EP2467192A2 - Mundpflegezusammensetzungen und -verfahren - Google Patents

Mundpflegezusammensetzungen und -verfahren

Info

Publication number
EP2467192A2
EP2467192A2 EP10745706A EP10745706A EP2467192A2 EP 2467192 A2 EP2467192 A2 EP 2467192A2 EP 10745706 A EP10745706 A EP 10745706A EP 10745706 A EP10745706 A EP 10745706A EP 2467192 A2 EP2467192 A2 EP 2467192A2
Authority
EP
European Patent Office
Prior art keywords
oral care
care composition
sensate
sweetener
flavor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP10745706A
Other languages
English (en)
French (fr)
Inventor
Jayanth Rajaiah
Arif Ali Baig
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Procter and Gamble Co
Original Assignee
Procter and Gamble Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Procter and Gamble Co filed Critical Procter and Gamble Co
Publication of EP2467192A2 publication Critical patent/EP2467192A2/de
Withdrawn legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
    • A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/20—Halogens; Compounds thereof
    • A61K8/21—Fluorides; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/25—Silicon; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/31—Hydrocarbons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34—Alcohols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/36—Carboxylic acids; Salts or anhydrides thereof
    • A61K8/361—Carboxylic acids having more than seven carbon atoms in an unbroken chain; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/37—Esters of carboxylic acids
    • A61K8/375—Esters of carboxylic acids the alcohol moiety containing more than one hydroxy group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/55—Phosphorus compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
    • A61K8/8105—Compositions of homopolymers or copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond; Compositions of derivatives of such polymers
    • A61K8/8111—Homopolymers or copolymers of aliphatic olefines, e.g. polyethylene, polyisobutene; Compositions of derivatives of such polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
    • A61K8/8105—Compositions of homopolymers or copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond; Compositions of derivatives of such polymers
    • A61K8/8117—Homopolymers or copolymers of aromatic olefines, e.g. polystyrene; Compositions of derivatives of such polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
    • A61K8/8123—Compositions of homopolymers or copolymers of compounds having one carbon-to-carbon double bond, and at least one being terminated by a halogen; Compositions of derivatives of such polymers, e.g. PVC, PTFE
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
    • A61K8/8135—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by an acyloxy radical of a saturated carboxylic acid, of carbonic acid or of a haloformic acid; Compositions of derivatives of such polymers, e.g. vinyl esters (polyvinylacetate)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
    • A61K8/87—Polyurethanes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/59—Mixtures
    • A61K2800/591—Mixtures of compounds not provided for by any of the codes A61K2800/592 - A61K2800/596

Definitions

  • This application relates to oral care compositions with a water insoluble component and varying combinations of sweetener, flavor, and/or sensate, and methods relating thereto.
  • One embodiment of the present invention is directed to an oral care composition, consisting essentially of a water insoluble carrier, a sweetener, and an additional component selected from the group consisting of a sensate, a flavor, and combinations thereof.
  • the oral care composition is configured for application within the oral cavity.
  • the present invention is directed to an oral care composition which includes from about 50 % to about 99 % of a water insoluble carrier, from about 0.5% to about 10% a sweetener, and an additional component selected from the group consisting of a sensate, a flavor, and combinations thereof.
  • the oral care composition is configured for application to the teeth.
  • the present invention is directed to an oral care composition, consisting essentially of: petrolatum; saccharin; mint oil; and menthol.
  • the oral care composition is configured for application to the teeth.
  • sensate refers to a material in which its predominant effect in the oral cavity is to impart a sensation, for example, a warming, cooling, and/or tingling sensation.
  • flavor refers to a material in which its predominant effect in the oral cavity is to impart a taste, excluding sweeteners.
  • sweetener refers to a material in which its predominant effect in the oral cavity is to impart a sweet taste.
  • water-insoluble refers to a material that is less than about 10% soluble in water, unless specifically stated otherwise.
  • Oral care products have variable functions within the oral cavity. For instance, when looking to clean the oral cavity, a consumer will generally look to toothpaste or a mouth rinse. To provide this cleaning benefit, both pastes and rinses generally use a foaming water soluble chassis. The foam provided in these chassis provides a cleaning action which can be used in combination with a brush or actives to provide a further cleaning benefit.
