic acid and a (meth)acrylic acid alkyl ester as the third polymeric material prior to neutralisation.
  • the present invention relates to a delayed release drug formulation
  • a delayed release drug formulation comprising a core and a coating for the core, the core comprising a drug; and the coating comprising an outer layer and an inner layer, wherein the outer layer comprises a mixture of starch and a copolymer of a (meth)acrylic acid and a (meth)acrylic acid C 1-4 alkyl ester; and the inner layer comprises a fully neutralized copolymer of a (meth)acrylic acid and a (meth)acrylic acid C 1-4 alkyl ester.
  • the disadvantageous swelling of materials susceptible to attack by colonic bacteria is controlled by the inclusion of a pH dependent material having a pH threshold of pH 6.5 or above.
  • a further technical advantage of the present invention is that substantially no drug is released for an extended period (that is, whilst the coating is intact and is being dissolved/disintegrated), following which the drug is released relatively quickly. This is in contrast to homogeneous tablets from which the drug release profile is gradual from the outset rather than delayed then pulsatile.
  • a yet further technical advantage of the present invention compared to WO 2007/122374 A is accelerated release of the drug once the formulation is exposed to the conditions of the colonic environment.
  • the first polymeric material typically comprises a polysaccharide, preferably containing a plurality of glucose units, e.g. a polyglucoside.
  • the polysaccharide is at least one polysaccharide selected from the group consisting of starch; amylose; amylopectin; chitosan; chondroitin sulfate; cyclodextrin; dextran; pullulan; carrageenan; scleroglucan; chitin; curdulan and levan. It is further preferred that the polysaccharide is starch, amylose or amylopectin, most preferably starch.
  • the person skilled in the art is capable of determining whether a polymeric material is susceptible to attack by colonic bacteria using techniques comprising part of the common general knowledge. For example, a pre-determined amount of a given material could be exposed to an assay containing an enzyme from a bacterium found in the colon and the change in weight of the material over time may be measured.
  • the polysaccharide is preferably starch.
  • Starches are usually extracted from natural sources such as cereals; pulses; and tubers. Suitable starches for use in the present invention are typically food grade starches and include rice starch; wheat starch; corn (or maize) starch; pea starch; potato starch; sweet potato starch; tapioca starch; sorghum starch; sago starch; and arrow root starch.
  • rice starch wheat starch; corn (or maize) starch
  • pea starch potato starch
  • sweet potato starch tapioca starch
  • sorghum starch sago starch
  • arrow root starch The use of maize starch is exemplified below.
  • Starch is typically a mixture of two different polysaccharides, namely amylose and amylopectin. Different starches may have different proportions of these two polysaccharides. Most natural (unmodified) maize starches have from about 20 wt % to about 30 wt % amylose with the remainder being at least substantially made up of amylopectin. Starches suitable for use in the present invention typically have at least 0.1 wt %, e.g. at least 10% or 15%, preferably at least 35 wt %, amylose.
  • High amylose starches i.e. starches having at least 50 wt % amylose, are suitable. Particularly suitable starches have from about 55 wt % to about 75 wt %, e.g . about 60 wt % or about 70 wt % amylose.
  • Starches suitable for use in the present invention may have up to 100 % amylopectin, more typically from about 0.1 wt % to about 99.9 wt % amylopectin.
  • "Low amylose" starches i.e. starches having no more than 50 wt % amylose and at least 50 wt % amylopectin, e.g . up to 75 wt % amylopectin and even as much as up to 99 wt % amylopectin, are still suitable.
  • the starch may be, for example, unmodified waxy corn starch. This typically comprises about 100 % amylopectin.
  • Preferred starches have no more than 50 wt % amylopectin.
  • particularly suitable starches are "high amylose" starches which have from about 25 wt % to about 45 wt % amylopectin, e.g . about 30 wt % or about 40 wt % amylopectin.
  • NIR near-infrared
  • starch could be hydrolysed to glucose using amyloglucosidase.
  • a series of phosphorylation and oxidation reactions catalysed by enzymes result in the formation of reduced nicotinamide adenine dinucleotide phosphate ("NADPH").
  • NADPH reduced nicotinamide adenine dinucleotide phosphate
  • test kits for this procedure are available (e.g ., R-Biopharm GmbH, Germany).
  • Another method that could be used involves subjecting the coating to digestion by bacterial enzymes, e.g . ⁇ -amylase, to produce short chain fatty acids ("SCFA") which can be quantified by gas-liquid chromatography using a capillary column.
  • SCFA short chain fatty acids
  • Preferred starches have amylose in its glassy form although amylose in its amorphous form may also be used in conjunction with the present invention.
  • Preferred starches are "off-the-shelf" starches, i.e. starches which require no processing prior to use in the context of the present invention.
  • "high amylose” starches include HylonTM VII (National Starch, Germany), EurylonTM VI or Amylo N-460 (Roquette, Lestrem, France), or Amylogel 03003 (Cargill, Minneapolis, USA) all of which are examples of a maize starch having from about 50 to about 75 wt% amylose.
  • the present invention involves the use of a second polymeric material that dissolves in a pH dependent manner.
  • the second material is a film forming polymer that is pH sensitive, i.e. has a "pH threshold" which is the pH below which it is insoluble in aqueous media and at or above which it is soluble in aqueous media.
  • pH threshold is the pH below which it is insoluble in aqueous media and at or above which it is soluble in aqueous media.
  • the term “insoluble” is used to mean that 1 g of a polymeric material requires more than 10,000 ml of solvent or "surrounding medium” to dissolve at a given pH.
  • the term “soluble” is used to mean that 1 g of a polymeric material requires less than 10,000 ml, preferably less than 5,000 ml, more preferably less than 1000 ml, even more preferably less than 100 ml or 10 ml of solvent or surrounding medium to dissolve at a given pH.
  • the Inventors mean to include the intestinal fluid.
  • the surrounding medium may be a solution designed to recreate in vitro intestinal fluid.
  • the normal pH of gastric juice is usually in the range of pH 1 to 3.
  • the second polymeric material is insoluble below pH 6.5 and soluble at about pH 6.5 or above and, thus, is usually insoluble in gastric juice.
  • Such a material may be referred to as a gastro-resistant material or an "enteric" material.
  • the second polymeric material has a pH threshold of about pH 6.5 or above.
  • the second polymeric material typically has a pH threshold of no more than about pH 8, e.g. no more than about pH 7.5 and preferably no more than about pH 7.2.
  • the second polymeric material has a pH threshold within the range of pH found in intestinal fluid.
  • the pH of intestinal fluid may vary from one person to the next, but in healthy humans is generally from about pH 5 to 6 in the duodenum, from about 6 to 8 in the jejunum, from about 7 to 8 in the ileum, and from about 6 to 8 in the colon.
  • the second polymeric material has a pH threshold of about 6.5, i.e. is insoluble below pH 6.5 and soluble at about pH 6.5 or above, and preferably has a pH threshold of about 7, i.e. is insoluble below pH 7 and soluble at about pH 7 or above.
  • the pH threshold at which a material becomes soluble may be determined by a simple titration technique which would be part of the common general knowledge to the person skilled in the art.
  • the second polymeric material is typically a film-forming polymeric material such as a polymethacrylate polymer, a cellulose polymer or a polyvinyl-based polymer.
  • suitable cellulose polymers include hydropropylmethylcellulose acetate succinate (HPMC-AS).
  • the second material is an "anionic" polymeric material, i. e. a polymeric material containing groups that are ionisable in aqueous media to form anions (see below), and more preferably a co-polymer of a (meth)acrylic acid and a (meth)acrylic acid C 1-4 alkyl ester, for example, a copolymer of methacrylic acid and methacrylic acid methyl ester.
  • a polymer is known as a poly(methacrylic acid/methyl methacrylate) co-polymer.
  • Suitable examples of such co-polymers are usually anionic and not sustained release polymethacrylates.
  • the ratio of carboxylic acid groups to methyl ester groups (the "acid:ester ratio") in these co-polymers determines the pH at which the co-polymer is soluble.
  • the acid:ester ratio may be from about 2:1 to about 1:3, e.g. about 1:1 or, preferably, about 1:2.
  • the molecular weight ("MW") of preferred anionic co-polymers is usually from about 120,000 to 150,000, preferably about 135,000.
  • Preferred anionic poly(methacrylic acid/methyl methacrylate) co-polymers include Eudragit® S (acid:ester ratio about 1:2; MW about 135,000; pH threshold of about 7); and Eudragit® FS (a poly(methyl acrylate/methyl methacrylate/methacrylic acid); acid:ester ratio of about 1:10; MW about 220,000; pH threshold of about 7).
  • the Eudragit® co-polymers are manufactured and/or distributed by Evonik GmbH, Darmstadt, Germany.
  • Film forming polymer materials may be used as appropriate.
