EP2384428A4 - Verfahren und vorrichtung für quantitativen analyt-assay - Google Patents

Verfahren und vorrichtung für quantitativen analyt-assay

Info

Publication number
EP2384428A4
EP2384428A4 EP09836476A EP09836476A EP2384428A4 EP 2384428 A4 EP2384428 A4 EP 2384428A4 EP 09836476 A EP09836476 A EP 09836476A EP 09836476 A EP09836476 A EP 09836476A EP 2384428 A4 EP2384428 A4 EP 2384428A4
Authority
EP
European Patent Office
Prior art keywords
assay device
analyte assay
quantitative analyte
quantitative
assay
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP09836476A
Other languages
English (en)
French (fr)
Other versions
EP2384428B1 (de
EP2384428A1 (de
Inventor
Jin Po Lee
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to EP17171225.0A priority Critical patent/EP3244189B1/de
Publication of EP2384428A1 publication Critical patent/EP2384428A1/de
Publication of EP2384428A4 publication Critical patent/EP2384428A4/de
Application granted granted Critical
Publication of EP2384428B1 publication Critical patent/EP2384428B1/de
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54386—Analytical elements
    • G01N33/54387—Immunochromatographic test strips
    • G01N33/54388—Immunochromatographic test strips based on lateral flow
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
    • G01N21/78—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator producing a change of colour
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
    • G01N2021/6439—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes" with indicators, stains, dyes, tags, labels, marks
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
    • G01N2021/7769—Measurement method of reaction-produced change in sensor
    • G01N2021/7786—Fluorescence
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
    • G01N2021/7793—Sensor comprising plural indicators
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
    • G01N2021/7796—Special mountings, packaging of indicators

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Physics & Mathematics (AREA)
  • Hematology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Endocrinology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Plasma & Fusion (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
EP09836476.3A 2008-12-30 2009-11-27 Verfahren und vorrichtung für quantitativen analyt-assay Active EP2384428B1 (de)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP17171225.0A EP3244189B1 (de) 2008-12-30 2009-11-27 Verfahren und vorrichtung für quantitativen analyt-assay

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US12/317,814 US8455263B2 (en) 2008-12-30 2008-12-30 Quantitative analyte assay device and method
PCT/US2009/006297 WO2010077268A1 (en) 2008-12-30 2009-11-27 Quantitative analyte assay device and method

Related Child Applications (1)

Application Number Title Priority Date Filing Date
EP17171225.0A Division EP3244189B1 (de) 2008-12-30 2009-11-27 Verfahren und vorrichtung für quantitativen analyt-assay

Publications (3)

Publication Number Publication Date
EP2384428A1 EP2384428A1 (de) 2011-11-09
EP2384428A4 true EP2384428A4 (de) 2013-03-06
EP2384428B1 EP2384428B1 (de) 2017-05-17

Family

ID=42285394

Family Applications (2)

Application Number Title Priority Date Filing Date
EP09836476.3A Active EP2384428B1 (de) 2008-12-30 2009-11-27 Verfahren und vorrichtung für quantitativen analyt-assay
EP17171225.0A Active EP3244189B1 (de) 2008-12-30 2009-11-27 Verfahren und vorrichtung für quantitativen analyt-assay

Family Applications After (1)

Application Number Title Priority Date Filing Date
EP17171225.0A Active EP3244189B1 (de) 2008-12-30 2009-11-27 Verfahren und vorrichtung für quantitativen analyt-assay

Country Status (5)

