EP2383017A1 - Dispositif de photothérapie - Google Patents

Dispositif de photothérapie Download PDF

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Publication number
EP2383017A1
EP2383017A1 EP10161245A EP10161245A EP2383017A1 EP 2383017 A1 EP2383017 A1 EP 2383017A1 EP 10161245 A EP10161245 A EP 10161245A EP 10161245 A EP10161245 A EP 10161245A EP 2383017 A1 EP2383017 A1 EP 2383017A1
Authority
EP
European Patent Office
Prior art keywords
light
patch
light source
body part
phototherapy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP10161245A
Other languages
German (de)
English (en)
Inventor
Giovanna Wagenaar Cacciola
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Koninklijke Philips NV
Original Assignee
Koninklijke Philips Electronics NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Koninklijke Philips Electronics NV filed Critical Koninklijke Philips Electronics NV
Priority to EP10161245A priority Critical patent/EP2383017A1/fr
Priority to PCT/IB2011/051770 priority patent/WO2011135502A1/fr
Publication of EP2383017A1 publication Critical patent/EP2383017A1/fr
Withdrawn legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N5/0613—Apparatus adapted for a specific treatment
    • A61N5/0616—Skin treatment other than tanning
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N2005/0635—Radiation therapy using light characterised by the body area to be irradiated
    • A61N2005/0643—Applicators, probes irradiating specific body areas in close proximity
    • A61N2005/0645—Applicators worn by the patient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N2005/065—Light sources therefor
    • A61N2005/0651—Diodes
    • A61N2005/0652—Arrays of diodes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N2005/0658—Radiation therapy using light characterised by the wavelength of light used
    • A61N2005/0659—Radiation therapy using light characterised by the wavelength of light used infrared
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N2005/0658—Radiation therapy using light characterised by the wavelength of light used
    • A61N2005/0662—Visible light

