EP2283860A3 - Use for interleukin-33 (il-33) and the il-33 receptor complex - Google Patents

Use for interleukin-33 (il-33) and the il-33 receptor complex Download PDF

Info

Publication number
EP2283860A3
EP2283860A3 EP10177117.8A EP10177117A EP2283860A3 EP 2283860 A3 EP2283860 A3 EP 2283860A3 EP 10177117 A EP10177117 A EP 10177117A EP 2283860 A3 EP2283860 A3 EP 2283860A3
Authority
EP
European Patent Office
Prior art keywords
interleukin
receptor complex
methods
receptor
antagonists
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP10177117.8A
Other languages
German (de)
French (fr)
Other versions
EP2283860A2 (en
Inventor
Jochen Schmitz
Martin Oft
Robert A. Kastelein
J. Fernando Bazan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp and Dohme LLC
Original Assignee
Merck Sharp and Dohme LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34886190&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EP2283860(A3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Merck Sharp and Dohme LLC filed Critical Merck Sharp and Dohme LLC
Publication of EP2283860A2 publication Critical patent/EP2283860A2/en
Publication of EP2283860A3 publication Critical patent/EP2283860A3/en
Withdrawn legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6863—Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors
    • G01N33/6869—Interleukin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/20—Interleukins [IL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Communicable Diseases (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pulmonology (AREA)
  • Genetics & Genomics (AREA)
  • Hematology (AREA)
  • Biophysics (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Cell Biology (AREA)
  • Urology & Nephrology (AREA)
  • Epidemiology (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)

Abstract

Provided are methods of modulating cytokine activity, e.g., for the purpose of treating immune and inflammatory disorders, including tumors and cancer. Also provided are methods of administering agonists or antagonists of IL-33 and IL-33 receptor.
EP10177117.8A 2004-02-17 2005-02-15 Use for interleukin-33 (il-33) and the il-33 receptor complex Withdrawn EP2283860A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US54573004P 2004-02-17 2004-02-17
EP05713577A EP1725261B1 (en) 2004-02-17 2005-02-15 Use of agonists and antagonists of interleukin-33 (il-33)

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
EP05713577.4 Division 2005-02-15

Publications (2)

Publication Number Publication Date
EP2283860A2 EP2283860A2 (en) 2011-02-16
EP2283860A3 true EP2283860A3 (en) 2013-06-05

Family

ID=34886190

Family Applications (2)

Application Number Title Priority Date Filing Date
EP05713577A Active EP1725261B1 (en) 2004-02-17 2005-02-15 Use of agonists and antagonists of interleukin-33 (il-33)
EP10177117.8A Withdrawn EP2283860A3 (en) 2004-02-17 2005-02-15 Use for interleukin-33 (il-33) and the il-33 receptor complex

Family Applications Before (1)

Application Number Title Priority Date Filing Date
EP05713577A Active EP1725261B1 (en) 2004-02-17 2005-02-15 Use of agonists and antagonists of interleukin-33 (il-33)

Country Status (14)

Country Link
US (5) US20050203046A1 (en)
EP (2) EP1725261B1 (en)
JP (4) JP4949859B2 (en)
CN (1) CN1917902A (en)
AT (1) ATE496636T1 (en)
AU (1) AU2005215528B2 (en)
BR (1) BRPI0507808A (en)
CA (1) CA2555236C (en)
DE (1) DE602005026105D1 (en)
NO (1) NO20064193L (en)
NZ (1) NZ549040A (en)
TW (2) TWI372628B (en)
WO (1) WO2005079844A2 (en)
ZA (1) ZA200606844B (en)

