CU24342B1 - FORMULATION OF DELAYED RELEASE DRUG - Google Patents
FORMULATION OF DELAYED RELEASE DRUGInfo
- Publication number
- CU24342B1 CU24342B1 CUP2016000014A CU20160014A CU24342B1 CU 24342 B1 CU24342 B1 CU 24342B1 CU P2016000014 A CUP2016000014 A CU P2016000014A CU 20160014 A CU20160014 A CU 20160014A CU 24342 B1 CU24342 B1 CU 24342B1
- Authority
- CU
- Cuba
- Prior art keywords
- core
- drug
- delayed release
- polymeric material
- inner layer
- Prior art date
Links
Abstract
<p>La liberación retardada de un fármaco al colon se logra de una formulación de liberación retardada que comprende un núcleo y un recubrimiento para el núcleo. El núcleo comprende un fármaco y un recubrimiento que comprende una capa interior y al menos una capa entre el núcleo y la capa exterior seleccionada del grupo que consiste de una capa de aislamiento y una capa interior. La capa exterior comprende una mezcla de un primer material polimérico que es susceptible a ataques por parte de la bacteria colónica, y un segundo material polimérico que tiene un umbral de pH en el intervalo de pH 6 a pH 8. La capa interior comprende un polímero no iónico que es soluble en el fluido intestinal o en el fluido gastrointestinal, y al menos un agente amortiguador y una base. La capa de aislamiento comprende un polímero no iónico que es soluble en el fluido intestinal o fluido gastrointestinal. El exterior es un medio acuoso con un segundo material polimérico en un medio orgánico. Las ventajas de las formulaciones de acuerdo con la presente invención incluyen la liberación acelerada del fármaco cuando se expone a condiciones colónicas y la reducción o eliminación del efecto de los alimentos y/o alcohol en la liberación del fármaco después de la administración .</p><p> Delayed release of a drug to the colon is achieved from a delayed release formulation comprising a core and a coating for the core. The core comprises a drug and a coating comprising an inner layer and at least one layer between the core and the outer layer selected from the group consisting of an insulation layer and an inner layer. The outer layer comprises a mixture of a first polymeric material that is susceptible to attacks by the colonic bacteria, and a second polymeric material that has a pH threshold in the range of pH 6 to pH 8. The inner layer comprises a polymer nonionic that is soluble in the intestinal fluid or gastrointestinal fluid, and at least one buffering agent and a base. The insulation layer comprises a non-ionic polymer that is soluble in the intestinal fluid or gastrointestinal fluid. The exterior is an aqueous medium with a second polymeric material in an organic medium. Advantages of the formulations according to the present invention include accelerated drug release when exposed to colonic conditions and reduction or elimination of the effect of food and / or alcohol on drug release after administration. </ P >
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261640217P | 2012-04-30 | 2012-04-30 | |
| EP12166110.2A EP2659881B1 (en) | 2012-04-30 | 2012-04-30 | A delayed release drug formulation |
| PCT/EP2013/058923 WO2013164316A1 (en) | 2012-04-30 | 2013-04-29 | A delayed release drug formulation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CU20160014A7 CU20160014A7 (en) | 2016-04-25 |
| CU24342B1 true CU24342B1 (en) | 2018-05-08 |
Family
ID=54196716
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CUP2016000026A CU24343B1 (en) | 2012-04-30 | 2013-04-29 | FORMULATION OF DELAYED RELEASE DRUG |
| CUP2016000014A CU24342B1 (en) | 2012-04-30 | 2013-04-29 | FORMULATION OF DELAYED RELEASE DRUG |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CUP2016000026A CU24343B1 (en) | 2012-04-30 | 2013-04-29 | FORMULATION OF DELAYED RELEASE DRUG |
