EP2275441B8 - Hochaffine HIV-T-Zellen-Rezeptoren - Google Patents
Hochaffine HIV-T-Zellen-Rezeptoren Download PDFInfo
- Publication number
- EP2275441B8 EP2275441B8 EP10008612.3A EP10008612A EP2275441B8 EP 2275441 B8 EP2275441 B8 EP 2275441B8 EP 10008612 A EP10008612 A EP 10008612A EP 2275441 B8 EP2275441 B8 EP 2275441B8
- Authority
- EP
- European Patent Office
- Prior art keywords
- high affinity
- cell receptors
- affinity hiv
- hiv
- receptors
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/7051—T-cell receptor (TcR)-CD3 complex
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/6425—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the peptide or protein in the drug conjugate being a receptor, e.g. CD4, a cell surface antigen, i.e. not a peptide ligand targeting the antigen, or a cell surface determinant, i.e. a part of the surface of a cell
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Cell Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Communicable Diseases (AREA)
- Virology (AREA)
- Oncology (AREA)
- Epidemiology (AREA)
- Tropical Medicine & Parasitology (AREA)
- AIDS & HIV (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicinal Preparation (AREA)
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PL10008612T PL2275441T3 (pl) | 2005-04-01 | 2006-03-29 | Receptory komórek T o wysokim powinowactwie dla HIV |
| SI200632107A SI2275441T1 (sl) | 2005-04-01 | 2006-03-29 | T celični receptorji z visoko afiniteto HIV |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0506760A GB0506760D0 (en) | 2005-04-01 | 2005-04-01 | High affinity HIV TCRS |
| GB0516487A GB0516487D0 (en) | 2005-08-10 | 2005-08-10 | High affinity HIV T cell receptors |
| EP06726555A EP1863842A2 (de) | 2005-04-01 | 2006-03-29 | Hochaffine hiv-t-zellen-rezeptoren |
Related Parent Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EP06726555.3 Division | 2006-03-29 | ||
| EP06726555A Division EP1863842A2 (de) | 2005-04-01 | 2006-03-29 | Hochaffine hiv-t-zellen-rezeptoren |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| EP2275441A1 EP2275441A1 (de) | 2011-01-19 |
| EP2275441A9 EP2275441A9 (de) | 2011-09-14 |
| EP2275441B1 EP2275441B1 (de) | 2016-08-24 |
| EP2275441B8 true EP2275441B8 (de) | 2016-10-19 |
Family
ID=37053744
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EP15171918.4A Not-in-force EP2985291B1 (de) | 2005-04-01 | 2006-03-29 | Hochaffine hiv-t-zell-rezeptoren |
| EP10008612.3A Active EP2275441B8 (de) | 2005-04-01 | 2006-03-29 | Hochaffine HIV-T-Zellen-Rezeptoren |
| EP06726555A Withdrawn EP1863842A2 (de) | 2005-04-01 | 2006-03-29 | Hochaffine hiv-t-zellen-rezeptoren |
| EP10014971A Withdrawn EP2301964A1 (de) | 2005-04-01 | 2006-03-29 | Hochaffine HIV-T-Zellen-Rezeptoren |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EP15171918.4A Not-in-force EP2985291B1 (de) | 2005-04-01 | 2006-03-29 | Hochaffine hiv-t-zell-rezeptoren |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EP06726555A Withdrawn EP1863842A2 (de) | 2005-04-01 | 2006-03-29 | Hochaffine hiv-t-zellen-rezeptoren |
| EP10014971A Withdrawn EP2301964A1 (de) | 2005-04-01 | 2006-03-29 | Hochaffine HIV-T-Zellen-Rezeptoren |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US8378074B2 (de) |
| EP (4) | EP2985291B1 (de) |
| JP (3) | JP2008535826A (de) |
| CN (2) | CN105461802A (de) |
| AU (1) | AU2006228308B2 (de) |
| CA (1) | CA2602463C (de) |
| CY (1) | CY1118160T1 (de) |
| DK (1) | DK2275441T3 (de) |
| ES (2) | ES2699320T3 (de) |
| HU (1) | HUE032037T2 (de) |
| LT (1) | LT2275441T (de) |
| NZ (2) | NZ561338A (de) |
| PL (1) | PL2275441T3 (de) |
| PT (1) | PT2275441T (de) |
| SI (1) | SI2275441T1 (de) |
