Classifications

• • B—PERFORMING OPERATIONS; TRANSPORTING
  • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
  • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
  • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
  • B01F35/71—Feed mechanisms
  • B01F35/717—Feed mechanisms characterised by the means for feeding the components to the mixer
  • B01F35/7174—Feed mechanisms characterised by the means for feeding the components to the mixer using pistons, plungers or syringes
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
  • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
  • A61M5/178—Syringes
  • A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
  • A61M5/2448—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic comprising means for injection of two or more media, e.g. by mixing
• • B—PERFORMING OPERATIONS; TRANSPORTING
  • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
  • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
  • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
  • B01F33/50—Movable or transportable mixing devices or plants
  • B01F33/501—Movable mixing devices, i.e. readily shifted or displaced from one place to another, e.g. portable during use
  • B01F33/5011—Movable mixing devices, i.e. readily shifted or displaced from one place to another, e.g. portable during use portable during use, e.g. hand-held
• • B—PERFORMING OPERATIONS; TRANSPORTING
  • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
  • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
  • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
  • B01F33/50—Movable or transportable mixing devices or plants
  • B01F33/501—Movable mixing devices, i.e. readily shifted or displaced from one place to another, e.g. portable during use
  • B01F33/5011—Movable mixing devices, i.e. readily shifted or displaced from one place to another, e.g. portable during use portable during use, e.g. hand-held
  • B01F33/50112—Movable mixing devices, i.e. readily shifted or displaced from one place to another, e.g. portable during use portable during use, e.g. hand-held of the syringe or cartridge type
• • B—PERFORMING OPERATIONS; TRANSPORTING
  • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
  • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
  • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
  • B01F35/50—Mixing receptacles
  • B01F35/52—Receptacles with two or more compartments
  • B01F35/522—Receptacles with two or more compartments comprising compartments keeping the materials to be mixed separated until the mixing is initiated
• • B—PERFORMING OPERATIONS; TRANSPORTING
  • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
  • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
  • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
  • B01F35/71—Feed mechanisms
• • B—PERFORMING OPERATIONS; TRANSPORTING
  • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
  • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
  • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
  • B01F35/71—Feed mechanisms
  • B01F35/712—Feed mechanisms for feeding fluids
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
  • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
  • A61M5/178—Syringes
  • A61M5/31—Details
  • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
  • A61M5/31511—Piston or piston-rod constructions, e.g. connection of piston with piston-rod
  • A61M2005/3152—Piston or piston-rod constructions, e.g. connection of piston with piston-rod including gearings to multiply or attenuate the piston displacing force