Definitions

  • the present disclosure relates to devices for pain relief, in particular for pain relief by phototherapy.
  • neuropathic pain is a consequence of damage to and/or malfuction of the nervous system.
  • Nociceptive pain is a consequence of triggering particular nerves, the nociceptors, of a normally functioning central or peripheric nervous system.
  • nociceptive pain in particular muscular pain and joint pain are known to be relieved by applying heat to the painful location, e.g. via a hot bath or shower, a heat pad such as a chemical or physical heat pad and/or via illumination with infrared light (IR light).
  • IR light infrared light
  • Heat may improve blood circulation and warm muscles. As the muscles are soothed by the heat, they automatically loosen up and relax. At the same time, improved blood circulation helps the irradiated body part get rid of impurities and quickly sends oxygen-rich blood to stressed or aching muscles, bringing effective pain relief.
  • heat may assist restoring the right viscosity of the synovial fluid to improve its lubricating and nourishing properties for the joint, thus reducing joint pain. Heat may further stimulate production of endorphins.
  • US 2004/166146 discloses a phototherapy bandage capable of providing radiation to a localized area of a patient for accelerating wound healing and pain relief, photodynamic therapy, and for aesthetic applications.
  • the phototherapy bandage may include a flexible light source that is continuous across the bandage for providing a selected light, such as a visible light, a near-infrared light, or other light, having substantially similar intensity across the bandage.
  • the bandage may also be flexible and capable of being attached to a patient without interfering with the patient's daily routine.
  • the phototherapy bandage may easily conform to the curves of a patient and may come in a variety of exterior shapes and sizes.
  • phototherapy patches are disclosed which provide improvements in relieving pain.
  • a phototherapy patch is provided for relieving nociceptive pain of a body part by illumination of at least part of the body part.
  • the patch is formed for conforming to at least part of the body part.
  • the patch comprises a first light source for emitting light.
  • the patch is arranged for illuminating at least a portion of the body part with light from the first light source.
  • the first light source is configured to emit light with a wavelength in the range of 430 nm to 475 nm.
  • the patch being formed for conforming to at least part of the body part, e.g. by being at least partly flexible, facilitates donning and wearing the patch without hindrance to a subject or a patient and his(/her) movements.
  • the patch may be flexible, textile-like and/or plaster-like and may be provided with means for attaching the patch to a body part, e.g. one or more straps, sticky portions and/or cuffs, preferably allowing fixation of the position of the patch with respect to the portion of the body part to be illuminated.
  • the wavelength range of the first light source may advantageously be 430-470 nm, such as 440-460 nm. It has been found that the reflection of the skin increases for increasing wavelengths in the visible range. Thus the effectivity of optical energy applied with longer blue light wavelengths is reduced. For decreasing wavelengths the absorption of the optical energy increases, but possibly undesired side effects may increase as well e.g. skin tanning and/or damaging. Such behaviour is substantially equal for both fair and dark skin types, be it at different absolute reflectivity.
  • a first light source which is configured to emit light with a predominant wavelength of approx. 450 nm, e.g. having a spectral bandwidth of about 1 to 5 nm centered around 450 nm, is considered suitable.
  • the first light source may comprise at least one LED.
  • a patch comprising a plurality of LEDs may facilitate uniform illumination of a significantly larger surface area than when comprising a single LED. LEDs may generate little heat per emitted optical energy compared to other types of light sources. Any heat that is, after all, generated by a patch comprising LEDs may be used to benefit treatment, as in a warmth pad.
  • relatively powerfull LEDs with an emission peak at approx. 450 nm and a full-width-at-half-maximum spectral bandwidth of approx. 20 nm are readily available and have proven particularly suitable.
  • the patch may comprise a second light source which is arranged for illuminating the body part with near-infrared light (near-IR) having a wavelength in the range of approx. 800-2500 nm, in particular 800-1500 nm (IR-A), and with the patch being arranged for, when in use, illuminating at least a portion of the body part with light from the second light source.
  • near-IR near-infrared light
  • IR-A near-infrared light
  • the penetration depth of near-IR light into human tissue through the skin has a global maximum absorption for near-IR light at approx. 1500 nm, and a local maximum at approx. 2200 nm, with a local minimum in between at approx. 1950 nm.
  • IR radiation is thermal radiation. Acceptance of (the use of) a phototherapy patch for pain relief may thus be improved when the patch comprises an IR light source.
  • IR-A light may efficiently be provided with one or more LEDs. Powerfull LEDs in the range 800-1500 nm are commercially available at moderate cost.
  • LEDs for blue and/or IR-A light can be rapidly switched and may be well controllable with respect to intensity.
  • LEDs may have emission bandwidths of several nanometers, the emission spectrum also depending on the temperature of the LED and/or the power with which it is driven. This facilitates control over (the light emitted by) the patch.
  • a patch comprising LEDs may comprise (combinations of) one or more separately packaged LEDs, encapsulated LEDS for one or more wavelengts, flat surface-emitting LEDs, textiles comprising LEDs such as Lumalive® technology, etc.
