EP2207539A1 - Haut- und oberflächendesinfizierende zusammensetzungen mit botanischen stoffen - Google Patents

Haut- und oberflächendesinfizierende zusammensetzungen mit botanischen stoffen

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Publication number
EP2207539A1
EP2207539A1 EP08797057A EP08797057A EP2207539A1 EP 2207539 A1 EP2207539 A1 EP 2207539A1 EP 08797057 A EP08797057 A EP 08797057A EP 08797057 A EP08797057 A EP 08797057A EP 2207539 A1 EP2207539 A1 EP 2207539A1
Authority
EP
European Patent Office
Prior art keywords
weight
oil
percent
composition
concentration
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP08797057A
Other languages
English (en)
French (fr)
Other versions
EP2207539A4 (de
Inventor
Shanta M. Modak
Nayana Baiju
Lauserpina A. Caraos
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Columbia University in the City of New York
Original Assignee
Columbia University in the City of New York
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Filing date
Publication date
Priority claimed from US12/016,788 external-priority patent/US20090035228A1/en
Priority claimed from US12/134,918 external-priority patent/US9511040B2/en
Application filed by Columbia University in the City of New York filed Critical Columbia University in the City of New York
Publication of EP2207539A1 publication Critical patent/EP2207539A1/de
Publication of EP2207539A4 publication Critical patent/EP2207539A4/de
Withdrawn legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
    • A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/0208—Tissues; Wipes; Patches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34—Alcohols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34—Alcohols
    • A61K8/345—Alcohols containing more than one hydroxy group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/36—Carboxylic acids; Salts or anhydrides thereof
    • A61K8/365—Hydroxycarboxylic acids; Ketocarboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
    • A61Q11/02—Preparations for deodorising, bleaching or disinfecting dentures
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q15/00—Anti-perspirants or body deodorants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/005—Antimicrobial preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/002—Aftershave preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/10—Washing or bathing preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q5/00—Preparations for care of the hair
    • A61Q5/02—Preparations for cleaning the hair
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q5/00—Preparations for care of the hair
    • A61Q5/12—Preparations containing hair conditioners
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/16—Organic compounds
    • C11D3/20—Organic compounds containing oxygen
    • C11D3/2003—Alcohols; Phenols
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/16—Organic compounds
    • C11D3/20—Organic compounds containing oxygen
    • C11D3/2075—Carboxylic acids-salts thereof
    • C11D3/2086—Hydroxy carboxylic acids-salts thereof
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/16—Organic compounds
    • C11D3/38—Products with no well-defined composition, e.g. natural products
    • C11D3/382—Vegetable products, e.g. soya meal, wood flour, sawdust
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/48—Medical, disinfecting agents, disinfecting, antibacterial, germicidal or antimicrobial compositions
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D7/00—Compositions of detergents based essentially on non-surface-active compounds
    • C11D7/22—Organic compounds
    • C11D7/26—Organic compounds containing oxygen
    • C11D7/261—Alcohols; Phenols
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D7/00—Compositions of detergents based essentially on non-surface-active compounds
    • C11D7/22—Organic compounds
    • C11D7/26—Organic compounds containing oxygen
    • C11D7/265—Carboxylic acids or salts thereof
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D7/00—Compositions of detergents based essentially on non-surface-active compounds
    • C11D7/22—Organic compounds
    • C11D7/40—Products in which the composition is not well defined
    • C11D7/44—Vegetable products

Definitions

  • the present invention relates to a skin or surface disinfectant composition with broad spectrum antimicrobial activity comprising one or more essential oil (and/or one or more component thereof) and one or more fruit acid.
  • the compositions of the invention may be used as non-toxic alternatives to conventional disinfectants or may be combined with other antimicrobial agents to enhance their activity.
  • the invention provides effective alternatives to harsher products, and may be particularly useful in personal care and household product applications and where children and/or pet exposure may be a concern. 2. BACKGROUND OF THE INVENTION
  • Essential oils are volatile oils obtained from plant or animal sources and are composed of complex mixtures of several constituents, such as monoterpenes and sesquiterpene hydrocarbons, monoterpene and sesquiterpene alcohols, esters, ethers, aldehydes, ketones, oxides and the like. These essential oils and their isolated constituents are frequently utilized as fragrance and flavor agents, and have been widely used in folk medicine for wound healing properties.
  • Essential oils of eucalyptus have been found to "possess central and peripheral analgesic effects as well as neutrophil-dependent and independent anti-inflammatory activities" (Silva et al., 2003, J. Ethnopharmacol. 89(2-3);277-283), and similar activity has been observed in essential oils from Lavendula angustifolia Mill. (Hajhashemi et al., 2003, J. Ethnopharmacol. 89(1):67-71). Essential oils have been demonstrated to exhibit antibacterial (Bezic et al., 2003, Phytother. Res. 17(9 :1037- 1040; Goren et al., 2003, Z.
  • Virucidal activity of essential oils has also been observed, including direct virucidal effects against Herpes simplex viruses types 1 and 2 (Garcia et al., Phytother. Res. 17(9): 1073-1075; Minami et al., 2003, Microbial Immunol. 47(a):681-684; Schuhmacher et al., 2003, Phytomedicine 10:504- 510).
  • United States Patent Application Publication No. 20050048139 by Modak et al., published March 3, 2005 relates to topical compositions comprising an emollient solvent and an essential oil, which may further comprise additional additives, among which citric acid, glycolic acid and lactic acid are cited. It does not recognize the synergistic activity between essential oils and fruit acids nor does it disclose the concentrations of fruit acids to be used to provide a synergistic effect.
  • United States Patent Application Publication No. 20050019431 by Modak et al., published January 27, 2005 relates to compositions comprising a quaternary ammonium compound and an essential oil (or active component thereof).
  • a number of patent applications relate to compositions comprising an essential oil (or component thereof) where zinc salts are added to inhibit irritation associated with essential oils. Examples of such patent applications include United States Patent Application Publication No. 20040102429 by Modak et al., published May 27, 2004 and United States Patent Application Publication No. 20050238602 by Modak et al., published October 27, 2005.
  • United States Patent No. 5,310,546 by Douglas, issued May 10, 1994 relates to a mouthrinse preparation comprising hydrogen peroxide, zinc chloride, sodium citrate, sodium lauryl sulfate, citric acid and ethanol and optionally an essential oil which is a denaturing agent.
  • BiON offers several skin care products comprising citric acid, botanicals, and other agents for topical use (San Diego, CA, US).
  • Johnson et al. U.S. Pat. No. 6,319,958 and US20020165130
  • sesquiterpenoids to promote uptake of exogenous antimicrobial compounds.
  • a related article discloses the use of sesquiterpenoids, such as nerolidol, farnesol, bisabolol and apritone, in enhancing bacterial permeability and susceptibility to exogenous antimicrobial compounds, suggesting that sesquiterpenoids have a non-specific and general effect (Brehm-Stecher et al.
  • United States Patent No. 6,753,305 by Raso and Caselli, issued June 22, 2004, relates to a hard surface disinfectant comprising up to 20 percent of cinnamon oil or a component thereof, 0.01-5 percent of an organic acid, and optionally an additional essential oil.
  • the present invention relates to a skin or surface disinfectant composition with broad spectrum antimicrobial activity comprising one or more essential oil (and/or one or more component (i.e. , an "Individual Constituent" or "IC") thereof) and one or more fruit acid. It is based, at least in part, on the discovery that a combination of an essential oil or component thereof together with a fruit acid can confer superior antimicrobial properties on personal care, veterinary, as well as household products.
  • the compositions of the invention further comprise up to about 20 percent alcohol, which facilitates the solubilization of the essential oil(s)/IC(s) and fruit acid.