Families Citing this family (67)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2002218026A1 (en) 2000-11-09 2002-05-21 The Brigham And Women's Hospital, Inc. Cardiovascular disease diagnostic and therapeutic targets
AU2003234407B2 (en) * 2002-05-09 2008-12-18 The Brigham And Women's Hospital, Inc. 1L1RL-1 as a cardiovascular disease marker and therapeutic target
NZ549040A (en) 2004-02-17 2009-07-31 Schering Corp Use for interleukin-33 (IL33) and the IL-33 receptor complex
WO2007046087A2 (en) * 2005-10-16 2007-04-26 Yeda Research And Development Co.Ltd. Pharmaceutical compositions and diagnostic methods for inflammatory skin disesaes, disorders or conditions
EP2386860B1 (en) 2006-04-24 2014-11-05 Critical Care Diagnostics, Inc. Predicting mortality and detecting severe disease
WO2007143295A2 (en) * 2006-04-27 2007-12-13 Critical Care Diagnostics, Inc. Interleukin-33 (il-33) for the diagnosis and prognosis of cardiovascular disease
EP2021796B1 (en) 2006-05-01 2012-02-08 Critical Care Diagnostics, Inc. Diagnosis of cardiovascular disease
PL2019965T3 (en) * 2006-05-02 2015-10-30 Critical Care Diagnostics Inc Differential diagnosis between pulmonary and cardiovascular disease
WO2007130627A2 (en) * 2006-05-04 2007-11-15 The Brigham And Women's Hospital, Inc. Il-33 in the treatment and diagnosis of diseases and disorders
US7560530B1 (en) 2006-07-20 2009-07-14 Schering Corporation IL-33 receptor
SE532250C2 (en) * 2006-11-28 2009-11-24 Theravac Pharmaceuticals Ab New formulations of IL-33 for the treatment of inflammatory conditions with a strong TH2 component by vaccination
EP2152740A1 (en) * 2007-04-26 2010-02-17 Provost, Fellows and Scholars of the College of the Holy and Undivided Trinity of Queen Elizabeth near Dublin Products for altering il-33 activity and methods therefor
CA2686683A1 (en) * 2007-05-18 2008-11-27 Medimmune, Llc Il-33 in inflammatory disease
SI2269063T1 (en) 2008-04-18 2014-01-31 Critical Care Diagnostics, Inc. Predicting risk of major adverse cardiac events
JP5539660B2 (en) * 2009-03-10 2014-07-02 公益財団法人ヒューマンサイエンス振興財団 Mucosal vaccine adjuvant
US20120263709A1 (en) 2009-09-10 2012-10-18 Schering Corporation Use of il-33 antagonists to treat fibrotic diseases
TW201238976A (en) 2011-02-23 2012-10-01 Hoffmann La Roche Antibodies against human IL33R and uses thereof
FR2972006B1 (en) 2011-02-24 2016-03-25 Centre Nat Rech Scient NOVEL IL-33 SUPERACTIVE FRAGMENTS AND USES THEREOF
WO2012141844A2 (en) 2011-03-17 2012-10-18 Critical Care Diagnostics, Inc. Methods predicting risk of an adverse clinical outcome
US9090694B2 (en) 2012-04-30 2015-07-28 Janssen Biotech, Inc. ST2L antibody antagonists
AR091069A1 (en) 2012-05-18 2014-12-30 Amgen Inc PROTEINS OF UNION TO ANTIGEN DIRECTED AGAINST THE ST2 RECEIVER
IN2015DN01767A (en) 2012-08-21 2015-05-29 Critical Care Diagnostics Inc
WO2014090800A1 (en) * 2012-12-10 2014-06-19 Vib Vzw Novel interleukin-33 inhibitors
KR101780575B1 (en) * 2013-02-14 2017-09-21 건국대학교 산학협력단 Composition of novel interleukin-33 receptor and binding protein, and use thereof
EP2958583B1 (en) * 2013-02-22 2018-04-11 Magic Epoch Holdings Limited Il-33 and treatment of neurodegenerative diseases
JO3532B1 (en) * 2013-03-13 2020-07-05 Regeneron Pharma Anti-il-33 antibodies and uses thereof
CN105007929B (en) 2013-03-15 2019-05-10 瑞泽恩制药公司 IL-33 antagonist and its purposes
CA3176712A1 (en) * 2013-03-15 2014-09-18 Elixirgen Therapeutics, Inc. Methods of using zscan4 for rejunevating human cells
EP3047024B1 (en) 2013-09-20 2019-04-24 University Of Virginia Patent Foundation Compositions and methods for treatment of autoimmune and inflammatory diseases and disorders
CN111012905B (en) * 2013-10-07 2023-12-22 宾夕法尼亚大学理事会 Vaccine with interleukin-33 as an adjuvant
EP4223874A3 (en) * 2013-12-26 2023-09-27 Mitsubishi Tanabe Pharma Corporation Human anti-il-33 neutralizing monoclonal antibody
CA2936366A1 (en) * 2014-01-10 2015-07-16 Anaptysbio, Inc. Antibodies directed against interleukin-33 (il-33)
US20170107300A1 (en) 2014-03-21 2017-04-20 The Brigham And Women's Hospital, Inc. Methods and compositions for treatment of immune-related diseases or disorders and/or therapy monitoring
CN107109494B (en) * 2014-11-10 2023-10-27 豪夫迈·罗氏有限公司 Methods of treatment and diagnosis of IL-33 mediated diseases