  • An example of a suitable mixture would include a mixture, e.g. a 1:1 mixture, of Eudragit® L (an anionic poly(methacrylic acid/methyl methacrylate) co-polymer having an acid:ester ratio about 1:1; MW about 135,000; and pH threshold of about 6) and Eudragit® S.
  • Eudragit® L an anionic poly(methacrylic acid/methyl methacrylate) co-polymer having an acid:ester ratio about 1:1; MW about 135,000; and pH threshold of about 6
  • Eudragit® S an anionic poly(methacrylic acid/methyl methacrylate) co-polymer having an acid:ester ratio about 1:1; MW about 135,000; and pH threshold of about 6
  • Eudragit® S an anionic poly(methacrylic acid/methyl methacrylate) co-polymer having an acid:ester ratio about 1:1; MW about 135,000; and pH threshold of about 6
  • the proportion of the first polymeric material to the second polymeric material is typically at least 1:99, e.g. at least 10:90 and preferably at least 25:75.
  • the proportion is typically no more than 99:1, e.g. no more than 75:25 and preferably no more than 60:40.
  • the proportion may be no more than 35:65.
  • the proportion is from 10:90 to 75:25, e.g. from 10:90 to 60:40 and preferably from 25:75 to 60:40.
  • the proportion is from 15:85 to 35:65, e.g. from 25:75 to 35:65 and preferably about 30:70.
  • the proportion is from 40:60 to about 60:40, e.g. about 50:50.
  • the mixture of first and second polymeric materials is preferably substantially homogenous.
  • excipients such as those excipients selected from plasticisers for film formation (for example, triethyl citrate), anti-tack agents (such as glyceryl monostearate or GMS) and surfactants (such as polysorbate 80), may be included in amounts up to 30 wt % of the final composition of the outer coating preparation.
  • plasticisers for film formation for example, triethyl citrate
  • anti-tack agents such as glyceryl monostearate or GMS
  • surfactants such as polysorbate 80
  • the thickness of the outer coating of the core is typically from about 10 ⁇ m to about 150 ⁇ m.
  • the thickness of a specific coating will, however, depend on the composition of the coating. For example, coating thickness is directly proportional to the amount of polysaccharide in the coating.
  • the coating thickness may be from about 70 ⁇ m to about 130 ⁇ m, and preferably from about 90 ⁇ m to about 110 ⁇ m.
  • the thickness (in ⁇ m) for a given coating composition is independent of core size.
  • the thickness of the outer coating is not related to the size of the core but is typically equivalent to about 2 mg/cm 2 to about 10 mg/cm 2 , preferably from about 2 mg/cm 2 to about 8 mg/cm 2 , and most preferably from about 4 mg/cm 2 to about 8 mg/cm 2 , based on the dry weight of the second polymeric material, for cores having a diameter from about 5 x 10 -4 m to about 25 mm.
  • the formulation according to the present invention additionally has an inner layer which is positioned between the core and the outer layer.
  • the inner layer comprises a third polymeric material which is soluble in intestinal fluid.
  • Intestinal fluid the Inventors mean the fluid in the lumen of the intestine of a mammal, particularly a human.
  • Intestinal fluid is a pale yellow aqueous fluid secreted from glands lining the walls of the intestine.
  • Intestinal fluid includes fluid found in the small intestine, i.e . fluid found in the duodenum (or “duodenal fluid"), fluid found in the jejunum (or “jejunal fluid") and fluid found in the ileum (or “ileal fluid”), and fluid found in the large intestine, e.g . "colonic fluid”.
  • a polymer is soluble in intestinal fluid. If a polymer is soluble in water (or aqueous solution, e.g . a buffer solution) at a pH from 5 to 8, then that polymer would typically be soluble in intestinal fluid. Alternatively, the composition of intestinal fluid is known and may be replicated in vitro. If a polymer is soluble in artificial intestinal fluid in vitro, then it would be soluble in intestinal fluid in vivo.
  • the solubility of the water soluble polymers may be dependent on pH, i.e. the third polymeric material may be a pH sensitive polymer having a pH threshold.
  • the pH threshold of the third polymeric material is less than, typically at least 0.5 pH units less than and preferably from 0.5 to 3.5 pH units less than, the pH threshold of the second polymeric material.
  • the pH threshold of the third polymeric material is typically from about pH 4.5 to about pH 7.5.
  • the third polymeric material may be soluble in at least one fluid selected from duodenal fluid, jejunal fluid and ileal fluid.
  • the solubility of the third polymeric material in water is not dependent on pH; at least not within the range of pH found in the intestine.
  • the third polymeric material is soluble in fluid at any point in the intestine.
  • Suitable polymers for use as the third polymeric material contain groups that are ionisable in aqueous media to form anions. Such polymers are known in the art as "anionic" polymers. Suitable anionic polymers are polycarboxylic acid polymers, i. e. polymers or co-polymers that contain a plurality of carboxylic acid functional groups that are ionisable in aqueous media such as intestinal fluid, to form carboxylate anions.
  • the third polymeric material is a polycarboxylic acid polymer that is at least partially neutralised with at least 10 %, preferably at least 25 %, more preferably at least 50 %, and most preferably at least 90 %, of the carboxylic acid groups in are the form of carboxylate anions. In particularly preferred embodiments, all of the carboxylic acid groups in the third polymeric material are in the form of carboxylate anions. Such polymers are referred to herein as "fully neutralised”.
  • the second and third polymeric materials are based on the same polycarboxylic acid polymer with the third polymeric material having a higher degree of neutralisation than the second polymeric material.
  • the second polymeric material may be in non-neutralised form with the third polymeric material in partially or fully neutralised form.
  • the second polymeric material may be in partially neutralised form, with the third polymeric material also in partially neutralised form (although partially neutralised to a greater extent), or in fully neutralised form.
  • polycarboxylic acid polymers examples include cellulose acetate phthalate (CAP), polyvinyl acetate phthalate (PVAP), hydroxypropyl methylcellulose phthalate (HPMCP), hydroxypropyl methylcellulose acetate succinate (HPMC-AS), cellulose acetate trimellitate (CAT), xanthan gum, alginates and shellac.
  • CAP cellulose acetate phthalate
  • PVAP polyvinyl acetate phthalate
  • HPMC-AS hydroxypropyl methylcellulose phthalate
  • CAT cellulose acetate trimellitate
  • xanthan gum alginates and shellac.
  • the polycarboxylic acid polymer is preferably selected from co-polymers of a (meth)acrylic acid and a (meth)acrylic acid alkyl, e.g. C 1-4 alkyl, ester and a copolymer of methacrylic acid and methacrylic acid methyl ester is particularly suitable.
  • Such a polymer is known as a poly(methacrylic acid/methyl methacrylate) co-polymer or a "polymethacrylate".
  • the ratio of carboxylic acid groups to methyl ester groups (the "acid:ester ratio") in these co-polymers determines the pH at which the co-polymer is soluble.
  • the acid:ester ratio may be from about 2:1 to about 1:3, e.g. about 1:1 or, preferably, about 1:2.
  • the molecular weight ("MW") of preferred anionic co-polymers is usually from about 120,000 to 150,000, preferably about 135,000.
  • Preferred co-polymers include Eudragit® L; Eudragit® S; Eudragit® FS; and Eudragit® L100-55.
  • the exemplary polymers may be used as the third polymeric material in non-neutralised form (provided the pH threshold of the polymer is less than the pH threshold of the second polymeric material - see above) or may be used in at least partially, more preferably fully, neutralised form.
  • Partially neutralised polymers suitable for use as the third polymeric material, and their methods of production, are known in the art, for example from US 2008/0200482 A and WO 2008/135090 A . These polymers may be fully neutralised by the addition of further base to the coating solutions.
  • the third polymeric material is an at least partially, preferably fully, neutralised co-polymer of (meth)acrylic acid and a (meth)acrylic acid C 1-4 alkyl ester.
  • the third polymeric material is a fully neutralised co-polymer of (meth)acrylic acid and (meth)acrylic acid methyl ester, particularly Eudragit® S.
  • Fully neutralised Eudragit® S is capable of forming a film and is readily and completely soluble in water independently of at least the range of pH found in the intestine, e.g. about pH 5 to about pH 8. Fully neutralised Eudragit® S is particularly preferred for use as the third polymeric material in the present invention.
  • film forming polymer materials may be used as appropriate.
  • the polymer components in such mixtures may be anionic polymers or a mixture of anionic and non-ionic polymers.
  • An example of a suitable mixture would include a mixture, e.g. a 1:1 mixture, of Eudragit® L and Eudragit® S, and a mixture, e.g . a 1:1 mixture, of Eudragit® S and HPMC.
  • a particular film forming polymeric material alone e.g. a poly(methacrylic acid/methyl methacrylate) co-polymer and Eudragit® S in particular, is preferred.
  • the inner layer comprises at least one base.
