EP2314336B1 - Arzneimittelinhalator - Google Patents

Arzneimittelinhalator Download PDF

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Publication number
EP2314336B1
EP2314336B1 EP10010833.1A EP10010833A EP2314336B1 EP 2314336 B1 EP2314336 B1 EP 2314336B1 EP 10010833 A EP10010833 A EP 10010833A EP 2314336 B1 EP2314336 B1 EP 2314336B1
Authority
EP
European Patent Office
Prior art keywords
yoke
cup
positions
inhaler
inhaler according
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
EP10010833.1A
Other languages
English (en)
French (fr)
Other versions
EP2314336A3 (de
EP2314336A2 (de
Inventor
Lawrence Keane
David O'leary
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Norton Healthcare Ltd
Original Assignee
Norton Healthcare Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
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Publication of EP2314336A2 publication Critical patent/EP2314336A2/de
Publication of EP2314336A3 publication Critical patent/EP2314336A3/de
Application granted granted Critical
Publication of EP2314336B1 publication Critical patent/EP2314336B1/de
Priority to CY20141100811T priority Critical patent/CY1115748T1/el
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A61M15/0045—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0001—Details of inhalators; Constructional features thereof
    • A61M15/0005—Details of inhalators; Constructional features thereof with means for agitating the medicament
    • A61M15/0006—Details of inhalators; Constructional features thereof with means for agitating the medicament using rotating means
    • A61M15/0008—Details of inhalators; Constructional features thereof with means for agitating the medicament using rotating means rotating by airflow
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A61M15/0045—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters
    • A61M15/0046—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters characterized by the type of carrier
    • A61M15/0048—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters characterized by the type of carrier the dosages being arranged in a plane, e.g. on diskettes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0065—Inhalators with dosage or measuring devices
    • A61M15/0068—Indicating or counting the number of dispensed doses or of remaining doses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0065—Inhalators with dosage or measuring devices
    • A61M15/0068—Indicating or counting the number of dispensed doses or of remaining doses
    • A61M15/007—Mechanical counters
    • A61M15/0071—Mechanical counters having a display or indicator
    • A61M15/0078—Mechanical counters having a display or indicator on a strip
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0086—Inhalation chambers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0091—Inhalators mechanically breath-triggered
    • A61M15/0093—Inhalators mechanically breath-triggered without arming or cocking, e.g. acting directly on the delivery valve
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0091—Inhalators mechanically breath-triggered
    • A61M15/0096—Hindering inhalation before activation of the dispenser
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06M—COUNTING MECHANISMS; COUNTING OF OBJECTS NOT OTHERWISE PROVIDED FOR
    • G06M1/00—Design features of general application
    • G06M1/04—Design features of general application for driving the stage of lowest order
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06M—COUNTING MECHANISMS; COUNTING OF OBJECTS NOT OTHERWISE PROVIDED FOR
    • G06M1/00—Design features of general application
    • G06M1/22—Design features of general application for visual indication of the result of count on counting mechanisms, e.g. by window with magnifying lens
    • G06M1/24—Drums; Dials; Pointers
    • G06M1/246—Bands; Sheets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
    • A61M11/02—Sprayers or atomisers specially adapted for therapeutic purposes operated by air or other gas pressure applied to the liquid or other product to be sprayed or atomised
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0065—Inhalators with dosage or measuring devices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0091—Inhalators mechanically breath-triggered
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/06—Solids
    • A61M2202/064—Powder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2206/00—Characteristics of a physical parameter; associated device therefor
    • A61M2206/10—Flow characteristics
    • A61M2206/16—Rotating swirling helical flow, e.g. by tangential inflows

Definitions

  • the present disclosure relates to an apparatus and method for administering medicament for inhalation by a patient and, more particularly, to a dry powdered medicament inhaler.
  • Metered dose medicament inhalers are well known for dispensing medicament to the lungs of a patient, for treating asthma for example.
  • Existing types of medicament dispensing inhalers include pressurized propellant inhalers, aqueous solution inhalers, and dry-powdered inhalers.
  • U.S. Patent No. 5,503,144 to Bacon shows a dry powdered inhaler.
