EP2228373A4 - PROCÉDÉ DE FABRICATION DE 4'-ÉTHYNYL-d4T - Google Patents

PROCÉDÉ DE FABRICATION DE 4'-ÉTHYNYL-d4T

Info

Publication number
EP2228373A4
EP2228373A4 EP08869172A EP08869172A EP2228373A4 EP 2228373 A4 EP2228373 A4 EP 2228373A4 EP 08869172 A EP08869172 A EP 08869172A EP 08869172 A EP08869172 A EP 08869172A EP 2228373 A4 EP2228373 A4 EP 2228373A4
Authority
EP
European Patent Office
Prior art keywords
ethynyl
producing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP08869172A
Other languages
German (de)
English (en)
Other versions
EP2228373A1 (fr
EP2228373B1 (fr
Inventor
Katsuyuki Nagai
Shinya Kiguchi
Hiroya Koyama
Ewan William Hume
Satoshi Tsujimoto
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Oncolys Biopharma Inc
Original Assignee
Oncolys Biopharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Oncolys Biopharma Inc filed Critical Oncolys Biopharma Inc
Publication of EP2228373A1 publication Critical patent/EP2228373A1/fr
Publication of EP2228373A4 publication Critical patent/EP2228373A4/fr
Application granted granted Critical
Publication of EP2228373B1 publication Critical patent/EP2228373B1/fr
Not-in-force legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/26—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D307/30—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/32—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/26—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D307/30—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/32—Oxygen atoms
    • C07D307/33—Oxygen atoms in position 2, the oxygen atom being in its keto or unsubstituted enol form
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
EP08869172.0A 2007-12-27 2008-12-26 PROCÉDÉ DE FABRICATION DE 4'-ÉTHYNYL-d4T Not-in-force EP2228373B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007336334 2007-12-27
PCT/JP2008/073783 WO2009084655A1 (fr) 2007-12-27 2008-12-26 PROCÉDÉ DE FABRICATION DE 4'-ÉTHYNYL-d4T

Publications (3)

Publication Number Publication Date
EP2228373A1 EP2228373A1 (fr) 2010-09-15
EP2228373A4 true EP2228373A4 (fr) 2011-11-30
EP2228373B1 EP2228373B1 (fr) 2017-02-08

Family

ID=40824368

Family Applications (1)

Application Number Title Priority Date Filing Date
EP08869172.0A Not-in-force EP2228373B1 (fr) 2007-12-27 2008-12-26 PROCÉDÉ DE FABRICATION DE 4'-ÉTHYNYL-d4T

Country Status (4)

Country Link
US (1) US9051288B2 (fr)
EP (1) EP2228373B1 (fr)
JP (2) JP5511389B2 (fr)
WO (1) WO2009084655A1 (fr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011099442A1 (fr) 2010-02-15 2011-08-18 日産化学工業株式会社 Procédé de préparation de composés β-glycosides
US9212174B2 (en) * 2010-02-15 2015-12-15 Nissan Chemical Industries, Ltd. Certain β-dihydrofuran derivatives
KR20130041792A (ko) * 2010-04-07 2013-04-25 닛산 가가쿠 고교 가부시키 가이샤 아실옥시피라논 화합물의 제조방법, 알킨 화합물의 제조방법 및 디하이드로푸란 화합물의 제조방법
EP2852583A1 (fr) 2012-05-23 2015-04-01 Bristol-Myers Squibb Company Procédés utilisant une sulfilimine et un sulfoxyde pour la fabrication de festinavir
EP2986602A1 (fr) * 2013-04-16 2016-02-24 Bristol-Myers Squibb Company Procédé de production de festinavir avec de la 5-méthyluridine en tant que matière de départ
US20160130260A1 (en) 2013-06-13 2016-05-12 Bristol-Myers Squibb Company Tert-butyl sulphoxide method for producing festinavir
MX2021008751A (es) 2019-01-25 2021-11-12 Univ Brown Composiciones y metodos para tratar, prevenir o revertir la inflamacion y los trastornos asociados a la edad.
JP2023518433A (ja) 2020-03-20 2023-05-01 ギリアード サイエンシーズ， インコーポレイテッド ４’－ｃ－置換－２－ハロ－２’－デオキシアデノシンヌクレオシドのプロドラッグ並びにその製造法及び使用法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69027076T2 (de) * 1989-09-06 1996-11-28 Japan Tobacco Inc Verfahren zur Herstellung von Levoglukosenon
JPH05213926A (ja) 1992-02-03 1993-08-24 Nippon Shokubai Co Ltd ２ーフランカルボン酸の製造方法
EP1653976A4 (fr) 2003-02-19 2009-07-29 Univ Yale Analogues de nucleosides antiviraux et methodes de traitement d'infections virales, notamment d'infections a vih

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
KAZUHIRO HARAGUCHI, MASANORI SUMINO, HIROMICHI TANAKA: "Nucleophilic substitution at the 4'-position of nucleosides: new access to a promising anti-HIV agent 2',3'-didehydro-3'-deoxy-4'-ethynylthymidine", J. ORG. CHEM., vol. 71, 2006, pages 4433 - 4438, XP002660977 *
KAZUHIRO HARAGUCHI, SHINGO TAKEDA, HIROMICHI TANAKA ET AL.: "Synthesis of a highly active new anti-HIV agent 2'.3'-didehydro-3'-deoxy-4'-ethynylthymidine", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 13, 2003, pages 3775 - 3777, XP002660976 *
See also references of WO2009084655A1 *

Also Published As

Publication number Publication date
US9051288B2 (en) 2015-06-09
WO2009084655A1 (fr) 2009-07-09
JPWO2009084655A1 (ja) 2011-05-19
JP2014148506A (ja) 2014-08-21
EP2228373A1 (fr) 2010-09-15
EP2228373B1 (fr) 2017-02-08
JP5511389B2 (ja) 2014-06-04
US20100280235A1 (en) 2010-11-04

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