TWI705976B (en) 2014-11-10 2020-10-01 美商建南德克公司 Anti-interleukin-33 antibodies and uses thereof
CA2978449A1 (en) 2015-03-02 2016-09-09 180 Therapeutics Lp Method of treating a localized fibrotic disorder using an il-33 antagonist
AU2016228147B2 (en) * 2015-03-03 2021-03-04 Cava Healthcare Inc. Modulation of cancer immunity with type 2 innate lymphoid cells, interleukin 33, and/or interferon induced protein 44
MY190209A (en) 2015-03-31 2022-04-05 Medimmune Ltd A novel il33 form, mutated forms of il33, antibodies, assays and methods of using the same
JP6501650B2 (en) * 2015-06-25 2019-04-17 田辺三菱製薬株式会社 Human anti-IL-33 neutralizing monoclonal antibody
WO2017009750A1 (en) * 2015-07-10 2017-01-19 The Hong Kong University Of Science And Technology Methods and compositions for treating neurodegenerative and neuroinflammatory conditions
EA201890891A1 (en) * 2015-10-06 2018-09-28 Ридженерон Фармасьютикалз, Инк. BIOMARKERS ASSOCIATED WITH INTERLEYKIN-33 DISEASES, AND THEIR APPLICATION
KR101765397B1 (en) 2015-12-02 2017-08-07 한국과학기술원 The use of il-33 to diagnose the susceptibility of intravaginal viral infection
BR112018071276A2 (en) 2016-04-27 2019-02-12 Pfizer Inc. anti-il-33 antibodies, compositions, methods and uses thereof
WO2018005682A2 (en) 2016-06-29 2018-01-04 Checkpoint Therapeutics, Inc. Pd-l1-specific antibodies and methods of using the same
JOP20190093A1 (en) 2016-10-28 2019-04-25 Lilly Co Eli Anti-il-33 antibodies and uses thereof
TW202332696A (en) 2016-12-01 2023-08-16 美商再生元醫藥公司 Methods of treating inflammatory conditions
US10738131B2 (en) 2017-02-10 2020-08-11 Genentech, Inc. Anti-tryptase antibodies, compositions thereof, and uses thereof
US20200339674A1 (en) * 2017-02-17 2020-10-29 The General Hospital Corporation Methods and compositions for treating a brain injury
JP7321939B2 (en) 2017-04-13 2023-08-07 リジェネロン・ファーマシューティカルズ・インコーポレイテッド Treatment and inhibition of inflammatory lung disease in patients with risk alleles in genes encoding IL33 and IL1RL1
AU2018261022B2 (en) 2017-05-05 2024-02-15 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Ocular applications of matrix bound vesicles (MBVs)
CN111107875A (en) 2017-08-31 2020-05-05 田边三菱制药株式会社 Therapeutic agent for endometriosis comprising IL-33 antagonist
KR20220098056A (en) 2018-02-09 2022-07-08 제넨테크, 인크. Therapeutic and diagnostic methods for mast cell-mediated inflammatory diseases
IL277890B2 (en) 2018-04-11 2024-03-01 Regeneron Pharma Methods for quantifying il-33
EP3787642A4 (en) * 2018-05-03 2022-09-21 University of Pittsburgh - of the Commonwealth System of Higher Education Matrix bound vesicles (mbvs) containing il-33 and their use
AU2019328575A1 (en) 2018-08-30 2021-02-25 HCW Biologics, Inc. Single-chain and multi-chain chimeric polypeptides and uses thereof
SG11202101779RA (en) 2018-08-30 2021-03-30 Hcw Biologics Inc Multi-chain chimeric polypeptides and uses thereof
KR20210069639A (en) 2018-08-30 2021-06-11 에이치씨더블유 바이올로직스, 인크. Single-chain chimeric polypeptides and uses thereof
TW202102260A (en) 2019-03-21 2021-01-16 美商再生元醫藥公司 Stabilized formulations containing anti-il-33 antibodies
JP2022537054A (en) 2019-06-21 2022-08-23 エイチシーダブリュー バイオロジックス インコーポレイテッド Multichain chimeric polypeptides and uses thereof
CA3145250A1 (en) * 2019-06-30 2021-01-07 Memorial Sloan Kettering Cancer Center Methods and compositions for treatment of pancreatic cancer
CN114555109A (en) * 2019-10-11 2022-05-27 交晨生物医药技术(上海)有限公司 Methods of treating cancer using IL-33 proteins
WO2021183849A1 (en) 2020-03-13 2021-09-16 Genentech, Inc. Anti-interleukin-33 antibodies and uses thereof
JP2023527869A (en) 2020-06-01 2023-06-30 エイチシーダブリュー バイオロジックス インコーポレイテッド Treatments for age-related disorders
WO2021247003A1 (en) 2020-06-01 2021-12-09 HCW Biologics, Inc. Methods of treating aging-related disorders
CN112210556A (en) * 2020-10-15 2021-01-12 扬州大学 Group of shRNA for targeted interference of IL-33 expression, recombinant adenovirus vector, and construction method and application thereof
WO2023086807A1 (en) 2021-11-10 2023-05-19 Genentech, Inc. Anti-interleukin-33 antibodies and uses thereof
CN114426981B (en) * 2022-02-21 2022-11-29 吉林农业大学 African swine fever virus antigen protein recombinant expression vector, recombinant plant lactic acid bacteria, and preparation method and application thereof