  • the purpose of the base is to provide an alkaline environment on the underside of the outer layer once intestinal fluid begins to penetrate the outer layer.
  • the alkaline environment facilitates disintegration of the outer layer since the pH of the alkaline environment is above the pH threshold of the second polymeric material, thereby accelerating release of the drug from the formulation once the outer coating is dissolved and/or disintegrates.
  • any pharmacologically acceptable base may be used.
  • Suitable bases include inorganic bases such as sodium hydroxide, potassium hydroxide and ammonium hydroxide, and organic bases such as triethanolamine, sodium bicarbonate, potassium carbonate, trisodium phosphate, trisodium citrate or physiologically tolerated amines such as triethylamine. Hydroxide bases in general, and sodium hydroxide in particular, are preferred.
  • the base entrapped within the inner layer is usually the base that was used to neutralise the polymer and to adjust the pH of the inner coating preparation to a pH from about pH 7.5 to about pH 10 (see below).
  • the amount of base present in the inner layer would depend at least in part on the final pH of the inner coating preparation prior to coating a given batch of cores; the number of cores to be coated in the batch; the amount of the inner coating preparation used in the coating process of the batch; and the efficiency of the coating process in terms of the amount of wasted coating preparation.
  • the inner coating preferably comprises at least one buffer agent.
  • the purpose of the buffer agent is to provide pH buffer capacity on the underside of the outer layer once intestinal fluid begins to penetrate the outer layer.
  • the buffer agent increases the buffer capacity in the dissolving inner layer and assists the ionisation and dissolution of the polymer in the outer layer. It is believed that, for a given pH, the higher the buffer capacity, the faster the rate of polymer dissolution.
  • the buffer agent helps maintains the alkaline environment under the outer layer once intestinal fluid penetrates the outer layer.
  • the buffer agent may be an organic acid such as a pharmacologically acceptable carboxylic acid having from 1 to 16, preferably 1 to 3, carbon atoms. Suitable carboxylic acids are disclosed in WO 2008/135090 A . Citric acid is an example of such a carboxylic acid.
  • the carboxylic acids may be used in carboxylate salt form, and mixtures of carboxylic acids, carboxylate salts or both may also be used.
  • the buffer agent may also be an inorganic salt such as an alkali metal salt, an alkali earth metal salt, an ammonium salt, and a soluble metal salt.
  • an inorganic salt such as an alkali metal salt, an alkali earth metal salt, an ammonium salt, and a soluble metal salt.
  • metals for the soluble metal salts manganese, iron, copper, zinc and molybdenum can be mentioned.
  • the inorganic salt is selected from chloride, fluoride, bromide, iodide, phosphate, nitrate, nitrite, sulphate and borate.
  • Phosphates such as potassium dihydrogen phosphate are preferred over other inorganic buffer salts and organic acid buffers due to their greater buffer capacity at the pH of the coating solution, for example pH 8.
  • the buffer(s) is usually present in the inner layer in an amount from about 0.1 to about 20 wt %, e.g. from about 0.1 to about 4 wt %, preferably from about 0.1 to about 3 wt %, and more preferably about 1 wt %, based on the dry weight of the third polymeric material.
  • the inner layer may comprise conventional excipients for polymer films, including those excipients selected from plasticizers (such a triethyl citrate), anti-tack agents (such as GMS), and surfactants (such as polysorbate 80).
  • plasticizers such as a triethyl citrate
  • anti-tack agents such as GMS
  • surfactants such as polysorbate 80
  • the thickness of the inner coating of the core is typically from about 10 ⁇ m to about 150 ⁇ m.
  • the thickness of the inner layer is not related to the size of the core but is typically equivalent to about 2 mg/cm 2 to about 10 mg/cm 2 , preferably from about 2 mg/cm 2 to about 8 mg/cm 2 , and most preferably from about 3 mg/cm 2 to about 7 mg/cm 2 , based on the dry weight of the third polymeric material, for cores having a diameter from about 0.2 mm to about 30 mm.
  • the formulation of the present invention may have an additional (or isolation) layer either between the active core and the inner layer and/or a top coating layer coating the outer layer.
  • an isolation layer between the active core and the inner layer is preferred. Any suitable isolation layer known to the skilled person can be used.
  • the isolation layer comprises a non-ionic polymer such as HMPC or PVA.
  • the isolation layer can additionally comprise polyethylene glycol.
  • the “core” is the solid body on which the inner layer is applied.
  • the core may be any suitable dosage form, for example, a tablet, a pellet, a granule, a microparticle, a hard or soft capsule, or a microcapsule.
  • the core comprises the drug(s).
  • the drug(s) may be contained within the body of the core, for example within the matrix of a tablet or pellet, or within the contents encapsulated within a capsule.
  • the drug may be in a coating applied to the core, for example where the core is a bead of edible material such as sugar, e.g . where the core is in the form of a nonpareil bead or dragee.
  • the core may consist of the drug(s) alone, or more usually may consist of the drug(s) and at least one pharmacologically acceptable excipient.
  • the core is typically a tablet or pellet and consists of a mixture of the drug(s) with a filler or diluent material, e.g . lactose or cellulose material such as microcrystalline cellulose; a binder, e.g . polyvinylpyrrolidone ("PVP") or hydroxypropyl methylcellulose (HPMC); a disintegrant, e.g. croscarmellose sodium ( e.g. Ac-Di-SolTM) and sodium starch glycolate ( e.g. ExplotabTM); and/or a lubricant, e.g. magnesium stearate and talc.
  • the core may be a compressed granulate comprising at least some of these materials.
  • the core may be uncoated or, as indicated above, the core may itself comprise a coating such as an isolation layer on to which the inner layer is applied.
  • each core is typically at least about 10 -4 m, usually at least about 5 x 10 -4 m and, preferably, at least about 10 -3 m.
  • the maximum diameter is usually no more than 30 mm, typically no more than 25 mm and, preferably, no more than 20 mm.
  • the core has a diameter from about 0.2 mm to about 25 mm, and preferably from about 0.2 mm to about 4 mm (e.g. for pellets or mini-tablets) or from about 15 mm to about 25 mm (e.g. for certain tablets or capsules).
  • the term "diameter" refers to the largest linear dimension through the core.
  • the formulation may comprise a plurality of coated cores in order to provide a single dose of the drug(s), particularly in embodiments in which the core is "small", e.g. having a diameter of less than 5 mm. Multiunit dosage forms comprising coated cores having a diameter of less than 3 mm may be preferred.
  • the present invention has application in a multi-phasic drug release formulation comprising at least two pluralities of coated cores, e.g. coated pellets, in the same dosage form, e.g. a capsule, in which the coated cores of one plurality are differentiated from the coated cores of the or each other plurality by the coating.
  • the coatings may differ from one plurality to the next in terms of coating thickness or composition, e.g. the ratio and/or identity of components.
  • Multi-phasic drug release formulations would be particularly suitable for suffers of Crohn's disease affecting different regions along the intestine.
  • Release from formulations according to the present invention is typically delayed until at least the distal ileum and, preferably, the colon. Release from certain formulations may also be sustained. However, in preferred formulations, release is pulsatile.
  • the time between initial exposure to conditions suitable for drug release and the start of drug release is known as the "lag time".
  • the lag time depends on a number of factors including coating thickness and composition and may vary from one patient to the next.
  • Formulations according to the present invention usually display a lag time in colonic conditions of at least 10 minutes. In most embodiments, the lag time is from about 10 minutes to about 8 hours.
  • the lag time in faecal slurry at pH 6.8 may be from about 10 minutes to about 2 hours, e.g . from about 30 minutes to about 1.5 hours.
  • Complete release of the drug may be achieved in no more than 5 hours, e.g. no more than 4 hours, after exposure to these conditions.
  • a formulation is usually defined as gastric resistant if there is less than 10 wt % drug release in acidic media after 2 hours.
  • Formulations according to the present invention typically display far less than 10 wt % drug release in acidic media and may be considered to be gastric resistant.
  • the formulations usually display less than 1 wt % drug release in acidic media and, typically, display substantially no drug release in acidic media.
  • starch is combined with an acrylate film forming material to form the outer layer of the coating for the core, typically less than 5% drug release occurs over 5 hours in conditions simulating the stomach and small intestine.
  • the core is a tablet having a diameter of 15-25 mm.
  • the outer layer preferably comprises a 30:70 mixture of high amylose starch, e.g. EurylonTM VII or VI, and a polymethacrylate polymer, e.g. EudragitTM S
  • the inner layer preferably comprises a fully neutralized polymethacrylate polymer, e.g. EudragitTM S, applied from an inner coating preparation having a pH of about 8.
  • the core is preferably coated with the inner layer to a thickness from about 3 to about 7 mg/cm 2 (based on dry weight of the polymethacrylate polymer) to form an inner layer coated core, which is then coated with the outer layer to a thickness from about 4 to about 8 mg/cm 2 (based on dry weight of polymethacrylate polymer).