Country Status (10)
| Country | Link |
|---|---|
| JP (2) | JP6700220B2 (en) |
| CL (2) | CL2017001990A1 (en) |
| CU (2) | CU24343B1 (en) |
| CY (1) | CY1121470T1 (en) |
| EC (2) | ECSP14028079A (en) |
| HK (3) | HK1202267A1 (en) |
| HR (3) | HRP20190470T1 (en) |
| IL (2) | IL235282A (en) |
| PH (3) | PH12017502369A1 (en) |
| ZA (1) | ZA201407675B (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3662902A1 (en) * | 2018-12-07 | 2020-06-10 | Tillotts Pharma AG | Colonic drug delivery formulation |
| EP3662900A1 (en) * | 2018-12-07 | 2020-06-10 | Tillotts Pharma AG | Colonic drug delivery formulation |
| CN113493220A (en) * | 2020-04-02 | 2021-10-12 | 杨洋 | Hollow metal oxide microsphere, preparation method thereof and drug sustained-release application |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5422121A (en) * | 1990-11-14 | 1995-06-06 | Rohm Gmbh | Oral dosage unit form |
| BRPI0721654B8 (en) * | 2007-05-07 | 2022-07-05 | Evonik Roehm Gmbh | solid dosage forms comprising an enteric coating with accelerated drug release, their method of manufacture and use |
| SI2659881T1 (en) * | 2012-04-30 | 2018-03-30 | Tillotts Pharma Ag | A delayed release drug formulation |
-
2013
- 2013-04-29 CU CUP2016000026A patent/CU24343B1/en unknown
- 2013-04-29 CU CUP2016000014A patent/CU24342B1/en unknown
-
2014
- 2014-10-22 IL IL235282A patent/IL235282A/en active IP Right Grant
- 2014-10-22 IL IL235283A patent/IL235283A/en active IP Right Grant
- 2014-10-22 ZA ZA2014/07675A patent/ZA201407675B/en unknown
- 2014-11-25 EC ECIEPI201428079A patent/ECSP14028079A/en unknown
- 2014-11-25 EC ECIEPI201428077A patent/ECSP14028077A/en unknown
-
2015
- 2015-03-19 HK HK15102824.1A patent/HK1202267A1/en unknown
- 2015-03-19 HK HK15102823.2A patent/HK1202266A1/en unknown
- 2015-03-19 HK HK18103919.2A patent/HK1244435B/en not_active IP Right Cessation
-
2017
- 2017-06-06 JP JP2017112044A patent/JP6700220B2/en not_active Expired - Fee Related
- 2017-06-06 JP JP2017112035A patent/JP6626470B2/en active Active
- 2017-08-03 CL CL2017001990A patent/CL2017001990A1/en unknown
- 2017-08-03 CL CL2017001989A patent/CL2017001989A1/en unknown
- 2017-12-20 PH PH12017502369A patent/PH12017502369A1/en unknown
-
2018
- 2018-02-12 PH PH12018500304A patent/PH12018500304B1/en unknown
- 2018-06-19 PH PH12018501311A patent/PH12018501311A1/en unknown
-
2019
- 2019-03-11 HR HRP20190470TT patent/HRP20190470T1/en unknown
- 2019-03-15 CY CY20191100312T patent/CY1121470T1/en unknown
- 2019-04-17 HR HRP20190727TT patent/HRP20190727T1/en unknown
- 2019-12-09 HR HRP20192210TT patent/HRP20192210T1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP6700220B2 (en) | 2020-05-27 |
| CY1121470T1 (en) | 2020-05-29 |
| IL235282A (en) | 2017-09-28 |
| PH12017502369A1 (en) | 2020-09-28 |
| CL2017001990A1 (en) | 2018-03-16 |
| HRP20190470T1 (en) | 2019-05-17 |
| HRP20192210T1 (en) | 2020-02-21 |
| PH12018500304A1 (en) | 2018-09-24 |
| JP2017145268A (en) | 2017-08-24 |
| ECSP14028079A (en) | 2015-12-31 |
| HK1202267A1 (en) | 2015-09-25 |
| IL235283A (en) | 2017-09-28 |
| CU24343B1 (en) | 2018-05-08 |
| CU20160014A7 (en) | 2016-04-25 |
| HRP20190727T1 (en) | 2019-06-14 |
| JP2017145267A (en) | 2017-08-24 |
| CU20160026A7 (en) | 2016-05-30 |
| HK1202266A1 (en) | 2015-09-25 |
| JP6626470B2 (en) | 2019-12-25 |
| PH12018501311A1 (en) | 2020-09-14 |
| PH12018500304B1 (en) | 2018-09-24 |
| ZA201407675B (en) | 2016-05-25 |
| HK1244435B (en) | 2019-10-25 |
| ECSP14028077A (en) | 2015-12-31 |
| CL2017001989A1 (en) | 2018-03-16 |
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| CU20140124A7 (en) | FORMULATION OF DELAYED RELEASE DRUG |