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5576191A (en) * 1994-06-17 1996-11-19 Immunex Corporation Cytokine that binds ST2
WO1999032626A1 (en) * 1997-12-23 1999-07-01 Immunex Corporation Sigirr dna and polypeptides
WO1999034217A1 (en) * 1997-12-24 1999-07-08 The University Court Of The University Of Glasgow Reagents specific for st2l and uses therefor

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5116964A (en) * 1989-02-23 1992-05-26 Genentech, Inc. Hybrid immunoglobulins
US6176962B1 (en) 1990-02-28 2001-01-23 Aclara Biosciences, Inc. Methods for fabricating enclosed microchannel structures
WO1992010210A1 (en) * 1990-12-14 1992-06-25 E.I. Du Pont De Nemours And Company Inhibition of angiogenesis by il-1
US5783415A (en) 1991-03-29 1998-07-21 Genentech, Inc. Method of producing an IL-8 receptor polypeptide
WO1995001997A1 (en) 1993-07-09 1995-01-19 Smithkline Beecham Corporation RECOMBINANT AND HUMANIZED IL-1β ANTIBODIES FOR TREATMENT OF IL-1 MEDIATED INFLAMMATORY DISORDERS IN MAN
US6132764A (en) 1994-08-05 2000-10-17 Targesome, Inc. Targeted polymerized liposome diagnostic and treatment agents
WO1997003715A1 (en) 1995-07-21 1997-02-06 The General Hospital Corporation Method and apparatus of enhancing the delivery of a pharmaceutical formulation
US6056973A (en) 1996-10-11 2000-05-02 Sequus Pharmaceuticals, Inc. Therapeutic liposome composition and method of preparation
US5842787A (en) 1997-10-09 1998-12-01 Caliper Technologies Corporation Microfluidic systems incorporating varied channel dimensions
ATE406441T1 (en) 1997-10-29 2008-09-15 Genentech Inc USE OF THE WNT-1 INDUCED SECRETED POLYPEPTIDE WISP-1
US6326482B1 (en) 1999-04-23 2001-12-04 Genentech, Inc. SH2 domain-containing peptides
CA2340579A1 (en) 1998-09-01 2000-03-09 Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo Interleukin 18-binding protein
JP2002531466A (en) 1998-12-01 2002-09-24 プロテイン デザイン ラブス， インコーポレイテッド Humanized antibodies to gamma interferon
US6323334B1 (en) * 1999-09-24 2001-11-27 Millennium Pharmaceuticals, Inc. Nucleic acid molecules encoding a 103 gene product and uses therefor
WO2001046697A2 (en) 1999-12-21 2001-06-28 Millennium Predictive Medicine Identification, assessment, prevention, and therapy of breast cancer
GB0020685D0 (en) * 2000-08-22 2000-10-11 Novartis Ag Organic compounds
EP1385993B8 (en) 2000-12-08 2011-09-21 Celldex Therapeutics, Inc. Method of detecting and treating tuberous sclerosis complex associated disorders
US20040009481A1 (en) * 2001-06-11 2004-01-15 Millennium Pharmaceuticals, Inc. Compositions, kits, and methods for identification, assessment, prevention, and therapy of human prostate cancer
AU2002324700A1 (en) 2001-08-14 2003-03-03 Bayer Ag Nucleic acid and amino acid sequences involved in pain
WO2002010210A2 (en) 2001-08-28 2002-02-07 Bayer Cropscience Ag Polypeptides for identifying herbicidally active compounds
WO2004056868A2 (en) * 2002-12-19 2004-07-08 Endocube Sas Nf-hev compositions and methods of use
JP2007537717A (en) 2004-01-07 2007-12-27 ブリストル−マイヤーズ　スクイブ　カンパニー Biomarkers and methods for determining susceptibility to epidermal growth factor receptor modulators
NZ549040A (en) 2004-02-17 2009-07-31 Schering Corp Use for interleukin-33 (IL33) and the IL-33 receptor complex
US7560530B1 (en) 2006-07-20 2009-07-14 Schering Corporation IL-33 receptor
CA2686683A1 (en) 2007-05-18 2008-11-27 Medimmune, Llc Il-33 in inflammatory disease

