PH12018501311A1 - A delayed release drug formulation - Google Patents
A delayed release drug formulationInfo
- Publication number
- PH12018501311A1 PH12018501311A1 PH12018501311A PH12018501311A PH12018501311A1 PH 12018501311 A1 PH12018501311 A1 PH 12018501311A1 PH 12018501311 A PH12018501311 A PH 12018501311A PH 12018501311 A PH12018501311 A PH 12018501311A PH 12018501311 A1 PH12018501311 A1 PH 12018501311A1
- Authority
- PH
- Philippines
- Prior art keywords
- polymeric material
- drug
- core
- layer
- inner layer
- Prior art date
Links
Landscapes
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
Delayed release of a drug to the colon is achieved from a delayed release formulation comprising a core and a coating for the core. The core comprises a drug and the coating comprises an outer layer and at least one layer between the core and the outer layer selected from the group consisting of an isolation layer and an inner layer. The outer layer comprises a mixture of a first polymeric material which is susceptible to attack by colonic bacteria, and a second polymeric material which has a pH threshold at about pH 5 or above. The inner layer comprises a third polymeric material which is soluble in intestinal fluid or gastrointestinal fluid, said third polymeric material being selected from an at least partially neutralised polycarboxylic acid and a non-ionic polymer. In embodiments in which the third polymeric material is a non-ionic polymer, the inner layer comprises at least one of a buffer agent and a base. The isolation layer comprises a non-ionic polymer which is soluble in intestinal fluid or gastrointestinal fluid. The outer is applied directly to the inner layer or the isolation layer using a coating preparation formed by combining the first polymeric material in an aqueous medium with a second polymeric material in an organic medium. Advantages of formulations according to the present invention include accelerated release of the drug when exposed to colonic conditions and reduction or elimination of a food and/or alcohol effect on drug release after administration.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261640217P | 2012-04-30 | 2012-04-30 | |
EP12166110.2A EP2659881B1 (en) | 2012-04-30 | 2012-04-30 | A delayed release drug formulation |
PCT/EP2013/058923 WO2013164316A1 (en) | 2012-04-30 | 2013-04-29 | A delayed release drug formulation |
Publications (1)
Publication Number | Publication Date |
---|---|
PH12018501311A1 true PH12018501311A1 (en) | 2020-09-14 |
Family
ID=54196716
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PH12017502369A PH12017502369A1 (en) | 2012-04-30 | 2017-12-20 | A delayed release drug formulation |
PH12018500304A PH12018500304B1 (en) | 2012-04-30 | 2018-02-12 | A delayed release drug formulation |
PH12018501311A PH12018501311A1 (en) | 2012-04-30 | 2018-06-19 | A delayed release drug formulation |
Family Applications Before (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PH12017502369A PH12017502369A1 (en) | 2012-04-30 | 2017-12-20 | A delayed release drug formulation |
PH12018500304A PH12018500304B1 (en) | 2012-04-30 | 2018-02-12 | A delayed release drug formulation |
Country Status (10)
Country | Link |
---|---|
JP (2) | JP6626470B2 (en) |
CL (2) | CL2017001989A1 (en) |
CU (2) | CU24343B1 (en) |
CY (1) | CY1121470T1 (en) |