  • the inhaler includes a reservoir for containing a dry powdered medicament, a metering chamber for removal of the powdered medicament from the reservoir in discrete amounts, and an air inlet for entraining the removed powdered medicament through a mouthpiece upon patient inhalation.
  • U.S. Patent No. 5,971,951 to Ruskewicz shows an inhaler including a motor driven cam mechanism for extruding aqueous medicament through a porous membrane to form a medicament aerosol for inhalation by a patient.
  • the inhaler also includes sensors, circuitry and a microprocessor that determines the rate of patient inhalation and operates the extrusion mechanism only upon adequate inhalation levels.
  • a pressurized propellant, or "aerosol" inhaler is shown in U.S. Patent No. 5,447,150 to Bacon , which also discloses a simple, mechanical actuation assembly for ensuring that medicament is dispensed from the inhaler only upon adequate inhalation by a patient.
  • the actuation assembly works by applying a pre-load to a valve of the aerosol container sufficient to cause a dose release, but prevents the release by applying a pneumatic resisting force. The dose of medicament is then released upon a patient inhalation strong enough to move a door within the assembly, which in turn releases the pneumatic resisting force.
  • the new and improved inhaler for administering medicament for patient inhalation.
  • the new and improved inhaler can be used with dry powdered medicament.
  • the new and improved inhaler will preferably include mechanical assemblies for metering doses of medicament, managing medicament reservoir pressure, and counting the number of doses remaining in the inhaler.
  • WO 94/05359 A discloses a medicament inhaler for dry powdered medicament.
  • the inhaler comprises a yoke for actuating a medicament metering and dispensing mechanism.
  • the inhaler also comprises a cam for moving the position of the yoke.
  • US 5657748 and GB 2242134 A disclose dose counters for dry powder medicament inhalers. These dose counters are arranged to count doses either when a dose of medicament is metered from a bulk reservoir or when a pre-metered dose of medicament is opened. In each case, the dose counter counts the dose before it has been inhaled by a patient.
  • GB 2320489 A discloses a dose counter for a pressurised metered dose inhaler in which a dose of medicament is counted during the downwards stroke of the medicament canister.
  • the present invention provides a medicament inhaler according to claim 1.
  • Optional features of the inhaler are set out in the dependent claims.
  • the present disclosure provides a new and improved inhaler including a simple, accurate and consistent mechanical dose metering system that dispenses dry powdered medicament in discrete amounts or doses for patient inhalation, a reservoir pressure system that ensures consistently dispensed doses, and a dose counter indicating the number of doses remaining in the inhaler.
  • the present disclosure provides a new and improved inhaler 10 for dispensing a dry-powdered medicament in metered doses for patient inhalation.
  • the inhaler 10 of the present disclosure provides many beneficial features including but not limited to a dose metering system that dispenses dry powdered medicament in discrete amounts or doses for patient inhalation, a medicament reservoir pressure system for managing pressure within the reservoir, and a dose counting system indicating the number of doses remaining in the inhaler 10.
  • the inhaler 10 generally includes a housing 18, and an assembly 12 received in the housing (see FIG. 2 ).
  • the housing 18 includes a case 20 having an open end 22 and a mouthpiece 24 for patient inhalation, a cap 26 secured to and closing the open end 22 of the case 20, and a cover 28 pivotally mounted to the case 20 for covering the mouthpiece 24 (see FIGS. 1, 2 and 9 ).
  • the housing 18 is preferably manufactured from a plastic such as polypropylene, acetal or moulded polystyrene, but may be manufactured from metal or another suitable material.
  • the internal assembly 12 includes a reservoir 14 for containing dry powered medicament in bulk form, a de-agglomerator 32 that breaks down the medicament between a delivery passageway 34 and the mouthpiece 24, and a spacer 38 connecting the reservoir to the de-agglomerator.
  • the reservoir 14 is generally made up of a collapsible bellows 40 and a hopper 42 having an dispenser port 44 (see FIGS. 2-5 and 7-8 ) for dispensing medicament upon the bellows 40 being at least partially collapsed to reduce the internal volume of the reservoir.