  • Certain embodiments are also based, at least in part, on the discovery that further addition of an alkanediol, particularly a bifunctional fatty alcohol, enhances antimicrobial activity still more.
  • the present invention may be utilized in personal care products such as soaps, scrubs, cosmetics, creams and lotions, wound care products, and veterinary products such as pet shampoos, therapeutic ointments , and pet cleansing wipes.
  • the present invention may be utilized in household products such as general purpose cleaning fluids, spray cleaners, laundry detergents, food washes, etc.
  • the compositions of the invention may be used as non-toxic alternatives to conventional disinfectants or may be combined with to other antimicrobial agents to enhance their activity.
  • the invention provides effective alternatives to harsher products which may be particularly useful in personal care and household products and where children and/or pet exposure may be a concern.
  • compositions comprising alkanediols; (4.6) personal care products;
  • Essential oils are volatile oils obtained from plant or animal sources, or their synthetic equivalents, and are composed of complex mixtures of several constituents as monoterpenes and sesquiterpene hydrocarbons, monoterpene and sesquiterpene alcohols, esters, ethers, aldehydes, ketones, oxides and the like.
  • Examples of EOs include, but are not limited to, cinnamon oil, basil oil, bergamot oil, clary sage oil, ylang-ylang oil, neroli oil, sandalwood oil, frankincense oil, ginger oil, peppermint oil, lavender oil, jasmine absolute, geranium oil bourbon, spearmint oil, clove oil, patchouli oil, rosemary oil, rosewood oil, sandalwood oil, tea tree oil, vanilla oil, lemongrass oil, cedarwood oil, balsam oils, tangerine oil, Hinoki oil, Hiba oil, ginko oil, eucalyptus oil, lemon oil, orange oil, sweet orange oil, and calendula oil.
  • the EO is selected from one or more EO from the group consisting of cinnamon oil (bark or leaf), lemongrass oil, citronella oil, basil oil, and orange oil.
  • Individual constituents ("ICs") of essential oils may be isolated from the oil (natural) or entirely or partially synthetic, and include, but are not limited to, curcumin, 1-citronellol, ⁇ -amylcinnarnaldehyde, lyral, geraniol, farnesol, hydroxycitronellal, isoeugenol, eugenol, camphor, eucalyptol, linalool, citral, thymol, limonene and menthol.
  • ICs include sesquiterpenoid compounds, which may be the active compounds in the essential oils.
  • Sesquiterpenoid compounds containing 15 carbons, are formed biosynthetically from three 5-carbon isoprene units.
  • Sesquiterpenoid compounds include, but are not limited to, farnesol, nerolidol, bisabolol, apritone, chamazulene, santalol, zingiberol, carotol, and caryophyllen.
  • Mixtures of one or more EO, one or more IC, and one or more EO as well as one or more IC are encompassed by the present invention.
  • an IC is selected from the (non-limiting) group consisting of camphor, curcumin, alpha-pinene, constituents of cinnamon leaf oil such as, cinnamaldehyde, cinnamylacetic ester, cinnamic acid, ethyl cinnamate, methyl chavicol, linalool, beta-caryophyllene, and eugenol; constituents of leniongrass oil such as d-limonene, geranyl acetate, nerol, geraniol, citral, and/or myrcene; constituents of citronella oil such as geraniol, citronellol, citronellal, geranyl acetate, limonene, methyl isoueugenol, and/or elemol; components of basil oil such as camphor, limonene, and/or ⁇ -selinene
  • An EO or IC for use in the invention may be obtained from its natural source or may be chemically synthesized.
  • Fruit acids which may be used according to the invention include but are not limited to citric acid, glycolic acid, lactic acid, malic acid, tartaric acid and acetic acid.
  • the fruit acid is citric acid.
  • a fruit acid for use in the invention may be obtained from its natural source or may be chemically synthesized.
  • bifunctional alcohols which may be used according to the present invention are alkanediols.
  • Suitable alkanediols include, but are not limited to, dodecanediol, decanediol, nonanediol, octanediol, heptanediol, hexanediol and pentanediol.
  • the alkanediols have a carbon backbone of between 9 and 25 carbon atoms, including but not limited to 1,9
  • the preferred alkanediols are 1,2-Decanediol, 1,10-Decanediol, 1 ,2-Dodecanediol, 1,12-Dodecanediol, Cyclododecanediol, 1,13- Tridecanediol, 1,2-Tetradecanediol, 1,14-Tetradecanediol and the most preferred alkanediols are 1,2-Decanediol, 1 ,2-Dodecanediol and 1,2-Tetradecanediol.
  • compositions comprising a combination of one or more essential oil (and/or one or more IC thereof) and one or more fruit acid.
  • this combination produces a synergistic anti-microbial effect against at least one microbe selected from the group consisting of Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, methicillin-resistant S. aureus, and Candida albicans ("synergistic" means that the antimicrobial effect of the combination is greater than the sum of the antimicrobial effects of the individual components).
  • the compositions comprise between about 0.1 and 1.2 percent (weight/weight) or between 0.1 and 1.0 percent (weight/weight) ("w/w") of one or more essential oils, one or more ICs, or a combination thereof (where a combination is used, the total of essential oil(s) and/or IC(s) is between about 0.1 and 1.0 percent (weight/weight) and between about 0.125 and 2.0 percent (weight/weight) of one or more fruit acid (where more than one fruit acid is used, the total amount of fruit acids present is between about 0.125 and 2.0 percent (weight/weight)).
  • "About” as used in this document means plus or minus 20 percent of the recited value, so that, for example, "between about 0.125 and 1.0 percent” means a range between 0.125 + .025 and 1.0 + 0.2.
  • the present invention provides for concentrates of essential oil/IC/fhiit acid combinations which are concentrated and may be diluted to provide a composition for personal, household, or industrial use.
  • the ratio of fruit acid to essential oil(s)/IC(s) is between about 1 and 16, for example, but not by way of limitation, fruit acid(s): EO(s)/IC(s) of between about 1:1 to 10:1, inclusive (weight/weight).
  • the present invention further provides for methods of providing an antimicrobial effect to a surface comprising applying, to the surface, an effective amount of a composition as described herein.
  • An antimicrobial effect means killing and/or inhibiting the growth/proliferation of a microbe.
  • the microbe is selected from the group consisting of from the group consisting of Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, methicillin-resistant S". aureus, and Candida albicans.
  • the composition is exposed to the surface for at least 20 seconds, at least 30 seconds, or at least 60 seconds, or at least 5 minutes or at least 10 minutes.
  • the surface may be the a skin or mucosal surface, a household surface ⁇ e.g., a surface of a countertop, Table sink, toilet, wall, floor, appliance, window, shower surface, rug, upholstery, fabric, etc.) or an industrial surface ⁇ e.g., a surface of a countertop, Table sink, toilet, wall, floor, appliance, window, shower surface, rug, upholstery, fabric, etc.).
  • a household surface e.g., a surface of a countertop, Table sink, toilet, wall, floor, appliance, window, shower surface, rug, upholstery, fabric, etc.
  • an industrial surface e.g., a surface of a countertop, Table sink, toilet, wall, floor, appliance, window, shower surface, rug, upholstery, fabric, etc.
  • the present invention provides for a composition
  • a composition comprising a component selected from the group consisting of cinnamon oil, cinnamaldehyde, eugenol, cinnamylacetic ester, and cinnamic acid, at a concentration of between about 0.1 and 1.2 percent (weight/weight) or between about 0.2 and 0.6 percent (weight/weight), as well as citric acid at a concentration of between about 0.5 and 1.5 percent (weight/weight), optionally further comprising triclosan at a concentration of between about 0.05 and 3 percent (weight/weight) or between about 0.05 and 0.1 percent (weight/weight) (this range, and all ranges herein, inclusive).