Country Link
US (1) US8455263B2 (de)
EP (2) EP2384428B1 (de)
AU (1) AU2009333937B2 (de)
CA (1) CA2747110C (de)
WO (1) WO2010077268A1 (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2194381B1 (de) * 2008-12-03 2015-12-02 Roche Diagnostics GmbH Testelement mit kombinierter Kontroll- und Kalibrationszone
US8900881B2 (en) * 2008-12-30 2014-12-02 Jin Po Lee Quantitative analyte assay device and method
US20100196200A1 (en) * 2009-02-05 2010-08-05 Jin Po Lee Biological test strip
CN101900733A (zh) * 2010-08-13 2010-12-01 中南大学 一种肿瘤标志物胶体金免疫层析定量检测试纸条及制备方法
US8956859B1 (en) 2010-08-13 2015-02-17 Aviex Technologies Llc Compositions and methods for determining successful immunization by one or more vaccines
US20140004539A1 (en) * 2012-06-15 2014-01-02 The Regents Of The University Of Michigan Systems and methods for multiplex solution assays
US20140349303A1 (en) * 2013-05-24 2014-11-27 Sunpower Technologies Llc System and Method for Producing and Reading DNA Barcodes
US10458974B2 (en) 2017-06-09 2019-10-29 Optimum Imaging Diagnostics LLC Universal testing system for quantitative analysis
CN114829941A (zh) * 2019-05-16 2022-07-29 施明哲 Lama2、plxdc2及mll4作为糖尿病前期和糖尿病的新型生物标记
CN114631025A (zh) * 2019-08-29 2022-06-14 米雷亚·C·阿罗诺维茨 侧向流动免疫化学中的定量分析物检测
CN110646616B (zh) * 2019-09-05 2023-05-30 桂林理工大学 一种检测血清中人cTnI的超敏荧光猝灭免疫传感器及检测方法
MA53878B1 (fr) * 2019-11-25 2023-02-28 Hoffmann La Roche Procédé pour déterminer une concentration d'un analyte dans un fluide corporel
KR102346178B1 (ko) * 2019-12-16 2022-01-03 (주)프로테옴텍 면역 크로마토그래피용 스트립, 키트 및 이를 이용하는 경쟁적 면역 크로마토그래피 분석 방법
CN112305229A (zh) * 2020-10-09 2021-02-02 桂林理工大学 一种定量检测全程c-反应蛋白的免疫层析试纸条及其定量检测方法
CN112305230A (zh) * 2020-10-09 2021-02-02 桂林理工大学 一种定量检测降钙素原的免疫层析试纸条及其定量检测方法
CN115728433A (zh) * 2021-08-27 2023-03-03 联邦生物科技(珠海横琴)有限公司 IgG4型单克隆抗体电荷异质性的离子交换色谱检测方法

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5384264A (en) * 1992-11-05 1995-01-24 Syntron Bioresearch, Inc. Method and apparatus for single step assays of ligand-containing fluids
WO2000031539A1 (en) * 1998-11-23 2000-06-02 Praxsys Biosystems, Inc. Method and apparatus for performing a lateral flow assay
US20030119203A1 (en) * 2001-12-24 2003-06-26 Kimberly-Clark Worldwide, Inc. Lateral flow assay devices and methods for conducting assays
US20060246513A1 (en) * 2005-05-02 2006-11-02 Bohannon Robert C Method and device to detect the presence of analytes in a sample
EP1879028A1 (de) * 2006-07-12 2008-01-16 Becton, Dickinson & Company Verwendung von Albumin, Bovin, P-Aminophenyl-N-Acetyl-ß-D-Glucosaminid als Steuerleitung für eine Immuntestvorrichtung