  • the hopper 42 is for holding the dry powder medicament in bulk form and has an open end 46 closed by the flexible accordion-like bellows 40 in a substantially air-tight manner.
  • An air filter 48 covers the open end 46 of the hopper 42 and prevents dry powder medicament from leaking from the hopper 42 (see FIG. 7 ).
  • a base 50 of the hopper 42 is secured to a spacer 38, which is in turn secured to the de-agglomerator 32 (see FIGS. 3-5 and 7-8 ).
  • the hopper 42, the spacer 38, and the de-agglomerator 32 are preferably manufactured from a plastic such as polypropylene, acetal or moulded polystyrene, but may be manufactured from metal or another suitable material.
  • the hopper 42, the spacer 38 and the de-agglomerator 32 are connected in a manner that provides an air tight seal between the parts. For this purpose heat or cold sealing, laser welding or ultrasonic welding could be used, for example.
  • the spacer 38 and the hopper 42 together define the medicament delivery passageway 34, which preferably includes a venturi 36 (see FIG. 16 ) for creating an entraining air flow.
  • the spacer 38 defines a slide channel 52 communicating with the dispenser port 44 of the hopper 42, and a chimney 54 providing fluid communication between the medicament delivery passageway 34 and a supply port 56 of the de-agglomerator 32 (see FIGS. 7 and 8 ).
  • the slide channel 52 extends generally normal with respect to the axis "A" of the inhaler 10.
  • the de-agglomerator 32 breaks down agglomerates of dry powder medicament before the dry powder leaves the inhaler 10 through the mouthpiece 24.
  • the de-agglomerator includes a swirl chamber 58 extending from the supply port 56 to an outlet port 60 connected to the mouthpiece 24 (see FIG. 16 ).
  • the de-agglomerator 32 also includes two diametrically opposed inlet ports 62 that extend substantially tangential to the circular cross-section of the swirl chamber.
  • Radial vanes 64 are positioned at the top of the swirl chamber and are sized such that at least a portion of breath-actuated air streams entering through the diametrically opposed inlet ports 62 collide with the vanes.
  • the inhaler 10 preferably includes a de-agglomerator of the type disclosed in copending provisional U.S. patent application serial no. 60/213,382, filed June 23, 2000 (entitled “De-Agglomerator for Breath-Actuated Dry Powder Inhaler 10"). It should be understood that although the inhaler 10 of the present disclosure is shown with a particular de-agglomerator 32, the inhaler 10 is not limited to use with the de-agglomerator shown and can be used with other types of de-agglomerators or a simple swirl chamber.
  • the dose metering system includes a first yoke 66 and a second yoke 68 mounted on the internal assembly 12 within the housing 18, and movable in a linear direction parallel with an axis "A" of the inhaler 10 (see FIG. 2 ).
  • An actuation spring 69 is positioned between the cap 26 of the housing 18 and the first yoke 66 for biasing the yokes in a first direction towards the mouthpiece 24.
  • the actuation spring 69 biases the first yoke 66 against the bellows 40 and the second yoke 68 against cams 70 mounted on the mouthpiece cover 28 (see FIG. 9 ).
  • the first yoke 66 includes an opening 72 that receives and retains a crown 74 of the bellows 40 such that the first yoke 66 pulls and expands the bellows 40 when moved towards the cap 26, i.e., against the actuation spring 69 (see FIG. 2 ).
  • the second yoke 68 includes a belt 76, which receives the first yoke 66, and two cam followers 78 extending from the belt in a direction opposite the first yoke 66 (see FIGS. 3 , 11 and 12 ), towards the cams 70 of the mouthpiece cover 28.
  • the dose metering system also includes the two cams 70 mounted on the mouthpiece cover 28 (see FIGS. 9 and 10 ), and movable with the cover 28 between open and closed positions.
  • the cams 70 each include an opening 80 for allowing outwardly extending hinges 82 of the case 20 to pass therethrough and be received in first recesses 84 of the cover 28.
  • the cams 70 also include bosses 86 extending outwardly and received in second recesses 88 of the cover 28, such that the cover 28 pivots about the hinges 82 and the cams 70 move with the cover 28 about the hinges.