  • the EO/IC is not cinnamon oil or pine oil or an IC thereof.
  • the present invention provides for compositions comprising a EO/IC mixture comprising two or more EO or IC from the group consisting of cinnamon oil or an IC thereof, lemongrass oil and/or an IC thereof, orange oil and/or an IC thereof, basil oil and/or an IC thereof, and citronella oil and/or an IC thereof, at a total EO/IC concentration of between about 0.1 and 1 percent (weight/weight); together with one or more fruit acid (preferably citric acid), at a total fruit acid concentration of between about 0.125 and 2 percent (weight/weight); and an alcohol (preferably ethanol at a concentration of between about 5-20 percent (weight/weight), optionally further comprising triclosan at a concentration of between about 0.05 and 3 percent (weight/weight) or between about 0.05 and 0.1 percent (weight/weight), where the ratio of EO/IC to fruit acid is between about 1 : 1 to about 1 :10.
  • the EO/IC is not cinnamon oil or pine oil
  • the present invention provides for compositions comprising a EO/IC mixture comprising lemongrass oil and/or an IC thereof, orange oil and/or an IC thereof, and optionally one or more additional EO and/or IC, at a total EO/IC concentration of between about 0.1 and 1 percent (weight/weight); together with one or more fruit acid (preferably citric acid), at a total fruit acid concentration of between about 0.125 and 2 percent; and an alcohol (preferably ethanol) at a concentration of between about 5-20 percent (weight/weight), optionally further comprising triclosan at a concentration of between about 0.05 and 1 percent (weight/weight) or between about 0.05 and 0.3 percent (weight/weight), where the ratio of EO/IC to fruit acid is between about 1 : 1 to about 1:10.
  • a EO/IC mixture comprising lemongrass oil and/or an IC thereof, orange oil and/or an IC thereof, and optionally one or more additional EO and/or IC, at a total EO/IC concentration of between about 0.1 and 1
  • the present invention provides for compositions comprising an essential oil, a fruit acid, an alcohol which is not an alkanediol, and an alkanediol.
  • the carbon backbone of the alkanediol has between 9 and 25 carbon atoms.
  • the present invention provides for compositions comprising (i) between about 0.2 and 0.7 percent (weight/weight) of one or more essential oil as set forth above and preferably selected from the group consisting of lemongrass, cinnamon oil, citronella oil, basil oil, orange oil and combinations thereof; (ii) a non-alkanediol alcohol solvent at a concentration between about 0.5 and 20 percent (weight/weight); (iii) an amount of alkanediol which increases the antimicrobial effect, for example at a concentration between about 0.3 and 1.0 percent (weight/weight), and (iv) one or more fruit acid at a total concentration between about 0.125 and 2.0 percent (weight/weight).
  • the preferred essential oils are the ones that show significant enhancement of antimicrobial activity in combination with citric acid. These oils include one or more selected from lemongrass oil, cinnamon oil, basil oil and citronella oil (preferably at a total concentration of between about 0.2 and 0.7 percent (weight/weight), with the optional further addition of orange oil to reduce the pungent odor of the other essential oils and to provide a fragrance which is mild and pleasant.
  • Fruit acids which may be used in such compositions include citric acid or lactic acid (preferably citric acid) at a concentration between about 0.5 and 1.0 percent (weight/weight).
  • non-alkanediol alcohols for solubilisation of both essential oils and citric acid are aliphatic alcohols having carbon atoms about 1 to 8 such as methanol, ethanol, n-propanol, isopropyl alcohol, 2- methyl-2 propanol, hexanol, or combinations thereof, at a concentration of between about 5 and 20 percent (weight/weight).
  • Aromatic alcohols for example, but not by way of limitation, phenoxy ethanol, benzyl alcohol, l-phenoxy-2propanol, and/or phenethyl alcohol, for example at a concentration of between about 0.5 and 5 percent (weight/weight) may also optionally be used in combination with aliphatic alcohols.
  • a further solvent which optionally may be comprised in a composition of the invention is iso propyl myristate.
  • Most preferred aliphatic alcohols include ethanol, denatured alcohol (SDA 4OB and SDA3C) and isopropanol.
  • Most preferred aromatic alcohols include phenoxyethanol and phenethanol.
  • compositions comprising lemongrass or cinnamon oils (0.2-0.5% (weight/weight)) and orange oil (0.1-0.2% (weight/weight), exhibit a pleasant and mild fragrance. Furthermore these oils even at these lower concentrations have been observed to provide superior antibacterial activity (more than 3 log reduction when challenged with 10 colony forming unit of a gram positive pathogen (S. aureus )in combination with a secondary alcohol (0.3-1.0% (weight/weight)) and alcohol (5- 20% (weight/weight)).
  • the present invention provides for a skin or surface disinfectant composition comprising the essential oil lemongrass
  • the pH of personal care products is between about 3.5-5.0, and preferably between about 4-4.7.
  • a composition of the invention may optionally further comprise an emollient to further reduce irritation, such as, but not limited to, a fatty alcohol, behentrimonium methosulfate -cetyl alcohol (Incroquat TMS), or a polyol such as glycerol, propylene glycol, diglycerol, ethylene glycol, diethylene glycol, Methylene glycol, dipropylene glycol, tripropylene glycol, hexylene glycol, butylene glycol, etc.
  • an emollient to further reduce irritation such as, but not limited to, a fatty alcohol, behentrimonium methosulfate -cetyl alcohol (Incroquat TMS), or a polyol such as glycerol, propylene glycol, diglycerol, ethylene glycol, diethylene glycol, Methylene glycol, dipropylene glycol, tripropylene glycol, hexylene glycol, butylene glycol, etc.
  • Essential oils are volatile and therefore it is desirable that the antimicrobial composition containing essential oils is incorporated in a suitable base in which it is stable at higher temperature and over a long period of time.
  • a composition of the invention may optionally comprise a hydrophilic or hydrophobic gel forming polymer, a fatty acids, a plant oils etc.
  • Suitable hydrophilic gel polymers include, but are not limited to, hydroxypropylmethyl cellulose, cationic hydroxyethyl cellulose (U-care polymers), ethyl cellulose, hydroxypropyl cellulose, hydroxymethyl cellulose, carboxy methyl cellulose, polyethylene oxide (polyox resins), and chitosan pyrrolidone carboxylate (Kytamer PC), silica gel, carbomerpolymers etc.
  • Suitable hydrophobic gel polymers include, but are not limited to, silicone polymers, for example polydimethylsiloxane polymer (Dow Corning 225 Silicone Fluid), dimethiconol fluid in dimethicone (Dow Corning 1403 Silicone Fluid), cyclomethicone and dimethicone copolyl (Dow Corning 3225C and Q2-5220 Silicone Fluid), silicone glycol (BASF 1066 DCG polyol ), KSG series Silicone gels (Shin-etsu ), and combinations thereof.
  • Suitable plant oils include, but are not limited to, olive oil, almond oil, avocado oil, basil oil, primrose oil, peanut oil, safflower oil, sesame oil, soyabean oil, wheat germ oil.
  • the present invention provides for personal care product compositions comprising a combination of one or more essential oil and/or IC together with one or more fruit acid, as set forth in section 4.4 or 4.5, above.
  • the amounts of the active agents are such that regular exposure of skin to the personal care product does not produce skin irritation in a normal subject.
