EP2566856A4 - Composés et méthodes permettant de traiter des troubles cérébraux - Google Patents

Composés et méthodes permettant de traiter des troubles cérébraux

Info

Publication number
EP2566856A4
EP2566856A4 EP11778247.4A EP11778247A EP2566856A4 EP 2566856 A4 EP2566856 A4 EP 2566856A4 EP 11778247 A EP11778247 A EP 11778247A EP 2566856 A4 EP2566856 A4 EP 2566856A4
Authority
EP
European Patent Office
Prior art keywords
compounds
methods
brain disorders
treating brain
disclosed
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP11778247.4A
Other languages
German (de)
English (en)
Other versions
EP2566856B1 (fr
EP2566856A2 (fr
Inventor
Gregory R J Thatcher
Zhihui Qin
Jia Luo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Illinois
Original Assignee
University of Illinois
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Illinois filed Critical University of Illinois
Publication of EP2566856A2 publication Critical patent/EP2566856A2/fr
Publication of EP2566856A4 publication Critical patent/EP2566856A4/fr
Application granted granted Critical
Publication of EP2566856B1 publication Critical patent/EP2566856B1/fr
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D277/24—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D277/28—Radicals substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/587—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with aliphatic hydrocarbon radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms, said aliphatic radicals being substituted in the alpha-position to the ring by a hetero atom, e.g. with m >= 0, Z being a singly or a doubly bound hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
EP11778247.4A 2010-05-05 2011-05-04 Composés et méthodes permettant de traiter des troubles cérébraux Active EP2566856B1 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US33148310P 2010-05-05 2010-05-05
US37135610P 2010-08-06 2010-08-06
US37641110P 2010-08-24 2010-08-24
PCT/US2011/035155 WO2011140198A2 (fr) 2010-05-05 2011-05-04 Composés et méthodes permettant de traiter des troubles cérébraux

Publications (3)

Publication Number Publication Date
EP2566856A2 EP2566856A2 (fr) 2013-03-13
EP2566856A4 true EP2566856A4 (fr) 2013-11-20
EP2566856B1 EP2566856B1 (fr) 2017-02-01

Family

ID=44904451

Family Applications (1)

Application Number Title Priority Date Filing Date
EP11778247.4A Active EP2566856B1 (fr) 2010-05-05 2011-05-04 Composés et méthodes permettant de traiter des troubles cérébraux

Country Status (6)

Country Link
US (1) US8957086B2 (fr)
EP (1) EP2566856B1 (fr)
CN (1) CN102958924B (fr)
AU (1) AU2011248124B2 (fr)
CA (1) CA2798272C (fr)
WO (1) WO2011140198A2 (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014013338A2 (fr) * 2012-07-16 2014-01-23 Sgc Pharma, Inc. Composés pour le traitement de la maladie d'alzheimer
US20150284357A1 (en) * 2012-10-24 2015-10-08 Gregory R. Thatcher Compositions and methods for treating estrogen-related medical disorders
EP2911660B1 (fr) 2012-10-24 2019-12-04 The Board of Trustees of the University of Illionis Compositions et procédés de traitement de troubles médicaux associés aux strogènes
CN117224483B (zh) * 2023-09-01 2024-05-10 山东京卫制药有限公司 一种适用于热辅助治疗的硝酸2-(4-甲基噻唑-5-基)乙酯盐脑靶向脂质体

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5712299A (en) * 1993-07-03 1998-01-27 Astra Aktiebolag (1-phenyl-1-heterocyclyl)methanol and (1-phenyl-1-heterocyclyl methylamine derivatives
US6310052B1 (en) * 1996-06-04 2001-10-30 Queen's University At Kingston Nitrate esters and their use for neurological conditions
WO2004076424A1 (fr) * 2003-02-27 2004-09-10 Abbott Laboratories Inhibiteurs de kinase heterocyclique
US20050137191A1 (en) * 1996-06-04 2005-06-23 Thatcher Gregory R. Nitrate esters and their use for mitigating cellular damage
US20080233163A1 (en) * 2004-05-05 2008-09-25 Renopharm Ltd. Thiazole-based Nitric Oxide donors having Acyl substuent(s) and uses thereof