  • Each cam 70 also includes first, second and third cam surfaces 90, 92, 94, and the cam followers 78 of the second yoke 68 are biased against the cam surfaces by the actuation spring 69.
  • the cam surfaces 90, 92, 94 are arranged such the cam followers 78 successively engage the first cam surfaces 90 when the cover 28 is closed, the second cam surfaces 92 when the cover 28 is partially opened, and the third cam surfaces 94 when the cover 28 is fully opened.
  • the first cam surfaces 90 are spaced further from the hinges 82 than the second and the third cam surfaces, while the second cam surfaces 92 are spaced further from the hinges 82 than the third cam surfaces 94.
  • the cams 70 therefore, allow the yokes 66, 68 to be moved by the actuation spring 69 parallel with the axis "A" of the inhaler 10 in the first direction (towards the mouthpiece 24) through first, second and third positions as the cover 28 is opened.
  • the cams 70 also push the yokes 66, 68 in a second direction parallel with the axis "A" (against the actuation spring 69 and towards the cap 26 of the housing 18) through the third, the second and the first positions as the cover 28 is closed.
  • the dose metering system further includes a cup assembly 96 movable between the dispenser port 44 of the reservoir 14 and the delivery passageway 34.
  • the cup assembly 96 includes a medicament cup 98 mounted in a sled 100 slidably received in the slide channel 52 of the spacer 38 below the hopper 42 (see FIGS. 5 and 6 ).
  • the medicament cup 98 includes a recess 102 adapted to receive medicament from the dispenser port 44 of the reservoir 14 and sized to hold a predetermined dose of dry powdered medicament when filled.
  • the cup sled 100 is biased along the slide channel 52 from the dispenser port 44 of the hopper 42 towards the delivery passageway 34 by a cup spring 104, which is secured on the hopper 42 (see FIGS. 4 and 5 ).
  • the dose metering system also includes a ratchet 106 and a push bar 108 on one of the cam followers 78 of the second yoke 68 that engage a boss 110 of the cup sled 100 (see FIGS. 5 , 11 and 12 ).
  • the ratchet 106 is mounted on a flexible flap 112 and is shaped to allow the boss 110 of the sled 100 to depress and pass over the ratchet 106, when the boss 110 is engaged by the push bar 108. Operation of the dose metering system is discussed below.
  • the reservoir pressure system includes a pressure relief conduit 114 in fluid communication with the interior of the reservoir 14 (see FIGS. 7 and 8 ), and a pressure relief port 116 in a wall of the slide channel 52 (see FIGS. 5 and 8 ) providing fluid communication with the pressure relief conduit 114 of the hopper 42.
  • the medicament cup assembly 96 includes a first sealing surface 118 adapted to seal the dispenser port 44 upon the cup assembly being moved to the delivery passageway 34 (see FIGS. 5 and 6 ).
  • a sealing spring 120 is provided between the sled 100 and the cup 98 for biasing the medicament cup 98 against a bottom surface of the hopper 42 to seal the dispenser port 44 of the reservoir 14.
  • the cup 98 includes clips 122 that allow the cup to be biased against the reservoir, yet retain the cup in the sled 100.
  • the sled 100 includes a second sealing surface 124 adapted to seal the pressure relief port 116 when the recess 102 of the cup 98 is aligned with the dispenser port 44, and an indentation 126 (see FIG. 6 ) adapted to unseal the pressure relief port 116 when the first sealing surface 118 is aligned with the dispenser port 44. Operation of the pressure system is discussed below.
  • the dose counting system 16 is mounted to the hopper 42 and includes a ribbon 128, having successive numbers or other suitable indicia printed thereon, in alignment with a transparent window 130 provided in the housing 18 (see FIG. 2 ).
  • the dose counting system 16 includes a rotatable bobbin 132, an indexing spool 134 rotatable in a single direction, and the ribbon 128 rolled and received on the bobbin 132 and having a first end 127 secured to the spool 134, wherein the ribbon 128 unrolls from the bobbin 132 so that the indicia is successively displayed as the spool 134 is rotated or advanced.