  • Non-limiting examples of personal care products which may utilize the invention include bar soap, liquid soap (e.g. hand soap), hand sanitizer, cleansing wipes, body wash, acne treatment products, shampoo, conditioner, cosmetics (including but not limited to liquid or powder foundation, liquid or solid eyeliner, mascara, cream eye shadow, tinted powder, "pancake” type powder to be used dry or moistened, etc.) deodorant, body lotion, hand cream, topical cream, aftershave lotion, skin toner, mouth wash, toothpaste, sunscreen lotion, and baby products such as, but not limited to, cleansing wipes, baby shampoo, baby soap, and diaper cream.
  • the present invention may also be applied to wound care items, such as, but not limited to, wound healing ointments, wound coverings, bandages, tape, and steri-strips, and medical articles such as medical gowns, caps, face masks, and shoe-covers, surgical drops, etc.
  • Personal care compositions according to the invention in addition to one or more essential oil and/or IC together with one or more fruit acid, may further comprise one or (preferably) more than one component selected from the group consisting of emollients, stabilizing agents, thickening agents, humectants, anti- inflammatory agents, antimicrobial agents, neutralizing agents, surfactants, water, silicone polymers, alcohols, and hydrogels, as well as additional components as may be known in the art. Non-limiting examples of such components are set forth below.
  • a personal care product comprising a combination of one or more essential oil and/or IC together with one or more fruit acid may further comprise an emollient, for example PEG 20 almond glycerides, Probutyl DB-IO, Glucam P-20, Glucam E-IO 5 Glucam P-10, Glucam E-20, Glucam P-20 distearate, glycerin, propylene glycol, octoxyglycerine, cetyl acetate, acetylated lanolin alcohol (e.g., Acetulan), cetyl ether (e.g., PPG-10), myristyril ether (e.g., PPG-3), hydroxylated milk glycerides (e.g., Cremeral HMG), polyquaternium compounds (e.g., U-care compounds), copolymers of dimethyl dialyl ammonium chloride and acrylic acid (e.g., Merquat), dipropyl glycerides, Probut
  • emollients may include hydrocarbon-based emollients such as petrolatum or mineral oil, fatty ester-based emollients, such as methyl, isopropyl and butyl esters of fatty acids such as isopropyl palmitate, isopropyl myristate, isopropyl isostearate, isostearyl isostearate, diisopropyl sebacate, and propylene dipelargonate, 2-ethylhexyl isononoate, 2-ethylhexyl stearate, C 12 - C 16 fatty alcohol lactates such as cetyl lactate and lauryl lactate, isopropyl lanolate, 2-ethylhexyl salicylate, cetyl myristate, oleyl myristate, oleyl stearate, oleyl oleate, hexyl laurate, and isohexyl Iaurate.
  • a personal care product comprising a combination of one or more essential oil and/or IC together with one or more fruit acid may further comprise a stabilizing agent consisting of antioxidants, including but not limited to vitamin C (ascorbic acid) and vitamin E (tocopherol), and surfactants, including but not limited to incromide or silicone-based surfactants (Masil SF-19, BASF).
  • a stabilizing agent consisting of antioxidants, including but not limited to vitamin C (ascorbic acid) and vitamin E (tocopherol), and surfactants, including but not limited to incromide or silicone-based surfactants (Masil SF-19, BASF).
  • a personal care product comprising a combination of one or more essential oil and/or IC together with one or more fruit acid may further comprise a thickening and/or gelling agent such as stearyl alcohol, cationic hydroxy ethyl cellulose (Ucare; JR30), hydroxy propyl methyl cellulose, hydroxy propyl cellulose (Klucel), chitosan pyrrolidone carboxylate (Kytamer), behenyl alcohol, zinc stearate, emulsifying waxes, including but not limited to Incroquat and Polawax, an addition polymer of acrylic acid, a resin such as Carbopol® ETDTM 2020, guar gum, acacia, acrylates/steareth-20 methacrylate copolymer, agar, algin, alginic acid, ammonium acrylate co-polymers, ammonium alginate, ammonium chloride, ammonium s
  • the gelling agents used in vehicles may be natural gelling agents such as natural gums, starches, pectins, agar and gelatin. Often, the gelling agents are based on polysaccharides or proteins Examples include but are not limited to guar gum, Xanthum gum, Alginic acid (E400), sodium alginate (E401), potassium alginate (E402), ammonium alginate (E403), calcium alginate (E404, - polysaccharides from brown algae), Agar (E406, a polysaccharide obtained from red seaweeds), Carrageenan (E407, a polysaccharide obtained from red seaweeds), Locust bean gum (E410, a natural gum from the seeds of the Carob tree), Pectin (E440, a polysaccharide obtained from apple or citrus-fruit), and Gelatin (E441, made by partial hydrolysis of animal collagen).
  • guar gum Alginic acid (E400), sodium alginate (E401
  • a personal care product comprising a combination of one or more essential oil and/or IC together with one or more fruit acid may further comprise a humectant, such as, for example, glycerin, 1-2-propylene glycol, dipropylene glycol, polyethylene glycol, 1,3-butylene glycol, or 1,2,6-hexanetriol.
  • a humectant such as, for example, glycerin, 1-2-propylene glycol, dipropylene glycol, polyethylene glycol, 1,3-butylene glycol, or 1,2,6-hexanetriol.
  • an antimicrobial composition consisting of one or more essential oil and/or one or more IC, together with a fruit acid and optionally an alcohol.
  • one or more additional antimicrobial agent may be comprised, for example, in the amount of between about 0.05 and 2.0 percent (weight/weight), where such antimicrobial agent may be selected from the group consisting of iodophors, iodine, benzoic acid, dihydroacetic acid, propionic acid, sorbic acid, methyl paraben, ethyl paraben, propyl paraben, butyl paraben, cetrimide, benzalkonium chloride, dequalinium chloride, chlorhexidine, chloroeresol, chlorxylenol, benzyl alcohol, bronopol, chlorbutanol, phenoxyethanol, phenylethyl alcohol, 2,4-dichlor
  • a personal care product comprising a combination of one or more essential oil and/or IC together with one or more fruit acid may further comprise a neutralizing agent to neutralize carboxyl groups present in one or more other component, such as carboxyl groups in a thickening agent.
  • Suitable neutralizing agents include diisopropylamine and triethanolamine.
  • a personal care product comprising a combination of one or more essential oil and/or IC together with one or more fruit acid may further comprise a surfactant.
  • the surfactant may be an anionic surfactant, a cationic surfactant, an ampholytic surfactant, or a nonionic surfactant.
  • nonionic surfactants include polyethoxylates, fatty alcohols ⁇ e.g., ceteth-20 (a cetyl ether of polyethylene oxide having an average of about 20 ethylene oxide units) and other "BRIJ”® nonionic surfactants available from ICI Americas, Inc.
  • Suitable anionic surfactants include ammonium lauryl sulfate and lauryl ether sulfosuccinate.
  • a preferred surfactant is lauroyl ethylenediamine triacetic acid sodium salt at a concentration between about 0.5 - 2.0% (weight/weight). In particular non-limiting embodiments of the invention, concentrations of surfactant are between about 0.05% and 2% (weight/weight).
  • a personal care product may comprise water.
  • a personal care product comprising a combination of one or more essential oil and/or IC together with one or more fruit acid may further comprise a hydrogel comprising, for example, a compound such as hydroxypropylmethyl cellulose, cationic hydroxyethyl cellulose (U-care polymers), ethyl cellulose, hydroxypropyl cellulose, hydroxymethyl cellulose, carboxy methyl cellulose, polyethylene oxide (polyox resins), and chitosan pyrrolidone carboxy late (Kytomer PC).
  • a hydrogel comprising, for example, a compound such as hydroxypropylmethyl cellulose, cationic hydroxyethyl cellulose (U-care polymers), ethyl cellulose, hydroxypropyl cellulose, hydroxymethyl cellulose, carboxy methyl cellulose, polyethylene oxide (polyox resins), and chitosan pyrrolidone carboxy late (Kytomer PC).