  • Other oral care products provide more of an aesthetic function, like breath freshening. These products come in many forms from dissolvable strips to mints. The one thing most all of these products have in common is that they are generally water soluble. The water soluble nature of these products limits the length of time for which they can provide their benefit as the benefit providing components are solubilized and/or washed away by the saliva in the oral cavity.
  • water insoluble carriers can be used in oral care compositions to give improved delivery of oral care components to the oral cavity.
  • Some of these oral care components include, for example, sensates, flavors, and sweeteners.
  • the use of the water insoluble carrier allows for a longer residence time in the oral cavity for the oral care components and thus provides a longer lasting benefit.
  • the water-insoluble carrier can be detected in the mouth even an hour or more after application.
  • Water insoluble components can be used as a carrier in the present invention.
  • the water insoluble carrier is less than about 10%, 8%, 5%, 4%, 3%, 2% or 1% soluble in water.
  • the water-insoluble carrier is at a level from about 25, 30, 35, 40, 45, 50, 55, 60, 65% to about 45, 50, 55, 60, 65, 70, 75, 80, 85, 90, 95, 99%, and/or any combination thereof, by weight of the composition.
  • the water-insoluble carrier level is from about 80% to about 99%, from about 80% to about 95%, or from about 85% to about 95% by weight of the composition.
  • the water insoluble carrier is at least about 75% by weight of the oral care composition.
  • the water-insoluble carrier is both water- insoluble and non-swellable in water.
  • the water insoluble carrier comprises a gel, liquid, or mixtures thereof.
  • the water- insoluble carrier may be a combination of two or more water-insoluble components.
  • the water insoluble carrier is selected from the group consisting of: natural wax, synthetic wax, petrolatum, rubber, elastomer, plastomer, polyvinyl chloride, nylon, polyvinyl acetate, natural oils, synthetic oils, fats, silicone, hydrocarbons, essential oils, caprilic/capric triglycerides, polybutene, oleic acid, stearic acid, fluorocarbon, polyurethane prepolymer, polyethylene, polystyrene, polypropylene, and mixtures thereof.
  • the water-insoluble carrier is a PDMS gum, or a mixture of PDMS gum with an MQ resin cast from a solvent such as volatile isoparrafin (see US Patent 6,074,654).
  • the water-insoluble carrier comprises a natural wax, synthetic wax, or a combination thereof.
  • Natural waxes include, for example, animal, vegetable, and mineral wax.
  • Animal waxes include, for example, beeswax, lanolin, shellac wax, Chinese wax, etc.
  • Vegetable waxes include carnauba, candelilla, bayberry, sugar cane, etc.
  • mineral waxes include fossil and earth waxes (ozocerite, ceresin, montan), and petroleum waxes such as paraffin, microcrystalline, etc.
  • the waxes herein are natural waxes selected from the group consisting of beeswax, candelilla, candela, carnauba, paraffin, microcrystalline wax, Fischer-Tropsch waxes, and mixtures thereof.
  • the water insoluble component comprises a natural oil.
  • the natural oil comprises mineral oil.
  • mineral oil is present in the composition at an amount from about 30% to about 50% and in another embodiment, from about 35% to about 45%.
  • elastomers include, but are not limited to, Ethylene-Ethylene-Propylene rubber, Ethylene-Propylene rubber, Styrene-Ethylene— Propylene-Styrene rubber, and combinations thereof, and these may optionally be further combined with waxes.
  • the water insoluble carrier comprises microcrystalline wax, paraffin wax, bees wax, petrolatum, mineral oil, polybutene, silicone, natural oil, synthetic oil, polyethylene, or combinations thereof.
  • the water insoluble carrier is selected from the group consisting of polybutene, silicones, petrolatum, and combinations thereof.
  • the carrier comprises petrolatum.
  • the carrier consists essentially of petrolatum.
  • the present invention may include one or more components that provide a sensory benefit, often called a sensate.
  • Sensates can have sensory attributes such as a warming, tingling, or cooling sensation.
  • Suitable sensates include, for example, menthol, menthyl lactate, leaf alcohol, camphor, clove bud oil, eucalyptus oil, anethole, methyl salicylate, eucalyptol, cassia, 1- 8 menthyl acetate, eugenol, oxanone, alpha-irisone, propenyl guaethol, thymol, linalool, benzaldehyde, cinnamaldehyde glycerol acetal known as CGA, and mixtures thereof.
  • the sensate comprises a coolant.
  • the coolant can be any of a wide variety of materials. Included among such materials are carboxamides, menthol, ketals, diols, and mixtures thereof.
