EP2439747A3 - 68 Ga-Generator - Google Patents

68 Ga-Generator Download PDF

Info

Publication number
EP2439747A3
EP2439747A3 EP11176249A EP11176249A EP2439747A3 EP 2439747 A3 EP2439747 A3 EP 2439747A3 EP 11176249 A EP11176249 A EP 11176249A EP 11176249 A EP11176249 A EP 11176249A EP 2439747 A3 EP2439747 A3 EP 2439747A3
Authority
EP
European Patent Office
Prior art keywords
generator
triethoxyphenyl group
support
triethoxyphenyl
linker
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP11176249A
Other languages
English (en)
French (fr)
Other versions
EP2439747B1 (de
EP2439747A2 (de
EP2439747A8 (de
Inventor
Konstantin Zhernosekov
Tuomo Nikula
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ITM Isotopen Technologien Muenchen AG
Original Assignee
ITM Isotopen Technologien Muenchen AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ITM Isotopen Technologien Muenchen AG filed Critical ITM Isotopen Technologien Muenchen AG
Priority to PL11176249T priority Critical patent/PL2439747T3/pl
Publication of EP2439747A2 publication Critical patent/EP2439747A2/de
Publication of EP2439747A3 publication Critical patent/EP2439747A3/de
Publication of EP2439747A8 publication Critical patent/EP2439747A8/de
Application granted granted Critical
Publication of EP2439747B1 publication Critical patent/EP2439747B1/de
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • G—PHYSICS
    • G21—NUCLEAR PHYSICS; NUCLEAR ENGINEERING
    • G21G—CONVERSION OF CHEMICAL ELEMENTS; RADIOACTIVE SOURCES
    • G21G1/00—Arrangements for converting chemical elements by electromagnetic radiation, corpuscular radiation or particle bombardment, e.g. producing radioactive isotopes
    • G21G1/0005—Isotope delivery systems
    • G—PHYSICS
    • G21—NUCLEAR PHYSICS; NUCLEAR ENGINEERING
    • G21G—CONVERSION OF CHEMICAL ELEMENTS; RADIOACTIVE SOURCES
    • G21G1/00—Arrangements for converting chemical elements by electromagnetic radiation, corpuscular radiation or particle bombardment, e.g. producing radioactive isotopes
    • G21G1/001—Recovery of specific isotopes from irradiated targets
    • G—PHYSICS
    • G21—NUCLEAR PHYSICS; NUCLEAR ENGINEERING
    • G21G—CONVERSION OF CHEMICAL ELEMENTS; RADIOACTIVE SOURCES
    • G21G1/00—Arrangements for converting chemical elements by electromagnetic radiation, corpuscular radiation or particle bombardment, e.g. producing radioactive isotopes
    • G21G1/001—Recovery of specific isotopes from irradiated targets
    • G21G2001/0021—Gallium

Landscapes

  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Engineering & Computer Science (AREA)
  • General Engineering & Computer Science (AREA)
  • High Energy & Nuclear Physics (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nuclear Medicine (AREA)
  • Catalysts (AREA)

Abstract

Die vorliegende Erfindung betrifft einen 68Ga-Generator, bei welchem dessen 68Ge-Mutternuklid spezifisch an einen Träger über eine Triethoxyphenylgruppe immobilisiert ist und kontinuierlich zu 68Ga zerfällt, wobei die Triethoxyphenylgruppe kovalent über einen Linker an ein Trägermaterial gebunden ist.
EP11176249.8A 2010-10-05 2011-08-02 68 Ga-Generator Active EP2439747B1 (de)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PL11176249T PL2439747T3 (pl) 2010-10-05 2011-08-02 Generator <sup>68</sup>GA

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE102010037964A DE102010037964B3 (de) 2010-10-05 2010-10-05 68Ga-Generator

Publications (4)

Publication Number Publication Date
EP2439747A2 EP2439747A2 (de) 2012-04-11
EP2439747A3 true EP2439747A3 (de) 2012-08-29
EP2439747A8 EP2439747A8 (de) 2013-01-02
EP2439747B1 EP2439747B1 (de) 2013-09-18

Family

ID=44645527

Family Applications (1)

Application Number Title Priority Date Filing Date
EP11176249.8A Active EP2439747B1 (de) 2010-10-05 2011-08-02 68 Ga-Generator

Country Status (11)