  • a personal care product comprising a combination of one or more essential oil and/or IC together with one or more fruit acid may further comprise an alcohol or a mixture of alcohols, for example, ethanol, isopropyl alcohol, n-propyl alcohol, and mixtures thereof; fatty alcohols, including, but not limited to, cetyl alcohol, myristol alcohol, stearyl alcohol, octyl alcohol, decyl alcohol and lauryl alcohol, and mixtures thereof; and hexanol.
  • alcohols for example, ethanol, isopropyl alcohol, n-propyl alcohol, and mixtures thereof
  • fatty alcohols including, but not limited to, cetyl alcohol, myristol alcohol, stearyl alcohol, octyl alcohol, decyl alcohol and lauryl alcohol, and mixtures thereof
  • hexanol for example, ethanol, isopropyl alcohol, n-propyl alcohol, and mixtures thereof.
  • a personal care product comprising a combination of one or more essential oil and/or IC together with one or more fruit acid may further comprise a silicone polymer, for example one or more than one polydimethylsiloxane polymer (Dow Corning 225 Silicone Fluid), dimethiconol fluid in dimethicone (Dow Corning 1403 Silicone Fluid), cyclomethicone and dimethicone copolyl (Dow Corning 3225C Silicone Fluid), and silicone glycol (BASF 1066 DCG polyol).
  • the amount of silicone polymer is between about 0.1 and 1.0 percent (volume/volume) .
  • a personal care product comprising a combination of one or more essential oil and/or IC together with one or more fruit acid may further comprise an emollient solvent such as a glycidyl ether having an alkyl chain up to and including 18 carbon molecules and ethoxylates and propoxylates thereof, a glyceryl ether having an alkyl chain up to and including 18 carbon molecules and ethoxylates and propoxylates thereof, a mono- or diglyceryl ether having an alkyl chain up to and including 18 carbon molecules and ethoxylates and propoxylates thereof, ethoxylate and propoxylate ethers, ethoxy diglycol esters, ethyl hexyl alcohol propoxylate, and propylene glycol esther ethoxylates and propoxylates, and Arlamol (Altas).
  • an emollient solvent such as a glycidyl ether having an alkyl chain up to and including 18 carbon molecules
  • a personal care product comprising a combination of one or more essential oil and/or IC together with one or more fruit acid may further comprise additives such as dyes, fragrances, pH adjusters, including basic pH adjusters such as ammonia, mono-, di- and tri- alkyl amines, mono-, di- and tri-alkanolamines, alkali metal and alkaline earth metal hydroxides (e.g., ammonia, sodium hydroxide, potassium hydroxide, lithium hydroxide, monoethanolamine, triethylamine, isopropylamine, diethanolamine and triethanolamine); acid pH adjusters such as mineral acids and polycarboxylic acids (e.g., hydrochloric acid, nitric acid, phosphoric acid, sulfuric acid, citric acid, gly colic acid, and lactic acid); vitamins such as vitamin A, vitamin E and vitamin C; polyamino acids and salts, such as ethylenediamine tetraacidic acid (
  • the present invention provides for personal care compositions comprising one or more EO/IC, preferably where the EO(s)/IC(s) are selected from the group consisting of lemongrass oil and/or an IC thereof, orange oil and/or an IC thereof, cinnamon leaf oil and/or an IC thereof, basil oil and/or an IC thereof, eugenol, cinnamaldehyde, cinnamylacetic ester, and cinnamic acid, at a total concentration of between about 0.1 and 1% (weight/weight); a fruit acid, preferably citric acid, at a concentration of between about 0.125 and 1 % (weight/weight); an alcohol, preferably ethanol, at a concentration of between about 5 and 20 % (weight/weight); and optionally triclosan at a concentration of between about 0.05 and 1 % (weight/weight), where the ratio of EO(s)/IC(s) to the fruit acid(s) is between about 1:1 to 1 :
  • the present invention provides for personal care compositions comprising lemongrass oil or an IC thereof and orange oil or an IC thereof at a total concentration of between about 0.2 and 0.7 % (weight/weight); a fruit acid, preferably citric acid, at a concentration of between about 0.25 and 1 % (weight/weight); an alcohol, preferably ethanol, at a concentration of between about 5 and 20 % (weight/weight); and optionally triclosan at a concentration of between about 0.05 and 1 % (weight/weight), where the ratio of EO(s)/IC(s) to fruit acid(s) is between about 1 :1 to 1:5 and the pH is between about 3 and about 7, preferably between 5 and 6.
  • a personal care product comprising a combination of one or more essential oil and/or IC together with one or more fruit acid may further comprise various anti-inflammatory, antimicrobial agents, anti-irritants, and gelling ingredients.
  • Such compositions may be included in, for example, wound healing ointments.
  • the antimicrobial botanicals contemplated for wound treatment include 0.2-0.7% (weight/weight) essential oils such as lemongrass oil (LG) or orange oil (O), and 0.2-1.0% (weight/weight) fruit acids such as citric acid (Cit) and lactic acid (L), and 0.5-1.0% (weight/weight) phenoxyethanol, which is a constituent of sage oil (PXE).
  • Anti-irritant, anti inflammatory botanicals include, but are not limited to 0.3-0.7% (weight/weight) Calendula oil (Co), 0.1-0.5% (weight/weight) turmeric extract (curcumin (Cr)), 0.2-2.0% (weight/weight) salicylic acid (S), 0.2-0.5% (weight/weight) Camphor (Cm) and 2-30% (weight/weight) honey (H).
  • Gelling agents would include, but are not limited to, Guar gum, Xanthum gum Alginic acid, and Pectin in amounts of 0.2-3.0% (weight/weight).
  • the present invention provides for a liquid soap product called "CNl-A" having one of the following compositions (CNl-Al OR CN1-A2).
  • the present invention provides for a liquid soap product called "CNl-B" having the following composition.
  • the present invention provides for a liquid soap product called "CNl-C" having the following composition.
  • the present invention provides for a soap comprising one or more essential oil, 1% citric acid, and a soap base comprising a surfactant, an emollient, and a thickener, and having a pH between about 3-5. Specific non-limiting examples of such soaps follow.
  • the present invention provides for the following combinations of agents in a soap base (percentages weight/weight):
  • the present invention provides for the following combinations of agents in a soap base (percentages w/w): . Cinnamon oil 0.5% + Orange Oil 0.2% + Citric acid 1.0% + alcohol (e.g., denatured ethyl alcohol, such as SDA 40 B) 5.5% + TC 0.14% (or TC 0.15%); or
  • Lemongrass oil 0.5% + Orange Oil 0.2% + Citric acid 1.0% + alcohol (e.g., denatured ethyl alcohol, such as SDA 40B) 5.5% +
  • Lemongrass oil 0.5% + Citric acid 1.0% + alcohol (e.g. denatured ethyl alcohol such as SDA 40 B)5.5% + TC 0.14% (or TC 0.15%).
  • alcohol e.g. denatured ethyl alcohol such as SDA 40 B
  • TC 0.14% or TC 0.15%
  • the present invention provides for compositions comprising (0.2-0.3 percent (weight/weight)) of essential oils such as lemongrass or cinnamon and 0.1-0.2 percent (weight/weight) orange oil when used in combination with 1% citric acid and alkanediols such as 1,2 decanediol, 1,2 dodecanediol and 1,12 dodecanediol, as set forth above.