  • carboxamide coolants include, for example, paramenthan carboxyamide agents such as N-ethyl-p-menthan-3-carboxamide, known commercially as "WS-3", N,2,3-trimethyl-2-isopropylbutanamide, known as "WS-23,” and N-(4- cyanomethylphenyl)-p-menthanecarboxamide, known as G- 180 and supplied by Givaudan.
  • G- 180 generally comes as a 7.5% solution in a flavor oil, such as spearmint oil or peppermint oil.
  • menthol coolants include, for example, menthol; 3-l-menthoxypropane-l,2-diol known as TK-10, manufactured by Takasago; menthone glycerol acetal known as MGA manufactured by Haarmann and Reimer; and menthyl lactate known as Frescolat® manufactured by Haarmann and Reimer.
  • menthol and menthyl as used herein include dextro- and levorotatory isomers of these compounds and racemic mixtures thereof.
  • the sensate comprises a coolant selected from the group consisting of menthol; 3-l-menthoxypropane-l,2-diol, menthyl lactate; N,2,3-trimethyl-2- isopropylbutanamide; N-ethyl-p-menthan-3-carboxamide; N-(4-cyanomethylphenyl)-p- menthanecarboxamide, and combinations thereof.
  • the sensate comprises menthol; N,2,3-trimethyl-2-isopropylbutanamide; N-(4-cyanomethylphenyl)-p- menthanecarboxamide; or a combination thereof.
  • the sensate comprises menthol.
  • the sensate consists essentially of menthol.
  • sensates can be present in amounts up to about 40% by weight of the oral care composition. In varying embodiments, the sensates can be present from about 0.1, 0.5, 1, 2, 3, 4, 5, 6, 7, 8, 9, or 10%, to about 2, 5, 6, 7, 8, 9, 10, 12, 15, 20, 30, or 40%, or any combination thereof. In varying embodiments, the sensate is present in an amount from about 0.1% to about 20.0%, from about 1% to about 10%, or from about 3% to about 6% by weight of the total composition.
  • the present invention may include one or more components that provide a flavor benefit.
  • the flavoring component can be chosen from natural and synthetic flavorings.
  • Natural flavors can include, for example, oils derived from plant leaves, flowers, fruits and so forth. Some representative flavorings include, for example, vanilla, sage, marjoram, parsley oil, spearmint oil, cinnamon oil, wintergreen oil (methylsalicylate), and peppermint oils.
  • artificial, natural or synthetic fruit flavors include, for example, citrus oil including lemon, orange, banana, grape, lime, apricot and grapefruit and fruit essences including apple, strawberry, cherry, orange, pineapple and so forth; bean and nut derived flavors such as coffee, cocoa, cola, peanut, almond and so forth. These can be in any form including liquid, powder, etc. Additionally, flavor adsorbed onto a hydrophilic matrix may be included, e.g. "spray-dried" flavors. Furthermore, encapsulated flavors may be included.
  • the flavor is selected from mint, wintergreen, spice, vanilla, fruit, citrus, cocoa, tea, or a combination thereof.
  • the flavor component is selected from the group consisting of peppermint, spearmint, vanilla, cinnamon, wintergreen, mint, strawberry, grape, apple, and combinations thereof.
  • the flavor component comprises mixed mint, peppermint, spearmint, wintergreen, or a combination thereof.
  • the flavor component comprises peppermint.
  • flavor employed is normally a matter of preference subject to such factors as type and strength of effect desired.
  • Flavors can be present in amounts up to about 40%.
  • the flavor can be present from about 0.1, 0.5, 1, 2, 3, 4, 5, 6, 7, 8, 9, or 10%, to about 2, 5, 6, 7, 8, 9, 10, 12, 15, 20, 30, or 40%, or any combination thereof.
  • the flavor is present in an amount from about 0.1% to about 20.0%, from about 1% to about 10%, or from about 3% to about 6% by weight of the total composition.
  • the present invention may include one or more components that provide a sweetening benefit.
  • Suitable sweeteners include both natural and artificial sweeteners.
  • the sweeteners can be water-soluble or water-insoluble.
  • the sweetener may also be an intense sweetener.
  • sweeteners include dextrose, sucrose, maltose, dextrin, dried invert sugar, mannose, xylose, ribose, glucose, fructose, levulose, galactose, corn syrup, high fructose corn syrup, corn syrup solids, partially hydrolyzed starch, aspartame, saccharin, sugar alcohols such as sorbitol, xylitol, maltitol, isomalt, and hydrogenated starch.
