EP2416756A2 - Stabile pharmazeutische zusammensetzungen mit hoher bioverfügbarkeit - Google Patents
Stabile pharmazeutische zusammensetzungen mit hoher bioverfügbarkeitInfo
- Publication number
- EP2416756A2 EP2416756A2 EP10731618A EP10731618A EP2416756A2 EP 2416756 A2 EP2416756 A2 EP 2416756A2 EP 10731618 A EP10731618 A EP 10731618A EP 10731618 A EP10731618 A EP 10731618A EP 2416756 A2 EP2416756 A2 EP 2416756A2
- Authority
- EP
- European Patent Office
- Prior art keywords
- strontium
- treatment
- pharmaceutical composition
- sodium
- composition according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
- A61K31/593—9,10-Secocholestane derivatives, e.g. cholecalciferol, i.e. vitamin D3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
- A61K9/0007—Effervescent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
Definitions
- the present invention relates to pharmaceutical compositions comprising an active agent alone or in combination with another active agent which is used for the treatment and/or prophylaxis of diseases and conditions associated with abnormal bone resorption and/or effective as a supplement.
- the present invention provides a pharmaceutical composition which is used for the treatment and/or prophylaxis of diseases and conditions associated with abnormal bone resorption and/or effective as a supplement
- Strontium is an earth-alkali metal that has high chemical reactivity. It was first discovered by Thomas Charles Hope in 1798. Strontium ranelate (Formula I) was first described in United States Patent application 5128367 (European Patent number 0415850 is also a member of the patent family). The process for the preparation of strontium ranelate and its use for the treatment of bone disorder, especially for osteoporosis, are described in this patent.
- Strontium is an element which has a high affinity to the bone tissue. Due to its high chemical and physical similarity to calcium, it can be used instead of calcium and can show the same activity. Its anti-osteoporotic effect is suggested to demonstrate itself with a dual mechanism of bone production improvement and bone resorption reduction.
- 89 Sr is a radiopharmaceutical used for bone pain secondary to metastatic bone cancer. The strontium acts like calcium and is preferentially incorporated into bone at sites of increased osteogenesis. This localization focuses the radiation exposure on the cancerous lesion.
- 90 Sr is used as radiotherapy in cancer treatment due to its beta emission and long half-life characteristics.
- Strontium ranelate being one of the strontium compounds is effective in bone growth, increasing bone density and lessening bone fractures and the use of granule form of strontium ranelate for oral suspension is approved in Europe.
- Vitamin D is a group of fat-soluble prohormones, the two major forms of which are vitamin D 2 (or ergocalciferol) and vitamin D 3 (or cholecalciferol). There are also D 1 , D 4 and D 5 forms. The term vitamin D also refers to these metabolites and other analogues of these substances. Vitamin D 3 is a vitamin D form with the chemical name (3 ⁇ ,5Z,7E)-9,10-secocholesta- 5,7,10(19)-trien-3-ol (Formula II).
- Vitamin D 3 is the form of vitamin D that is synthesized naturally in the body. It is synthesized in the skin from 7-dehydrocholesterol, a sterol present in the mammalian skin, under the action of ultraviolet light. Vitamin D 3 can be obtained partially from animal products. Vitamin D 3 is hydroxylated in the liver and kidney, and becomes calcitriol (1,25- dihydroxyvitamin D 3 ).
- Calcitriol plays an important role in the maintenance of the calcium balance and the parathyroid hormone regulation. It stimulates the renal reabsorption of calcium, and increases the intestinal absorption of calcium and phosphorus and their mobilization from the bone to the plasma. It is believed that the absorption of calcium in the intestines is achieved by the calcitriol by binding to specific receptors in the cytoplasm of intestinal mucosa cells. Then calcium is absorbed by formation of a calcium binding protein. When calcium and phosphorus levels of plasma reach saturation, mineralization occurs in the bone. Vitamin D affects the absorption of strontium in the same way as it affects calcium absorption. Hence, Vitamin D can be added to a strontium composition to be used for the treatment and/or prophylaxis of diseases and conditions associated with abnormal bone resorption and/or as a supplement.
- the present invention relates to pharmaceutical compositions which are effective for the treatment and/or prophylaxis of diseases and conditions associated with abnormal bone resorption and/or as a supplement.
- the mentioned compositions comprise a strontium compound alone or in combination with vitamin D.