Country Link
US (2) US8487047B2 (de)
EP (1) EP2439747B1 (de)
JP (1) JP5335048B2 (de)
CN (1) CN102446570B (de)
AU (1) AU2011211435B2 (de)
BR (1) BRPI1103916B1 (de)
CA (1) CA2749505C (de)
DE (1) DE102010037964B3 (de)
DK (1) DK2439747T3 (de)
ES (1) ES2439821T3 (de)
PL (1) PL2439747T3 (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112017016492B1 (pt) * 2015-01-30 2022-09-20 Advanced Accelerator Applications International S.A.. Processo para a purificação de ga-68 a partir de eluato que deriva de geradores de 68ge/ 68ga e colunas cromatográficas para uso no dito processo
SI3343570T1 (sl) * 2016-12-27 2019-10-30 Itm Isotopen Tech Muenchen Ag Generator 68Ge/68Ga
PL3401283T3 (pl) 2017-05-10 2020-05-18 ITM Isotopen Technologien München AG Sposób wytwarzania wysoce oczyszczonego materiału 68ge do celów radiofarmaceutycznych
KR102218075B1 (ko) * 2018-06-04 2021-02-19 동국대학교 경주캠퍼스 산학협력단 방사성동위원소 발생장치용 키토산 코팅 금속산화물 흡착제, 그 제조방법 및 이를 이용한 방사성동위원소 발생방법
WO2020118426A1 (en) 2018-12-11 2020-06-18 Societe de Commercialisation des Produits de la Recherche Appliquée Socpra Sciences et Génie S.E.C. Processes and systems for producing and/or purifying gallium-68

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT334084B (de) * 1975-02-25 1976-12-27 Radiation Int Ag Verfahren zur herstellung von insbesondere fur die selektive abtrennung mehrwertiger metalle aus wasserigen losungen geeigneten harzen
GB2056471A (en) * 1979-08-14 1981-03-18 Deutsches Krebsforsch Ion-exchanger for Separating Gallium-68 from its Parent Nuclide Germanium-68
US4264468A (en) * 1979-01-08 1981-04-28 Massachusetts Institute Of Technology Generator for gallium-68 and compositions obtained therefrom
US4333911A (en) * 1979-04-24 1982-06-08 Commissariat A L'energie Atomique Method of preparing a solution of gallium 68 from germanium 68
US20100202915A1 (en) * 2009-02-06 2010-08-12 Konstantin Zhernosekov Molecule for functionalizing a support, attachment of a radionuclide to the support and radionuclide generator for preparing the radionuclide, and preparation process

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT383643B (de) * 1984-10-19 1987-07-27 Blum Gmbh Julius Scharnier
US7011816B2 (en) * 2001-12-26 2006-03-14 Immunomedics, Inc. Labeling targeting agents with gallium-68 and gallium-67
US7023000B2 (en) * 2003-05-21 2006-04-04 Triumf Isotope generator
DE102004057225B4 (de) * 2004-11-26 2006-10-12 Johannes-Gutenberg-Universität Mainz Verfahren und Vorrichtung zur Isolierung eines chemisch und radiochemisch gereinigten 68Ga-Radionuklids und zum Markieren eines Markierungsvorläufers mit dem 68Ga-Radionuklid
US20070009409A1 (en) * 2005-07-11 2007-01-11 Hariprasad Gali 212Bi or 213Bi Generator from supported parent isotope
JP4509083B2 (ja) 2006-10-24 2010-07-21 パナソニック株式会社 ディスク駆動装置
JP5005024B2 (ja) * 2007-03-02 2012-08-22 国立大学法人 長崎大学 Ｇｅ吸着剤

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT334084B (de) * 1975-02-25 1976-12-27 Radiation Int Ag Verfahren zur herstellung von insbesondere fur die selektive abtrennung mehrwertiger metalle aus wasserigen losungen geeigneten harzen
US4264468A (en) * 1979-01-08 1981-04-28 Massachusetts Institute Of Technology Generator for gallium-68 and compositions obtained therefrom
US4333911A (en) * 1979-04-24 1982-06-08 Commissariat A L'energie Atomique Method of preparing a solution of gallium 68 from germanium 68
GB2056471A (en) * 1979-08-14 1981-03-18 Deutsches Krebsforsch Ion-exchanger for Separating Gallium-68 from its Parent Nuclide Germanium-68
US20100202915A1 (en) * 2009-02-06 2010-08-12 Konstantin Zhernosekov Molecule for functionalizing a support, attachment of a radionuclide to the support and radionuclide generator for preparing the radionuclide, and preparation process

Also Published As

Publication number Publication date
US8937166B2 (en) 2015-01-20
US20140163211A1 (en) 2014-06-12
CN102446570A (zh) 2012-05-09
DK2439747T3 (da) 2013-10-07
AU2011211435A1 (en) 2012-04-19
US8487047B2 (en) 2013-07-16
US20120252981A1 (en) 2012-10-04
EP2439747B1 (de) 2013-09-18
PL2439747T3 (pl) 2014-02-28
EP2439747A2 (de) 2012-04-11
EP2439747A8 (de) 2013-01-02
CN102446570B (zh) 2014-12-03
CA2749505C (en) 2013-12-03
BRPI1103916B1 (pt) 2020-10-20
JP2012078353A (ja) 2012-04-19
JP5335048B2 (ja) 2013-11-06
ES2439821T3 (es) 2014-01-24
DE102010037964B3 (de) 2012-03-22
BRPI1103916A2 (pt) 2015-03-31
AU2011211435B2 (en) 2012-11-08
CA2749505A1 (en) 2012-04-05

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