  • Intense sweeteners are often dipeptide based. Some examples of intense sweeteners include monellin, haumatoccous danielli, and L-aspartyl L-phenylalanine methyl ester and soluble saccharin salts.
  • the sweetener is selected from the group consisting of dextrose, sucrose, maltose, dextrin, dried invert sugar, mannose, xylose, ribose, glucose, fructose, levulose, galactose, corn syrup, high fructose corn syrup, corn syrup solids, partially hydrolyzed starch, aspartame, saccharin, sugar alcohols, hydrogenated starch, monellin, haumatoccous danielli, L- aspartyl L-phenylalanine methyl ester, soluble saccharin salts, and combinations thereof.
  • the sweetener is selected from the group consisting of saccharin, sucralose, Rebiana, xylitol, aspartame, Acesulfame K, mono ammoniated glycyrrhizinate, and mixtures thereof.
  • the sweetener comprises saccharin, sucralose, Rebiana, or a combination thereof.
  • the sweetener comprises saccharin.
  • the sweetener consists essentially of saccharin.
  • the amount of the sweetener will vary with the type of sweetener selected and the desired level of sweetness.
  • Sweeteners can be present in amounts up to about 20%. In other embodiments the sweeteners can be present from about 0.1, 0.15, 0.25, 0.5, 0.75, 1, 1.25, 1.5, 1.75, 2, 2.25, 2.5, 2.75, 3, 4, 5, or 10%, to about 1, 2, 3, 4, 5, 10, or 20%, or any combination thereof by weight of the oral care composition. In varying embodiments, the sweetener is present in an amount from about 0.1% to about 10.0%, from about 1% to about 5%, or from about 1.5% to about 3%, by weight of the total composition.
  • the oral care composition may additionally include other components.
  • additional components includes substantivity agents.
  • One group of substantivity agents is organophosphates. Suitable organophosphate compounds have a strong affinity for the tooth surface and have sufficient surface binding propensity to desorb pellicle proteins and remain affixed thereon.
  • the phosphate groups of the organophosphate attach themselves to cations, in particular calcium ions in teeth or some other positively charged sites such as protein residues on the mucosal surface and thus serve to anchor the hydrophobic portion of the molecule onto the surface thereby modifying it to be hydrophobic.
  • the phosphate groups provide ready bonding/binding to cationic and charged surfaces via electrostatic interaction, hydrogen bonding, or complexation, which leads to ready deposition of the organophosphate upon application to form a coating on the treated surface.
  • the strong bond results in longer retention or durability and substantivity of the coating.
  • organophosphate compounds are mono-, di- or triesters represented by the following general structure wherein Z 1 , Z 2 , or Z 3 may be identical or different, at least one being an organic moiety, preferably selected from linear or branched, alkyl or alkenyl group of from 6 to 22 carbon atoms, optionally substituted by one or more phosphate groups; alkoxylated alkyl group or alkoxylated alkenyl group.
  • alkoxylated alkyl or alkenyl phosphate esters represented by the following structure:
  • R 1 represents a linear or branched, alkyl or alkenyl group of from 6 to 22 carbon atoms, optionally substituted by one or more phosphate groups; n and m, are individually and separately, 2 to 4, and a and b, individually and separately, are 0 to 20; Z 2 and Z 3 may be identical or different, each represents hydrogen, alkali metal, ammonium, protonated alkyl amine or protonated functional alkyl amine such as an alkanolamine, or a R 1 — (OC n H 2n ) a (OC m H 2m ) b — group.
  • R 1 is an alkyl group of at least 10 carbon atoms and a and b are each no more than 10 in order to maintain overall hydrophobic character of the organophosphate and the degree of hydrophobicity imparted to the surface.
  • the substantivity agent includes mono- di- and tri- alkyl and alkyl (poly)alkoxy phosphates such as dodecyl phosphate, lauryl phosphate; laureth-1 phosphate; laureth-3 phosphate; laureth-9 phosphate; dilaureth-10 phosphate; trilaureth-4 phosphate; Ci 2-I8 PEG-9 phosphate and salts thereof. Many are commercially available from suppliers including Croda; Rhodia; Nikkol Chemical; Sunjin; Alzo; Huntsman Chemical; Clariant and Cognis.