  • near-IR light for an in-depth treatment at a base-level and use blue light in addition to achieve a desired illumination level, and to modify the blue light to provide a massage at the same time. It has been found that such effect may be achieved with sufficiently strong light at the cited wavelengths but it is most easily provided and controlled with LEDs.
  • the second light source may comprise a photoluminescent material, e.g. nanocrystals and/or a phosphor, in particular a fluorescent phosphor in the form of a remote phosphor, for transforming incident light of one wavelength and emitting light of another wavelength.
  • a photoluminescent material e.g. nanocrystals and/or a phosphor, in particular a fluorescent phosphor in the form of a remote phosphor, for transforming incident light of one wavelength and emitting light of another wavelength.
  • Photoluminescent materials are available with various absorption and emission characteristics facilitating manufacture of a patch with desired optical properties. Phosphors may further have long operational lifetimes, comparable to LEDs.
  • the first light source may be arranged for illuminating and exciting the photoluminescent material of a photoluminescent second light source.
  • a single light source need be powered to provide treatment light with plural desired wavelengths.
  • the longer the wavelenght generated by the photoluminescent second light the more efficient the generation of such second light may be by excitation of the photoluminescent material with first light of a shorter wavelength, such as supplied by a first light source emitting blue-light.
  • a patch emitting blue light at 450 nm and near-IR light at approx. 2200 nm may therefore be more energy-efficient than a patch emitting blue light at 450 nm and near-IR light at approx. 1500 nm.
  • Photoluminescent material in particular a dusty or fine-grain particulate material embedded in, coated, glued or painted on a substrate, etc., may be used for providing a desired intensity distribution.
  • the photoluminescent material may also be patterned i.e. applied in a predetermined pattern on and/or in a substrate, to provide a desired predetermined intensity distribution.
  • the intensity distribution may be defined for both the first and second light sources.
  • a random or regular pattern may comprise denser portions for relatively intense emission of IR light interspersed with less dense or open portions for (partial) transmission of blue light from the first light source.
  • the patch may comprise a light guide for receiving and redistributing at least a portion of the light from the first and/or second light source, e.g. for redistributing light from a first intensity distribution to a second intensity distribution which differ from each other in at least one of an intensity and a direction of propagation.
  • the patch may be substantially flat, extending substantially in a plane in bandage-like or plaster-like form.
  • the light guide may then also be substantially flat and redistribute the light from the first and/or second light source from substantially parallel to or in the plane of extension of the patch to a direction substantially normal to the patch for illuminating a body part.
  • the light guide may act as a diffuser or rather a concentrator between at least the first light source and an optically active portion of the patch.
  • the light guide may comprise at least one of a flexible sheet-like material and a fiberoptic material.
  • a flexible sheet-like material may comprise a flexible, at least partially translucent, slab or foil, e.g. one or more ribbon-like or sheet-like portions.
  • a fiberoptic material may comprise one or more optical fibers, splitters, and/or fiberoptic mats, possibly woven, knitted and/or otherwise worked to form a textile. Combinations are also conceivable.
  • the flexibility of the patch should advantageously be such, that the patch may closely follow the shape of the body part. Different patches may be provided for different body parts, which may include differences in the optical power and/or wavelength delivered by the first and/or second light sources.
  • the light guide and the second light source may be integrated, such as by inserting and/or mixing one or more photoluminescent materials in the light guide material, or coating at least part of a surface of the light guide with a photoluminescent material.
  • the patch may comprise a controller.
  • the controller may be configured to operate the first and/or second light sources so as to modify at least part of the spatial illumination intensity distribution of the patch in at least one of a spatially-varying and a temporally-varying pattern, to provide a dynamic illumination and possibly a massaging effect.
  • a varying pattern may spread the feeling of heat due to the illumination intensity and thus prevent an occasional local unpleasant feeling or even inadvertent pain, whereas overall a desired high optical energy may be deposited in the tissue to be treated. Thus, user comfort is increased.
  • the controller may be programmable.
  • a program may comprise a predetermined modification function for operation and/or adjustment of the first and/or second light source, e.g. for massaging, in dependence of treatment parameters and/or input user data.
  • Such program may be used for customisation and/or personalisation of the patch for use with different afflictions and/or subjects.
  • the patch may comprise a user interface for receiving user input.
  • the controller may be configured for controlling the first and/or second light source as a function of the user input. This further increases user friendliness and versatility of the patch. E.g. with such patch a user, advantageously the subject him-/herself to be treated, may modify the intensity distribution, e.g. to increase user comfort and/or safety.