  • the spool 134 is arranged to rotate upon movement of the yokes 66, 68 to effect delivery of a dose of medicament from the reservoir 14 into the delivery passageway 34, such that the number on the ribbon 128 is advanced to indicate that another dose has been dispensed by the inhaler 10.
  • the ribbon 128 can be arranged such that the numbers, or other suitable indicia, increase or decrease upon rotation of the spool 134.
  • the ribbon 128 can be arranged such that the numbers, or other suitable indicia, decrease upon rotation of the spool 134 to indicate the number of doses remaining in the inhaler 10.
  • the ribbon 128 can be arranged such that the numbers, or other suitable indicia, increase upon rotation of the spool 134 to indicate the number of doses dispensed by the inhaler 10.
  • the indexing spool 134 includes radially extending teeth 136, which are engaged by a pawl 138 extending from one of the cam followers 78 (see FIGS. 3 and 11 ) of the second yoke 68 upon movement of the yoke to rotate, or advance, the indexing spool 134. More particularly, the pawl 138 is shaped and arranged such that it engages the teeth 136 and advances the indexing spool 134 only upon the mouthpiece 24 cover 28 being closed and the yokes 66, 68 moved back towards the cap 26 of the housing 18.
  • the dose counting system 16 also includes a chassis 140 that secures the dose counting system to the hopper 42 and includes shafts 142, 144 for receiving the bobbin 132 and the indexing spool 134.
  • the bobbin shaft 142 is preferably forked and includes radially nubs 146 for creating a resilient resistance to rotation of the bobbin 132 on the shaft 142.
  • a clutch spring 148 is received on the end of the indexing spool 134 and locked to the chassis 140 to allow rotation of the spool 134 in only a single direction (counterclockwise as shown in FIG. 14 ). Operation of the dose counting system 16 is discussed below.
  • FIG. 13 illustrates the relative movements of the boss 110 of the cup sled 100, and the ratchet 106 and the push bar 108 of the second yoke 68 as the mouthpiece cover 28 is opened and closed.
  • the ratchet 106 prevents the cup spring 104 from moving the cup sled 100 to the delivery passageway 34.
  • the dose metering system is arranged such that when the yokes are in the first position, the recess 102 of the medicament cup 98 is directly aligned with the dispenser port 44 of the reservoir 14 and the pressure relief port 116 of the spacer 38 is sealed by the second sealing surface 124 of the cup sled 100.
  • the actuator spring 69 is allowed to move the yokes 66, 68 linearly towards the mouthpiece 24 to the second position and partially collapse the bellows 40 of the medicament reservoir 14.
  • the partially collapsed bellows 40 pressurizes the interior of the reservoir 14 and ensures medicament dispensed from the dispenser port 44 of the reservoir fills the recess 102 of the medicament cup 98 such that a predetermined dose is provided.
  • the ratchet 106 prevents the cup sled 100 from being moved to the delivery passageway 34, such that the recess 102 of the medicament cup 98 remains aligned with the dispenser port 44 of the reservoir 14 and the pressure relief port 116 of the spacer 38 remains sealed by the second sealing surface 124 of the cup assembly 96.
  • the actuator spring 69 is allowed to move the yokes 66, 68 further towards the mouthpiece 24 to the third position.
  • the ratchet 106 disengages, or falls below the boss 110 of the cup sled 100 and allows the cup sled 100 to be moved by the cup spring 104, such that the filled recess 102 of the cup 98 is position in the venturi 36 of the delivery passageway 34 and the dispenser port 44 of the reservoir 14 is sealed by the first sealing surface 118 of the cup assembly 96.
  • the pressure relief port 116 is uncovered by the indentation 126 in the side surface of the sled 100 to release pressure from the reservoir 14 and allow the bellows 40 to further collapse and accommodate the movement of the yokes 66, 68 to the third position.
  • the inhaler 10 is then ready for inhalation by a patient of the dose of medicament placed in the delivery passageway 34.
  • a breath-induced air stream 150 diverted through the delivery passageway 34 passes through the venturi 36, entrains the medicament and carries the medicament into the de-agglomerator 32 of the inhaler 10.
