EP2207614A1 - Dispositif et procédé de préparation d'un mélange de liquides de préférence variable dans le temps - Google Patents

Dispositif et procédé de préparation d'un mélange de liquides de préférence variable dans le temps

Info

Publication number
EP2207614A1
EP2207614A1 EP08843040A EP08843040A EP2207614A1 EP 2207614 A1 EP2207614 A1 EP 2207614A1 EP 08843040 A EP08843040 A EP 08843040A EP 08843040 A EP08843040 A EP 08843040A EP 2207614 A1 EP2207614 A1 EP 2207614A1
Authority
EP
European Patent Office
Prior art keywords
mixing container
pump
liquid mixture
level
arrangement according
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP08843040A
Other languages
German (de)
English (en)
Inventor
Sebastian BÖCKER
Sascha Kolanos
Hendrik Schmale
Frank Behrendt
Christian Pickert
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Bayer Technology Services GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Technology Services GmbH filed Critical Bayer Technology Services GmbH
Publication of EP2207614A1 publication Critical patent/EP2207614A1/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G05—CONTROLLING; REGULATING
    • G05D—SYSTEMS FOR CONTROLLING OR REGULATING NON-ELECTRIC VARIABLES
    • G05D11/00—Control of flow ratio
    • G05D11/02—Controlling ratio of two or more flows of fluid or fluent material
    • G05D11/13—Controlling ratio of two or more flows of fluid or fluent material characterised by the use of electric means
    • G05D11/139—Controlling ratio of two or more flows of fluid or fluent material characterised by the use of electric means by measuring a value related to the quantity of the individual components and sensing at least one property of the mixture
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/20—Measuring; Control or regulation
    • B01F35/21—Measuring
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
    • B01D15/16—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the conditioning of the fluid carrier
    • B01D15/163—Pressure or speed conditioning
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
    • B01D15/16—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the conditioning of the fluid carrier
    • B01D15/166—Fluid composition conditioning, e.g. gradient
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
    • B01F23/40—Mixing liquids with liquids; Emulsifying
    • B01F23/45—Mixing liquids with liquids; Emulsifying using flow mixing
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/20—Measuring; Control or regulation
    • B01F35/21—Measuring
    • B01F35/211—Measuring of the operational parameters
    • B01F35/2112—Level of material in a container or the position or shape of the upper surface of the material
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/20—Measuring; Control or regulation
    • B01F35/22—Control or regulation
    • B01F35/221—Control or regulation of operational parameters, e.g. level of material in the mixer, temperature or pressure
    • B01F35/2212—Level of the material in the mixer
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/71—Feed mechanisms
    • B01F35/712—Feed mechanisms for feeding fluids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/75—Discharge mechanisms
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/75—Discharge mechanisms
    • B01F35/754—Discharge mechanisms characterised by the means for discharging the components from the mixer
    • B01F35/7544—Discharge mechanisms characterised by the means for discharging the components from the mixer using pumps
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/80—Forming a predetermined ratio of the substances to be mixed
    • B01F35/83—Forming a predetermined ratio of the substances to be mixed by controlling the ratio of two or more flows, e.g. using flow sensing or flow controlling devices
    • B01F35/833—Flow control by valves, e.g. opening intermittently
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F2101/00—Mixing characterised by the nature of the mixed materials or by the application field
    • B01F2101/23—Mixing of laboratory samples e.g. in preparation of analysing or testing properties of materials
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/20—Measuring; Control or regulation
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/26—Conditioning of the fluid carrier; Flow patterns
    • G01N30/28—Control of physical parameters of the fluid carrier
    • G01N30/34—Control of physical parameters of the fluid carrier of fluid composition, e.g. gradient
    • G01N2030/347—Control of physical parameters of the fluid carrier of fluid composition, e.g. gradient mixers