  • a formulation according to the first aspect for use in a method of medical treatment of the human or animal body by therapy.
  • the core comprises at least one drug.
  • the formulation is usually used to administer a single drug as the sole therapeutically active component. However, more than one drug may be administered in a single formulation.
  • the formulation of the present invention is designed to administer a wide range of drugs. Suitable drugs include those drugs which are known for intestinal administration using known delayed release oral formulations.
  • the present invention may be used to administer drugs having a local or a systemic effect.
  • the formulation of the present invention has particular application in the intestinal administration of a drug comprising at least one acidic group such as a carboxylic acid group.
  • a drug comprising at least one acidic group such as a carboxylic acid group.
  • Such drugs may be acidic drugs or zwitterionic drugs.
  • An example of such a drug is 5-aminosalicylic acid (5ASA or mesalazine).
  • the identity of the drug(s) in the formulation obviously depends on the condition to be treated.
  • the formulation has particular application in the treatment of IBD (including Crohn's disease and ulcerative colitis); IBS; constipation; diarrhoea; infection; and carcinoma, particularly colon or colorectal cancer.
  • the formulation may comprise at least one drug selected from the group consisting of non-steroidal anti-inflammatory agents (e.g. 5ASA); steroids (e.g. prednisolone; budesonide or fluticasone); immunosuppressants (e.g. azathioprine; cyclosporin; and methotrexate); and antibiotics.
  • non-steroidal anti-inflammatory agents e.g. 5ASA
  • steroids e.g. prednisolone; budesonide or fluticasone
  • immunosuppressants e.g. azathioprine; cyclosporin; and methotrexate
  • antibiotics e.g. azathioprine; cyclosporin; and methotrexate
  • the formulation may comprise at least one antineoplastic agent.
  • Suitable antineoplastic agents include fluorouracil; methotrexate; dactinomycin; bleomycin; etoposide; taxol; vincristine; doxorubicin; cisplatin; daunorubicin; VP-16; raltitrexed; oxaliplatin; and pharmacologically acceptable derivatives and salts thereof.
  • the formulation may comprise the anti-inflammatory agent, 5ASA.
  • the formulation may comprise at least one active agent suitable for the treatment or prevention of these conditions.
  • Pharmacologically acceptable derivatives and/or salts of the drugs may also be used in the formulation.
  • An example of a suitable salt of prednisolone is methyl prednisolone sodium succinate.
  • a further example is fluticasone propionate.
  • the present invention has particular application in either the treatment of IBD (particularly, ulcerative colitis) or the prevention of colon cancer or colorectal cancer (primarily in colitis patients), both using 5ASA. It also has application as a portal of entry of drugs into the systemic circulation via the colon. This is particularly advantageous for peptide and protein drugs which are unstable in the upper gastrointestinal tract.
  • the present invention may also be utilised for the purpose of chronotherapy.
  • a method of targeting a drug to the colon comprising administering to a patient a formulation as defined above.
  • a formulation as defined above in the manufacture of a medicament for the treatment or prevention of IBD (particularly ulcerative colitis); IBS; constipation; diarrhoea; infection; and cancer.
  • At least one drug selected from anti-inflammatory agents and steroids in the manufacture of a medicament comprising a formulation as defined above for use in the treatment of IBD.
  • at least one antineoplastic agent in the manufacture of a medicament comprising a formulation as defined above for use in the treatment of carcinoma.
  • 5ASA in the manufacture of a medicament comprising a formulation as defined above for use in the prevention of colon cancer or colorectal cancer.
  • a method of medical treatment or prevention of IBD or carcinoma comprises administering to a patient a therapeutic amount of a formulation as defined above.
  • the formulation will typically comprise a therapeutically effective amount of the or each drug which may be from about 0.01 wt % to about 99 wt %, based on the total weight of the formulation.
  • the actual dosage would be determined by the skilled person using his common general knowledge.
  • "low" dose formulations typically comprise no more than about 20 wt % of the drug, and preferably comprise from about 1 wt % to about 10 wt %, e.g. about 5 wt %, of the drug.
  • "High” dose formulations typically comprise at least 40 wt % of the drug, and preferably from about 45 wt % to about 85 wt %, e.g. about 50 wt % or about 80 wt %.
  • a method of producing a delayed release drug formulation for oral administration to deliver a drug to the colon according to the first aspect comprises:
  • the solvent system of the inner coating preparation is preferably aqueous.
  • the method typically comprises dispersing a polycarboxylic acid polymer in a solvent, optionally with a buffer agent, and adding base to at least partially neutralise the polycarboxylic acid polymer to form the inner coating preparation.
  • the amount of base added is at least sufficient to fully neutralise the polycarboxylic acid polymer.
  • the pH of the inner coating preparation is preferably adjusted to be from about pH 7.5 to about pH 10, e.g. from about pH 7.5 to about pH 8.5, preferably from about pH 7.8 to about pH 8.2, and more preferably about pH 8.
  • the outer coating may be applied using the method described in WO 2007/122374 A .
  • 5-aminosalicylic acid (mesalazine EP) was purchased from Cambrex Karlskoga AB, Karlskoga, Sweden. Lactose (Tablettose 80) was purchased from Meggle, Hamburg, Germany. Sodium starch glycolate (ExplotabTM) was purchased from JRS Pharma, Rosenberg, Germany. Talc was purchased from Luzenac Kunststoff GmbH, Düsseldorf, Germany. Polyvinylpyrolidon (PVP) was purchased from ISP Global Technologies, Wie, Germany. Magnesium stearate was purchased from Peter Greven GmbH, Bad Wegeifel, Germany. Eudragit® S 100 was purchased from Evonik, Darmstadt, Germany. Maize starch (N-460) was purchased from Roquette, Lestrem, France.
  • Oblong shaped tablets with dimensions 14.5 x 5.7 mm were prepared by fluid bed granulation followed by blending and compression. Each tablet contains 76.9 wt % 5ASA (400 mg; drug); 14.7 wt % lactose (filler); 1.7 wt % PVP (binder); 3.5 wt % sodium starch glycolate (disintegrant); and 2 wt % talc and 1.2 wt % magnesium stearate (lubricants).
  • the obtained tablet cores were coated as discussed below.
  • the inner coating layer was applied using an aqueous preparation of Eudragit ® S 100, where the pH is adjusted to pH 8.
  • the composition of the inner layer also includes 50% of triethyl citrate (based on dry polymer weight), 10% potassium dihydrogen phosphate (based on dry polymer weight), 10% glyceryl monostearate (GMS; based on dry polymer weight) and 40% polysorbate 80 (based on GMS weight).
  • the pH was adjusted using 1M NaOH until the pH 8 was obtained. Potassium dihydrogen phosphate and triethyl citrate were dissolved in distilled water, followed by dispersion of the Eudragit ® S 100 under mechanical agitation. The pH of the dispersion was then adjusted to pH 8 with 1M NaOH and left mixing for 1 hour.
  • a GMS dispersion was prepared at a concentration of 10% w/w.
  • Polysorbate 80 (40% based on GMS weight) was dissolved in distilled water followed by dispersion of the GMS. The dispersion was then heated to 75 °C for 15 minutes under strong magnetic stirring in order to form an emulsion. The emulsion was cooled at room temperature and under stirring.
  • the GMS dispersion was added to the neutralised Eudragit ® S 100 solution and the final preparation was coated on to 400 mg 5ASA tablet cores, using a fluid bed spray coating machine until the coating amount reached 5 mg polymer/cm 2 .
  • the total solids content of the coating solution is 10%.
  • the coating parameters were as follows: spraying rate 20 ml/min/kg tablets, atomizing pressure 0.2 bar and inlet air temperature 40 °C.
  • the outer coating layer was applied from a mixture of an aqueous starch dispersion and an organic Eudragit ® S 100 solution.
  • the aqueous starch dispersion was prepared by dispersing maize starch into butan-1-ol, followed by water, under magnetic stirring. The ratio of maize starch : butan-1-ol : water was 1 : 2 : 22.
  • the resulting dispersion was heated to boiling and then cooled under stirring overnight. The % solids content of the cooled preparation was calculated based on the final weight of the dispersion (considering the evaporation during heating).
  • the organic Eudragit ® S 100 solution was prepared by dissolving Eudragit ® S 100 in 96% ethanol under high speed stirring. The final solution contained about 6% polymer solids.
  • the starch dispersion was added dropwise to the Eudragit ® S 100 solution to obtain a ratio of starch : Eudragit ® S of 30 : 70.
  • the mixture was mixed for 2 hours and 20% triethyl citrate (based on total polymer weight) and 5% glyceryl monostearate (GMS, based on total polymer weight) were added and mixed for further 2 hours.
  • the GMS was added in the form of a dispersion prepared at a concentration of 5% w/w.