  • Two other breath-induced air streams 152 enter the de-agglomerator 32 through the diametrically opposed inlet ports 62 and combine with the medicament entrained air stream 150 from the delivery passageway 34.
  • the combined flows 154 and entrained dry powder medicament then travel to the outlet port 60 of the de-agglomerator and pass through the mouthpiece 24 for patient inhalation.
  • the mouthpiece cover 28 can be closed.
  • the trigger cams 70 force the yokes 66, 68 upwardly such that the first yoke 66 expands the bellows 40, and the pawl 138 of the second yoke 68 advances the indexing spool 134 of the dose counting system 16 to provide a visual indication of a dose having been dispensed.
  • the cup assembly 96 is forced back to the first position by the pusher bar 108 of the upwardly moving second yoke 68 (see FIG. 13 ) such that the boss 110 of the cup sled 100 is engaged and retained by the ratchet 106 of the second yoke 68.
  • the foregoing detailed description and preferred embodiment are only illustrative of inhalers constructed in accordance with the present invention.
  • Various alternatives and modifications to the presently disclosed inhalers can be devised by those skilled in the art without departing from the scope of the present invention, as defined by the claims.
  • the medicament cup could be provided on a rotary sled, advanced by movement of the yokes.
  • the outlet port of the pressure relief could be provided in other locations than the side wall of the slide channel.
  • the dose counting system could be adapted to provide an audible indication in addition to a visual indication of a dispensed dose. Accordingly, the present invention is intended to embrace all such alternatives and modifications that fall within the scope of the appended claims.

Claims (15)

  1. Arzneimittelinhalator (10), umfassend:
    ein Mundstück (24) zum Inhalieren durch Patienten; ein Zuströmdurchlass (34) zur Leitung eines inhalationsinduzierten Luftstromes (150) durch das Mundstück; ein sich vom Zuströmdurchlass (34) erstreckender Kanal (52); ein Behälter (14) zur Arzneimittelaufnahme, der eine mit dem Kanal (52) verbundene Abgabeöffnung (44) besitzt; eine Schale (98), die im Kanal aufgenommen wird und zwischen Abgabeöffnung (44) und Zuströmdurchlass (34) bewegbar ist; eine Schalenfeder (104), die die Schale in Richtung Abgabeöffnung (44) und Zuströmdurchlass (34) vorspannt;
    ein Bügel (68), der zwischen mindestens zwei Positionen bewegbar ist und eine Ratsche (106) umfasst, die mit der Schale (98) einrastet und ein Bewegen der Schale (98) zu verhindern, wenn der Bügel (68) in einer der Positionen ist, und das Bewegen des Schale zu erlauben, wenn der Bügel in einer der anderen Positionen ist;
    mindestens eine bewegbare Nocke (70) mit mindestens zwei aufeinanderfolgenden Nockenflächen; und eine Feder (69), die den Bügel (68) gegen die Nocke (70) vorspannt, sodass jene Bewegung der Nocke (70) bewirkt, dass der Bügel (68) sukzessive in die Nockenoberflächen eingreift und sich der Bügel (68) zwischen den mindestens zwei Bügelpositionen bewegt;
    eine Abdeckung (28), die durch Bewegung das Mundstück (24) öffnet und schließt, wobei mindestens eine Nocke (70) an der Abdeckung (28) zwecks gemeinsamer Bewegung befestigt ist, wobei durch Öffnen und Schließen des Mundstücks (24) der Bügel (68) zwischen den mindestens 2 Positionen des Bügels (68) bewegt wird; und gekennzeichnet durch
    eine sich vom Bügel (68) erstreckende Klinke (138) und einen Dosiszähler (16), beinhaltend einen Spulenkörper (Bobine) (132),
    eine drehbare Spule (134), ein gerolltes Band (128), das von der Bobine aufgenommen und um eine Achse der Bobine (132) drehbar ist, wobei das Band (128) mit Markierungen versehen ist, die sich sukzessive zwischen einem ersten Ende des an der Spule (134) befestigten Bands (128) und einem zweiten Ende des auf der Bobine (132) positionierten Bands (128) erstrecken, und Zähne (136), die sich radial nach außen von der Spule (134) in einem vorbestimmten Pfad der Klinke (138) während der Bewegung des Bügel (132) zwischen den mindestens zwei Positionen erstrecken, sodass die Spule (134) durch die Klinke (138) gedreht wird und das Band (128) während der bewegung der Schale (98) auf die Spule (134) weiterbefördert wird,
    wobei die Klinke (138) so geformt und angebracht ist, dass sie in die Zähne (136) der Spule nur eingreift, wenn die Abdeckung (28) geschlossen wird, damit sich der Bügel (68) zwischen den mindestens zwei Positionen des Bügels (68) bewegt.