  • the present invention provides for a soap formulation comprising 0.3% (weight/weight) of lemongrass oil or cinnamon oil in combination with 0.1%
  • Antibacterial topical lotion comprising LG-O-Cit A + l,2Decanediol
  • Antibacterial topical lotion comprising LG-O-Cit A + 1 ,2Decanediol+
  • antimicrobial formulations follow below.
  • the present invention provides for the preparation of topical cream formulations containing anti-irritant, antiinflammatory agents, gelling agents, and botanicals for minor cuts and wounds.
  • Specific cream formulations are as follows.
  • the present invention provides for veterinary products comprising a combination of one or more essential oil and/or IC together with one or more fruit acid, as set forth in section 4.4 or 4.5, above.
  • veterinary means "pet care”, and includes home use as well as use in a veterinary office or other pet care establishment.
  • Non-limiting examples of veterinary care products which may utilize the invention include pet shampoo, pet cleansing wipes including body wipes, ear wipes, and eye wipes, ear cleaning liquid, cage cleaner, surface cleaner for housebreaking accidents, topical creams, ointments, teat dip therapeutic for mastitis and liquid to be applied to pet's skin (as in a "body splash").
  • Veterinary care compositions according to the invention in addition to one or more essential oil and/or IC together with one or more fruit acid, may further comprise one or (preferably) more than one component selected from the group consisting of emollients, stabilizing agents, thickening agents, humectants, antimicrobial agents, neutralizing agents, surfactants, water, silicone polymers, alcohols, and hydrogels, anti-inflammatory agents, wound healing agents, salicylic acid, as well as additional components as may be known in the art.
  • pet care products include the components listed above for personal care products.
  • compositions may be prepared for teat dip to treat mastitis.
  • a general formulation for teat dip compositions is as follows.
  • the anti-irritants used for teat dip may include but are not limited to zinc salts with panthenol, or Bisabolol with ginger root extract (symrelief), or symrelief with a zinc salt.
  • the gelling agents in the vehicle may include but are not limited to natural gelling agents such as natural gums, starches, pectins, agar and gelatin.
  • Antimicrobial botanicals may include but are not limited to lemongrass oil, orange oil and fruit acids such as citric and lactic acid, phenoxyethanol (constituent of sage oil).
  • Table 40 summarize various non limiting examples of formulations. Table 40.
  • the present invention provides for household/industrial products comprising a combination of one or more essential oil and/or IC together with one or more fruit acid, as set forth in section 4.4 and 4.5, above.
  • Non-limiting embodiments of household/industrial products which may utilize the invention include householder cleaners such as concentrated liquid cleaners and spray cleaners, cleaning wipes, dish washing liquid, dish washer detergent, spray-mop liquid, furniture polish, indoor paint, outdoor paint, dusting spray, laundry detergent, fabric softener, rug/fabric cleaner, window and glass cleaner, toilet bowl cleaner, liquid/cream cleanser, etc.
  • the invention may be used in a food wash product, designed to clean fruits and vegetables prior to consumption.
  • “Household products” are products, other than personal care products, that would be used by individual consumers.
  • “Industrial products” refers to products that are used in industry.
  • Household-industrial compositions according to the invention in addition to one or more essential oil and/or IC together with one or more fruit acid, may further comprise one or (preferably) more than one component selected from the group consisting of surfactants, builders (e.g., sequestering builders, precipitating builders, ion exchange builders), solvents, thickeners, abrasives, acids, bases (alkalis), antimicrobial agents, soaps, bleaching agents, enzymes, preservatives, and sudsing agents, as well as additional components as may be known in the art.
  • surfactants e.g., sequestering builders, precipitating builders, ion exchange builders
  • solvents e.g., abrasives, acids, bases (alkalis), antimicrobial agents, soaps, bleaching agents, enzymes, preservatives, and sudsing agents, as well as additional components as may be known in the art.
  • builders e.g., sequestering builders, precipitating builders, ion exchange builders
  • solvents
  • a household/industrial product comprising a combination of one or more essential oil and/or IC together with one or more fruit acid may further comprise a surfactant, for example, but not limited to, an anionic surfactant such as an alkyl sulfate, an alkyldiphenyloxide disulfonate salt (e.g.
  • an alkylbenzenesulfonate an alcohol ethoxysulfate
  • a cationic surfactant such as a secondary alcohol ethoxylate (e.g., the TERGITAOL series by the Dow Chemical Company) or an alkyl polyglucoside (e.g. the TRITON series by the Dow Chemical Company); or an amphoteric surfactant such as an imidazoline or betaine compound.
  • a secondary alcohol ethoxylate e.g., the TERGITAOL series by the Dow Chemical Company
  • an alkyl polyglucoside e.g. the TRITON series by the Dow Chemical Company
  • an amphoteric surfactant such as an imidazoline or betaine compound.
  • a household/industrial product comprising a combination of one or more essential oil and/or IC together with one or more fruit acid may further comprise a builder, for example, but not limited to, a sequestering builder (chelating agent) such as ethylenediaminetetraacetic acid (“EDTA”), sodium citrate, or a complex phosphate; an ion exchange builder such as zeolite, or a precipitating builder such as sodium carbonate or sodium silicate.
  • a sequestering builder such as ethylenediaminetetraacetic acid (“EDTA”), sodium citrate, or a complex phosphate
  • EDTA ethylenediaminetetraacetic acid
  • ion exchange builder such as zeolite
  • precipitating builder such as sodium carbonate or sodium silicate.
  • a household/industrial product comprising a combination of one or more essential oil and/or IC together with one or more fruit acid may further comprise a solvent, for example, but not limited to, water, an alcohol such as methanol, ethanol, isopropyl alcohol, or butanol; a hydrocarbon such as an aromatic hydrocarbon, propylene glycol, methylene chloride, acetone, a petroleum distillate, and/or a glycol ether.
  • a solvent for example, but not limited to, water, an alcohol such as methanol, ethanol, isopropyl alcohol, or butanol
  • a hydrocarbon such as an aromatic hydrocarbon, propylene glycol, methylene chloride, acetone, a petroleum distillate, and/or a glycol ether.
  • a household/industrial product comprising a combination of one or more essential oil and/or IC together with one or more fruit acid may further comprise a thickener, for example, but not limited to, a polyethylene glycol, a methoxypolyethylene glycol, and/or hydroxyethyl cellulose.
  • a household/industrial product comprising a combination of one or more essential oil and/or IC together with one or more fruit acid may further comprise an abrasive, such as, but not limited to, silica, feldspar or calcite.
  • a household/industrial product comprising a combination of one or more essential oil and/or IC together with one or more fruit acid may further comprise an acid, such as, but not limited to, acetic acid, hydroacetic acid, phosphoric acid or hydrochloric acid.
  • a household/industrial product comprising a combination of one or more essential oil and/or IC together with one or more fruit acid may further comprise a base (alkali) such as, but not limited to, ammonia or sodium bicarbonate.
  • a base such as, but not limited to, ammonia or sodium bicarbonate.
  • a household/industrial product comprising a combination of one or more essential oil and/or IC together with one or more fruit acid may further comprise an antimicrobial agent, for example, but not limited to, compounds as set forth above for personal care compositions, and also pine oil and sodium hypochlorite.
  • an antimicrobial agent for example, but not limited to, compounds as set forth above for personal care compositions, and also pine oil and sodium hypochlorite.
  • a household/industrial product comprising a combination of one or more essential oil and/or IC together with one or more fruit acid may further comprise a bleaching agent, for example, but not limited to, sodium hypochlorite, hydrogen peroxide, sodium percarbonate and sodium perborate.
  • a bleaching agent for example, but not limited to, sodium hypochlorite, hydrogen peroxide, sodium percarbonate and sodium perborate.