- the object of the invention is to provide a composition comprising the active agent or agents in a pharmaceutically acceptable, non-toxic and therapeutically effective amount according to the invention and the formulation of these active agent/agents to achieve this desired effect.
- European Patent No. 1534305 describes the use of strontium malonate with a solubility of 1- 100 g/1 at room temperature, for prevention and/or treatment of various bone conditions.
- European Patent No. 1534305 European Application No. 1745791 describes the use of some strontium salts also with a solubility of 1-100 g/1 at room temperature, for prevention and/or treatment of various bone conditions. It has been indicated in these patents that these novel salts encounter no solubility problems.
- vitamin D The tendency of vitamin D to degrade when exposed to heat, light, air, moisture, oxidizing agents or an acidic environment raises the problem of stability with the formulations comprising vitamin D. This situation raises the necessity of using an auxiliary agent to ensure the stability of vitamin D in the tablet.
- the present invention provides stable, highly soluble and hence bioavailable pharmaceutical compositions comprising a strontium compound alone or in combination with Vitamin D to formulate the composition for maintaining the "desired effect".
- the present invention relates to the use of pharmaceutical compositions comprising a strontium compound alone or in combination with vitamin D, in the manufacture of a medicament used for the treatment and/or prophylaxis of diseases and conditions associated with abnormal bone resorption and/or as a supplement in a liquid dosage form or a solid dosage form which transforms into liquid form just before administration.
- the present invention is directed to obtain stable, highly soluble and hence bioavailable pharmaceutical compositions comprising a strontium compound alone or in combination with Vitamin D to formulate the composition for maintaining the "desired effect".
- Strontium ranelate a strontium salt effective in the treatment of osteoporosis, released to market in Europe in the form of granules for oral suspension.
- the present invention is directed to solution formulations which are preferred instead of suspension formulations in order to increase the bioavailability of pharmaceutical compositions comprising a strontium compound.
- These previously mentioned solution compositions might be either in a liquid dosage form or in a solid dosage form which transforms into liquid phase just before administration.
- the pharmaceutical compositions of the invention preferably in the effervescent tablet form highly improve the bioavailability because they are already administered in dissolved form and already provide the use of active agent in high amounts.
- the pharmaceutical formulation composition of the present invention are characterized in that they provide formulations comprising a high dose of a strontium compound in effervescent form to improve solubility, thus bioavailability; instead of restrictive and complicated methods, which require both time and capital, such as use of a solubility enhancing agent, preparation of novel strontium salts with improved solubility, addition of at least two strontium salts to enhance bioavailability and enhancement of the release characteristics of tablet dosage form.
- Strontium carbonate can be used alone or in combination with other strontium compounds because of the fact that the effervescent formulations of the invention are effective as a carbondioxide source and improve bioavailability by increasing active agent dose.
- the pharmaceutical compositions preferably in tablet dosage form may also comprise a small amount of sweetener and/or flavoring agent as taste promoter.
- compositions of the present invention may be formulated comprising a strontium compound alone or also a strontium compound in combination with vitamin D as an active agent.
- a strontium compound alone or also a strontium compound in combination with vitamin D as an active agent.
- the stability problem arises due to vitamin D.
- Pharmaceutical compositions of the invention in effervescent form comprise disintegrants which cause tablets to disintegrate, in other words to dissolve, thus increasing the bioavailability and also providing the stability of the composition.
- Pharmaceutical compositions of the invention preferably in effervescent form can also comprise at least one stabilizing agent.
- compositions comprising a strontium compound alone or in combination with vitamin D, in liquid or solid dosage form which transforms into liquid form just before administration, preferably in effervescent tablet form, and optionally comprising an additive selected from the group consisting of diluents, binders, disintegrants, lubricants, glidants, surfactants, stabilizing agents, sweeteners and flavoring agents, have improved solubility, bioavailability and stability characteristics and the pharmaceutical compositions are used for the treatment and/or prophylaxis of diseases and conditions associated with abnormal bone resorption and/or effective as a supplement.
- the term "used for the treatment and/or prophylaxis of diseases and conditions associated with abnormal bone resorption and/or as a supplement” used herein refers to the use of treatment of osteoporosis; treatment of osteoporosis by reducing the risk of post-menopausal bone fractures of the spine and hip bones in women; treatment of osteoporosis for reducing the risk of bone fractures in men; treatment of idiopathic osteoporosis; treatment of various disease related osteoporosis; treatment of steroid and glucocorticoid related osteoporosis; treatment of osteoarthritis; treatment of osteopetrosis; treatment of osteopenia; treatment of osteomalacia; treatment of osteodystrophy; treatment of osteogenesis imperfecta; treatment of osteochondrodysplasia; treatment of Sudeck's atrophy, treatment of rheumatoid arthritis, treatment of Paget's disease, treatment of Bechterew's disease, treatment of Behcet's disease, treatment of periodon
- the pharmaceutical compositions contain strontium compound in the range of 0.1-75% by weight and an amount of vitamin D in the range of 100-100000 IU to achieve the desired therapeutic effect.
