CL2017001990A1 - Delayed-release drug formulation (divisional application 2796-2014) - Google Patents
Delayed-release drug formulation (divisional application 2796-2014)Info
- Publication number
- CL2017001990A1 CL2017001990A1 CL2017001990A CL2017001990A CL2017001990A1 CL 2017001990 A1 CL2017001990 A1 CL 2017001990A1 CL 2017001990 A CL2017001990 A CL 2017001990A CL 2017001990 A CL2017001990 A CL 2017001990A CL 2017001990 A1 CL2017001990 A1 CL 2017001990A1
- Authority
- CL
- Chile
- Prior art keywords
- polymer material
- polymer
- layer
- core
- drug
- Prior art date
Links
Landscapes
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
<p>LA LIBERACIÓN RETARDADA DE UN FÁRMACO AL COLON SE LOGRA DE UNA FORMULACIÓN DE LIBERACIÓN RETARDADA QUE COMPRENDE UN NÚCLEO Y UN RECUBRIMIENTO PARA EL NÚCLEO. EL NÚCLEO COMPRENDE UN FÁRMACO Y UN RECUBRIMIENTO QUE COMPRENDE UNA CAPA INTERIOR Y AL MENOS UNA CAPA ENTRE EL NÚCLEO Y LA CAPA EXTERIOR SELECCIONADA DEL GRUPO QUE CONSISTE DE UNA CAPA DE AISLAMIENTO Y UNA CAPA INTERIOR. LA CAPA EXTERIOR COMPRENDE UNA MEZCLA DE UN PRIMER MATERIAL POLIMÉRICO QUE ES SUSCEPTIBLE A ATAQUES POR PARTE DE LA BACTERIA COLÓNICA, Y UN SEGUNDO MATERIAL POLIMÉRICO QUE TIENE UN UMBRAL DE PH A APROXIMADAMENTE PH 5 O MÁS ALTO. LA CAPA INTERIOR COMPRENDE UN TERCER MATERIAL POLIMÉRICO QUE ES SOLUBLE EN EL FLUIDO INTESTINAL O EN EL FLUIDO GASTROINTESTINAL, TAL TERCER MATERIAL POLIMÉRICO SE SELECCIONA DE ÁCIDO POLICARBOXÍLICO AL MENOS PARCIALMENTE NEUTRALIZADO Y UN POLÍMERO NO IÓNICO. EN MODALIDADES EN DONDE EL TERCER MATERIAL POLIMÉRICO ES UN POLÍMERO NO IÓNICO, LA CAPA INTERIOR COMPRENDE AL MENOS UN AGENTE AMORTIGUADOR Y UNA BASE. LA CAPA DE AISLAMIENTO COMPRENDE UN POLÍMERO NO IÓNICO QUE ES SOLUBLE EN EL FLUIDO INTESTINAL O FLUIDO GASTROINTESTINAL. EL EXTERIOR ES UN MEDIO ACUOSO CON UN SEGUNDO MATERIAL POLIMÉRICO EN UN MEDIO ORGÁNICO. LAS VENTAJAS DE LAS FORMULACIONES DE ACUERDO CON LA PRESENTE INVENCIÓN INCLUYEN LA LIBERACIÓN ACELERADA DEL FÁRMACO CUANDO SE EXPONE A CONDICIONES COLÓNICAS Y LA REDUCCIÓN O ELIMINACIÓN DEL EFECTO DE LOS ALIMENTOS Y/O ALCOHOL EN LA LIBERACIÓN DEL FÁRMACO DESPUÉS DE LA ADMINISTRACIÓN.</p><p> THE DELAYED RELEASE OF A DRUG TO THE COLON IS ACHIEVED BY A FORMATION OF DELAYED RELEASE THAT INCLUDES A CORE AND A COVER FOR THE CORE. THE CORE INCLUDES A DRUG AND COVERING THAT INCLUDES AN INTERIOR LAYER AND AT LEAST ONE LAYER BETWEEN THE CORE AND THE SELECTED EXTERNAL LAYER OF THE GROUP THAT CONSISTS OF AN INSULATION LAYER AND AN INSIDE LAYER. THE OUTER LAYER INCLUDES A MIXTURE OF A FIRST POLYMER MATERIAL THAT IS SUSCEPTIBLE TO ATTACKS BY THE COLONIC BACTERIA, AND A SECOND POLYMER MATERIAL THAT HAS A THRESHOLD OF PH TO APPROXIMATELY PH 5 OR HIGHER. THE INNER LAYER INCLUDES A THIRD POLYMER MATERIAL THAT IS SOLUBLE IN THE INTESTINAL FLUID OR IN THE GASTROINTESTINAL FLUID, SUCH THIRD POLYMER MATERIAL IS SELECTED FROM POLYCARBOXYLIC ACID AT LEAST PARTIALLY NEUTRALIZED AND A NON-POLYMER POLYMER. IN MODALITIES WHERE THE THIRD POLYMER MATERIAL IS A NON-IONIC POLYMER, THE INNER LAYER INCLUDES AT LEAST A SHOCK AGENT AND A BASE. THE INSULATION LAYER INCLUDES A NON-IONIC POLYMER THAT IS SOLUBLE IN THE INTESTINAL FLUID OR GASTROINTESTINAL FLUID. THE OUTSIDE IS A WATERFUL ENVIRONMENT WITH A SECOND POLYMER MATERIAL IN AN ORGANIC ENVIRONMENT. THE ADVANTAGES OF THE FORMULATIONS IN ACCORDANCE WITH THE PRESENT INVENTION INCLUDE THE ACCELERATED RELEASE OF THE DRUG WHEN IT IS EXPOSED TO COLONIC CONDITIONS AND THE REDUCTION OR ELIMINATION OF THE EFFECT OF THE FOODS AND / OR ALCOHOL IN THE RELEASE OF THE DRUG ADMINISTRATION. >
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261640217P | 2012-04-30 | 2012-04-30 | |
| EP12166110.2A EP2659881B1 (en) | 2012-04-30 | 2012-04-30 | A delayed release drug formulation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CL2017001990A1 true CL2017001990A1 (en) | 2018-03-16 |
Family
ID=54196716