  2. Inhalator nach Anspruch 1, wobei die Schalenfeder (104) die Schale (98) zum Zuströmdurchlass (34) hin vorspannt.
  3. Inhalator nach Ansprüchen 1 oder 2, wobei der Bügel (68) weiter einen Druckgriff (108) umfasst, der zum Zurückführen der Schale (98) zur Abgabeöffnung (44) des Behälters bei Bewegung des Bügels (68) zu einer der Positionen dient.
  4. Inhalator nach Anspruch 1, wobei die Nocke (70) drei aufeinanderfolgende Nockenflächen zur Bewegung des Bügels (68) zwischen drei Positionen umfasst, wobei die Ratsche (106) so angebracht ist, dass sie die Bewegung der Schale (98) zum Zuströmdurchlass (34) verhindert, wenn der Bügel (68) in einer dritten der drei Positionen ist, und der Druckgriff (108) so angebracht ist, dass die Schale (98) zur Abgabeöffnung (44) des Behälters bei Bewegung des Bügels (68) zu einer ersten der Positionen zurückgeführt wird.
  5. Inhalator nach Anspruch 4, wobei durch Öffnen und Schließen des Mundstücks der Bügel (68) zwischen den drei Positionen des Bügels (68) bewegt wird.
  6. Inhalator nach Anspruch 1, wobei die Nocke (70) durch Drehen bewegbar ist.
  7. Inhalator nach Anspruch 1, wobei der Behälter (14) ein Volumen eines Trockenpulverarzneimittels enthält.
  8. Inhalator nach Anspruch 1, der weiterhin einen Desagglomerator (32) zwischen dem Zuströmdurchlass (34) und dem Mundstück (24) enthält.
  9. Inhalator (10) nach Anspruch 1, wobei: der Kanal (52) eine Druckentlastungsöffnung (116) enthält; eine Leitung eine Fluidverbindung zwischen einem Inneren des Behälters (14) und der Druckentlastungsöffnung (116) gewährleistet; und die Schale (98) enthält eine Ausnehmung (102), die ausgelegt ist, ein Medikament aufzunehmen, wenn sie an der Abgabeöffnung (44) des Behälters ausgerichtet ist, eine erste Verschlussfläche (118), die ausgelegt ist, die Abgabeöffnung (44) zu verschließen, wenn die Ausnehmung nicht an der Abgabeöffnung (44) ausgerichtet ist, und eine zweite Verschlussfläche (124), die ausgelegt ist, die Druckentlastungsöffnung (116) des Kanals zu verschließen, wenn die Ausnehmung an der Abgabeöffnung (44) ausgerichtet ist und die Druckentlastungsöffnung (116) zu öffnen, wenn die Ausnehmung an der Abgabeöffnung (44) nicht ausgerichtet ist.
  10. Inhalator nach einem der vorangehenden Ansprüche, wobei die Spule (134) sich in einer einzigen Richtung dreht.
  11. Inhalator einem der vorangehenden Ansprüche, wobei der Dosiszähler eine Kupplungsfeder (148) beinhaltet, die an der Spule (134) befestigt ist und eine Drehung der Spule in einer einzigen Richtung erlaubt.
  12. Inhalator einem der vorangehenden Ansprüche, wobei die Markierungen Zahlen umfassen.
  13. Inhalator nach einem der vorangehenden Ansprüche, weiter umfassend ein Gehäuse (18), das den Dosiszähler und ein transparentes Fenster (13) über den Markierungen des Bandes (128) enthält.