| WO (1) | WO2006103429A2 (de) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040191260A1 (en) | 2003-03-26 | 2004-09-30 | Technion Research & Development Foundation Ltd. | Compositions capable of specifically binding particular human antigen presenting molecule/pathogen-derived antigen complexes and uses thereof |
| CA2476625A1 (en) | 2002-02-20 | 2003-08-28 | Dyax Corp. | Mhc-peptide complex binding ligands |
| WO2006036445A2 (en) | 2004-09-24 | 2006-04-06 | Trustees Of Dartmouth College | Chimeric nk receptor and methods for treating cancer |
| WO2008042814A2 (en) * | 2006-09-29 | 2008-04-10 | California Institute Of Technology | Mart-1 t cell receptors |
| JP5292550B2 (ja) * | 2007-03-23 | 2013-09-18 | 静岡県 | Ｔ細胞レセプターβ鎖遺伝子及びα鎖遺伝子 |
| US8747855B2 (en) | 2008-04-09 | 2014-06-10 | Technion Research & Development Foundation Limited | Anti human immunodeficiency antibodies and uses thereof |
| GB0816096D0 (en) * | 2008-09-04 | 2008-10-15 | Medigene Ltd | Diabetes t cell receptors |
| EP2411545B1 (de) * | 2009-03-25 | 2017-03-08 | Altor BioScience Corporation | Vpr-spezifische t-zell-rezeptoren für hiv |
| US10464987B2 (en) * | 2009-10-06 | 2019-11-05 | Abbvie Inc. | Human single-chain T cell receptors |
| WO2011059836A2 (en) | 2009-10-29 | 2011-05-19 | Trustees Of Dartmouth College | T cell receptor-deficient t cell compositions |
| US9273283B2 (en) | 2009-10-29 | 2016-03-01 | The Trustees Of Dartmouth College | Method of producing T cell receptor-deficient T cells expressing a chimeric receptor |
| GB201016672D0 (en) | 2010-10-04 | 2010-11-17 | Electronic Shipping Solutions Ltd | Secure exchange/authentication of electronic documents |
| EP2502934B1 (de) | 2011-03-24 | 2018-01-17 | Universitätsmedizin der Johannes Gutenberg-Universität Mainz | Einfachkettenantigenerkennende Konstrukte, die durch die Einführung von neuartigen Disulfid-Verbindungen stabilisiert werden |
| WO2013033626A2 (en) | 2011-08-31 | 2013-03-07 | Trustees Of Dartmouth College | Nkp30 receptor targeted therapeutics |
| ES2719495T3 (es) | 2012-05-07 | 2019-07-10 | Dartmouth College | Anticuerpo dirigido contra b7-h6, proteínas de fusión, y métodos de uso de los mismos |
| AU2013295652B2 (en) | 2012-07-27 | 2018-02-08 | The Board Of Trustees Of The University Of Illinois | Engineering T-cell receptors |
| KR102618267B1 (ko) | 2014-05-29 | 2023-12-27 | 더 유나이티드 스테이츠 오브 어메리카, 애즈 리프리젠티드 바이 더 세크러테리, 디파트먼트 오브 헬쓰 앤드 휴먼 서비씨즈 | 항-인유두종바이러스 16 e7 t 세포 수용체 |
| EP3172325B1 (de) | 2014-07-22 | 2023-06-28 | The University of Notre Dame du Lac | Molekulare konstrukte und verwendungen davon |
| NL2014935B1 (en) | 2015-06-08 | 2017-02-03 | Applied Immune Tech Ltd | T cell receptor like antibodies having fine specificity. |
| GB201516277D0 (en) | 2015-09-15 | 2015-10-28 | Adaptimmune Ltd And Immunocore Ltd | TCR libraries |
| GB201516272D0 (en) * | 2015-09-15 | 2015-10-28 | Adaptimmune Ltd And Immunocore Ltd | TCR Libraries |
| EP3211003A1 (de) * | 2016-02-24 | 2017-08-30 | Institut Pasteur | T-zell-rezeptoren aus dem hiv-spezifischen repertoire, mittel zu deren herstellung und therapeutische verwendung davon |
| GB201604953D0 (en) * | 2016-03-23 | 2016-05-04 | Immunocore Ltd | T cell receptors |
| RS63371B1 (sr) | 2016-04-08 | 2022-08-31 | Immunocore Ltd | T ćelijski receptori |
| DE102017115966A1 (de) * | 2017-07-14 | 2019-01-17 | Immatics Biotechnologies Gmbh | Polypeptidmolekül mit verbesserter zweifacher Spezifität |
| CR20200013A (es) | 2017-07-14 | 2020-03-11 | Immatics Biotechnologies Gmbh | Molécula de polipéptido con especificidad dual mejorada |
| EP4252759A3 (de) * | 2018-05-11 | 2023-11-08 | Memorial Sloan Kettering Cancer Center | Gegen pik3ca-mutationen gerichtete t-zell-rezeptoren und verwendungen davon |