  • Polysorbate 80 (40% based on GMS weight) was dissolved in distilled water followed by dispersion of the GMS. This dispersion was then heated to 75 °C for 15 minutes under strong magnetic stirring in order to form an emulsion. The emulsion was cooled at room temperature and under stirring.
  • the final preparation was coated on to 5ASA tablet cores, previously coated with the inner coating layer, using a fluid bed spray coating machine until a coating having 7 mg Eudragit ® polymer/cm 2 was obtained.
  • the spray coating parameters were as follows: spraying rate 14 ml/min/kg tablets, atomizing pressure 0.2 bar and inlet air temperature 40 °C.
  • the coating layer containing Eudragit ® S 100 was applied as an organic coating composition.
  • the coating composition contained 20% triethyl citrate (based on dry polymer weight), 10% glyceryl monostearate (based on dry polymer weight) and 40% polysorbate 80 (based on GMS weight). Briefly, triethyl citrate was dissolved in 96% ethanol followed by Eudragit ® S 100 under mechanical stirring and mixing continued for 1 hour.
  • the GMS was added in the form of a dispersion prepared at a concentration of 10% w/w.
  • Polysorbate 80 (40% based on GMS weight) was dissolved in distilled water followed by dispersion of GMS. This preparation was then heated to 75°C for 15 minutes under strong magnetic stirring in order to form an emulsion. The emulsion was cooled at room temperature and under stirring.
  • the GMS dispersion was added to the organic Eudragit ® S solution and the final coating solution was coated on to the 5ASA tablet cores, using a fluid bed spray coating machine to achieve a coating amount of 5 mg polymer/cm 2 .
  • the coating parameters were as follows: spraying rate 16 ml/min/kg tablets, atomizing pressure 0.2 bar and inlet air temperature 40°C.
  • the coating layer composition contains a mixture of an aqueous starch dispersion and an organic Eudragit ® S 100 solution.
  • the aqueous starch dispersion was prepared by dispersing maize starch into butan-1-ol, followed by water, under magnetic stirring. The ratio of maize starch : butan-1-ol : water was 1 : 2 : 22. The resulting dispersion was heated to boiling and then cooled under stirring overnight. The % solids content of the cooled preparation was calculated based on the final weight of the dispersion (considering the evaporation during heating).
  • the organic Eudragit ® S solution was prepared by dissolution of Eudragit ® S 100 in 96% ethanol under high speed stirring. The final solution contained about 6% polymer solids.
  • the starch dispersion was added dropwise to the Eudragit ® S 100 solution to obtain a ratio of starch : Eudragit S of 30 : 70.
  • the mixture was mixed for 2 hours and 20% triethyl citrate (based on total polymer weight) and 5% glyceryl monostearate (based on total polymer weight) were added and the mixture was mixed for further 2 hours.
  • the GMS was added in the form of a dispersion prepared at a concentration of 5% w/w.
  • Polysorbate 80 (40% based on GMS weight) was dissolved in distilled water followed by dispersion of GMS. This preparation was then heated to 75 °C for 15 minutes under strong magnetic stirring in order to form an emulsion. The emulsion was cooled at room temperature and under stirring.
  • the final preparation was coated on to the 5ASA tablet cores in a fluid bed spray coating machine until a 7 mg Eudragit ® S polymer/cm 2 was obtained.
  • the spray coating parameters were as follows: spraying rate 14 ml/min/kg tablets, atomizing pressure 0.2 bar and inlet air temperature 40 °C.
  • the inner coating layer is composed by an aqueous preparation of Eudragit ® S 100, where the pH is adjusted to pH 8.
  • the composition of the inner layer also includes 50% of triethyl citrate (based on dry polymer weight), 10% potassium dihydrogen phosphate (based on dry polymer weight), 10% glyceryl monostearate (based on dry polymer weight) and 40% polysorbate 80 (based on GMS weight).
  • the pH was adjusted using 1M NaOH until the pH 8 is obtained. Potassium dihydrogen phosphate and triethyl citrate were dissolved in distilled water, followed by dispersion of the Eudragit ® S 100 under mechanical agitation. The pH was then adjusted to pH 8 with 1M NaOH and left mixing for 1 hour.
  • a GMS dispersion was prepared at a concentration of 10% w/w.
  • Polysorbate 80 (40% based on GMS weight) was dissolved in distilled water followed by dispersion of GMS. This preparation was then heated to 75 °C for 15 minutes under strong magnetic stirring in order to form an emulsion. The emulsion was cooled at room temperature and under stirring.
  • the GMS dispersion was added to the neutralised Eudragit ® S solution and the final preparation was coated on to 5ASA tablet cores, using a fluid bed spray coating machine until the coating amount reached 5 mg polymer/cm 2 .
  • the total solids content of the coating solution is 10%.
  • the coating parameters were as follows: spraying rate 20 ml/min/kg tablets, atomizing pressure 0.2 bar and inlet air temperature 40 °C.
  • the outer coating layer is composed of Eudragit ® S 100, applied as an organic solution.
  • the coating solution contains 20% triethyl citrate (based on dry polymer weight), 10% glyceryl monostearate (based on dry polymer weight) and 40% polysorbate 80 (based on GMS weight). Briefly, triethyl citrate was dissolved in 96% ethanol followed by Eudragit ® S 100 under mechanical stirring and mixing continued for 1 hour.
  • a GMS dispersion was prepared at a concentration of 10% w/w.
  • Polysorbate 80 (40% based on GMS weight) was dissolved in distilled water followed by dispersion of the GMS. This dispersion was then heated to 75 °C for 15 minutes under strong magnetic stirring in order to form an emulsion. The emulsion was cooled at room temperature and under stirring.
  • the GMS preparation was added to the Eudragit® S 100 solution and the final coating solution was coated on to 5ASA tablet cores, previously coated with the inner coating layer, using a fluid bed spray coating machine to achieve a coating amount of 5 mg Eudragit ® S polymer/cm 2 .
  • the coating parameters were as follows: spraying rate 16 ml/min/kg tablets, atomizing pressure 0.2 bar and inlet air temperature 40°C.
  • the composition per litre of Krebs buffer is 0.16 g of KH 2 PO 4 , 6.9 g of NaCl, 0.35 g KCl, 0.29 g MgSO 4 .7H 2 O, 0.376 g CaCl 2 .2H 2 O and 2.1 g NaHCO 3 . Only the measurements taken at 15 minute intervals are depicted in Fig. 1 .
  • the fermentation assays used to test the formulations were based on the method described by Hughes et al. ("In vitro fermentation of oat and parley derived beta-glucans by human faecal microbiota" FEMS Microbiol. Ecol.; 2008; 64(3); pp 482 to 493 ).
  • the basal medium used to allow bacteria growth was prepared accordingly to the supracited publication and the composition per litre is as follows: 2 g peptone water; 2 g yeast extract; 0.1 g NaCl; 0.04 g K 2 HPO 4 ; 0.01 g MgSO 4 .7H 2 O; 0.01 g CaCl 2 .6H 2 O; 2 g NaHCO 3 ; 0.005 g haemin; 0.5 g L-cysteine HCl; 0.5 g bile salts; 2 mL Tween 80; 10 mL vitamin K; and 4 mL of 0.025% (w/v) resazurin solution.
  • This composition was mixed in a ratio of 1:1 with a faecal slurry, which was prepared by homogenizing fresh human faeces (3 different donors) in phosphate buffered saline pH 6.8 at a concentration of 40% w/w.
  • the final concentration of the prepared faecal slurry (diluted with basal medium) is 20% w/w.
  • the donors had not received antibiotic treatment for at least 3 months before the study.
  • the pH of the slurry was adjusted to 6.8 by adding 4M NaOH dropwise, dispersing the NaOH with a sterile spoon and remeasuring the pH.
  • the pH meter was allowed to equilibrate inside the anaerobic working station (at 37°C and 70% RH) for approximately 10 minutes before calibration.
  • the pH electrode was calibrated using a two point method with pH 7.01 and 4.01 buffer solutions.
  • Each tablet being tested was placed in an individual plastic transparent container containing 210mL of slurry.
  • the containers were placed on an IKA® VXR basic Vibrax® bench top shaker at a speed of 100 shakes per minute. This agitation speed did not cause mechanical damage to the tablet coatings.
  • 1.5 ml samples were removed at 0, 1, 2, 3, 4, 5, 6, 7, 8 and 24 hours into 1.5 ml labelled eppendorf tubes. After time 0, before a sample was withdrawn, the slurry was stirred manually to ensure the active drug was homogeneously dissolved in the slurry. Samples were withdrawn from 2 different sites.
  • the pH was found to drop below pH 6.8 during the first four hours. Thus, during this period, the pH was measured every 30 minutes and adjusted to pH 6.8 using 4 M NaOH. After 4 hours, the pH was checked every hour and adjusted using NaOH or HCl when necessary.
