EP2493459A4 - Dispositifs d'administration de médicaments par voie oculaire - Google Patents

Dispositifs d'administration de médicaments par voie oculaire

Info

Publication number
EP2493459A4
EP2493459A4 EP10827563.7A EP10827563A EP2493459A4 EP 2493459 A4 EP2493459 A4 EP 2493459A4 EP 10827563 A EP10827563 A EP 10827563A EP 2493459 A4 EP2493459 A4 EP 2493459A4
Authority
EP
European Patent Office
Prior art keywords
drug delivery
delivery devices
ocular drug
ocular
devices
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP10827563.7A
Other languages
German (de)
English (en)
Other versions
EP2493459A1 (fr
EP2493459B1 (fr
Inventor
Jean Theresa Jacob
Kevin John Halloran
Yuri Mckee
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Louisiana State University
Aton Pharma Inc
Original Assignee
Louisiana State University
Aton Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Louisiana State University, Aton Pharma Inc filed Critical Louisiana State University
Publication of EP2493459A1 publication Critical patent/EP2493459A1/fr
Publication of EP2493459A4 publication Critical patent/EP2493459A4/fr
Application granted granted Critical
Publication of EP2493459B1 publication Critical patent/EP2493459B1/fr
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A61K9/0051—Ocular inserts, ocular implants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/133—Amines having hydroxy groups, e.g. sphingosine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/7036—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin having at least one amino group directly attached to the carbocyclic ring, e.g. streptomycin, gentamycin, amikacin, validamycin, fortimicins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A61K38/13—Cyclosporins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/04—Artificial tears; Irrigation solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L1/00—Compositions of cellulose, modified cellulose or cellulose derivatives
    • C08L1/08—Cellulose derivatives
    • C08L1/26—Cellulose ethers
    • C08L1/28—Alkyl ethers
    • C08L1/284—Alkyl ethers with hydroxylated hydrocarbon radicals

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Emergency Medicine (AREA)
  • Molecular Biology (AREA)
  • Polymers & Plastics (AREA)
  • Inorganic Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
EP10827563.7A 2009-10-30 2010-10-29 Dispositifs d'administration de médicaments par voie oculaire Active EP2493459B1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US25691509P 2009-10-30 2009-10-30
US39104010P 2010-10-07 2010-10-07
PCT/US2010/054823 WO2011053841A1 (fr) 2009-10-30 2010-10-29 Dispositifs d'administration de médicaments par voie oculaire

Publications (3)

Publication Number Publication Date
EP2493459A1 EP2493459A1 (fr) 2012-09-05
EP2493459A4 true EP2493459A4 (fr) 2013-09-04
EP2493459B1 EP2493459B1 (fr) 2016-08-24

Family

ID=43922594

Family Applications (1)

Application Number Title Priority Date Filing Date
EP10827563.7A Active EP2493459B1 (fr) 2009-10-30 2010-10-29 Dispositifs d'administration de médicaments par voie oculaire

Country Status (8)

Country Link
US (3) US20110129516A1 (fr)
EP (1) EP2493459B1 (fr)
JP (1) JP5886204B2 (fr)
BR (1) BR112012010026B8 (fr)
CA (1) CA2779104C (fr)
ES (1) ES2603057T3 (fr)
PL (1) PL2493459T3 (fr)
WO (1) WO2011053841A1 (fr)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7431710B2 (en) 2002-04-08 2008-10-07 Glaukos Corporation Ocular implants with anchors and methods thereof
US10206813B2 (en) 2009-05-18 2019-02-19 Dose Medical Corporation Implants with controlled drug delivery features and methods of using same
US10245178B1 (en) 2011-06-07 2019-04-02 Glaukos Corporation Anterior chamber drug-eluting ocular implant
CA2856044C (fr) * 2011-11-15 2016-11-29 Allergan, Inc. Preparation a effet prolonge de la forme 2 de la cyclosporine
EP3013790A1 (fr) 2013-06-27 2016-05-04 Mylan Laboratories Ltd. Procédé pour la préparation de népafénac
EP3148491B1 (fr) 2014-05-29 2020-07-01 Glaukos Corporation Implants avec des caractéristiques d'administration de médicament contrôlées et procédé de fabrication de ces implants
US11925578B2 (en) 2015-09-02 2024-03-12 Glaukos Corporation Drug delivery implants with bi-directional delivery capacity
WO2017053885A1 (fr) 2015-09-25 2017-03-30 Glaukos Corporation Implants lacrymaux à caractéristiques d'administration de médicament régulée et leurs procédés d'utilisation
EP3442479A1 (fr) 2016-04-20 2019-02-20 Harold Alexander Heitzmann Dispositif d'administration de médicament oculaire biorésorbable
US20180092776A1 (en) 2016-09-30 2018-04-05 Sara Heikali Method and device for treating and managing diseased ocular tissue
US20180318319A1 (en) 2017-05-04 2018-11-08 Ocular Science, Inc. Compositions and Methods for Treating Eyes and Methods of Preparation
US11071724B2 (en) 2019-05-17 2021-07-27 Ocular Science, Inc. Compositions and methods for treating presbyopia
CN117531051A (zh) 2019-06-27 2024-02-09 雷尔生物公司 眼部装置递送方法和系统
BE1030503B1 (fr) * 2022-05-06 2023-12-04 Eyed Pharma Insert pour le traitement de la sécheresse oculaire
BE1030504B1 (fr) * 2022-05-06 2023-12-04 Eyed Pharma Insert composite pour le traitement de la sécheresse oculaire
WO2023214027A1 (fr) * 2022-05-06 2023-11-09 Eyed Pharma Insert pour le traitement des yeux secs