  14. Inhalator nach einem der vorangehenden Ansprüche, wobei der Behälter (14) für die Aufnahme eines unverpackten Trockenpulvermedikaments ausgelegt ist.
  15. Inhalator nach einem der vorangehenden Ansprüche, wobei die Markierungen Zahlen umfassen, die so ausgelegt sind, dass sie sukzessive abnehmen, wenn das Band (128) auf die Spule (134) weiterbewegt wird.
EP10010833.1A 2000-06-23 2001-06-23 Arzneimittelinhalator Expired - Lifetime EP2314336B1 (de)

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US21366800P 2000-06-23 2000-06-23
US21338200P 2000-06-23 2000-06-23
EP04020854A EP1486227B1 (de) 2000-06-23 2001-06-23 Inhalator
EP01948661A EP1330280B1 (de) 2000-06-23 2001-06-23 Inhalator

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JP (3) JP4015943B2 (de)
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AU (2) AU7011301A (de)
CA (2) CA2552468C (de)
DE (1) DE60107107T2 (de)
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GB2366208A (en) 2002-03-06
US20020078949A1 (en) 2002-06-27
US8006690B2 (en) 2011-08-30
EP1486227A3 (de) 2007-02-21
PT1486227E (pt) 2012-04-10
ES2382734T3 (es) 2012-06-13
TWI224512B (en) 2004-12-01
UY26794A1 (es) 2002-01-31
KR100517900B1 (ko) 2005-10-04
GB2365779B (en) 2004-09-29
JP2007252946A (ja) 2007-10-04
ES2520966T3 (es) 2014-11-12
EP1486227B1 (de) 2012-03-07
PE20020163A1 (es) 2002-03-04
AU7011301A (en) 2002-01-08
JP4015943B2 (ja) 2007-11-28
GB0115519D0 (en) 2001-08-15
US6701917B2 (en) 2004-03-09
JP2004501685A (ja) 2004-01-22
KR20050039884A (ko) 2005-04-29
PE20020074A1 (es) 2002-02-05
EP1486227A2 (de) 2004-12-15
US20020078950A1 (en) 2002-06-27
US20020073996A1 (en) 2002-06-20
EP2314336A3 (de) 2013-07-10
US7540282B2 (en) 2009-06-02
ATE281861T1 (de) 2004-11-15
PE20020075A1 (es) 2002-02-05
CA2407262C (en) 2007-08-28
JP2007289716A (ja) 2007-11-08
PT1330280E (pt) 2005-04-29
KR100518723B1 (ko) 2005-10-05
JP4897570B2 (ja) 2012-03-14
JP4897569B2 (ja) 2012-03-14
TWI224513B (en) 2004-12-01
DK1486227T3 (da) 2012-04-02
DE60107107T2 (de) 2005-11-03
GB2366208B (en) 2004-10-13
US20090178678A1 (en) 2009-07-16
DE60107107D1 (de) 2004-12-16
UY26796A1 (es) 2002-01-31
KR100518721B1 (ko) 2005-10-05
GB2365778B (en) 2004-10-13
CA2552468A1 (en) 2002-01-03
ATE548062T1 (de) 2012-03-15
GB2365778A (en) 2002-02-27
GB2365779A (en) 2002-02-27
UY26795A1 (es) 2002-01-31
TWI224514B (en) 2004-12-01
US6718972B2 (en) 2004-04-13
CA2552468C (en) 2008-02-19
WO2002000281A3 (en) 2003-01-03
GB0115525D0 (en) 2001-08-15
AU2001270113B2 (en) 2004-08-12
KR20030066328A (ko) 2003-08-09
EP1330280B1 (de) 2004-11-10
DK2314336T3 (da) 2014-11-03
WO2002000281A2 (en) 2002-01-03
EP1330280A2 (de) 2003-07-30
EP2314336A2 (de) 2011-04-27
PT2314336E (pt) 2014-10-29
GB0115518D0 (en) 2001-08-15
KR20050048687A (ko) 2005-05-24
ES2233659T3 (es) 2005-06-16
CA2407262A1 (en) 2002-01-03

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