| WO2020028595A2 (en) * | 2018-07-31 | 2020-02-06 | Janux Therapeutics, Inc. | Inhibitory t cell receptor peptides and discovery methods |
| US12103971B2 (en) | 2022-02-20 | 2024-10-01 | Immunocore Limited | HIV specific binding molecules |
| IL314832A (en) * | 2022-02-20 | 2024-10-01 | Immunocore Ltd | TCR and HIV-specific binding molecules |
| WO2024038165A1 (en) | 2022-08-18 | 2024-02-22 | Immunocore Ltd | T cell receptor fusion proteins specific for mage a4 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6759243B2 (en) * | 1998-01-20 | 2004-07-06 | Board Of Trustees Of The University Of Illinois | High affinity TCR proteins and methods |
| JP2002515244A (ja) | 1998-05-19 | 2002-05-28 | アヴィデックス リミテッド | 可溶性ｔ細胞受容体 |
| PL208712B1 (pl) | 2001-08-31 | 2011-05-31 | Avidex Ltd | Rozpuszczalny receptor komórek T (sTCR), rozpuszczalna αβ-postać receptora komórek T (sTCR), wielowartościowy kompleks receptora komórek T (TCR), sposób wykrywania kompleksów MHC-peptyd, środek farmaceutyczny zawierający sTCR i/lub wielowartościowy kompleks TCR, cząsteczka kwasu nukleinowego, wektor, komórka gospodarz, sposób otrzymywania całości lub części łańcucha α TCR albo całości lub części łańcucha β TCR, sposób otrzymywania rozpuszczalnego receptora komórek T (sTCR), sposób otrzymywania rozpuszczalnej αβ-postaci receptora komórek T (sTCR) oraz sposób wykrywania kompleksów MHC-peptyd |
| US7751825B2 (en) | 2002-06-27 | 2010-07-06 | Qualcomm Incorporated | Controlling geographic location information of devices operating in wireless communication systems |
| AU2003271904B2 (en) | 2002-10-09 | 2009-03-05 | Adaptimmune Limited | Single chain recombinant T cell receptors |
| JP4975324B2 (ja) * | 2002-11-09 | 2012-07-11 | イムノコア リミテッド | Ｔ細胞レセプターディスプレイ |
| JP4972549B2 (ja) * | 2004-05-19 | 2012-07-11 | イムノコア リミテッド | Ｔ細胞レセプターを改善する方法 |
-
2006
- 2006-03-29 NZ NZ561338A patent/NZ561338A/en not_active IP Right Cessation
- 2006-03-29 JP JP2008503585A patent/JP2008535826A/ja active Pending
- 2006-03-29 EP EP15171918.4A patent/EP2985291B1/de not_active Not-in-force
- 2006-03-29 HU HUE10008612A patent/HUE032037T2/en unknown
- 2006-03-29 PL PL10008612T patent/PL2275441T3/pl unknown
- 2006-03-29 EP EP10008612.3A patent/EP2275441B8/de active Active
- 2006-03-29 EP EP06726555A patent/EP1863842A2/de not_active Withdrawn
- 2006-03-29 NZ NZ584523A patent/NZ584523A/en not_active IP Right Cessation
- 2006-03-29 ES ES15171918T patent/ES2699320T3/es active Active
- 2006-03-29 ES ES10008612.3T patent/ES2599010T3/es active Active
- 2006-03-29 LT LTEP10008612.3T patent/LT2275441T/lt unknown
- 2006-03-29 PT PT100086123T patent/PT2275441T/pt unknown
- 2006-03-29 DK DK10008612.3T patent/DK2275441T3/en active
- 2006-03-29 CA CA2602463A patent/CA2602463C/en not_active Expired - Fee Related
- 2006-03-29 AU AU2006228308A patent/AU2006228308B2/en not_active Ceased
- 2006-03-29 CN CN201510785932.6A patent/CN105461802A/zh active Pending
- 2006-03-29 CN CN201210563915.4A patent/CN103059128B/zh not_active Expired - Fee Related
- 2006-03-29 EP EP10014971A patent/EP2301964A1/de not_active Withdrawn
- 2006-03-29 US US11/887,536 patent/US8378074B2/en not_active Expired - Fee Related
- 2006-03-29 SI SI200632107A patent/SI2275441T1/sl unknown
- 2006-03-29 WO PCT/GB2006/001147 patent/WO2006103429A2/en active Application Filing
-
2012
- 2012-03-06 JP JP2012049174A patent/JP5612623B2/ja not_active Expired - Fee Related
-
2013
- 2013-01-03 US US13/733,545 patent/US9255135B2/en not_active Expired - Fee Related
-
2014
- 2014-05-01 JP JP2014094723A patent/JP5885220B2/ja not_active Expired - Fee Related
-
2016
- 2016-10-26 CY CY20161101092T patent/CY1118160T1/el unknown
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