  • 100 ⁇ l of the filtered supernatant was measured using a micropipette into labelled 2ml amber glass HPLC vials and diluted with 900 ⁇ l of mobile phase (95% water, 5% methanol and 0.05% trifluoracetic acid (TFA)).
  • mobile phase 95% water, 5% methanol and 0.05% trifluoracetic acid (TFA)
  • the composition per litre of Hanks buffer is 0.06 g of KH 2 PO 4 , 0.06g Na 2 HPO 4 .2H 2 O 8.0 g NaCl, 0.4 g KCl, 0.2 g MgSO 4 .7H 2 O 0.139 g CaCl 2 .2H 2 O and 0.350 g NaHCO 3 .
  • the delayed release formulation according to the present invention is significantly superior to comparative formulations.
  • the word 'or' is used in the sense of an operator that returns a true value when either or both of the stated conditions is met, as opposed to the operator 'exclusive or' which requires that only one of the conditions is met.
  • the word 'comprising' is used in the sense of 'including' rather than in to mean 'consisting of'.

Claims (16)

  1. Formulation de médicament à libération retardée pour une administration orale pour administrer un médicament au côlon d'un sujet, ladite formulation comprenant un coeur et un enrobage pour le coeur, le coeur comprenant un médicament et l'enrobage comprenant une couche externe et une couche interne, la couche externe comprenant un mélange d'une première matière polymère qui est sensible à une attaque par des bactéries coliques et une deuxième matière polymère qui a un seuil de pH à pH 6,5 ou au-dessus, et la couche interne comprenant une troisième matière polymère qui est soluble dans le fluide intestinal, ladite troisième matière polymère étant un polymère d'acide polycarboxylique qui est au moins partiellement neutralisé, au moins 10 % des groupes acide carboxylique du polymère d'acide polycarboxylique se présentant sous la forme d'anions carboxylate.
  2. Formulation de médicament à libération retardée selon la revendication 1, dans laquelle au moins 90 % des groupes acide carboxylique du polymère d'acide polycarboxylique se présentent sous la forme d'anions carboxylate.
  3. Formulation de médicament à libération retardée selon la revendication 1 ou la revendication 2, dans laquelle la troisième matière polymère est totalement neutralisée.
  4. Formulation de médicament à libération retardée selon l'une quelconque des revendications 1 à 3, dans laquelle les deuxième et troisième matières polymères sont à base du même polymère d'acide polycarboxylique que la troisième matière polymère ayant un degré supérieur de neutralisation par rapport à la deuxième matière polymère.
  5. Formulation de médicament à libération retardée selon l'une quelconque des revendications précédentes, dans laquelle la troisième matière polymère est choisie parmi les polyméthacrylates ; l'acétate phtalate de cellulose (CAP) ; le polyvinyl acétate phtalate (PVAP) ; le phtalate d'hydroxypropyl méthylcellulose (HPMCP) ; l'acétate succinate d'hydroxypropyl méthylcellulose (HPMC-AS) ; l'acétate trimellitate de cellulose (CAT) ; la gomme xanthane ; les alginates et la gomme-laque.
  6. Formulation de médicament à libération retardée selon l'une quelconque des revendications précédentes, dans laquelle la troisième matière polymère est un copolymère au moins partiellement neutralisé d'acide (méth) acrylique et d'un alkyl en C1-4 ester de l'acide (méth)acrylique.
  7. Formulation de médicament à libération retardée selon l'une quelconque des revendications précédentes, dans laquelle la troisième matière polymère est un copolymère totalement neutralisé d'acide (méth)acrylique et d'ester méthylique de l'acide (méth)acrylique.
  8. Formulation de médicament à libération retardée selon l'une quelconque des revendications précédentes, dans laquelle la couche interne comprend un agent tampon choisi parmi un sel inorganique ou un acide carboxylique pharmacologiquement acceptable ayant de 1 à 16 atomes de carbone.
  9. Formulation de médicament à libération retardée selon l'une quelconque des revendications précédentes, dans laquelle la couche interne comprend une base pharmacologiquement acceptable choisie parmi une base inorganique ou une amine physiologiquement tolérée.
  10. Formulation de médicament à libération retardée selon l'une quelconque des revendications précédentes, dans laquelle la troisième matière polymère est soluble dans l'eau indépendamment du pH.
  11. Procédé de fabrication d'une formulation de médicament à libération retardée pour une administration orale pour administrer un médicament au côlon, selon la revendication 1, ledit procédé comprenant :
    former un coeur comprenant un médicament ;
    enrober le coeur à l'aide d'une préparation d'enrobage interne comprenant une troisième matière polymère qui est soluble dans le fluide intestinal, dans un système solvant pour former un coeur à enrobage interne ; et
    enrober le coeur à enrobage interne par une préparation d'enrobage externe comprenant une première matière polymère qui est sensible à une attaque par des bactéries coliques et une deuxième matière polymère qui a un seuil de pH de pH 6,5 ou au-dessus dans un système solvant, pour former un coeur à enrobage externe ;
    ladite troisième matière polymère étant un polymère d'acide polycarboxylique qui est au moins partiellement neutralisé, au moins 10 % des groupes acide carboxylique du polymère d'acide polycarboxylique se présentant sous la forme d'anions carboxylate.
  12. Procédé selon la revendication 11, dans lequel le système solvant de la préparation d'enrobage interne est aqueux.
  13. Procédé selon la revendication 11 ou la revendication 12, ledit procédé comprenant la dispersion d'un polymère d'acide polycarboxylique dans un solvant, facultativement avec un agent tampon, et l'addition d'une base pour au moins partiellement neutraliser le polymère d'acide polycarboxylique pour former la préparation d'enrobage interne.
  14. Procédé selon la revendication 13, dans lequel la quantité de base ajoutée est au moins suffisante pour neutraliser au moins 90 % des groupes acide carboxylique dans le polymère d'acide polycarboxylique.
  15. Procédé selon la revendication 13 ou la revendication 14, dans lequel la quantité de base ajoutée est supérieure à celle suffisante pour neutraliser totalement le polymère d'acide polycarboxylique.
  16. Procédé selon l'une quelconque des revendications 11 à 15, dans lequel le pH de la préparation d'enrobage interne est ajusté pour être de pH 7,5 à pH 10.
EP12166110.2A 2012-04-30 2012-04-30 Formulation de médicament à libération retardée Active EP2659881B1 (fr)

Priority Applications (158)

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RS20180067A RS56839B1 (sr) 2012-04-30 2012-04-30 Formulacija leka sa odloženim otpuštanjem
SI201231190T SI2659881T1 (en) 2012-04-30 2012-04-30 Formulation of the delayed release medicinal product
EP12166110.2A EP2659881B1 (fr) 2012-04-30 2012-04-30 Formulation de médicament à libération retardée
HUE12166110A HUE036187T2 (hu) 2012-04-30 2012-04-30 Késleltetett leadású gyógyszerkészítmény
EP17157257.1A EP3187171A1 (fr) 2012-04-30 2012-04-30 Formulation de médicament à libération retardée
DK12166110.2T DK2659881T3 (en) 2012-04-30 2012-04-30 Delayed release drug formulation
JOP/2020/0144A JOP20200144A1 (ar) 2012-04-30 2012-04-30 تركيبة عقار ذو إطلاق متأخر
PL12166110T PL2659881T3 (pl) 2012-04-30 2012-04-30 Formulacja leku o opóźnionym uwalnianiu
ES12166110.2T ES2655622T3 (es) 2012-04-30 2012-04-30 Una formulación de fármaco de liberación retardada
LTEP12166110.2T LT2659881T (lt) 2012-04-30 2012-04-30 Uždelsto atpalaidavimo vaisto forma
PT121661102T PT2659881T (pt) 2012-04-30 2012-04-30 Formulação de fármaco de libertação retardada
NO12166110A NO2659881T3 (fr) 2012-04-30 2012-04-30
JOP/2013/0111A JO3574B1 (ar) 2012-04-30 2013-04-21 تركيبة عقار ذو إطلاق متأخر
TW109117718A TWI705833B (zh) 2012-04-30 2013-04-25 緩釋藥物配方
TW102114911A TWI618547B (zh) 2012-04-30 2013-04-25 緩釋藥物配方
TW106104627A TWI700102B (zh) 2012-04-30 2013-04-25 緩釋藥物配方
SA113340508A SA113340508B1 (ar) 2012-04-30 2013-04-28 تركيبة عقار ذو إطلاق متأخر
SA115370043A SA115370043B1 (ar) 2012-04-30 2013-04-28 تركيبة عقار ذو إطلاق متأخر
PT137230330T PT2844222T (pt) 2012-04-30 2013-04-29 Formulação de fármaco de libertação retardada
HUE13723033A HUE046628T2 (hu) 2012-04-30 2013-04-29 Késleltetett felszabadulású gyógyszerkészítmény
SI201331070T SI3189830T1 (en) 2012-04-30 2013-04-29 FORMULATION OF THE MEDICINAL PRODUCT WITH LOWER REMEDY
TR2019/03569T TR201903569T4 (tr) 2012-04-30 2013-04-29 Bir gecikmeli salım ilaç formülasyonu.