  • the user interface may comprise any suitable input device.
  • Useful input devices comprise a wired or wireless remote controller.
  • the patch may comprise an indicator with a (schematic) indication of one or more operating parameters of the patch.
  • the controller may be programmable with a program, which may define a variation sequence.
  • a program may be provided by hand via the user interface and/or it may be obtained from a data storage medium e.g. a CD, DVD, memory card, USB-stick, internal memory of the patch, or remote sources via the Internet etc.
  • the patch may suitably comprise a memory for storing one or more settings, functions, programs, etc.
  • the patch may comprise an output for outputting data stored in the memory, e.g. on a data storage medium etc. discussed above for a program. This allows portability of such data to another patch and/or sharing such data with a therapist.
  • Fig. 1 shows a person 1 carrying a phototherapy patch 3 on a body part 5 of the person 1 (here on an elbow).
  • a cross-section of the patch 3 is shown in Fig. 2 .
  • the patch 3 comprises a flexible carrier 7, to which a plurality of light sources 9, 11 are attached.
  • the first light sources 9 are configured to emit light with a wavelength in the range of 430 nm to 475 nm.
  • the second light sources 11 are configured to emit light with a wavelength in the range of 800 nm to 1500 nm.
  • the light sources 9, 11 comprise encapsulated LEDs which are partially embedded in an optional flexible padding layer 13.
  • different light sources e.g.
  • non-encapsulated and/or surface-emitting LEDs may be used also or alternatively, which may result in a thinner patch 1.
  • the first and/or second light sources 9, 11 are covered with a transparent cover and/or one or more lenses which allow easy cleaning.
  • the carrier 7 comprises electrical conductors (not shown), and/or a flexible PCB via which the light sources 9, 11 are connected to an optional controller 15 and to a power source 17, here in the form of a (possibly rechargeable) battery pack 17 but any other suitable power source may be employed.
  • the light sources 9, 11 are arranged to emit light in a direction substantially normal to the patch 3 to provide an optically active portion of the patch 3, which is indicated with a wide arrow 19.
  • Each light source 9, 11 generates a somewhat divergent light cone such that a substantially homogeneous intensity distribution is provided at a distance from the light sources 9, 11. The exact arrangement of the light sources 9, 11 and their respective light cones determines the resulting intensity distribution.
  • the controller 15 and/or the power source 17 may be arranged elswhere with respect to (the carrier 7 of) the patch 3, e.g. on an exterior side opposite the light sources 9, 11 and/or partially comprised in the carrier 7.
  • Fig. 3 indicates, in cross section, another patch 3 conforming to a body part 5 to which the patch 3 is attached by means of a strap 21 looped around the body part 5 and closed in any suitable manner, such as with a clasp, a buckle, a button, a knot, hook-and-loop-type fastener (e.g. Velcro®), etc.
  • the light sources 9, 11 are arranged on an optional flexible intermediate layer 23 attached to the flexible carrier layer 7.
  • the carrier layer 7 here has a decreasing thickness towards its edges to reduce possible dragging to clothes and to improve user comfort.
  • the first light sources 9 and/or the second light sources 11 may be operated independently, e.g. to flash consecutively as running lights to provide a spatially dynamic massaging effect.
  • Contemporaneous flashing may provide a massaging effect in a stationary position. Both effects may be combined.
  • Flashing should be interpreted as oscillating regularly or irregularly the emitted intensity of the light source(s) 9, 11 concerned between intensity levels separated by a modulation depth of sufficient amount to be percieved, in particular between maximum and minimum intensity levels wherein a minimum intensity level is less than approx. one quarter the intensity of the directly preceding maximum intensity level. Flashing may include fully switching off a light source to provide a large modulation depth. Due to the difference in perception for blue and IR light, the blue light may be used for providing a clearly discernible massaging effect whereas the IR light is continuously operated. Thus, pain treatment and user comfort can be optimised together.
  • Fig. 4 indicates an embodiment of a patch comprising light guides 25A, 25B in the form of bundles of fiberoptic material attached to a flexible carrier 7.
  • one first light source 9 illuminates one end 29A of a bundle of optical fibers 27A (indicated with arrow 28A).
  • the fibers 27A are arranged close together.
  • the light received in the fibers 27A is guided through the fibers 27A and re-emitted from an opposite end 31A of the fiber bundle (see arrow 19).
  • the fibers 27A are spread out over an area which is different and substantially larger than at the end 29A, to provide a relatively large effective optical area for the patch 3.
  • Fig. 4 indicates an embodiment of a patch comprising light guides 25A, 25B in the form of bundles of fiberoptic material attached to a flexible carrier 7.
  • one first light source 9 illuminates one end 29A of a bundle of optical fibers 27A (indicated with arrow 28A).
  • the fibers 27A are arranged close together.
  • a second light source 11 is arranged at an opposite side of the patch 3 and is arranged for illuminating (arrow 28B) another light guide 25B comprising a bundle of optical fibres 27B extending between a first end 29B and a second end 31B in similar fashion the what is described above.
  • the ends 31A and 31B overlap by having the ends of the respective fibers 27A, 27B arranged in interspersed fashion in any desired random or regular pattern.