  • a household/industrial product comprising a combination of one or more essential oil and/or IC together with one or more fruit acid may further comprise an enzyme, such as, but not limited to, a protease or a lipase.
  • a household/industrial product comprising a combination of one or more essential oil and/or IC together with one or more fruit acid may further comprise a preservative, such as, but not limited to, butylated hydroxytoluene, glutaraldehyde, and EDTA.
  • a preservative such as, but not limited to, butylated hydroxytoluene, glutaraldehyde, and EDTA.
  • a household/industrial product comprising a combination of one or more essential oil and/or IC together with one or more fruit acid may further comprise a sudsing agent, such as, but not limited to, diethanolamine or triethanolamine.
  • the present invention provides for surface cleaner compositions comprising (i) one or more EO/IC, preferably where the EO(s)/IC(s) are selected from the group consisting of lemongrass oil and/or an IC thereof; orange oil and/or an IC thereof; cinnamon leaf oil and/or an IC thereof; basil oil and/or an IC thereof; and/or pine oil and/or an IC thereof; at a total concentration of between about 0.1 and 1 percent (weight/weight); (ii) a fruit acid, preferably citric acid, at a concentration of between about 1 and 2 percent (weight/weight); (iii) an alcohol, preferably ethanol, at a concentration of between about 5 and 20 percent (weight/weight); and (iv) optionally triclosan at a concentration of between about 0.05 and 1 percent (weight/weight), where the ratio of EO(s)/IC(s) to fruit acid is between about 1 :1 to 1 :10 (inclusive) and the pH is between about 3
  • the present invention provides for the following surface cleaners, having concentrations of active ingredients as indicated, as well as concentrated stock solutions of these formulations which may be diluted to achieve the respective concentrations.
  • Softsoap® is a commercially sold liquid soap comprising water, sodium laureth sulfate, cocamidopropyl betaine, decylglucoside, sodium chloride, fragrance, DMDM hydantoin, PEG- 120 methyl glucose dioleate, tetrasodium ethylene diamine tetracetic acid, sodium sulfate, polyquaternium-7, citric acid, poloxamer 124, PEG-7 glyceryl, cocoate, benzophenine-4, and colors.
  • Dial® soap is a commercially sold liquid soap, where Dial®
  • Antibacterial hand soap comprises, as active agent, 0.15 percent triclosan, and the inactive agents are water, sodium laureth sulfate, ammonium lauryl sulfate, decyl glucoside, cocamidopropyl betaine, glycerine, sodium chloride, PEG-18 gylceryl oleate/cocoate, fragrance, cocamide MEA, DMDM hydantoin, tetrasodium ethylene diamine tetracetic acid and colors.
  • the inactive agents are water, sodium laureth sulfate, ammonium lauryl sulfate, decyl glucoside, cocamidopropyl betaine, glycerine, sodium chloride, PEG-18 gylceryl oleate/cocoate, fragrance, cocamide MEA, DMDM hydantoin, tetrasodium ethylene diamine tetracetic acid and colors.
  • the compositions may be formulated as preservative compositions to be used alone or in conjunction with personal care, household or veterinary, products for preservation purposes.
  • Such compositions may contain lemongrass oil, orange oil, lactic or citric acid, phenoxyethanol and/or an alkanediol.
  • Alkanediols include but are not limited to 1,2- decanediol, 1,12-dodecanediol, and/or 1,2-octanediol.
  • the ingredients are combined in an appropriate solvent including but not limited to ethanol, butanol, 3-methoxy-3- methyl-1-butanol, or combinations thereof.
  • the pH of these solutions are adjusted to 5.0, with an appropriate buffer, including for example sodium hydroxide (NaOH).
  • 0.5-5.0% of the preservative compositions can be used in various formulations, preferably 2.0-3.0% of the preservative compositions.
  • a general formulation for preservative compositions (which may optimally be in the form of stock solutions, which may be diluted prior to use) is as follows.
  • preservative compositions follow below, with the compositions of stock solutions as well as varying percentages of the preservative compositions in products.
  • EXAMPLE 1 Various concentrations of basil oil and acetic, lactic, and citric acids, separately and in combination, were prepared in 10 percent SDA40-B alcohol and water, and adjusted to 100 percent. Except for citric acid, which was added by weight, all other ingredients were measured by volume. 0.9 ml of each solution were dispensed in sterile culture tubes, in triplicate, and 0.1 ml of a 10 7 cfu/ml S. aureus culture was added to the tubes, vortexed, and then, five minutes later, 9.0 ml of drug inactivating medium was added to each tube. Serial dilutions were made with the drug inactivating medium.
  • Two stock solutions of a hard surface cleaner/disinfectant was prepared, with the following ingredients (the two solutions contained different amounts of cinnamon leaf oil, and therefore the amount of alcohol to bring the solution to 100 % also varied).
  • 0.1 ml of culture containing approximately 1 x 10 7 colony forming units (“cfu”) per milliliter was spread evenly on the surface of 2.5 x 11 cm 2 tiles using a glass rod and left at room temperature for 10 minutes to dry. After 10 minutes 0.3 ml of the diluted surface disinfectant was spread evenly on the tiles with a sterile glass rod and left for another 10 minutes to dry.
  • the tiles were rinsed with 9.6 ml of inactivating medium (BPBNS), which was collected for testing.
  • the collected medium was serially diluted and 0.5 ml was plated onto TSA plates and incubated at 37° C for 18-24 hours. The colonies on the plates were counted and the values converted to log 10 .
  • Pinesol® which contains pine oil
  • Pinesol® containing 15% pine oil was diluted with water as per the manufacturer's instructions to a final concentration of 0.9 % pine oil.
  • Table 70 The results show that the composition comprising 0.5 % cinnamon leaf oil and 1 % citric acid exhibited greater antimicrobial activity than the pine oil cleaner against 4 out of 5 microbes tested.
  • cinnamon oil orange oil, citric acid, and phenoxyethanol are dissolved in the alcohol, the remaining ingredients are dissolved in/mixed with water, and then the alcohol and water solutions are mixed. The pH of the mixture was then adjusted to between 5.5 and 6.5 with 0.1 N NaOH.
  • a liquid soap, called "CNl-B” containing cinnamon oil and citric acid was prepared, having the following composition.
  • TSA trypticase soy agar
  • control counts ranges from 1x10 to
  • Soaps were prepared containing one or more essential oil, 1% citric acid, and a soap base containing surfactants, emollients, thickeners etc.
  • the pH of the Soaps ranged from 3.2-3.3.
  • Citric acid (CRO-Cit 6) (6 represents total oil 0.6%)
  • S. aureus culture and 0.1ml of bovine serum were placed in a sterile culture tube.
  • test soap formulation 0.8ml was added to the tube and vortexed for 30 seconds. 9.0 ml DFN was added to the tube to neutralize the activity of the soap; this tube was then vortexed and serially diluted with DFN. 0.5ml of the diluted solution was plated on trypticase soy agar plates, incubated at 37 0 C for 24-48 hrs and the colony counts were determined. Soft soap® and Dial® soaps containing 0.15% triclosan was also tested similarly at the same time. The soap base without essential oils and citric acid containing the culture were used as controls. The results, showing 30 second kill activity, are shown in Table 90.
  • Patent application WO/2007 '/077 '573 by Mukhopadhyay et al describes an antimicrobial composition containing triclosan and an essential oil where the ratio of triclosan to the essential oil is 1:5 to 1:100 and the preferred ratio range is 1 :10 to 1 :90.
  • TC and essential oil at 1:1 ratio showed neither synergistic nor enhanced activity.
  • Triclosan (TC) is often used in personal care products at a concentration of 0.15-0.3%.
  • S. aureus culture and 0.1ml of bovine serum were placed in a sterile culture tube.