Definitions

  • the invention relates to an arrangement for providing a preferably time-varying liquid mixture of at least two liquids, with at least two supply lines for each supplying one of the liquids, each supply line is provided with at least one control valve for adjusting the supplied flow of the respective liquid, and with a Pump, wherein the supply lines are combined on a common pump supply line and the pump supply is guided to a suction-side connection of the pump.
  • the invention further relates to a method for providing a preferably temporally variable liquid mixture of at least two liquids.
  • time-varying liquid mixtures is z.
  • chromatography the so-called gradient procedure is frequently used, in which at least two solvents or solvent mixtures having a composition that changes with time are mixed with one another and conveyed to a chromatography column. In this way, depending on the separation problem, an improved separation result or a shortening of the retention time can be achieved.
  • this z. B. can be achieved with the help of two pumps, the one pump which promotes a solvent or solvent mixture and the other pump the other solvent or solvent mixture.
  • the two streams of the various solvents or solvent mixtures are combined on the high pressure side of the pump and mixed and then transported to the chromatography column.
  • By a corresponding adjustment and change in the pump power of the two pumps can thus be generated a solvent mixture that changes in time defined in its composition.
  • the so-called low-pressure gradient procedure is suitable.
  • the gradient described above is generated only by a single pump by the streams of solvent or solvent mixtures on the suction side of the pump are combined and mixed in time-varying composition.
  • the Niederbuchgradientenfahrweise is thus easier and less expensive to implement than the Hochdruckgradientenfahrweise, since only a common pump is required.
  • control valves and mass flow meters are generally provided in the supply lines. These are used to set the inflow of the solvents or solvent mixtures in the supply lines.
  • control valves and mass flow meters Since the control valves and mass flow meters generate a pressure loss on the suction side of the pump, a certain minimum pre-pressure must be present on the supply lines in order to avoid cavitation of the pump. It has also been shown that it can happen when adjusting the control valves in the context of a gradient mode that the sum of the Offhungs vom the control valves by a deviation or inertia of the system is too small This can also lead to cavitation of the pump. Thus, it is necessary that the control valves are very accurate and also react very quickly.
  • this object is achieved in that for merging the leads to the pumping line, a mixing container is provided, which the two supply lines are supplied and from which the pump supply line is discharged
  • the above-described object is achieved in that a mixing container is provided to which the liquids are supplied and from which the liquid mixture is fed to a suction-side connection of a pump.
  • the device according to the invention and the method according to the invention thus make possible an operating mode in which an additional "hold up" volume is introduced with the aid of the mixing vessel, which leads to an additional residence time of the liquid mixture in the mixing vessel
  • the pump used in the process according to the invention for providing a preferably time-varying liquid mixture preferably has at least the possibility of being regulated in respect of a flow signal taken off in it, in its suction-side supply line or in its discharge-side discharge.
  • a pump which has a measuring device for Determining the flow includes and their flow in terms of a control at least in response to the signal of the measuring device hm adapts to the desired value
  • the hold-up volume varies between 10 and 100% of the maximum filling volume of the mixing container
  • a regulation is provided which is at least one predetermined one
  • a minimum residence time preferably 3 seconds, preferably 6 seconds, most preferably 10 seconds, is provided for the retention time of the liquid mixture in the mixing container
  • the mixing container can follow different geometric shapes and configurations. According to a preferred embodiment of the invention, however, it is provided that the mixing container has a frusto-conical portion. Preferably, this frustoconical portion is designed such that its maximum or minimum filling essentially corresponds to the previously mentioned hold-up volume of 100%. In this way, a particularly compact mixing container, particularly a particularly short one, is achieved, since the shape of a truncated cone entails substantially lower differences in height in comparison to, for example, one exclusively tubular design of the mixing container. In principle, the mixing container can be oriented differently in its design with a truncated cone-shaped section in operation.
  • the mixing container is oriented during operation in such a way that the frustoconical portion widens upwards.
  • the supply lines for supplying the liquids to the mixing container are fed in an upper area.
  • this z. Example be realized in that the leads are felt through a flange, which practically forms an upper "lid" for the mixing container