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5576191A (en) * 1994-06-17 1996-11-19 Immunex Corporation Cytokine that binds ST2
WO1999032626A1 (en) * 1997-12-23 1999-07-01 Immunex Corporation Sigirr dna and polypeptides
WO1999034217A1 (en) * 1997-12-24 1999-07-08 The University Court Of The University Of Glasgow Reagents specific for st2l and uses therefor

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
A. COYLE ET AL.: "Crucial role of the interleukin 1 receptor family member T1/ST2 in T helper cell type 2-mediated lung mucosal immune responses.", THE JOURNAL OF EXPERIMENTAL MEDICINE, vol. 190, no. 7, 4 October 1999 (1999-10-04), Tokyo, Japan, pages 895 - 902, XP002331976 *
G. WALZL ET AL.: "Inhibition of T1/ST2 during respiratory syncytial virus infection prevents T helper cell type 2 (Th2)- but not Th1-driven immunopathology.", THE JOURNAL OF EXPERIMENTAL MEDICINE, vol. 193, no. 7, 2 April 2001 (2001-04-02), Tokyo, Japan, pages 785 - 792, XP002344562 *
J. SIMS: "IL-1 and IL-18 receptors, and their extended family.", CURRENT OPINION IN IMMUNOLOGY, vol. 14, no. 1, February 2002 (2002-02-01), pages 117 - 122, XP004332743 *
L. O'NEILL: "SIGIRR puts the brakes on Toll-like receptors.", NATURE IMMUNOLOGY, vol. 4, no. 9, September 2003 (2003-09-01), New York, NY, USA, pages 823 - 824, XP002344563 *
S. KUMAR ET AL.: "ST2/T1 protein functionally binds to two secreted proteins from Balb/c 3T3 and human umbilical vein endothelial cells but does not bind interleukin 1.", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 270, no. 46, 17 November 1995 (1995-11-17), Baltimore, MD, USA, pages 27905 - 27913, XP000604708 *

Also Published As

Publication number Publication date
AU2005215528B2 (en) 2009-04-30
NO20064193L (en) 2006-11-16
CA2555236A1 (en) 2005-09-01
ZA200606844B (en) 2008-05-28
AU2005215528A1 (en) 2005-09-01
TWI372628B (en) 2012-09-21
US20070160579A1 (en) 2007-07-12
JP4949859B2 (en) 2012-06-13
US20090041718A1 (en) 2009-02-12
WO2005079844A3 (en) 2005-11-24
TW200539891A (en) 2005-12-16
TW201304802A (en) 2013-02-01
US20140140954A1 (en) 2014-05-22
DE602005026105D1 (en) 2011-03-10
NZ549040A (en) 2009-07-31
JP2014098026A (en) 2014-05-29
ATE496636T1 (en) 2011-02-15
US20050203046A1 (en) 2005-09-15
EP2283860A2 (en) 2011-02-16
CA2555236C (en) 2015-05-05
JP2007523089A (en) 2007-08-16
EP1725261A2 (en) 2006-11-29
US9970944B2 (en) 2018-05-15
JP2016034948A (en) 2016-03-17
EP1725261B1 (en) 2011-01-26
US20180128837A1 (en) 2018-05-10
WO2005079844A2 (en) 2005-09-01
CN1917902A (en) 2007-02-21
JP2011178810A (en) 2011-09-15
BRPI0507808A (en) 2007-07-10