  • the substantivity agent comprises monoalkyl phosphate.
  • an additional component includes actives.
  • actives include various fluoride salts for caries prevention and remineralization; gingivitis prevention by the use of antimicrobial agents such as triclosan, cetylpyridinium chloride, stannous fluoride, zinc citrate or essential oils; and hypersensitivity control through the use of ingredients such as strontium chloride, stannous fluoride, or potassium nitrate; pyrophosphate salts can be used as antitartar agents; peroxides can be used for bleaching and antiseptics; and polymeric mineral surface active agents such as phosphorylated polymers, in particular polyphosphates that bind to teeth, or metal ions such as stannous, zinc or copper that form insoluble compounds that deposit onto teeth, can be used for erosion protection or sensitivity protection. These actives can be used alone or in combination.
  • an additional component includes adhesive components.
  • the present invention may comprise a safe and effective amount of an adhesive component, generally at a level of from about 1% to about 75% by weight of the composition.
  • the adhesive component is in the range of from about 1%, 5%, 10%, 15%, 20%, 25%, 30%, 35%, 40% to about 10%, 15%, 20%, 50%, 60%, 75%, or any combination thereof.
  • the adhesive component is in an amount from about 10.0% to about 60.0%.
  • the adhesive component is in an amount from about 1% to about 15%.
  • adhesive components are hydrophilic particles that become sticky when activated by moisture or are hydrophilic liquids.
  • moisture can be present, for example, in the oral care composition itself as well as in the oral cavity of the user.
  • the adhesive components herein are mucoadhesive, adhesive to the teeth, hydrophilic, water soluble, have the property of swelling upon exposure to moisture, or any combination thereof.
  • the adhesive component is selected from the group consisting of: glycerin, polyoxamer, sorbitol, polyox, carbomer, polyacrylamides, polypeptides, natural gums; synthetic polymeric gums; AVE/MA; AVE/MA/IB; copolymers of maleic acid or anhydride and ethylene, styrene, and/or isobutylene, polyacrylic acid and/or polyacrylates thereof; polyitaconic acid, mucoadhesive polymers; water-soluble hydrophilic colloids; saccharide; cellulose; cellulosic resin, acrylic resin, their derivatives, and mixtures thereof.
  • Such materials include karaya gum; guar gum; gelatin; algin; sodium alginate; tragacanth; chitosan; acrylamide polymers; carboxypolymethylene; polyvinyl alcohol; polyamines; polyquarternary compounds; polyvinylpyrrolidone or its copolymers; cationic polyacrylamide polymers; salts and mixed salts of AVE/MA; polymeric acids, polymeric salts, and copolymers thereof; polyitaconic acid salts; polyhydroxy compounds; their derivatives; and mixtures thereof.
  • the adhesive component is selected from the group consisting of: cellulose, cellulose derivatives (such as methylcellulose, carboxymethylcellulose, hydroxyethylcellulose, hydroxypropylcellulose, hydroxy-propylmethylcellulose, corn starch, and mixtures thereof), starch, starch derivatives, saccharide, saccharide derivatives, polyethylene oxides, polyethylene glycols, polyvinyl alcohols, carrageenan, alginates, karaya gums, xanthan gums, guar gums, gelatins, algins, tragacanth, chitosan, acrylamide polymers, carboxypolymethylenes, polyamines, poly quaternary compounds, polyvinylpyrrolidone, AVE/MA, salts of AVE/MA, mixed salts of AVE/MA, polymeric acids, polymeric salts, polyhydroxy compounds, and mixtures thereof.
  • cellulose cellulose derivatives (such as methylcellulose, carboxymethylcellulose, hydroxyethylcellulose, hydroxyprop
  • compositions of the present invention with the components present in the specific ratios disclosed herein are believed to offer superior flavor benefits to those compositions that do not contain the components disclosed herein or are present in different ratios, and thus, give a more consumer acceptable product. Since consumer acceptance helps drive the use of the product, it is an important feature in the development of a successful product.
  • the first ratio is the weight of sensate to the weight of flavor ("Rl"). This ratio is calculated by dividing the weight percentage of sensate by the weight percentage of flavor. In one embodiment, this ratio is from about 0 to about 4.0. In another embodiment, this ratio is from about 0.25 to about 2.0. In another embodiment, this ratio is about 1.0.