  • the first and second light sources 9, 11, again shown as encapsulated LEDs for exemplary purposes and for facilitating comparison to Figs. 2 and 3 may be arranged for emitting substantially parallel to the carrier 7 (cf arrows 28A, 28B) whereas the light effectively is emitted normal to (the carrier 7 of) the patch 3 via the light guide 25A, 25B.
  • Fig. 5 shows a patch 3 comprising surface-emitting LEDs 9 for emitting light with a wavelength of approx. 450 nm.
  • the patch 3 further comprises a tapered light guide 25 having a first end 29 with a relatively small surface area and a second end 31 with a relatively large surface area.
  • the light guide 25 comprises a material mixed with a photoluminescent material which is excitable by the light of the first light sources 9.
  • the first light sources 9 and the light guide 25 are arranged such that the light sources 9 illuminate the first end 29 of the light guide 25. A first portion of the light of the first light sources 9 received in the light guide 25 is emitted redistributed over the surface area of the second end 31.
  • a second portion of the light of the first light sources 9 received in the light guide 25 excites the photoluminescent material, which subsequently fluoresces at one or more wavelengths in a range between 800 and 1500 nm. This light is also emitted distributed over the surface area of the second end 31.
  • the light guide 25 serves the double purpose of being a redistributing light guide and being a light source for a second wavelength, i.e. a second light source.
  • the blue light and the IR light are substantially homogeneously mixed.
  • the relative intensities of the blue light and the IR light may be determined by selecting the (relative) amount of photoluminescent material in the light guide 25, and possibly its location, during manufacuring of the light guide.
  • Fig. 6 illustrates a light guide 25 which is a solid, but flexible, object, e.g. a piece of silicone material which is transparent to at least the first light source's wavelength.
  • the light guide 25 of Fig. 6 comprises a first end 29 with a relatively small surface area and a second end 31 with a relatively large surface area.
  • Other shapes of a light guide 25 in between a first end 29 with a relatively small surface area and a second end 31 with a relatively large surface area are conceivable and may be used.
  • a coating 33 is applied comprising a fluorescent phosphor which is photoexcitable by the light from the first light source 9 to emit light with a wavelength in the range of 800-1500 nm.
  • the coating 33 is arranged in a chessboard-pattern, leaving portions free from coating material.
  • the chess-board pattern may be arranged such that a substantially homogeneous illumination of the body part 5 to be treated is applied.
  • Other patterns e.g. stripes, dots, combinations, aperiodic, etc. may be used and the size of pattern features, e.g. the size of squares in a chess-board pattern may be selected to provide a desired effect.
  • Fig. 7 illustrates a patch 3 comprising side-illumination of a flexible light guide 25 by blue light sources 9 via first ends 29A, 29B.
  • the light guide 25 comprises a material mixed with a photoluminescent material which is excitable by the light of the blue light sources 9, emitting near-IR light.
  • the resultant blue and near-IR light is scattered within the light guide 25, possibly being reflected by an optional reflector 35, to be emitted substantially homogeneously from the light guide 25 via second end 31 (see the open white arrows).
  • one or more optical fibers may be optimised for transmission of light, and one or more fibers may be optimised for leaking light, e.g. by roughening the fiber surface and/or by having an asymmetrically shaped core. Thus, a more homogeneous illumination may be provided.
  • One or more fibers may be doped and/or coated with a photoluminescent material which is photoexcitable by blue light in the wavelength range 430-475 nm to emit light in the wavelength range 800-1500 nm, so as to perform the double function of light guide and second light source.
  • One or more light sources may be fibre-coupled to one or more fibres of a fiberoptic light guide e.g. pigtailed.
  • Combinations of an integrated light guide and second light source with individual second light sources configured to emit IR light in the wavelength range 800-1500 nm may be applied to allow modifying the illumination intensity and/or pattern of the IR light independent of modification of the blue light from the first light sources.
  • a patch may comprise one or more reflectors to improve directing light to a desired location and/or providing a desired illumination distribution.
  • a patch may comprise plural flexible light guides which may be stacked.
  • each light guide (to be) arranged closer to the body part to be illuminated is substantially translucent for light emitted and/or transmitted from a light guide arranged closer to a flexible carrier and/or arranged for being further away from the body part to be illuminated.
  • Different light guides may have different properties.
  • a patch may be water resitant, allowing wearing in outdoors situation and/or during sports.
  • a patch may be formed for use with an at least partially translucent fluid e.g. a gel, for outcoupling and transmitting light to the portion to be illuminated.
  • an at least partially translucent fluid e.g. a gel
  • One or more portions of the patch may be washable.
  • a computer program may be stored/distributed on a suitable medium, such as an optical storage medium or a solid-state medium supplied together with or as part of other hardware, but may also be distributed in other forms, such as via the Internet or other wired or wireless telecommunication systems. Any reference signs in the claims should not be construed as limiting the scope.