  • the pump line discharged from the mixing container in a lower region This can be realized, for example, such that the "bottom" of the mixing container is formed by a, typically smaller, flange.
  • the pumping line can then be led away from the mixing container by the flange which forms the "bottom” a further flange mounted on the side of the lower portion of the outlet end of the frusto-conical mixing container If the discharge of the pumping line from the mixing container takes place through a flange forming the "bottom", the outlet can be in relation to the axis of symmetry of the Truncated cone staggered arrangement take place n, in order to create space for optionally at the "bottom" to be mounted
  • the mixing container acts practically as a decoupling of the pump from the control valves.
  • the mixing container is vented, preferably vented upwards.
  • the mixing container is depressurized and cavitation of the pump is avoided by the decoupling achieved thereby.
  • the operation of the arrangement according to the invention or the use of the method according to the invention without level measurement in the mixing container is possible.
  • the inventive method thus thus includes a level measurement of the liquid mixture in Mischbehalter means of at least one Golfstandsmessein ⁇ chtung.
  • a "overflow” and / or a "run-empty” of the mixing container can be avoided by appropriate regulation.
  • the level measurement can be carried out continuously borrowed and / or by discontinuous procedures such as an input and / or Multi-point full-level measurement can be realized with at least one upper and / or at least one lower limit switch.
  • the filling level measurement is carried out continuously, z B by a continuous level measurement, which is characterized by a arranged as a bypass level measuring tube, or by a continuous level measurement, which directly determines the level of the mixing container by mounting a level sensor on the mixing vessel , so that both arrangements output a continuous signal with respect to the level.
  • the continuous level measurement is preferred because a continuous signal in the sense of a later-to-use control mechanism allows a high setting accuracy and control speed.
  • the speed describes the rate of approximation of an actual value determined by a measuring device, eg a foot-mounted measuring device, to one Target value, which is specified as a value and / or obtained by another measuring device after suitable conversion, by changing another process parameter.
  • a level sensor for mounting on the mixing container for the direct determination of the level of the mixing container can be e.g. horizontally upward ultrasonic sensors mounted on the "bottom” of the mixing vessel, pressure sensors mounted on the “bottom” of the mixing vessel, or inductive sensors using a float. Preference is given to the "bottom” of the mixing container mounted, horizontally upwardly directed ultrasonic sensors.
  • the level measurement is carried out by means of two one-point level measuring devices in the form of a two-point level measurement
  • the one-point Greinttung is vertically above the other one-point level measuring device in and / or on the mixing container.
  • the one-point Fullstandsmessein ⁇ chtitch give a binary signal on the presence of liquid in one of their vertical orientation on the mixing vessel corresponding horizontal level So "overflow” and “emptying" of Mischbehalters be avoided by appropriate regulation.
  • the two-point level measurement is preferred because, compared to the continuous floor level measurement, it achieves less setting accuracy and control speed, but is economically advantageous due to the simpler embodiment of the level measuring devices
  • a particularly preferred development of the invention combines a one-point level measurement to avoid "overflow" with a continuous level measurement.
  • GE measure a preferred embodiment of the invention can, for. B. be provided that at least one of the control valves of the supply lines in each case depending on the signal or the signals from the at least one level measuring device continuously and / or discontinuously change the inflow.
  • a continuous change of the inflow through at least one of the control valves in the present case comprises the continuous adjustment of the volume and / or mass flow through at least one of the control valves, e.g. by continuously changing the free flow cross section in the control valve, as a function of continuous and / or binary signals of the at least one fill level measuring device.
  • a discontinuous change of the inflow through at least one of the control valves comprises in the present case the binary adjustment of the volume and / or mass flow through at least one of the control valves by m dependence of continuous and / or binary signals of at least one level measuring device at least one of the control valves Switches between two flow settings, so that a flow results from the time average of the two flow settings.
  • a non-exhaustive example of this is switching between the open and closed states of at least one of the control valves so that a mean flow rate is proportional to the ratio of the open to the closed state.