- strontium compound indicates strontium adipate, strontium alendronate, strontium alginate, strontium acetate, strontium ascorbate, strontium aspartate, strontium benzenesulfonate, strontium benzoate, strontium borate, strontium bromate, strontium bromide, strontium butanoate, strontium butirate, strontium decanoate, strontium ethanesulfonate, strontium etidronate, strontium fluoride, strontium formate, strontium phosphate, strontium fumarate, strontium glyconate, strontium glycocholate, strontium glutamate, strontium glutarate, strontium hexanoate,
- the pharmaceutically acceptable diluents can be selected from the group of lactose, microcrystalline cellulose, starch, pregelatinized starch, modified starch, calcium phosphate (dibasic and/or tribasic), calcium sulphate trihydrate, calcium sulphate dihydrate, calcium carbonate, caolin, lactitol, powdered cellulose, dextrose, dextrates, dextrin, sucrose, maltose, fructose, mannitol, sorbitol and xylitol.
- the diluent is present in the formulation preferably in a range of 0-85% by weight, more preferably in a range of 0.1-75% by weight.
- the pharmaceutically acceptable binders can be selected from the group of starch (e.g. potato starch, cornstarch or wheat starch), sucrose, glucose, dextrose, lactose, sugars like maltodexrin, natural and synthetic gums (e.g. acacia tree), gelatin, cellulose derivatives (e.g. microcrystalline cellulose, HPC, HEC, HPMC, carboxymethylcellulose, methylcellulose, ethylcellulose), polyethylene glycol (PEG), waxes, calcium carbonate, calcium phosphate, alcohols (e.g. sorbitol, xylitol and mannitol) and water.
- the binder is present in the formulation preferably in a range of 0-10% by weight, more preferably in a range of 0.1-5% by weight.
- the pharmaceutically acceptable disintegrants can be selected from the group of starch (e.g. potato starch, cornstarch or wheat starch), sodium starch glycolate, pregelatinized starch, cellulose derivatives (such as croscarmellose sodium or microcrystalline cellulose), polyvinylpyrrolidone (PVP), crospovidone, alginic acid, sodium alginate, clays (such as Xanthan gum or Veegum), ion-exchange resins and effervescent systems (alkali or alkaline earth metal carbonates (e.g. sodium carbonate, sodium hydrogen carbonate, potassium carbonate, potassium hydrogen carbonate, calcium carbonate, and strontium carbonate), water-soluble organic acids and salts (e.g.
- starch e.g. potato starch, cornstarch or wheat starch
- sodium starch glycolate e.g. potato starch, cornstarch or wheat starch
- pregelatinized starch e.g. potato starch, cornstarch or wheat starch
- the disintegrant is present in the formulation preferably in a range of 0-85% by weight, more preferably in a range of 0.1-75% by weight.
- the pharmaceutically acceptable lubricants can be selected from the group of metallic stearates (e.g. magnesium stearate, calcium stearate, aluminum stearate), fatty acid esters (e.g. sodium stearyl fumarate), fatty acids (e.g. stearic acid), fatty alcohols, glyceryl behenate, mineral oils, paraffins, hydrogenated vegetable oils, leucine, polyethylene glycols (PEG), metallic lauryl sulfates (e.g. sodium lauryl sulfate, magnesium lauryl sulfate), sodium chloride, sodium benzoate and sodium acetate.
- metallic stearates e.g. magnesium stearate, calcium stearate, aluminum stearate
- fatty acid esters e.g. sodium stearyl fumarate
- fatty acids e.g. stearic acid
- fatty alcohols e.g. glyceryl behenate
- mineral oils e
- the lubricant is present in the formulation preferably in a range of 0-10% by weight, more preferably in a range of 0.1-5% by weight.
- the pharmaceutically acceptable glidants can be selected from the group of silicon dioxide, magnesium trisilicate, powdered cellulose, starch, talc, tribasic calcium phosphate, metallic stearates, calcium silicate and metallic lauryl sulfate.
