ECSP14028079A - DELAYED RELEASE DRUG FORMULATION (2) - Google Patents
DELAYED RELEASE DRUG FORMULATION (2)Info
- Publication number
- ECSP14028079A ECSP14028079A ECIEPI201428079A ECPI201428079A ECSP14028079A EC SP14028079 A ECSP14028079 A EC SP14028079A EC IEPI201428079 A ECIEPI201428079 A EC IEPI201428079A EC PI201428079 A ECPI201428079 A EC PI201428079A EC SP14028079 A ECSP14028079 A EC SP14028079A
- Authority
- EC
- Ecuador
- Prior art keywords
- polymeric material
- core
- inner layer
- drug
- delayed release
- Prior art date
Links
Landscapes
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
La liberación retardada de un fármaco al colon se logra de una formulación de liberación retardada que comprende un núcleo y un recubrimiento para el núcleo. El núcleo comprende un fármaco y un recubrimiento que comprende una capa interior y al menos una capa entre el núcleo y la capa exterior seleccionada del grupo que consiste de una capa de aislamiento y una capa interior. La capa exterior comprende una mezcla de un primer material polimérico que es susceptible a ataques por parte de la bacteria colónica, y un segundo material polimérico que tiene un umbral de pH a aproximadamente pH 5 o más alto. La capa interior comprende un tercer material polimérico que es soluble en el fluido intestinal o en el fluido gastrointestinal, tal tercer material polimérico se selecciona de ácido policarboxílico al menos parcialmente neutralizado y un polímero no iónico. En modalidades en donde el tercer material polimérico es un polímero no iónico, la capa interior comprende al menos un agente amortiguador y una base. La capa de aislamiento comprende un polímero no iónico que es soluble en el fluido intestinal o fluido gastrointestinal. El exterior es un medio acuoso con un segundo material polimérico en un medio orgánico. Las ventajas de las formulaciones de acuerdo con la presente invención incluyen la liberación acelerada del fármaco cuando se expone a condiciones colónicas y la reducción o eliminación del efecto de los alimentos y/o alcohol en la liberación del fármaco después de la admiDelayed release of a drug to the colon is achieved from a delayed release formulation comprising a core and a coating for the core. The core comprises a drug and a coating comprising an inner layer and at least one layer between the core and the outer layer selected from the group consisting of an insulating layer and an inner layer. The outer layer comprises a mixture of a first polymeric material that is susceptible to attack by colonic bacteria, and a second polymeric material that has a pH threshold at about pH 5 or higher. The inner layer comprises a third polymeric material that is soluble in intestinal fluid or gastrointestinal fluid, such third polymeric material is selected from at least partially neutralized polycarboxylic acid and a non-ionic polymer. In embodiments where the third polymeric material is a non-ionic polymer, the inner layer comprises at least one damping agent and a base. The isolation layer comprises a nonionic polymer that is soluble in intestinal fluid or gastrointestinal fluid. The exterior is an aqueous medium with a second polymeric material in an organic medium. Advantages of formulations according to the present invention include accelerated drug release when exposed to colonic conditions and reduction or elimination of the effect of food and / or alcohol on drug release after administration.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261640217P | 2012-04-30 | 2012-04-30 | |
| EP12166110.2A EP2659881B1 (en) | 2012-04-30 | 2012-04-30 | A delayed release drug formulation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ECSP14028079A true ECSP14028079A (en) | 2015-12-31 |
Family
ID=54196716
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ECIEPI201428079A ECSP14028079A (en) | 2012-04-30 | 2014-11-25 | DELAYED RELEASE DRUG FORMULATION (2) |