Similar Documents

Publication Publication Date Title
EP2283860A3 (en) Use for interleukin-33 (il-33) and the il-33 receptor complex
TW200531679A (en) Methods of modulating cytokine activity; related reagents
IL245462A0 (en) Humanized anti-cmet antagonists
ZA200606620B (en) Methods of modulating IL-23 activity ; related reagents
TW200505479A (en) Uses of IL-23 agonists and antagonists; related reagents
TW200616632A (en) Compounds modulating c-kit activity and uses therefor
WO2002099054A3 (en) Hccss as modifiers of the p53 pathway and methods of use
WO2006015060A3 (en) Isoindoline compounds and methods of their use
WO2004058191A3 (en) Multivalent lymphotoxin beta receptor agonists and therapeutic uses thereof
EP1589998A4 (en) Uses of mammalian cytokine; related reagents
WO2005085188A3 (en) Compounds and methods for anti-tumor therapy
SE0202598D0 (en) Alpha-7 Nicotinic receptor agonists and statins in combination
WO2005118592A8 (en) Tetrahydropyridothiophenes for use in the treatment of cancer
WO2005089294A3 (en) Synthesis of indenoisoquinoliniums and methods of use
EP1898950A4 (en) Galk1s as modifiers of the pten/akt pathway and methods of use
WO2005010148A3 (en) Marks as modifiers of the pten pathway and methods of use
WO2005060998A3 (en) Methods of modulating cytokine activity; related reagents
WO2005090992A3 (en) Mptens as modifiers of the pten pathway and methods of use
WO2005072470A3 (en) Mbms as modifiers of branching morphogenesis and methods of use
WO2005017123A3 (en) Mptens as modifiers of the pten pathway and methods of use
WO2005017118A3 (en) Sulfs as modifiers of the beta catenin pathway and methods of use
WO2005052131A3 (en) C140rf35 as modifier of the beta catenin pathway and methods of use
WO2005003305A3 (en) Usps as modifiers of the beta catenin pathway and methods of use
WO2004067721A3 (en) Tkts as modifiers of the beta-catenin pathway and methods of use
WO2005003303A3 (en) Nadks as modifiers of branching morphogenesis and methods of use

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

AC Divisional application: reference to earlier application

Ref document number: 1725261

Country of ref document: EP

Kind code of ref document: P

AK Designated contracting states

Kind code of ref document: A2

Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU MC NL PL PT RO SE SI SK TR

AX Request for extension of the european patent

Extension state: AL BA HR LV MK YU

REG Reference to a national code

Ref country code: HK

Ref legal event code: DE

Ref document number: 1152487

Country of ref document: HK

RAP1 Party data changed (applicant data changed or rights of an application transferred)

Owner name: MERCK SHARP & DOHME CORP.

PUAL Search report despatched

Free format text: ORIGINAL CODE: 0009013

AK Designated contracting states

Kind code of ref document: A3

Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU MC NL PL PT RO SE SI SK TR

AX Request for extension of the european patent

Extension state: AL BA HR LV MK YU

RIC1 Information provided on ipc code assigned before grant

Ipc: C07K 16/28 20060101ALI20130426BHEP

Ipc: A61K 39/395 20060101AFI20130426BHEP

Ipc: A61P 37/00 20060101ALI20130426BHEP

Ipc: C07K 16/24 20060101ALI20130426BHEP

Ipc: A61P 35/00 20060101ALI20130426BHEP

Ipc: C07K 14/54 20060101ALI20130426BHEP

Ipc: A61K 38/20 20060101ALI20130426BHEP

Ipc: A61P 31/00 20060101ALI20130426BHEP

Ipc: A61P 11/06 20060101ALI20130426BHEP

Ipc: A61P 25/02 20060101ALI20130426BHEP

Ipc: C07K 14/715 20060101ALI20130426BHEP

Ipc: A61P 19/02 20060101ALI20130426BHEP

Ipc: A61K 38/00 20060101ALN20130426BHEP

Ipc: A61K 38/17 20060101ALI20130426BHEP

17P Request for examination filed

Effective date: 20131128

RAX Requested extension states of the european patent have changed

Extension state: LV

Payment date: 20131128

Extension state: BA

Payment date: 20131128

Extension state: MK

Payment date: 20131128

Extension state: AL

Payment date: 20131128

Extension state: HR

Payment date: 20131128

Extension state: YU

Payment date: 20131128

RBV Designated contracting states (corrected)

Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU MC NL PL PT RO SE SI SK TR

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION HAS BEEN WITHDRAWN

18W Application withdrawn

Effective date: 20151204

REG Reference to a national code

Ref country code: HK

Ref legal event code: WD

Ref document number: 1152487

Country of ref document: HK