- the weight % of the glidant in the formulation is lower than 1%.
- the pharmaceutically acceptable surfactants can be selected from the group of polyoxyethylene sorbitan fatty acid (polysorbates), sodium lauryl sulphate, sodium stearyl fumarate, polyoxyethylene castor oil derivatives, docusate sodium, quatenary ammonia compounds, amino acids like L-leucine, sugar esters of fatty acids and glycerides of fatty acids.
- the lubricant is present in the formulation preferably in a range of 0-10% by weight, more preferably in a range of 0.1-5% by weight.
- the stabilizing agent(s) and antioxidants can be selected from the group of chelating agents, alkalizing agents and photoprotectors.
- the stabilizing agent is present in the formulation preferably in a range of 0-10% by weight, more preferably in a range of 0.1-5% by weight.
- the antioxidants can be selected from the group of butylated hydroxyanisole (BHA), sodium ascorbate, butylated hydroxytoluene (BHT), sodium sulphite, gallates (e.g. propyl gallate), tocopherol, citric acid, malic acid, ascorbic acid, acetylcysteine, fumaric acid, lecithin, ascorbyl palmitate, ethylenediamine tetraacetate.
- BHA butylated hydroxyanisole
- BHT butylated hydroxytoluene
- gallates e.g. propyl gallate
- tocopherol citric acid, malic acid, ascorbic acid, acetylcysteine, fumaric acid, lecithin, ascorbyl palmitate, ethylenediamine tetraacetate.
- the chelating agents can be selected from the group of disodium EDTA, edetic acid, citric acid, sodium citrate, potassium citrate and combinations.
- the alkalizing agents can be selected from the group of alkali metal salts like sodium hydrogen carbonate, sodium dihydroxide, sodium silicate, disodium hydrogen orthophosphate, sodium aluminate; earth alkali salts like calcium carbonate, calcium hydroxide, dibasic calcium phosphate, tribasic calcium phosphate, calcium sulphate, calcium acetate, calcium gluconate, calcium glycerophosphate, magnesium carbonate, magnesium hydroxide, magnesium sulphate, magnesium acetate, magnesium silicate, magnesium aluminate; primary, secondary and tertiary amines, cyclic amines, N 5 N'- dibenzylethylenediamine, diethanolamin, ethylenediamine, meglumine, monosodium glutamate, polacrilin sodium and sodium alginate.
- alkali metal salts like sodium hydrogen carbonate, sodium dihydroxide, sodium silicate, disodium hydrogen orthophosphate, sodium aluminate
- earth alkali salts
- the photoprotectors can be selected from the group of titanium oxide, iron oxide and zinc.
- the pharmaceutically acceptable sweeteners can be selected from the group of sucralose, sucrose, fructose, glucose, galactose, xylose, dextrose, levulose, lactose, maltose, maltodextrin, mannitol, maltitol, maltol, sorbitol, xylitol, erythriol, lactitol, isomalt, corn syrup, saccarine, saccarine salts, acesulfame potassium, aspartam, D-tryptophan, monoammonium glycyrrhizinate, neohesperidin dihydrochalcone, thaumatin, neotame, alitame, stevioside and cyclamate.
- the sweeteners are present in the formulation preferably in a range of 0-10% by weight, more preferably in a range of 0.1-5% by weight.
- the pharmaceutically acceptable flavoring agents can be selected from the following group; natural aroma oils (peppermint oil, partridge currant oil, clove bud oil, parsley oil, eucalyptus oil, lemon oil, orange oil, etc.), menthol, menthane, anethole, methyl salicylate, eucalyptol, cinnamon, 1 -methyl acetate, sage, eugenol, oxanone, ⁇ -irisone, marjoram, lemon, orange, propenyl guaethol acetyl, vanillin, thymol, linalool, cinnamaldehyde glycerol acetal, N- substituted-p-menthane-3-carboxamide, 3,1-methoxy propane- 1,2-diol.
- the flavoring agent is present in the formulation preferably in a range of 0-10% by weight, more preferably in a range of 0.1 -5% by weight.
- solubility modulators In addition to these, solubility modulators, electrolytes, colorants and coatings can be used as other pharmaceutical excipients in the formulation.
- Example 1 Example 2.