EC (2) | ECSP14028079A (en) |
HK (3) | HK1202267A1 (en) |
HR (3) | HRP20190470T1 (en) |
IL (2) | IL235283A (en) |
PH (3) | PH12017502369A1 (en) |
ZA (1) | ZA201407675B (en) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP3662900A1 (en) * | 2018-12-07 | 2020-06-10 | Tillotts Pharma AG | Colonic drug delivery formulation |
EP3662902A1 (en) * | 2018-12-07 | 2020-06-10 | Tillotts Pharma AG | Colonic drug delivery formulation |
CN113493220A (en) * | 2020-04-02 | 2021-10-12 | 杨洋 | Hollow metal oxide microsphere, preparation method thereof and drug sustained-release application |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5422121A (en) * | 1990-11-14 | 1995-06-06 | Rohm Gmbh | Oral dosage unit form |
WO2008135090A1 (en) * | 2007-05-07 | 2008-11-13 | Evonik Röhm Gmbh | Solid dosage forms comprising an enteric coating with accelerated drug release |
ES2655622T3 (en) * | 2012-04-30 | 2018-02-20 | Tillotts Pharma Ag | A delayed release drug formulation |
-
2013
- 2013-04-29 CU CUP2016000026A patent/CU24343B1/en unknown
- 2013-04-29 CU CUP2016000014A patent/CU24342B1/en unknown
-
2014
- 2014-10-22 IL IL235283A patent/IL235283A/en active IP Right Grant
- 2014-10-22 ZA ZA2014/07675A patent/ZA201407675B/en unknown
- 2014-10-22 IL IL235282A patent/IL235282A/en active IP Right Grant
- 2014-11-25 EC ECIEPI201428079A patent/ECSP14028079A/en unknown
- 2014-11-25 EC ECIEPI201428077A patent/ECSP14028077A/en unknown
-
2015
- 2015-03-19 HK HK15102824.1A patent/HK1202267A1/en unknown
- 2015-03-19 HK HK18103919.2A patent/HK1244435B/en not_active IP Right Cessation
- 2015-03-19 HK HK15102823.2A patent/HK1202266A1/en unknown
-
2017
- 2017-06-06 JP JP2017112035A patent/JP6626470B2/en active Active
- 2017-06-06 JP JP2017112044A patent/JP6700220B2/en not_active Expired - Fee Related
- 2017-08-03 CL CL2017001989A patent/CL2017001989A1/en unknown
- 2017-08-03 CL CL2017001990A patent/CL2017001990A1/en unknown
- 2017-12-20 PH PH12017502369A patent/PH12017502369A1/en unknown
-
2018
- 2018-02-12 PH PH12018500304A patent/PH12018500304B1/en unknown
- 2018-06-19 PH PH12018501311A patent/PH12018501311A1/en unknown
-
2019
- 2019-03-11 HR HRP20190470TT patent/HRP20190470T1/en unknown
- 2019-03-15 CY CY20191100312T patent/CY1121470T1/en unknown
- 2019-04-17 HR HRP20190727TT patent/HRP20190727T1/en unknown
- 2019-12-09 HR HRP20192210TT patent/HRP20192210T1/en unknown
Also Published As
Publication number | Publication date |
---|---|
PH12018500304A1 (en) | 2018-09-24 |
HRP20190727T1 (en) | 2019-06-14 |
JP2017145267A (en) | 2017-08-24 |
HRP20190470T1 (en) | 2019-05-17 |
JP6700220B2 (en) | 2020-05-27 |
JP6626470B2 (en) | 2019-12-25 |
PH12017502369A1 (en) | 2020-09-28 |
CU20160026A7 (en) | 2016-05-30 |
PH12018500304B1 (en) | 2018-09-24 |
CL2017001990A1 (en) | 2018-03-16 |
CU20160014A7 (en) | 2016-04-25 |
HRP20192210T1 (en) | 2020-02-21 |
JP2017145268A (en) | 2017-08-24 |
HK1202267A1 (en) | 2015-09-25 |
ECSP14028079A (en) | 2015-12-31 |
CU24342B1 (en) | 2018-05-08 |
CY1121470T1 (en) | 2020-05-29 |
ZA201407675B (en) | 2016-05-25 |
IL235282A (en) | 2017-09-28 |
CU24343B1 (en) | 2018-05-08 |
HK1244435B (en) | 2019-10-25 |
ECSP14028077A (en) | 2015-12-31 |
CL2017001989A1 (en) | 2018-03-16 |
IL235283A (en) | 2017-09-28 |
HK1202266A1 (en) | 2015-09-25 |
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