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  • Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pathology (AREA)
  • Biophysics (AREA)
  • Radiology & Medical Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Radiation-Therapy Devices (AREA)
EP10161245A 2010-04-28 2010-04-28 Dispositif de photothérapie Withdrawn EP2383017A1 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP10161245A EP2383017A1 (fr) 2010-04-28 2010-04-28 Dispositif de photothérapie
PCT/IB2011/051770 WO2011135502A1 (fr) 2010-04-28 2011-04-22 Dispositif de photothérapie

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP10161245A EP2383017A1 (fr) 2010-04-28 2010-04-28 Dispositif de photothérapie

Publications (1)

Publication Number Publication Date
EP2383017A1 true EP2383017A1 (fr) 2011-11-02

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EP10161245A Withdrawn EP2383017A1 (fr) 2010-04-28 2010-04-28 Dispositif de photothérapie

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EP (1) EP2383017A1 (fr)
WO (1) WO2011135502A1 (fr)

Cited By (6)

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CN109568800A (zh) * 2018-11-02 2019-04-05 浙江大学 一种用于改善血液循环缓解风湿的可重复利用的理疗贴片
DE202018101617U1 (de) 2018-03-22 2019-07-11 Rp-Technik Gmbh Lichtbestrahlungsgerät, insbesondere als Teil eines Therapiegeräts
CN112206423A (zh) * 2019-07-10 2021-01-12 财团法人工业技术研究院 可挠式光疗装置
IT201900020138A1 (it) * 2019-10-31 2021-05-01 Fabio Fontana Dispositivo terapeutico per patologia infiammatoria, dolorosa e una rimodulazione neuro-muscolare e posturale
EP3943151A4 (fr) * 2019-03-19 2022-12-07 Seoul Viosys Co., Ltd. Dispositif d'émission de lumière
IT202200019506A1 (it) * 2022-09-23 2024-03-23 Fabio Fontana Dispositivo terapeutico per patologia infiammatoria, dolorosa e una rimodulazione neuro-muscolare e posturale

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WO2013105007A1 (fr) 2012-01-12 2013-07-18 Koninklijke Philips N.V. Textile électroluminescent
US10667883B2 (en) 2013-03-15 2020-06-02 Virtual Incision Corporation Robotic surgical devices, systems, and related methods
WO2015049108A1 (fr) 2013-10-02 2015-04-09 Koninklijke Philips N.V. Système et procédé d'éclairage de corps

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DE202018101617U1 (de) 2018-03-22 2019-07-11 Rp-Technik Gmbh Lichtbestrahlungsgerät, insbesondere als Teil eines Therapiegeräts
CN109568800A (zh) * 2018-11-02 2019-04-05 浙江大学 一种用于改善血液循环缓解风湿的可重复利用的理疗贴片
CN109568800B (zh) * 2018-11-02 2020-09-25 浙江大学 改善血液循环缓解风湿的可重复利用的理疗贴片制备方法
EP3943151A4 (fr) * 2019-03-19 2022-12-07 Seoul Viosys Co., Ltd. Dispositif d'émission de lumière
US11992698B2 (en) 2019-03-19 2024-05-28 Seoul Viosys Co., Ltd. Light irradiation device
CN112206423A (zh) * 2019-07-10 2021-01-12 财团法人工业技术研究院 可挠式光疗装置
IT201900020138A1 (it) * 2019-10-31 2021-05-01 Fabio Fontana Dispositivo terapeutico per patologia infiammatoria, dolorosa e una rimodulazione neuro-muscolare e posturale
WO2021084424A1 (fr) * 2019-10-31 2021-05-06 Fabio Fontana Dispositif thérapeutique pour pathologies inflammatoires douloureuses et pour la modulation neuro-musculaire et neuro-posturale
IT202200019506A1 (it) * 2022-09-23 2024-03-23 Fabio Fontana Dispositivo terapeutico per patologia infiammatoria, dolorosa e una rimodulazione neuro-muscolare e posturale
WO2024062448A1 (fr) * 2022-09-23 2024-03-28 Fabio Fontana Dispositif thérapeutique pour la pathologie inflammatoire, douloureuse et la remodulation neuro-musculaire et posturale

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