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5087618A (en) 1982-05-18 1992-02-11 University Of Florida Redox carriers for brain-specific drug delivery
US4522811A (en) 1982-07-08 1985-06-11 Syntex (U.S.A.) Inc. Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides
JPS59171956A (ja) 1983-03-18 1984-09-28 Fuji Photo Film Co Ltd カラ−画像形成方法
US5374548A (en) 1986-05-02 1994-12-20 Genentech, Inc. Methods and compositions for the attachment of proteins to liposomes using a glycophospholipid anchor
MX9203291A (es) 1985-06-26 1992-08-01 Liposome Co Inc Metodo para acoplamiento de liposomas.
US5166320A (en) 1987-04-22 1992-11-24 University Of Connecticut Carrier system and method for the introduction of genes into mammalian cells
US5108921A (en) 1989-04-03 1992-04-28 Purdue Research Foundation Method for enhanced transmembrane transport of exogenous molecules
US5807847A (en) 1996-06-04 1998-09-15 Queen's University At Kingston Nitrate esters
US7115661B1 (en) * 1999-12-29 2006-10-03 Queen's University At Kingston Methods and compositions for mitigating pain
US6472387B1 (en) 1996-10-07 2002-10-29 Eli Lilly And Company Methods of using compounds as neuro-protective agents
EP1753734A1 (fr) 2004-05-05 2007-02-21 Renopharm Ltd. Donneurs d'oxyde nitrique et utilisations de ceux-ci
WO2008125199A1 (fr) 2007-04-11 2008-10-23 Bayer Materialscience Ag Acrylates d'uréthane aromatiques à indice de réfraction élevé

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5712299A (en) * 1993-07-03 1998-01-27 Astra Aktiebolag (1-phenyl-1-heterocyclyl)methanol and (1-phenyl-1-heterocyclyl methylamine derivatives
US6310052B1 (en) * 1996-06-04 2001-10-30 Queen's University At Kingston Nitrate esters and their use for neurological conditions
US20050137191A1 (en) * 1996-06-04 2005-06-23 Thatcher Gregory R. Nitrate esters and their use for mitigating cellular damage
WO2004076424A1 (fr) * 2003-02-27 2004-09-10 Abbott Laboratories Inhibiteurs de kinase heterocyclique
US20080233163A1 (en) * 2004-05-05 2008-09-25 Renopharm Ltd. Thiazole-based Nitric Oxide donors having Acyl substuent(s) and uses thereof

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
EDWIN R. BUCHMAN ET AL: "Studies of Crystalline Vitamin B 1 . 1 X. Sulfite Cleavage. III. Chemistry of the Basic Product", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 57, no. 10, 1935, pages 1849 - 1851, XP055084105, ISSN: 0002-7863, DOI: 10.1021/ja01313a026 *
See also references of WO2011140198A2 *
SOHDA T ET AL: "STUDIES ON ANTIDIABETIC AGENTS. II. SYNTHESIS OF 5-Ä4-(1-METHYLCYCLOHEXYLMETHOXY)-BENZYLÜTHIAZOLIDINE-2,4-DIONE (ADD-3878) AND ITS DERIVATIVES", CHEMICAL AND PHARMACEUTICAL BULLETIN, PHARMACEUTICAL SOCIETY OF JAPAN, JP, vol. 30, no. 10, 1982, pages 3580 - 3600, XP008057136, ISSN: 0009-2363 *

Also Published As

Publication number Publication date
EP2566856B1 (fr) 2017-02-01
CN102958924A (zh) 2013-03-06
US8957086B2 (en) 2015-02-17
CN102958924B (zh) 2017-06-27
CA2798272A1 (fr) 2011-11-10
EP2566856A2 (fr) 2013-03-13
CA2798272C (fr) 2019-03-26
WO2011140198A2 (fr) 2011-11-10
WO2011140198A3 (fr) 2012-03-01
AU2011248124B2 (en) 2016-07-21
US20130131099A1 (en) 2013-05-23
AU2011248124A1 (en) 2012-12-06

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