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US733A (en) 1838-05-10 Machxbte fob hulling clover-seed
US4062A (en) 1845-05-29 Walter hunt
NL154600B (nl) 1971-02-10 1977-09-15 Organon Nv Werkwijze voor het aantonen en bepalen van specifiek bindende eiwitten en hun corresponderende bindbare stoffen.
US3654090A (en) 1968-09-24 1972-04-04 Organon Method for the determination of antigens and antibodies
US3646346A (en) 1968-12-26 1972-02-29 Pharmacia Ab Antibody-coated tube system for radioimmunoassay
US3817838A (en) 1972-03-01 1974-06-18 Us Army Method of detecting and measuring lipase activity
US3791392A (en) 1972-09-28 1974-02-12 Pitney Bowes Inc Currency dispenser
GB1474184A (en) 1973-05-08 1977-05-18 Shell Int Research Process for removing sulphur oxides and particulate matter from waste gases and apparatus therefor
US3996345A (en) 1974-08-12 1976-12-07 Syva Company Fluorescence quenching with immunological pairs in immunoassays
GB1524372A (en) 1975-01-09 1978-09-13 Radiochemical Centre Ltd Radioassay of oestrogens
US4067959A (en) 1976-05-10 1978-01-10 International Diagnostic Technology, Inc. Indirect solid surface test for antigens or antibodies
US4120945A (en) 1976-07-06 1978-10-17 Becton, Dickinson & Company Substrate coated with receptor and labeled ligand for assays
US4104099A (en) 1977-01-27 1978-08-01 International Telephone And Telegraph Corporation Method and apparatus for lapping or polishing materials
US4160645A (en) 1977-07-14 1979-07-10 Syva Company Catalyst mediated competitive protein binding assay
US4233402A (en) 1978-04-05 1980-11-11 Syva Company Reagents and method employing channeling
US4235601A (en) 1979-01-12 1980-11-25 Thyroid Diagnostics, Inc. Test device and method for its use
US4287300A (en) 1979-07-26 1981-09-01 Syva Company Charge effects in enzyme immunoassays
US4720450A (en) 1985-06-03 1988-01-19 Polaroid Corporation Thermal imaging method
EP0560411B1 (de) * 1987-04-27 2000-07-26 Unilever N.V. Spezifische Bindungstestverfahren
US5821073A (en) 1996-05-09 1998-10-13 Syntron Bioresearch, Inc. Method and apparatus for single step assays of whole blood
US6528323B1 (en) * 1999-06-14 2003-03-04 Praxsys Biosystems, Inc. Bidirectional lateral flow test strip and method
US7175992B2 (en) 2002-04-10 2007-02-13 Response Biomedical Corporation Sensitive immunochromatographic assay
US7781172B2 (en) 2003-11-21 2010-08-24 Kimberly-Clark Worldwide, Inc. Method for extending the dynamic detection range of assay devices
US7344893B2 (en) 2005-10-13 2008-03-18 Auric Enterprises, Llc Immuno-gold lateral flow assay
US20080125582A1 (en) 2006-10-13 2008-05-29 Bio-Rad Laboratories, Inc. Methods and compositions for stabilizing prostate specific antigen

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5384264A (en) * 1992-11-05 1995-01-24 Syntron Bioresearch, Inc. Method and apparatus for single step assays of ligand-containing fluids
WO2000031539A1 (en) * 1998-11-23 2000-06-02 Praxsys Biosystems, Inc. Method and apparatus for performing a lateral flow assay
US20030119203A1 (en) * 2001-12-24 2003-06-26 Kimberly-Clark Worldwide, Inc. Lateral flow assay devices and methods for conducting assays
US20060246513A1 (en) * 2005-05-02 2006-11-02 Bohannon Robert C Method and device to detect the presence of analytes in a sample
EP1879028A1 (de) * 2006-07-12 2008-01-16 Becton, Dickinson & Company Verwendung von Albumin, Bovin, P-Aminophenyl-N-Acetyl-ß-D-Glucosaminid als Steuerleitung für eine Immuntestvorrichtung

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
GEERTRUIDA A POSTHUMA-TRUMPIE ET AL: "Lateral flow (immuno)assay: its strengths, weaknesses, opportunities and threats. A literature survey", ANALYTICAL AND BIOANALYTICAL CHEMISTRY, SPRINGER, BERLIN, DE, vol. 393, no. 2, 13 August 2008 (2008-08-13), pages 569 - 582, XP019652854, ISSN: 1618-2650 *
See also references of WO2010077268A1 *

Also Published As

Publication number Publication date
WO2010077268A1 (en) 2010-07-08
EP2384428B1 (de) 2017-05-17
US8455263B2 (en) 2013-06-04
EP3244189B1 (de) 2020-02-26
AU2009333937B2 (en) 2015-04-30
US20100167264A1 (en) 2010-07-01
EP2384428A1 (de) 2011-11-09
CA2747110A1 (en) 2010-07-08
EP3244189A1 (de) 2017-11-15
CA2747110C (en) 2019-07-02
AU2009333937A1 (en) 2011-07-07

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