  • test soap formulation 0.8ml was added to the tube and vortexed for 30 seconds.
  • aureus culture and 0.1ml of bovine serum were placed in a sterile culture tube.
  • 0.8ml of the test soap formulation was added to the tube and vortexed for 30 seconds.
  • 9.0 ml DFN was added to the tube to neutralize the activity of the soap; this tube was then vortexed and serially diluted with DFN.
  • 0.5ml of the diluted solution was plated on trypticase soy agar plates, incubated at 37 0 C for 24-48hrs and the colony counts were determined. The results are shown in Table 92.
  • triclosan/essential oil/citric acid were dissolved in SDA40 B alcohol and added to Softsoap® (lacking triclosan) and diluted with water, so that the final concentration of alcohol was 5.5 % and the final concentration of Softsoap® was 92 percent.
  • Softsoap® lacking triclosan
  • a mixture of 0.1ml of 10 8 cfu/ml of S. aureus culture and 0.1ml of bovine serum were placed in a sterile culture tube.
  • 0.8ml of the test soap formulation was added to the tube and vortexed for 30 seconds.
  • 9.0 ml DFN was added to the tube to neutralize the activity of the soap; this tube was then vortexed and serially diluted with DFN.
  • 0.5ml of the diluted solution was plated on trypticase soy agar plates, incubated at 37 0 C for 24-48hrs and the colony counts were determined. The results are shown in Table 93.
  • citric acid was found to enhance the activity of soaps containing triclosan; the combination of citric acid and essential oils was found to increase the antimicrobial activity of soap containing triclosan, and superior antimicrobial action was associated with a combination of citric acid, lemongrass and orange oils, and triclosan.
  • EXAMPLE 18 Household cleansers were prepared comprising citric acid (1-2%), alcohol, and either (i) lemongrass oil; (ii) a combination of lemongrass oil and pine oil; (iii) a combination of lemongrass oil and orange oil; or (iv)a combination of pine oil and orange oil.
  • the antimicrobial effectiveness of these formulations were tested and compared to commercial Pinesol® cleanser (containing 8.7 percent pine oil and other ingredients including detergent and other cleaning agents) as a control.
  • Table 100 Stock solution of hard surface Disinfectant-LG-Cit 2
  • the disinfectant contained the following percentages (w/w) of each ingredient.
  • Pinesol® To prepare the solution of Pinesol® to serve as control, as per the manufacturer's instruction, 6ml of the Pinesol® containing 8.5% pine oil was diluted to 100 ml. This diluted sample contained 0.52% pine oil.
  • Example 18 The method used in Example 18 was used to test antimicrobial activity. Table 109.
  • the test organism used was Candida albicans. Where soap was employed, the following method was used. A mixture of 0.1ml of 10 7 cfu/ml of C. albicans culture and 0.1ml of bovine serum were placed in a sterile culture tube. 0.8ml of the test soap formulation was added to the tube and vortexed for 30 seconds. 9.0 ml DFN was added to the tube to neutralize the activity of the soap; this tube was then vortexed and serially diluted with DFN. 0.5ml of the diluted solution was plated on trypticase soy agar plates, incubated at 37 0 C for 24- 48hrs and the colony counts were determined. The results, showing 30 second kill activity, are shown in Table 110.
  • LGO-Cit 5 comprises 0.3 percent (weight/weight) lemongrass oil, 0.3 percent (weight/weight) orange oil, 1.0 percent (weight/weight) citric acid, 1.0 percent (weight/weight) 2-phenoxyethanol and 15 percent (weight/weight) SDA-40B alcohol.
  • LG-O-Cit 4 comprises 0.3 percent (weight/weight) lemongrass oil, 0.1 percent (weight/weight) orange oil, 1.0 percent (weight/weight) citric acid, 1.0 percent (weight/weight) 2-phenoxyethanol and 15 percent (weight/weight) SDA-40B alcohol.
  • the amount of alkanediol, where present, is 0.3 percent (weight/weight).
  • the complete formulations for the soaps specified are set forth in section 4.6, above. The results are shown in Table 111 below.
  • LG- O-Cit 4A comprises 0.3 percent (weight/weight) lemongrass oil, 0.1 percent (weight/weight) orange oil, 1.0 percent (weight/weight) citric acid, 1.0 percent (weight/weight) 2-phenoxyethanol and 17 percent (weight/weight) SDA-40B alcohol.
  • the amount of alkanediol, where present, is 0.5 percent (weight/weight).
  • the complete formulations for the soaps specified are set forth in section 4.6, above. The results are shown in Table 112 below. Table 112. Enhancement of the antibacterial activity of LG-O-Cit A Composition by 0.5% of alkanediols
  • Dial® soap containing 0.15% Triclosan (Dial -T Soap) was used for this test.
  • the following formulation was prepared.
  • the antibacterial activity was then tested using the method set forth in Section 25, Example 21. The results are shown in Table 114.
  • LG-O-CitA-D-T Lotion having the following formulation, was tested in a pigskin model.
  • the pigskin model assay was as follows. Six sets of 3x3cm pig skin each mounted on a petriplate were rinsed in 70% isopropanol , and air dried. One piece of the pair was contaminated with 30 ⁇ l of 10 8 cfu of MRSA culture; the two pieces were then rubbed against each other for 30 seconds , and left at 37 0 C to dry for one hour. 3 pairs were used for control and another 3 pairs were used for the test, which was as follows.
  • 0.1 gm of placebo cream same as LG-O-Cit4-D (above) without SDA-40-B, lemongrass oil, tea tree oil , orange oil, 1,2 decanediol(Symclairol) was applied , and rubbed against the other piece for 15 seconds and left at 37 0 C for 1 hour .
  • the same procedure was repeated with the test skins in which LG-O-CitA-D-T was applied.
  • 0.2 ml dilution media (DM) was added to one skin piece and both pieces rubbed again for 15 seconds. The surviving organisms were recovered from the skin by rinsing each piece with 9.9 ml of DM.
  • TSB Trypticase Soy Broth
  • Control growth for S. aureus and P aeruginosa are 6.5x10 8 and 1x10 8 cfu/gm respectively.
  • Wound dressings (Dukal non adherent pad) were dipped into the antimicrobial impregnation solution and dried for 24 hours . The dressings were cut into lcm 2 and the zones of inhibition against various organisms were determined.
  • Zones of inhibition test 1x1 cm piece of each dressing was placed on Trypticase soy agar plate seeded on the surface with 0.3mL of 10 8 colony forming units (CFU)/mL) of the test organism. The plates were incubated at 37 0 C for 24 hours. The zone of inhibition around the catheter segments, excluding the diameter of patch was measured. The results are shown in Table 127.
  • Creams containing 2.0% - 3.0% of preservative compositions were prepared and tested according to the following method. Table 128. Formulation
  • TSB Trypticase Soy Broth
  • 2% of the preservative was added to 10 grams of the cream and mixed well. From this sample, 1 gram aliquots were placed into 10 ml sterile plastic culture tubes and 0.1 ml (100 microliters) of the test inoculum was added and vortexed until uniformly blended. The tubes were then placed into incubators under the following temperatures: 300 0 C for Aspergillus niger and 37O 0 C for the remaining three microbes. All tubes were incubated for a total of 3 days.
  • Control growth for S. aureus and P aeruginosa were 6.5x10 and 1x10 cfu/gm, respectively, and for A.niger was 6x10 4 - 1x10 5 . Based on these results, all of the above preservative compositions were effective.

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BE1027897A1 (nl) 2019-12-20 2021-07-13 Minasolve Sas Geparfurmeerde samenstellingen, werkwijze voor het bereiden daarvan en toepassingen

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