PL13723033T PL2844222T3 (pl) 2012-04-30 2013-04-29 Formulacja leku o opóźnionym uwalnianiu
DK13723033T DK2844222T3 (da) 2012-04-30 2013-04-29 Lægemiddelformulering med forsinket udløsning
GEAP201313617A GEP201706736B (en) 2012-04-30 2013-04-29 A delayed release drug formulation
EA201491781A EA032811B1 (ru) 2012-04-30 2013-04-29 Лекарственный препарат с отсроченным высвобождением и способ его получения
KR1020147033588A KR102104070B1 (ko) 2012-04-30 2013-04-29 지연 방출형 약물 제형
CR20190246A CR20190246A (es) 2012-04-30 2013-04-29 Formulación de fármaco de liberación retardada
ES17156227.5T ES2673931T3 (es) 2012-04-30 2013-04-29 Una formulación de fármaco de liberación retardada
JP2015509406A JP6621661B2 (ja) 2012-04-30 2013-04-29 遅延放出性薬物製剤
PT17188821T PT3278792T (pt) 2012-04-30 2013-04-29 Formulação de farmaco de libertação retardada
KR1020197032680A KR20190127986A (ko) 2012-04-30 2013-04-29 지연 방출형 약물 제형
CA3052460A CA3052460C (fr) 2012-04-30 2013-04-29 Formulation medicamenteuse a liberation retardee
PT17156227T PT3189830T (pt) 2012-04-30 2013-04-29 Formulação de fármaco de libertação retardada
CUP2014000124A CU24302B1 (es) 2012-04-30 2013-04-29 Formulación de fármaco de liberación retardada
CN201380022729.2A CN104302274A (zh) 2012-04-30 2013-04-29 延迟释放的药物制剂
SG11201406798WA SG11201406798WA (en) 2012-04-30 2013-04-29 A delayed release drug formulation
SI201331380T SI2844220T1 (sl) 2012-04-30 2013-04-29 Formulacija zdravila z zakasnjenim sproščanjem
KR1020197032656A KR102177773B1 (ko) 2012-04-30 2013-04-29 지연 방출형 약물 제형
EA201491783A EA032514B1 (ru) 2012-04-30 2013-04-29 Лекарственный препарат с отсроченным высвобождением и способ его получения
CA2871016A CA2871016C (fr) 2012-04-30 2013-04-29 Formulation medicamenteuse a liberation retardee
MX2018010475A MX367127B (es) 2012-04-30 2013-04-29 Formulación de fármaco de liberación retardada que comprende un núcleo y un recubrimiento para el núcleo que comprende al menos dos o tres capas poliméricas.
RS20180739A RS57431B1 (sr) 2012-04-30 2013-04-29 Formulacija leka sa odloženim otpuštanjem
DK17156227.5T DK3189830T3 (en) 2012-04-30 2013-04-29 PHARMACEUTICAL FORMULATION WITH DELAYED DELIVERY
DK17188821.7T DK3278792T3 (da) 2012-04-30 2013-04-29 Lægemiddelformulering med forsinket udløsning
MEP-2019-111A ME03641B (fr) 2012-04-30 2013-04-29 Formulation de médicament à libération retardée
MYPI2014703154A MY169088A (en) 2012-04-30 2013-04-29 A delayed release drug formulation
PL17156227T PL3189830T3 (pl) 2012-04-30 2013-04-29 Formulacja leku o opóźnionym uwalnianiu
LTEP17188821.7T LT3278792T (lt) 2012-04-30 2013-04-29 Uždelsto atpalaidavimo vaisto forma
MYPI2018702635A MY190392A (en) 2012-04-30 2013-04-29 A delayed release drug formulation
HUE17188821A HUE043238T2 (hu) 2012-04-30 2013-04-29 Késleltetett felszabadulású gyógyszerkészítmény
GEAP201313924A GEP201706759B (en) 2012-04-30 2013-04-29 Delayed release drug formulation
BR112014026935A BR112014026935A2 (pt) 2012-04-30 2013-04-29 formulação de droga de liberação retardada, e, método para produzir uma formulação de droga de liberação retardada
US14/398,005 US9364440B2 (en) 2012-04-30 2013-04-29 Delayed release drug formulation
MYPI2014703153A MY169161A (en) 2012-04-30 2013-04-29 A delayed release drug formulation
EP17188821.7A EP3278792B1 (fr) 2012-04-30 2013-04-29 Formulation de médicament à libération retardée
CN201710241732.3A CN106983735A (zh) 2012-04-30 2013-04-29 延迟释放的药物制剂
CUP2014000123A CU24304B1 (es) 2012-04-30 2013-04-29 Formulación de fármaco de liberación retardada
EP17156227.5A EP3189830B1 (fr) 2012-04-30 2013-04-29 Formulation de médicament à libération retardée
KR1020207017103A KR102198621B1 (ko) 2012-04-30 2013-04-29 지연 방출형 약물 제형
PCT/EP2013/058921 WO2013164315A1 (fr) 2012-04-30 2013-04-29 Formulation médicamenteuse à libération retardée
MX2014012888A MX366677B (es) 2012-04-30 2013-04-29 Formulación de fármaco de liberación retardada que comprende un núcleo y un recubrimiento para el núcleo que comprende al menos dos o tres capas poliméricas.
CN201380022727.3A CN104271113B (zh) 2012-04-30 2013-04-29 延迟释放的药物制剂
CN201910669166.5A CN110237056B (zh) 2012-04-30 2013-04-29 延迟释放的药物制剂
GEAP201313618A GEP201706753B (en) 2012-04-30 2013-04-29 Delayed release drug formulation
PE2014001779A PE20142442A1 (es) 2012-04-30 2013-04-29 Formulacion de farmaco de liberacion retardada
CA2871017A CA2871017A1 (fr) 2012-04-30 2013-04-29 Formulation medicamenteuse a liberation retardee
EP13719543.4A EP2844220B1 (fr) 2012-04-30 2013-04-29 Formulation de médicament à libération retardée
PT13719543T PT2844220T (pt) 2012-04-30 2013-04-29 Formulação de fármaco de libertação retardada
ES13719543T ES2714448T3 (es) 2012-04-30 2013-04-29 Una formulación de fármaco de liberación retardada
BR122019022551-6A BR122019022551B1 (pt) 2012-04-30 2013-04-29 Formulação de fármaco de liberação retardada, e, método para produzir uma formulação de fármaco de liberação retardada
GEAP201313923A GEP201706758B (en) 2012-04-30 2013-04-29 Delayed release drug formulation
NZ629262A NZ629262A (en) 2012-04-30 2013-04-29 A delayed release drug formulation
RS20190330A RS58625B1 (sr) 2012-04-30 2013-04-29 Formulacija leka sa odloženim otpuštanjem
KR1020147033589A KR102102198B1 (ko) 2012-04-30 2013-04-29 지연 방출형 약물 제형
LTEP17156227.5T LT3189830T (lt) 2012-04-30 2013-04-29 Uždelsto atpalaidavimo vaisto forma
ES13723033T ES2761341T3 (es) 2012-04-30 2013-04-29 Una formulación de fármaco de liberación retardada
MEP-2019-72A ME03364B (fr) 2012-04-30 2013-04-29 Formulation médicamenteuse à libération retardée
LTEP13719543.4T LT2844220T (lt) 2012-04-30 2013-04-29 Uždelsto atpalaidavimo vaisto forma
PCT/EP2013/058923 WO2013164316A1 (fr) 2012-04-30 2013-04-29 Formulation médicamenteuse à libération retardée
TR2018/09416T TR201809416T4 (tr) 2012-04-30 2013-04-29 Bir gecikmeli salım ilaç formülasyonu.