  • the second ratio is for the weight of flavor to the weight of sweetener in the oral care composition ("R2"). To calculate this ratio, the weight percentage of flavor is divided by the weight percentage of sweetener. In one embodiment, this ratio is from about 0 to about 20. In another embodiment, the ratio is from about 1.0 to about 4.0. In another embodiment, the ratio is from about 1.5 to about 2.5. In a further embodiment, the ratio is about 2.0.
  • the next ratio is for the weight of sensate to the weight of sweetener ("R3"). This ratio is calculated by dividing the weight percentage of sensate by the weight percentage of sweetener. In one embodiment, this ratio is from about 0 to about 20. In another embodiment, the ratio is from about 1.0 to about 4.0. In another embodiment, the ratio is from about 1.5 to about 2.5. In a further embodiment, the ratio is about 2.0.
  • the last ratio is the weight of sensates and weight of flavors to the weight of sweetener ("R4"). This ratio is calculated by adding the weight percentage of sensates to the weight percentage of flavors and dividing that total by the weight percentage of sweeteners. In one embodiment, this ratio is from about 0.4 to about 40. In varying embodiments, this ratio is from about 2.0 to about 8.0., from about 3.0 to about 7.0, or from about 3.0 to about 5.0. In an additional embodiment, the ratio is about 4.0.
  • Rl is from about 0.25 to about 4.0, R2 is from about 0.2 to about 20, and R3 is from about 0.2 to about 20.
  • Rl is from about 0.5 to about 2.0, R2 is from about 1.0 to about 4.0, and R3 is from about 1.0 to about 4.0.
  • Rl is about 1.0, R2 is about 2.0, and R3 is about 2.0.
  • an oral care composition comprises a water insoluble carrier, a sweetener, and an additional component selected from a sensate, a flavor, or combination thereof.
  • an oral care composition consists essentially of a water insoluble carrier, a sweetener, and an additional component selected from a sensate, a flavor, or a combination thereof. Both of these embodiments are configured for application within the oral cavity. In one embodiment, the oral care compositions are configured for application to the teeth.
  • the oral care composition comprises at least 75% by weight of the water insoluble carrier.
  • the water insoluble carrier is from about
  • the water insoluble carrier is from about 50% to about 99% by weight of the oral care composition.
  • the water insoluble carrier is rubber and/or natural wax and/or synthetic wax and/or polyvinyl chloride and/or nylon and/or fluorocarbon and/or polyurethane prepolymer and/or polyethylene and/or polystyrene and/or polypropylene and/or petrolatum and/or polyvinyl acetate and/or natural oil and/or synthetic oil and/or fats and/or silicone and/or hydrocarbons and/or caprilic/capric triglycerides and/or oleic acid and/or stearic acid and/or mixtures thereof.
  • the water insoluble carrier comprises microcrystalline wax and/or paraffin wax and/or bees wax and/or petrolatum and/or mineral oil and/or polybutene and/or silicone and/or natural oil and/or synthetic oil and/or polyethylene and/or combinations thereof.
  • the water insoluble carrier is selected from the group consisting of polybutene and/or silicones and/or petrolatum and/or combinations thereof.
  • the carrier comprises petrolatum.
  • the carrier consists essentially of petrolatum.
  • the oral care composition comprises from about 0.5% to about 10% by weight of a sweetener.
  • the sweetener is selected from a group consisting of dextrose, fructose, corn syrup, high fructose corn syrup, aspartame, saccharin, sugar alcohols, and mixtures thereof.
  • the sweetener is selected from the group consisting of saccharin, sucralose, Rebiana, xylitol, aspartame, Acesulfame K, mono ammoniated glycyrrhizinate, and mixtures thereof.
  • the sweetener comprises saccharin, sucralose, Rebiana, or a combination thereof.
  • the sum of the weight percentages of the sweetener and the additional component is less than about 25%. In another embodiment the sum of the weight percentages of the sweetener and the additional component is less than 25%. In an additional embodiment, the sum of the weight percentages of the sweetener and the additional component is from about 8% to about 15%.
  • the additional component comprises a flavor.
  • the flavor is selected from the group consisting of: peppermint, spearmint, vanilla, cinnamon, wintergreen, mint, strawberry, grape, apple, and combinations thereof.
  • the flavor component comprises mixed mint, peppermint, spearmint, wintergreen, or a combination thereof.
  • the flavor component consists essentially of mint.
  • the ratio of flavor to sweetener is from about 0.2 to about 20.