  • the pump is additionally controlled in terms of their capacity in response to the detected by the at least one level measuring device level of the liquid mixture in the mixing vessel.
  • This type of regulation of the volume and / or mass flow would be carried out by a person skilled in the art in terms of a feedforward control to the flow control of the pump.
  • Level of the liquid mixture in the mixing container is regulated by means of the control valves and / or the pump.
  • z. B. by means of the level measurement of the inflow of liquids via provided in the supply lines mass flow meter and control valves are regulated (Flow control), while in the outflow, the flow rate of the pump is controlled.
  • Flow control Flow control
  • the flow rate of the pump is controlled.
  • a cascade control with level on flow-controlled pumps is possible.
  • Fig. 1 shows schematically an arrangement according to a first preferred embodiment of the invention for providing a preferably time-varying solvent mixture for a chromatographic separation process in Niederdruckgradientenfahrweise and
  • FIG. 2 schematically shows an arrangement according to a second preferred embodiment of the invention for providing a time-varying solvent mixture for a low-pressure gradient-type chromatographic separation process.
  • FIG. 1 schematically shows an arrangement for providing a time-varying solvent mixture for a low-pressure gradient-type chromatographic separation process according to a first preferred exemplary embodiment of the invention.
  • the two solvents are fed via two supply lines 1, 2 to a mixing container 3.
  • In the supply lines 1, 2 are each a mass flow meter 4, 5 and a control valve 6, 7. In this way, the respective inflow of the various solvents can be adjusted in the mixing container 3.
  • the supply lines 2, 3 are passed through a lid flange 8 which closes the mixing container 3 at the top. In this way, the supply of the two solvents takes place in the mixing container from above. Through the cover flange 8, a venting tube 9 is also passed, so that a non-pressure mixing container 3 is achieved.
  • the mixing container 3 itself has a central portion 10, which follows substantially the shape of a truncated cone. In its lower part of the mixing container 3 is closed by means of a bottom flange 15, through which a leading to a pump 11 pumping line 12 is discharged.
  • the pump supply line 12 is offset relative to the axis of symmetry of the mixing container, so that a level gauge 17 is also mounted and the pumping line 12 is connected saugsei tig to the pump 11 so that a required through the mixing container 3 through the solvent mixture by means of the pump 11 of a chromatography column 13 can be supplied.
  • the filling level meter may comprise an Em-point level measuring device, giving a binary signal, or a continuously operating level measuring device, giving a continuous signal.
  • the mixing container 3 further includes a level limit switch 14. This detects the maximum level of the solvent mixture in the mixing container 3, so that it can be ensured that the level reaches a maximum of the height of the level limit switch 14. In this way, overflow of the mixing container 3 can be reliably prevented.
  • the "emptying" of the mixing container can be prevented by regulation according to the signal or the signals originating from the level gauge 17.
  • the procedure is now such that a predetermined residence time of the solvent mixture in the mixing container 3 is achieved by means of a suitable control method.
  • the residence time in the mixing vessel 3 is preferably at least 10 seconds.
  • the volume flow of the pump 11, which conveys the solvent mixture from the mixing vessel 3 to the chromatography column 13 it is preferable to ensure identical residence times in the mixing vessel 3, so that the same process conditions prevail even with different, adjusted pumping powers.
  • FIG. 2 an arrangement for providing a time-varying solvent mixture according to a second preferred embodiment of the invention can be seen.
  • no level gauge 17 is provided on the bottom flange 15 of the mixing container 3, but it is provided in a bypass circuit, a level tube 16 with a level gauge 17.
  • This construction as a filling tube 16 in bypass circuit has the advantage that fluctuations in the filling level in the mixing container 3, z. B. due to the supply of the two liquids are attenuated, so that in general a stable reading for the level can be determined.
  • a level limit switch 14 is still provided.
  • the level measurement described above not only ensures that the mixing container 3 is not empty or overflow, but at the same time the control of Inflow of the solvents via the mass flow meters 4, 5 and the control valves 6, 7.
  • the delivery rate of the pump 11 is controlled by a flow measurement in the pump.
  • a disturbance size switching by the level on the flow-controlled pump 11 is possible, as previously mentioned.
  • the invention can be used in particular whenever a liquid mixture which is variable in time, in particular, is to be realized with only a single pump.
  • the device according to the invention and the method according to the invention up to a quaternary gradient can be implemented in a reliable manner.
  • the invention can of course be used for any number of leads to the mixing vessel.