| ECIEPI201428077A ECSP14028077A (en) | 2012-04-30 | 2014-11-25 | DELAYED RELEASE DRUG FORMULATION (1) |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ECIEPI201428077A ECSP14028077A (en) | 2012-04-30 | 2014-11-25 | DELAYED RELEASE DRUG FORMULATION (1) |
Country Status (10)
| Country | Link |
|---|---|
| JP (2) | JP6700220B2 (en) |
| CL (2) | CL2017001989A1 (en) |
| CU (2) | CU24343B1 (en) |
| CY (1) | CY1121470T1 (en) |
| EC (2) | ECSP14028079A (en) |
| HK (3) | HK1244435B (en) |
| HR (3) | HRP20190470T1 (en) |
| IL (2) | IL235283A (en) |
| PH (3) | PH12017502369A1 (en) |
| ZA (1) | ZA201407675B (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3662902A1 (en) * | 2018-12-07 | 2020-06-10 | Tillotts Pharma AG | Colonic drug delivery formulation |
| EP3662900A1 (en) * | 2018-12-07 | 2020-06-10 | Tillotts Pharma AG | Colonic drug delivery formulation |
| CN113493220A (en) * | 2020-04-02 | 2021-10-12 | 杨洋 | Hollow metal oxide microsphere, preparation method thereof and drug sustained-release application |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5422121A (en) * | 1990-11-14 | 1995-06-06 | Rohm Gmbh | Oral dosage unit form |
| SI2152250T1 (en) * | 2007-05-07 | 2020-06-30 | Evonik Operations Gmbh | Solid dosage forms comprising an enteric coating with accelerated drug release |
| EP2659881B1 (en) * | 2012-04-30 | 2017-11-29 | Tillotts Pharma Ag | A delayed release drug formulation |
-
2013
- 2013-04-29 CU CUP2016000026A patent/CU24343B1/en unknown
- 2013-04-29 CU CUP2016000014A patent/CU24342B1/en unknown
-
2014
- 2014-10-22 IL IL235283A patent/IL235283A/en active IP Right Grant
- 2014-10-22 IL IL235282A patent/IL235282A/en active IP Right Grant
- 2014-10-22 ZA ZA2014/07675A patent/ZA201407675B/en unknown
- 2014-11-25 EC ECIEPI201428079A patent/ECSP14028079A/en unknown
- 2014-11-25 EC ECIEPI201428077A patent/ECSP14028077A/en unknown
-
2015
- 2015-03-19 HK HK18103919.2A patent/HK1244435B/en not_active IP Right Cessation
- 2015-03-19 HK HK15102823.2A patent/HK1202266A1/en unknown
- 2015-03-19 HK HK15102824.1A patent/HK1202267A1/en unknown
-
2017
- 2017-06-06 JP JP2017112044A patent/JP6700220B2/en not_active Expired - Fee Related
- 2017-06-06 JP JP2017112035A patent/JP6626470B2/en active Active
- 2017-08-03 CL CL2017001989A patent/CL2017001989A1/en unknown
- 2017-08-03 CL CL2017001990A patent/CL2017001990A1/en unknown
- 2017-12-20 PH PH12017502369A patent/PH12017502369A1/en unknown
-
2018
- 2018-02-12 PH PH12018500304A patent/PH12018500304B1/en unknown
- 2018-06-19 PH PH12018501311A patent/PH12018501311A1/en unknown
-
2019
- 2019-03-11 HR HRP20190470TT patent/HRP20190470T1/en unknown
- 2019-03-15 CY CY20191100312T patent/CY1121470T1/en unknown
- 2019-04-17 HR HRP20190727TT patent/HRP20190727T1/en unknown
- 2019-12-09 HR HRP20192210TT patent/HRP20192210T1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ZA201407675B (en) | 2016-05-25 |
| JP2017145268A (en) | 2017-08-24 |
| PH12018500304A1 (en) | 2018-09-24 |
| PH12018500304B1 (en) | 2018-09-24 |
| CU20160014A7 (en) | 2016-04-25 |
| CU24342B1 (en) | 2018-05-08 |
| IL235282A (en) | 2017-09-28 |
| HRP20190470T1 (en) | 2019-05-17 |
| CU20160026A7 (en) | 2016-05-30 |
| PH12017502369A1 (en) | 2020-09-28 |
| JP6700220B2 (en) | 2020-05-27 |
| CL2017001989A1 (en) | 2018-03-16 |
| HK1202267A1 (en) | 2015-09-25 |
| JP2017145267A (en) | 2017-08-24 |
| HK1244435B (en) | 2019-10-25 |
| HRP20192210T1 (en) | 2020-02-21 |
| CY1121470T1 (en) | 2020-05-29 |
| HRP20190727T1 (en) | 2019-06-14 |
| PH12018501311A1 (en) | 2020-09-14 |
| HK1202266A1 (en) | 2015-09-25 |
| CU24343B1 (en) | 2018-05-08 |
| CL2017001990A1 (en) | 2018-03-16 |
| ECSP14028077A (en) | 2015-12-31 |
| IL235283A (en) | 2017-09-28 |
| JP6626470B2 (en) | 2019-12-25 |
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