  • the additional component comprises a sensate.
  • the sensate comprises a coolant.
  • the sensate is selected from the group consisting of menthol, menthyl lactate, leaf alcohol, camphor, clove bud oil, eucalyptus oil, anethole, methyl salicylate, eucalyptol, cassia, 1-8 menthyl acetate, eugenol, oxanone, alpha- irisone, propenyl guaethol, thymol, linalool, benzaldehyde, cinnamaldehyde glycerol acetal, and mixtures thereof.
  • the sensate is selected from the group consisting of menthol; 3-l-menthoxypropane-l,2-diol; methyl lactate; N,2,3-trimethyl-2-isopropylbutanamide; N-ethyl-p-menthan-3-carboxamide; N-(4-cyanomethylphenyl)-p-menthanecarboxamide, and combinations thereof.
  • the sensate comprises menthol; N,2,3-trimethyl- 2-isopropylbutanamide; N-(4-cyanomethylphenyl)-p-menthanecarboxamide; or a combination thereof.
  • the ratio of sensate to sweetener is from about 0.2 to about 20.
  • the additional component comprises a combination of flavor and sensate.
  • the ratio by weight of flavor plus sensate to sweetener is from about 0.4 to about 40.
  • the ratio by weight of sensate to flavor is from about 0.5 to about 2.0
  • the ratio by weight of flavor to sweetener is from about 1.0 to about 4.0
  • the ratio by weight of sensate to sweetener is from about 1.0 to about 4.0
  • the ratio by weight of flavor plus sensate to sweetener is from about 2.0 to about 8.0.
  • the oral care composition comprises from about 1% to about 10% by weight of flavor and from about 1% to about 10% by weight of sensate.
  • the oral care composition comprises a water soluble carrier comprising microcrystalline wax and/or paraffin wax and/or bees wax and/or petrolatum and/or mineral oil and/or polybutene and/or silicone and/or natural oil and/or synthetic oil and/or polyethylene; and a flavor comprising peppermint and/or spearmint and/or vanilla and/or cinnamon and/or wintergreen and/or mint and/or strawberry and/or grape and/or apple; and a sweetener comprising dextrose and/or fructose and/or corn syrup and/or high fructose corn syrup and/or aspartame and/or saccharin and/or sugar alcohols; and a sensate comprising menthol and/or menthyl lactate and/or leaf alcohol and/or camphor and/or clove bud oil and/or eucalyptus oil and/or anethole and/or methyl salicylate and/or eucalyptol and/or cassia and/or 1-8 men
  • the oral care composition consists of a water insoluble carrier, a sweetener, and an additional component selected from the group consisting of sensate, flavor, and combinations thereof, wherein the ratio by weight of sensate to flavor is from about 0.5 to about 2.0 and/or the ratio by weight of flavor to sweetener is from about 1.0 to about 4.0 and/or the ratio by weight of sensate to sweetener is from about 1.0 to about 4.0 and/or and the ratio by weight of flavor plus sensate to sweetener is from about 2.0 to about 8.0.
  • an oral care composition consists essentially of petrolatum, saccharin, mint oil, and menthol and is configured for application to the teeth, wherein the ratio by weight of sensate to flavor is from about 0.5 to about 2.0 and/or the ratio by weight of flavor to sweetener is from about 1.0 to about 4.0 and/or the ratio by weight of sensate to sweetener is from about 1.0 to about 4.0 and/or and the ratio by weight of flavor plus sensate to sweetener is from about 2.0 to about 8.0. In another embodiment, the ratio by weight of flavor plus sensate to sweetener is from about 0.4 to about 40.
  • the ratio by weight of sensate to flavor is about 1.0, the ratio by weight of flavor to sweetener is about 2.0, the ratio by weight of sensate to sweetener is about 2.0, and the ratio by weight of flavor plus sensate to sweetener is about 4.0.
  • the composition is free of surfactants, abrasives, fluoride sources, therapeutic actives, muco-adhesives, polybutenes, silicones, and/or antimicrobial agents.
  • the oral care composition is not a dentifrice. In another embodiment, the oral care composition is not a rinse. In another embodiment, the oral care composition is not a denture adhesive.
  • the oral care composition will be in the form of a liquid or gel.
  • the liquid or gel form of the oral care composition may be applied with an applicator.