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Inorganic Chemistry (AREA)
- Physical Education & Sports Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
TR200902817 | 2009-04-10 | ||
PCT/TR2010/000081 WO2010117346A2 (en) | 2009-04-10 | 2010-04-09 | Stable pharmaceutical compositions with high bioavailibility |
Publications (1)
Publication Number | Publication Date |
---|---|
EP2416756A2 true EP2416756A2 (de) | 2012-02-15 |
Family
ID=42711940
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP10731618A Withdrawn EP2416756A2 (de) | 2009-04-10 | 2010-04-09 | Stabile pharmazeutische zusammensetzungen mit hoher bioverfügbarkeit |
Country Status (2)
Country | Link |
---|---|
EP (1) | EP2416756A2 (de) |
WO (1) | WO2010117346A2 (de) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US11219594B2 (en) | 2015-12-12 | 2022-01-11 | Steerlife India Private Limited | Effervescent compositions of metformin and processes for preparation thereof |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TR201110525A2 (tr) * | 2011-01-06 | 2012-07-23 | Bi̇lgi̇ç Mahmut | Kemik hastalıklarının tedavisinde kullanılmak üzere suda çözünebilir farmasötik bileşimler. |
EP2530068A1 (de) | 2011-05-31 | 2012-12-05 | Lacer, S.A. | Neue Strontiumsalze, deren Synthese und Verwendung bei der Behandlung von Osteoporose |
PT106978A (pt) * | 2013-05-31 | 2014-12-02 | Tecnimede Sociedade Tecnico Medicinal S A | Composição sólida oral contendo ácido ibandrónico e vitamina d |
TWI651103B (zh) | 2013-12-13 | 2019-02-21 | 萊特醫技股份有限公司 | 多相骨移植替代材料 |
US20170252295A1 (en) | 2014-09-17 | 2017-09-07 | Steerlife India Private Limited | Effervescent composition and method of making it |
CN108777992A (zh) * | 2016-01-07 | 2018-11-09 | 谱赛科美国股份有限公司 | 高溶解性甜菊醇糖苷 |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3888976A (en) * | 1972-09-21 | 1975-06-10 | William P Mlkvy | Zinc and strontium ion containing effervescent mouthwash tablet |
FR2651497B1 (fr) | 1989-09-01 | 1991-10-25 | Adir | Nouveaux sels de metaux bivalents de l'acide n, n-di (carboxymethyl)amino-2 cyano-3 carboxymethyl-4 carboxy-5 thiophene, leur procede de preparation et les compositions pharmaceutiques les renfermant. |
ATE342722T1 (de) | 2003-05-07 | 2006-11-15 | Osteologix As | Behandlung von knorpel/knochen-erkrankungen mit wasserlöslichen strontiumsalzen |
PL1622629T3 (pl) * | 2003-05-07 | 2013-12-31 | Osteologix As | Kompozycja do kontrolowanego uwalniania zawierająca sól strontu |
ITFI20030194A1 (it) * | 2003-07-17 | 2005-01-18 | Menarini Int Operations Lu Sa | Composizione farmaceutiche effervescenti contenenti |
JP5070046B2 (ja) * | 2004-06-25 | 2012-11-07 | モクワロ エスペーエフ エス.アー. | ストロンチウムおよびビタミンdを含む組成物およびその使用 |
RU2008104410A (ru) | 2005-07-06 | 2009-08-20 | Остеологикс А/С (Dk) | Способы синтеза органических солей стронция с высоким выходом |
US20090012163A1 (en) * | 2007-07-02 | 2009-01-08 | Gaffar Maria C | Compositions containing Mg/Zn/F-CaP plus inhibitors of pro-inflammatory cytokines (alpha ketoalkanoic acid compound) for osteoporosis prevention, therapy and treatment of bone diseases |
AT9980U1 (de) * | 2007-09-13 | 2008-07-15 | Tritthart Technology & Consult | Zusammensetzung enthaltend ein vitamin d und vorzugsweise einen mineralstoff |
-
2010
- 2010-04-09 WO PCT/TR2010/000081 patent/WO2010117346A2/en active Application Filing
- 2010-04-09 EP EP10731618A patent/EP2416756A2/de not_active Withdrawn
Non-Patent Citations (1)
Title |
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See references of WO2010117346A2 * |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US11219594B2 (en) | 2015-12-12 | 2022-01-11 | Steerlife India Private Limited | Effervescent compositions of metformin and processes for preparation thereof |
Also Published As
Publication number | Publication date |
---|---|
WO2010117346A2 (en) | 2010-10-14 |
WO2010117346A3 (en) | 2010-12-02 |
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