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CL2017001989A CL2017001989A1 (en) | 2012-04-30 | 2017-08-03 | Delayed-release drug formulation. (divisional application 2795-2014) |
| CL2017001990A CL2017001990A1 (en) | 2012-04-30 | 2017-08-03 | Delayed-release drug formulation (divisional application 2796-2014) |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CL2017001989A CL2017001989A1 (en) | 2012-04-30 | 2017-08-03 | Delayed-release drug formulation. (divisional application 2795-2014) |
Country Status (10)
| Country | Link |
|---|---|
| JP (2) | JP6700220B2 (en) |
| CL (2) | CL2017001989A1 (en) |
| CU (2) | CU24342B1 (en) |
| CY (1) | CY1121470T1 (en) |
| EC (2) | ECSP14028077A (en) |
| HK (3) | HK1202266A1 (en) |
| HR (3) | HRP20190470T1 (en) |
| IL (2) | IL235283A (en) |
| PH (3) | PH12017502369A1 (en) |
| ZA (1) | ZA201407675B (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3662902B1 (en) * | 2018-12-07 | 2024-07-31 | Tillotts Pharma AG | Colonic drug delivery formulation |
| EP3662900A1 (en) * | 2018-12-07 | 2020-06-10 | Tillotts Pharma AG | Colonic drug delivery formulation |
| CN113493220A (en) * | 2020-04-02 | 2021-10-12 | 杨洋 | Hollow metal oxide microsphere, preparation method thereof and drug sustained-release application |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5422121A (en) * | 1990-11-14 | 1995-06-06 | Rohm Gmbh | Oral dosage unit form |
| SI2152250T1 (en) * | 2007-05-07 | 2020-06-30 | Evonik Operations Gmbh | Solid dosage forms comprising an enteric coating with accelerated drug release |
| NO2659881T3 (en) * | 2012-04-30 | 2018-04-28 |
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2013
- 2013-04-29 CU CUP2016000014A patent/CU24342B1/en unknown
- 2013-04-29 CU CUP2016000026A patent/CU24343B1/en unknown
-
2014
- 2014-10-22 IL IL235283A patent/IL235283A/en active IP Right Grant
- 2014-10-22 IL IL235282A patent/IL235282A/en active IP Right Grant
- 2014-10-22 ZA ZA2014/07675A patent/ZA201407675B/en unknown
- 2014-11-25 EC ECIEPI201428077A patent/ECSP14028077A/en unknown
- 2014-11-25 EC ECIEPI201428079A patent/ECSP14028079A/en unknown
-
2015
- 2015-03-19 HK HK15102823.2A patent/HK1202266A1/en unknown
- 2015-03-19 HK HK15102824.1A patent/HK1202267A1/en unknown
- 2015-03-19 HK HK18103919.2A patent/HK1244435B/en not_active IP Right Cessation
-
2017
- 2017-06-06 JP JP2017112044A patent/JP6700220B2/en not_active Expired - Fee Related
- 2017-06-06 JP JP2017112035A patent/JP6626470B2/en active Active
- 2017-08-03 CL CL2017001989A patent/CL2017001989A1/en unknown
- 2017-08-03 CL CL2017001990A patent/CL2017001990A1/en unknown
- 2017-12-20 PH PH12017502369A patent/PH12017502369A1/en unknown
-
2018
- 2018-02-12 PH PH12018500304A patent/PH12018500304B1/en unknown
- 2018-06-19 PH PH12018501311A patent/PH12018501311A1/en unknown
-
2019
- 2019-03-11 HR HRP20190470TT patent/HRP20190470T1/en unknown
- 2019-03-15 CY CY20191100312T patent/CY1121470T1/en unknown
- 2019-04-17 HR HRP20190727TT patent/HRP20190727T1/en unknown
- 2019-12-09 HR HRP20192210TT patent/HRP20192210T1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PH12018500304A1 (en) | 2018-09-24 |
| CU20160014A7 (en) | 2016-04-25 |
| ECSP14028077A (en) | 2015-12-31 |
| CY1121470T1 (en) | 2020-05-29 |
| IL235282A (en) | 2017-09-28 |
| HRP20192210T1 (en) | 2020-02-21 |
| CL2017001989A1 (en) | 2018-03-16 |
| HK1202267A1 (en) | 2015-09-25 |
| CU24342B1 (en) | 2018-05-08 |
| PH12018500304B1 (en) | 2018-09-24 |
| IL235283A (en) | 2017-09-28 |
| PH12017502369A1 (en) | 2020-09-28 |
| JP6700220B2 (en) | 2020-05-27 |
| CU20160026A7 (en) | 2016-05-30 |
| JP6626470B2 (en) | 2019-12-25 |
| HK1244435B (en) | 2019-10-25 |
| PH12018501311A1 (en) | 2020-09-14 |
| HRP20190470T1 (en) | 2019-05-17 |
| CU24343B1 (en) | 2018-05-08 |
| JP2017145268A (en) | 2017-08-24 |
| HRP20190727T1 (en) | 2019-06-14 |
| ECSP14028079A (en) | 2015-12-31 |
| HK1202266A1 (en) | 2015-09-25 |
| JP2017145267A (en) | 2017-08-24 |
| ZA201407675B (en) | 2016-05-25 |
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