Definitions

• the present invention relates to a by-pass cartridge and in particular to a device and method for storing, mixing and delivering pharmaceuticals.
• dual chambered syringes which use a by-pass channel to provide fluid communication between the two chambers.
• the two chambers are commonly defined within a syringe barrel by two separate pistons and an end stopper spaced apart within the syringe barrel.
• the two chambers are placed in fluid communication by the by-pass channel by actuation of the outer most piston within the syringe barrel. This causes both pistons within the syringe barrel to advance to a point where the inner most piston becomes aligned with the by-pass channel. At that point, further actuation of the outer most piston causes fluid contained in the chamber between the two pistons to flow into the outwardly extending by-pass channel and around the inner most piston which remains stationary.
• a device for mixing a substance comprised of two constituents comprising a cartridge, a cartridge holder, a tubular container having a fluid communication end and an actuation end, the fluid communication end being receivable in the cartridge holder, the tubular container having a first closure member disposed at the fluid communication end, a second closure member disposed at the actuation end, a piston within the container intermediate the first and second closure members, and a by-pass channel for enabling fluid to by-pass the piston when the piston is in the by-pass position, a plunger rod engageable with the second closure member for moving the second closure member within the container, the plunger rod having a rack gear formed thereon, a housing, a pinion gear mounted within the housing, the pinion gear being engageable with the rack gear, and a handle connected to the pinion gear.
• the transfer device of the present invention may be utilized with any suitable by-pass type cartridge or container. Many such by-pass cartridges or containers are known in the art
• Utilizing the transfer device of the present invention significantly reduces the possibility of the piston moving past the by-pass channel prior to transfer of the diluent to the chamber containing the active ingredient. In other words, it becomes difficult to rapidly move the second closure at the actuation end.
• Figure 1 is a partially exploded perspective view of a device according to the present invention.
• Figure 2 is a side elevational view of the device
• Figures 3A, 3B and 3C are side sectional view illustrating operation of the device
• Figure 4 illustrates the detachment of the cartridge holder from the housing
• Figure 5 illustrates a pen injector utilizing the cartridge of the present invention
• Figure 6 is a side view of a further embodiment of the present invention.
• Figure 7 is cross-sectional view of the device of Figure 6 illustrating operation thereof;
• Figure 8 is a cross-sectional view illustrating removal of the cover for access to the plunger rod.
• Figure 9 is a cross-sectional view showing the final step of the operation.
• Cartridge 12 is of a substantially conventional structure and includes an activation end 16 and a fluid communication end 14.
• a first closure member 18 seals fluid communication end 14 while a second closure member 20 seals activation end 16.
• first chamber 26 Situated interiorly of the cartridge 12 and intermediate closure members 18 and 20 is a plunger 22 which divides the cartridge into a first chamber 26 and a second chamber 28.
• a by-pass 24 provides fluid communication between first chamber 26 and second chamber 28.
• first chamber 26 will carry the dry pharmaceutical component to be reconstituted while second chamber 28 normally will carry a liquid diluent.
• second chamber 28 normally will carry a liquid diluent.
• other arrangements such as two liquids can be utilized.
• cartridge 12 At it's upper end (fluid communication end) cartridge 12 has a shoulder 30.
• Cartridge holder 32 surrounds cartridge 12 and has screw threads 31 at its lower end. A shoulder 36 of cartridge holder 32 abuts shoulder 30 of cartridge 12.
• a cap 38 having screw threads thereon is arranged to fit on fluid communication end 14 of cartridge 12.
• Cap 38 includes a piercing member 40 which has a passageway 43 therein.
• a gas permeable hydrophobic membrane 41 is secured to the top of cap 38 and covers passageway 43.
• Assembly 10 includes a pair of half housings 42 and 44 which are secured together. At their upper ends, housings 42 and 44 have external threads 45 designed to engage with threads on the inner bottom wall of cartridge holder 32.
• a plunger rod 46 Interiorly of housing 42, 44 is a plunger rod 46 which has a rack gear 48 formed on one side thereof.
• Rack gear 48 is designed to engage with a pinon gear 50.
• a wheel 54 is arranged to drive pinon gear 50.
• housing 42, 44 is screw threadedly engaged with cartridge holder 32.
• plunger rod 46 abuts closure member 20.
• Operation of wheel 54 will cause movement of plunger rod 46 which will then advance closure member 20 which in turn causes pressure to advance plunger 22 to the position shown in Figure 3B wherein it is located at by-pass 24.
• Continued slow and steady advancement will then cause the diluent in second chamber 28 to enter first chamber 26 until closure member 20 abuts plunger 22.
• the two components in chambers 26 and 28 are then mixed; any air present is evacuated through passageway 43 in piercing member 40 while the liquid is retained due to hydrophobic membrane 41.
• cartridge holder 32 When fully mixed, cartridge holder 32 can be unscrewed from housing 42, 44 and is then attached to a pen injector 56 in a conventional manner as shown in Figures 4 and 5.
• FIG. 1 In this embodiment, there is provided a housing 142 which is not as elongated as the housing of the previous embodiment. Instead, there is provided a cover 139 which is screwthreadedly engaged with housing 142.
• a plunger 122 to separate a solid portion 129 and a diluent 127.
• a bottom closure 120 is provided.
• a plunger rod 146 having a rack gear 148 on one side thereof.
• Pinion gear 150 is operatively engaged with rack gear 148 and by means of a wheel 154, pinion gear 150 is driven as indicated by the arrows.
• the arrangement is such that the length of the rack gear 148 permits driving of the plunger rod 146 to an extent as shown in Figure 8 wherein the substances in the two compartments have been mixed. Subsequently, cover 139 may be removed as indicated by the arrow and access gained to plunger rod 146 which may then be pushed by the user as shown in Figure 9 to inject the active ingredients. This arrangement thus provides for an assurance that all the diluent is mixed with the drug while permitting a conventional injection by means of needle 151.

Landscapes

• Chemical & Material Sciences (AREA)
• Chemical Kinetics & Catalysis (AREA)
• Health & Medical Sciences (AREA)
• Vascular Medicine (AREA)
• Engineering & Computer Science (AREA)
• Anesthesiology (AREA)
• Biomedical Technology (AREA)
• Heart & Thoracic Surgery (AREA)
• Hematology (AREA)
• Life Sciences & Earth Sciences (AREA)
• Animal Behavior & Ethology (AREA)
• General Health & Medical Sciences (AREA)
• Public Health (AREA)
• Veterinary Medicine (AREA)
• Infusion, Injection, And Reservoir Apparatuses (AREA)
• Medical Preparation Storing Or Oral Administration Devices (AREA)
• Accessories For Mixers (AREA)

Applications Claiming Priority (2)

Publications (3)

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ID=41413831

Family Applications (1)

Country Status (7)

Families Citing this family (17)

Citations (4)

Family Cites Families (23)

• 2008
  • 2008-06-13 US US12/157,866 patent/US20090308895A1/en not_active Abandoned
• 2009
  • 2009-06-10 WO PCT/CA2009/000806 patent/WO2009149547A1/en active Application Filing
  • 2009-06-10 AU AU2009257142A patent/AU2009257142B2/en not_active Ceased
  • 2009-06-10 EP EP09761205.5A patent/EP2296797B1/de active Active
  • 2009-06-10 CA CA2725620A patent/CA2725620C/en not_active Expired - Fee Related
  • 2009-06-10 US US12/737,013 patent/US8123084B2/en active Active
  • 2009-06-10 JP JP2011512794A patent/JP2011523873A/ja active Pending
• 2010
  • 2010-12-12 IL IL209941A patent/IL209941A/en active IP Right Grant
• 2014
  • 2014-07-04 JP JP2014139028A patent/JP2014223397A/ja active Pending
• 2016
  • 2016-06-23 JP JP2016124716A patent/JP6306096B2/ja active Active

Patent Citations (4)

Non-Patent Citations (1)

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