Landscapes

  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Engineering & Computer Science (AREA)
  • Automation & Control Theory (AREA)
  • Accessories For Mixers (AREA)
  • Feeding, Discharge, Calcimining, Fusing, And Gas-Generation Devices (AREA)

Abstract

L'invention concerne un dispositif et un procédé de préparation d'un mélange d'au moins deux liquides de préférence variable dans le temps. Le dispositif comporte au moins deux conduites d'amenée (1, 2) pour l'amenée respective d'un liquide, chaque conduite d'amenée (1, 2) étant pourvue d'au moins une soupape de régulation (4, 5) pour le réglage du débit de liquide respectif transporté; et une pompe (11). Les conduites d'amenée sont réunies sur une conduite d'amenée de pompe commune (12) qui est guidée sur une connexion côté aspiration de la pompe (11). Selon l'invention, un contenant de mélange (3) est prévu pour la réunion des conduites d'amenée (1, 2) sur la conduite de pompe (12), les deux conduites d'amenée (1, 2) aboutissant dans ledit contenant de mélange et la conduite d'amenée de pompe (12) s'étendant à partir de celui-ci. De cette manière, il est possible d'obtenir par exemple une séparation chromatographique fiable en mode à gradients basse pression.
EP08843040A 2007-10-18 2008-10-07 Dispositif et procédé de préparation d'un mélange de liquides de préférence variable dans le temps Withdrawn EP2207614A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102007050335A DE102007050335A1 (de) 2007-10-18 2007-10-18 Anordnung und Verfahren zur Bereitstellung eines vorzugsweise zeitlich veränderlichen Flüssigkeitsgemisches
PCT/EP2008/008453 WO2009052943A1 (fr) 2007-10-18 2008-10-07 Dispositif et procédé de préparation d'un mélange de liquides de préférence variable dans le temps

Publications (1)

Publication Number Publication Date
EP2207614A1 true EP2207614A1 (fr) 2010-07-21

Family

ID=40254340

Family Applications (1)

Application Number Title Priority Date Filing Date
EP08843040A Withdrawn EP2207614A1 (fr) 2007-10-18 2008-10-07 Dispositif et procédé de préparation d'un mélange de liquides de préférence variable dans le temps

Country Status (3)

Country Link
EP (1) EP2207614A1 (fr)
DE (1) DE102007050335A1 (fr)
WO (1) WO2009052943A1 (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2819114A1 (fr) * 2010-11-30 2012-06-07 Ge Healthcare Bio-Sciences Ab Pompe de chromatographie
CA3182539A1 (fr) 2018-07-10 2020-01-16 Precision Planting Llc Systeme d'echantillonnage agricole et procedes associes
EP4357009A1 (fr) * 2022-10-17 2024-04-24 Sartorius Stedim Biotech GmbH Procédé et appareil de fonctionnement d'un processus en aval continu

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2011268A (en) * 1977-11-09 1979-07-11 Advanced Water Services Ltd Mixing of two liquids
DE2905160C2 (de) 1979-02-10 1981-01-08 Hewlett-Packard Gmbh, 7030 Boeblingen Vorrichtung für die Erzeugung von Elutionsmittelgradienten in der Flüssigkeitschromatographie
JPS57204453A (en) * 1981-06-12 1982-12-15 Japan Spectroscopic Co Preparation of eluate in liquid chromatography
EP0231566A1 (fr) 1986-02-05 1987-08-12 Magnetopulse Ltd. Chromatographie liquide
KR930008856B1 (ko) * 1991-05-15 1993-09-16 금성일렉트론 주식회사 혼합용액의 일정비율 혼합장치
DE10351087A1 (de) * 2003-10-31 2005-05-25 Bayer Technology Services Gmbh Feste Wirkstoff-Formulierung

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See references of WO2009052943A1 *

Also Published As

Publication number Publication date
WO2009052943A1 (fr) 2009-04-30
DE102007050335A1 (de) 2009-04-23

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