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1611877A1 (fr) * 2004-06-28 2006-01-04 Universidade de Coimbra Méthodes pour la préparation d'articles ophthalmiques thérapeutiques à la libération prolongée en utilisant des fluides compressés pour l'imprégnation des medicaments
US20090036552A1 (en) * 2005-07-29 2009-02-05 Santen Pharmaceutical Co. Ltd. Noninvasive Drug Delivery System To Tissue of Posterior Segment of Eye Using Solid Composition
WO2009134371A2 (fr) * 2008-04-30 2009-11-05 Qlt Plug Delivery, Inc. Insert lacrymal composite et procédés apparentés

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4179497A (en) * 1973-12-17 1979-12-18 Merck & Co., Inc. Solid state ophthalmic medication
DK137946B (da) * 1973-12-17 1978-06-12 Merck & Co Inc Bæremedium i fast form til anvendelse i ophthalmiske præparater.
US3923939A (en) * 1974-06-07 1975-12-02 Alza Corp Process for improving release kinetics of a monolithic drug delivery device
US4304765A (en) * 1980-10-14 1981-12-08 Alza Corporation Ocular insert housing steroid in two different therapeutic forms
EP0108661A1 (fr) * 1982-10-04 1984-05-16 Merck & Co. Inc. Insertions oculaires en hydroxypropyl cellulose stabilisées et procédé de stérilisation
US5164188A (en) * 1989-11-22 1992-11-17 Visionex, Inc. Biodegradable ocular implants
US5660851A (en) * 1989-12-26 1997-08-26 Yissum Research Development Company Of The Hebrew Univ. Of Jerusalem Ocular inserts
DE69211157T2 (de) * 1991-12-20 1996-10-02 Pfizer Poröse geformte abgabevorrichtung und verfahren zur herstellung derselbe
US5443505A (en) * 1993-11-15 1995-08-22 Oculex Pharmaceuticals, Inc. Biocompatible ocular implants
US5788687A (en) * 1994-02-01 1998-08-04 Caphco, Inc Compositions and devices for controlled release of active ingredients
JPH0987203A (ja) * 1995-09-27 1997-03-31 Kanegafuchi Chem Ind Co Ltd 薬剤含有粒子及びその製造方法
US6217896B1 (en) * 1999-04-01 2001-04-17 Uab Research Foundation Conjunctival inserts for topical delivery of medication or lubrication
US6331313B1 (en) * 1999-10-22 2001-12-18 Oculex Pharmaceticals, Inc. Controlled-release biocompatible ocular drug delivery implant devices and methods
US20050013845A1 (en) * 2002-11-12 2005-01-20 Warren Stephen L. Adhesive bioerodible ocular drug delivery system
JP2005187376A (ja) * 2003-12-25 2005-07-14 Shin Etsu Chem Co Ltd 低置換度セルロースエーテル含有カプセル及びその製造方法
US20050244463A1 (en) * 2004-04-30 2005-11-03 Allergan, Inc. Sustained release intraocular implants and methods for treating ocular vasculopathies
IN266731B (fr) * 2007-05-14 2015-05-28 Sustained Nano Systems Llc
CA2750242C (fr) * 2009-02-12 2018-05-22 Incept, Llc Delivrance de medicament par bouchons d'hydrogels

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1611877A1 (fr) * 2004-06-28 2006-01-04 Universidade de Coimbra Méthodes pour la préparation d'articles ophthalmiques thérapeutiques à la libération prolongée en utilisant des fluides compressés pour l'imprégnation des medicaments
US20060008506A1 (en) * 2004-06-28 2006-01-12 Cipriano De Sousa Herminio J Method for preparing therapeutic ophthalmic articles using compressed fluids
US20090036552A1 (en) * 2005-07-29 2009-02-05 Santen Pharmaceutical Co. Ltd. Noninvasive Drug Delivery System To Tissue of Posterior Segment of Eye Using Solid Composition
WO2009134371A2 (fr) * 2008-04-30 2009-11-05 Qlt Plug Delivery, Inc. Insert lacrymal composite et procédés apparentés

Also Published As

Publication number Publication date
BR112012010026B1 (pt) 2020-10-27
JP5886204B2 (ja) 2016-03-16
PL2493459T3 (pl) 2017-06-30
US20140187497A1 (en) 2014-07-03
US11730697B2 (en) 2023-08-22
JP2013509436A (ja) 2013-03-14
US20190133934A1 (en) 2019-05-09
US20110129516A1 (en) 2011-06-02
BR112012010026A2 (pt) 2017-07-04
BR112012010026B8 (pt) 2021-02-02
EP2493459A1 (fr) 2012-09-05
CA2779104A1 (fr) 2011-05-05
WO2011053841A1 (fr) 2011-05-05
CA2779104C (fr) 2018-07-17
ES2603057T3 (es) 2017-02-23
EP2493459B1 (fr) 2016-08-24

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