  • the applicator may be used with any oral care applicator, for example, a swab, brush, foam tipped applicator, etc. While a few embodiments are discussed above, additional embodiments enabled based on the discussion above, for example specific types of each component, its weight percentages, and ratios, are believed to also be within the scope of the invention.
  • the oral care composition as discussed herein may be used to deliver any oral care components compatible with the water insoluble carrier to the oral cavity.
  • an oral care composition may be used as a breath freshener by including a breath freshening agent, like a flavor, in the oral care composition or the composition may be used as an active delivery vehicle by including an active.
  • the oral care composition can be used to form a water insoluble barrier on the teeth.
  • Some benefits expected from such a barrier include: reduction in caries, plaque, and calculus due at least in part to the inability of bacteria to stick to the teeth, reduction in sensitivity due at least in part to the blocking of dentin tubules, reduction in erosion and prevention of staining due at least in part to the coating operating as a barrier to erosive agents, and overall improvements in mouth feel impression and/or appearance which can be broadly characterized as aesthetics, such as shine, gloss, luster, smoothness, slickness, and clean mouth feel.
  • Example 1 Various Compositions of the Invention
  • compositions B, E, I, and J the wax is melted at 95°C and the other components are mixed into it at the elevated temperature.
  • the petrolatum and/or Versagel is heated to about 70 0 C and the other components are mixed in at the elevated temperature.
  • the compositions are allowed to come to room temperature prior to use.
  • each of the above example formulations may also be mixed with each other to provide hybrid-examples.
  • Sample A is strongly preferred over and rated much higher than Sample B.
  • Sample A with R1/R2/R3/R4 ratios of 1/2/2/4, is strongly preferred over and rated much higher than Sample B with R1/R2/R3/R4 ratios of l/>100/>100/>100.
  • the petrolatum is heated to about 70 0 C and the other components are mixed in at the elevated temperature.
  • the compositions are allowed to come to room temperature prior to use. After the samples are made, they are placed into a container. The consumer preference for taste is tested by allowing a consumer to dip a disposable lip gloss applicator into the container and tasting the sample. The consumer then picks the sample they prefer. The consumer also rates each sample on a scale of - 4 to +4 (with -4 being "Dislike Extremely” and +4 being “Like Extremely”). The preferences and ratings for these comparisons are below.
  • Sample B is preferred over and rated higher than Sample A. Specifically, Sample B, with R1/R2/R3/R4 ratios of 1/2/2/4, is preferred over and rated higher than Sample A with R1/R2/R3/R4 ratios of 1/25/25/50.
  • Sample D is strongly preferred over and rated much higher than Sample C. Specifically, Sample D, with R1/R2/R3/R4 ratios of 1/2/2/4, is strongly preferred over and rated much higher than Sample C with R1/R2/R3/R4 ratios of 1/25/25/50.
  • the petrolatum is heated to about 70 0 C and the other components are mixed in at the elevated temperature.
  • the compositions are allowed to come to room temperature prior to use. After the samples are made, they are placed into a container. The consumer preference for taste is tested by allowing a consumer to dip a disposable lip gloss applicator into the container and tasting the sample. The consumer then picks the sample they prefer. The consumer also rates each sample on a scale of -4 to +4 (with -4 being "Dislike Extremely” and +4 being “Like Extremely”). The preferences and ratings for these comparisons are below.
  • Sample B is preferred over and rated higher than Sample A. Specifically, Sample B, with a total Saccharin+Mint+Menthol level of 10% [and R1/R2/R3/R4 ratios of 1/2/2/4], is preferred over and rated higher than Sample A with total Saccharin+Mint+Menthol level of 1.5% [and the same R1/R2/R3/R4 ratios of 1/2/2/4].

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EP10745706A 2009-08-17 2010-08-17 Mundpflegezusammensetzungen und -verfahren Withdrawn EP2467192A2 (de)

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US23451209P 2009-08-17 2009-08-17
PCT/US2010/045677 WO2011022343A2 (en) 2009-08-17 2010-08-17 Oral care compositions and methods

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WO2021168696A1 (en) * 2020-02-26 2021-09-02 The Procter & Gamble Company Oral care compositions for gum health

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CN106176306A (zh) 2016-12-07
AU2010284339B2 (en) 2014-09-18
CN102625722A (zh) 2012-08-01
WO2011022343A2 (en) 2011-02-24
WO2011022343A3 (en) 2012-05-31
AU2010284339A1 (en) 2012-03-08

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