PE2014001778A PE20150129A1 (es) 2012-04-30 2013-04-29 Formulacion de farmaco de liberacion retardada
EP13723033.0A EP2844222B1 (fr) 2012-04-30 2013-04-29 Formulation de médicament à libération retardée
CN201910669128.XA CN110200949B (zh) 2012-04-30 2013-04-29 延迟释放的药物制剂
SI201331409T SI3278792T1 (sl) 2012-04-30 2013-04-29 Formulacija zdravila z zakasnjenim sproščanjem
JP2015509407A JP6621662B2 (ja) 2012-04-30 2013-04-29 遅延放出性薬物製剤
KR1020207017101A KR20200075024A (ko) 2012-04-30 2013-04-29 지연 방출형 약물 제형
US14/397,977 US10226430B2 (en) 2012-04-30 2013-04-29 Delayed release drug formulation
DK13719543.4T DK2844220T3 (en) 2012-04-30 2013-04-29 PHARMACEUTICAL FORMULATION WITH DELAYED DELIVERY
PE2019000231A PE20190625A1 (es) 2012-04-30 2013-04-29 Formulacion de farmaco de liberacion retardada
CUP2016000026A CU24343B1 (es) 2012-04-30 2013-04-29 Formulación de fármaco de liberación retardada
LTEP13723033.0T LT2844222T (lt) 2012-04-30 2013-04-29 Uždelsto atpalaidavimo vaisto forma
NZ629260A NZ629260A (en) 2012-04-30 2013-04-29 A delayed release drug formulation
ES17188821T ES2720258T3 (es) 2012-04-30 2013-04-29 Una formulación de fármaco de liberación retardada
RS20190466A RS58735B1 (sr) 2012-04-30 2013-04-29 Formulacija leka sa odloženim otpuštanjem
BR112014026933-5A BR112014026933B1 (pt) 2012-04-30 2013-04-29 Formulação de fármaco de liberação retardada, e, método para produzir uma formulação de fármaco de liberação retardada
TR2019/05226T TR201905226T4 (tr) 2012-04-30 2013-04-29 Bir gecikmeli salım ilaç formülasyonu.
AU2013255913A AU2013255913B2 (en) 2012-04-30 2013-04-29 A delayed release drug formulation
SG11201406799XA SG11201406799XA (en) 2012-04-30 2013-04-29 A delayed release drug formulation
PL13719543T PL2844220T3 (pl) 2012-04-30 2013-04-29 Formulacja leku o opóźnionym uwalnianiu
CR20190245A CR20190245A (es) 2012-04-30 2013-04-29 FORMULACIÓN DE FÁRMACO DE LIBERACIÓN RETARDADA (Divisional del Expediente 2014-0486)
SI201331640T SI2844222T1 (sl) 2012-04-30 2013-04-29 Formulacija zdravila z zakasnjenim sproščanjem
CA3080035A CA3080035A1 (fr) 2012-04-30 2013-04-29 Formulation medicamenteuse a liberation retardee
CUP2016000014A CU24342B1 (es) 2012-04-30 2013-04-29 Formulación de fármaco de liberación retardada
NZ725409A NZ725409A (en) 2012-04-30 2013-04-29 A delayed release drug formulation
HUE17156227A HUE037702T2 (hu) 2012-04-30 2013-04-29 Késleltetett kibocsájtású gyógyszerkészítmény
HUE13719543A HUE042833T2 (hu) 2012-04-30 2013-04-29 Késleltetett kibocsátású gyógyszerkészítmény
RS20191589A RS59697B1 (sr) 2012-04-30 2013-04-29 Formulacija leka sa odloženim otpuštanjem
AU2013255914A AU2013255914B2 (en) 2012-04-30 2013-04-29 A delayed release drug formulation
MX2014012887A MX362529B (es) 2012-04-30 2013-04-29 Formulación de fármaco de liberación retardada que comprende un núcleo y un recubrimiento multicapa para el núcleo que comprende al menos tres capas poliméricas.
PL17188821T PL3278792T3 (pl) 2012-04-30 2013-04-29 Formulacja leku o opóźnionym uwalnianiu
UY34772A UY34772A (es) 2012-04-30 2013-04-30 ?una formulación de fármaco de liberación retardada?.
ARP130101470 AR090898A1 (es) 2012-04-30 2013-04-30 Una formulacion de farmaco de liberacion retardada
US14/066,054 US9814681B2 (en) 2012-04-30 2013-10-29 Delayed release drug formulation
CL2014002795A CL2014002795A1 (es) 2012-04-30 2014-10-17 Una formulacion de farmaco de liberacion retardada oral para suministrar un farmaco al colon que comprende un nucleo y un recubrimiento para el nucleo, el nucleo comprende un farmaco y el recubrimiento comprende una capa exterior con una mezcla de un primer y segundo material polimerico y una capa interior con un tercer material polimerico; y su metodo de preparacion.
CL2014002796A CL2014002796A1 (es) 2012-04-30 2014-10-17 Formulación de fármaco de liberación retardada que comprende una capa externa formada por una mezcla de un primer material polimerico que es suceptible ataques por parte de la bacteria colonica y un segundo material polimerico que tiene un umbral de ph 5 o superior, y la capa interna contiene un material polimerico de acido policarboxilico soluble en fluido intestinal o gastrointestinal.
PH12014502339A PH12014502339A1 (en) 2012-04-30 2014-10-20 A delayed release drug formulation
TN2014000442A TN2014000442A1 (en) 2012-04-30 2014-10-20 A delayed release drug formulation
TN2014000441A TN2014000441A1 (en) 2012-04-30 2014-10-20 A delayed release drug formulation
PH12014502340A PH12014502340A1 (en) 2012-04-30 2014-10-20 A delayed release drug formulation
CR20140486A CR20140486A (es) 2012-04-30 2014-10-21 Formulacion de farmaco de liberacion retardada
CR20140485A CR20140485A (es) 2012-04-30 2014-10-21 Formulacion de farmaco de liberacion retardada
IL235283A IL235283A (en) 2012-04-30 2014-10-22 Formula for drug with delayed release
ZA2014/07675A ZA201407675B (en) 2012-04-30 2014-10-22 A delayed release drug formulation
IL235282A IL235282A (en) 2012-04-30 2014-10-22 Formula for drug with delayed release
ECIEPI201428077A ECSP14028077A (es) 2012-04-30 2014-11-25 Formulación de fármaco de liberación retardada (1)
ECIEPI201428079A ECSP14028079A (es) 2012-04-30 2014-11-25 Formulación de fármaco de liberación retardada (2)
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HK18103919.2A HK1244435B (zh) 2012-04-30 2015-03-19 延遲釋放的藥物製劑
HK15102823.2A HK1202266A1 (en) 2012-04-30 2015-03-19 A delayed release drug formulation
HK15102824.1A HK1202267A1 (en) 2012-04-30 2015-03-19 A delayed release drug formulation
US15/267,156 US10272048B2 (en) 2012-04-30 2016-09-16 Delayed release drug formulation
US15/612,065 US11517534B2 (en) 2012-04-30 2017-06-02 Delayed release drug formulation
JP2017112035A JP6626470B2 (ja) 2012-04-30 2017-06-06 遅延放出性薬物製剤
JP2017112044A JP6700220B2 (ja) 2012-04-30 2017-06-06 遅延放出性薬物製剤
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AU2017210571A AU2017210571B2 (en) 2012-04-30 2017-08-03 A delayed release drug formulation
AU2017210577A AU2017210577B2 (en) 2012-04-30 2017-08-03 A delayed release drug formulation
PH12017502369A PH12017502369A1 (en) 2012-04-30 2017-12-20 A delayed release drug formulation
HRP20180068TT HRP20180068T1 (hr) 2012-04-30 2018-01-15 Formulacije lijeka s produljenim oslobađanjem
PH12018500304A PH12018500304B1 (en) 2012-04-30 2018-02-12 A delayed release drug formulation
CY20181100237T CY1120215T1 (el) 2012-04-30 2018-02-27 Μια μορφοποιηση φαρμακου καθυστερημενης εκλυσης
PH12018501311A PH12018501311A1 (en) 2012-04-30 2018-06-19 A delayed release drug formulation
HRP20180965TT HRP20180965T1 (hr) 2012-04-30 2018-06-26 Formulacija lijeka s produženim otpuštanjem
CY20181100815T CY1120492T1 (el) 2012-04-30 2018-08-06 Μια μορφοποιηση φαρμακου καθυστερημενης εκλυσης
HRP20190470TT HRP20190470T1 (hr) 2012-04-30 2019-03-11 Formulacija lijeka s odgođenim otpuštanjem
CY20191100312T CY1121470T1 (el) 2012-04-30 2019-03-15 Μια μορφοποιηση φαρμακου καθυστερημενης εκλυσης
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HRP20190727TT HRP20190727T1 (hr) 2012-04-30 2019-04-17 Formulacija odgođenog otpuštanja lijeka
HRP20192210TT HRP20192210T1 (hr) 2012-04-30 2019-12-09 Formulacija lijeka s produženim otpuštanjem
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US16/823,094 US11534406B2 (en) 2012-04-30 2020-03-18 Delayed release drug formulation
JOP/2020/0147A JOP20200147B1 (ar) 2012-04-30 2020-06-09 تركيبة عقار ذو إطلاق متأخر
JOP/2020/0146A JOP20200146B1 (ar) 2012-04-30 2020-06-09 تركيبة عقار ذو إطلاق متأخر
JOP/2020/0145A JOP20200145B1 (ar) 2012-04-30 2020-06-09 تركيبة عقار ذو إطلاق متأخر
JOP/2020/0148A JOP20200148B1 (ar) 2012-04-30 2020-06-09 تركيبة عقار ذو إطلاق متأخر

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