EP2172215A3 - Variantes hypoallergéniques du principal allergène du pollen Betula verrucosa - Google Patents

Variantes hypoallergéniques du principal allergène du pollen Betula verrucosa Download PDF

Info

Publication number
EP2172215A3
EP2172215A3 EP09175143A EP09175143A EP2172215A3 EP 2172215 A3 EP2172215 A3 EP 2172215A3 EP 09175143 A EP09175143 A EP 09175143A EP 09175143 A EP09175143 A EP 09175143A EP 2172215 A3 EP2172215 A3 EP 2172215A3
Authority
EP
European Patent Office
Prior art keywords
major allergen
betula verrucosa
hypoallergenic variants
verrucosa pollen
pollen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP09175143A
Other languages
German (de)
English (en)
Other versions
EP2172215B1 (fr
EP2172215A2 (fr
Inventor
Giovanni Mistrello
Stefania Zanotta
Daniela Roncarolo
Paolo Falagiani
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Lofarma SpA
Original Assignee
Lofarma SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lofarma SpA filed Critical Lofarma SpA
Publication of EP2172215A2 publication Critical patent/EP2172215A2/fr
Publication of EP2172215A3 publication Critical patent/EP2172215A3/fr
Application granted granted Critical
Publication of EP2172215B1 publication Critical patent/EP2172215B1/fr
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/415—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from plants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/35—Allergens
    • A61K39/36—Allergens from pollen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Botany (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Dermatology (AREA)
  • Otolaryngology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
EP09175143.8A 2005-12-29 2006-12-19 Variantes hypoallergéniques du principal allergène du pollen Betula verrucosa Active EP2172215B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT002517A ITMI20052517A1 (it) 2005-12-29 2005-12-29 Varianbtio ipoallergeniche dell'allergene maggiore bet v 1 di polline di betula verrucosa
EP06829727A EP1973567B1 (fr) 2005-12-29 2006-12-19 Variantes hypoallergeniques du principal allergene du pollen betula verrucosa

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
EP06829727.4 Division 2006-12-19

Publications (3)

Publication Number Publication Date
EP2172215A2 EP2172215A2 (fr) 2010-04-07
EP2172215A3 true EP2172215A3 (fr) 2010-05-26
EP2172215B1 EP2172215B1 (fr) 2013-10-16

Family

ID=37891495

Family Applications (2)

Application Number Title Priority Date Filing Date
EP09175143.8A Active EP2172215B1 (fr) 2005-12-29 2006-12-19 Variantes hypoallergéniques du principal allergène du pollen Betula verrucosa
EP06829727A Not-in-force EP1973567B1 (fr) 2005-12-29 2006-12-19 Variantes hypoallergeniques du principal allergene du pollen betula verrucosa

Family Applications After (1)

Application Number Title Priority Date Filing Date
EP06829727A Not-in-force EP1973567B1 (fr) 2005-12-29 2006-12-19 Variantes hypoallergeniques du principal allergene du pollen betula verrucosa

Country Status (18)

Country Link
US (1) US8945574B2 (fr)
EP (2) EP2172215B1 (fr)
JP (1) JP2009521910A (fr)
CN (1) CN101351224B (fr)
AT (1) ATE457738T1 (fr)
AU (1) AU2006331005B2 (fr)
BR (1) BRPI0620749A2 (fr)
CA (1) CA2634955C (fr)
DE (1) DE602006012376D1 (fr)
DK (2) DK2172215T3 (fr)
EA (1) EA015446B1 (fr)
ES (2) ES2341367T3 (fr)
IT (1) ITMI20052517A1 (fr)
MX (1) MX2008008578A (fr)
NO (1) NO20082881L (fr)
PT (1) PT1973567E (fr)
UA (1) UA93894C2 (fr)
WO (1) WO2007073907A1 (fr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2028188A1 (fr) * 2007-08-21 2009-02-25 Biomay AG Molécules hypoallergéniques
ITMI20071819A1 (it) 2007-09-19 2009-03-20 Lofarma Spa Varianti ipoallergeniche dell'allergene maggiore bet v 2 di polline di betula verrucosa
FI20115374A0 (fi) 2011-04-18 2011-04-18 Teknologian Tutkimuskeskus Vtt Oy Uudet hypoallergeenit
FI20115375A0 (fi) 2011-04-18 2011-04-18 Teknologian Tutkimuskeskus Vtt Oy Uudet hypoallergeenit
ITMI20111489A1 (it) * 2011-08-03 2013-02-04 Lofarma Spa Varianti ipoallergeniche dell'allergene maggiore mal d 1 di malus domestica
WO2018222854A1 (fr) 2017-06-01 2018-12-06 Regeneron Pharmaceuticals, Inc. Anticorps humains contre bet v 1 et leurs procédés d'utilisation
BR112022026279A2 (pt) 2020-07-01 2023-02-14 Regeneron Pharma Métodos de tratamento de alergia usando anticorpos anti-bet v 1

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999047680A1 (fr) * 1998-03-16 1999-09-23 Alk-Abelló A/S Allergenes recombines mutants
WO2002040676A2 (fr) * 2000-11-16 2002-05-23 Alk-Abelló A/S Nouveaux allergenes mutants
WO2003096869A2 (fr) * 2002-05-16 2003-11-27 Alk Abelló A/S Mutants allergenes

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU5411594A (en) * 1992-10-27 1994-05-24 Biomay Produktions- Und Handelsgesellschaft M.B.H. Molecule fragments (peptides) of the main allergens contained in the pollen of trees of the (fagales) order
DK0885244T4 (da) * 1996-03-01 2008-06-16 Novartis Ag Peptidimmunogener til vaccination imod og til behandling af allergi
US20040043438A1 (en) * 2002-05-16 2004-03-04 Alk-Abello A/S Allergen mutants

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999047680A1 (fr) * 1998-03-16 1999-09-23 Alk-Abelló A/S Allergenes recombines mutants
WO2002040676A2 (fr) * 2000-11-16 2002-05-23 Alk-Abelló A/S Nouveaux allergenes mutants
WO2003096869A2 (fr) * 2002-05-16 2003-11-27 Alk Abelló A/S Mutants allergenes

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
FERREIRA F ET AL: "DISSECTION OF IMMUNOGLOBULIN E AND T LYMPHOCYTE REACTIVITY OF ISOFORMS OF THE MAJOR BIRCH POLLEN ALLERGEN VET V 1: POTENTIAL USE OF HYPOALLERGENIC ISOFORMS FOR IMMUNOTHERPY", JOURNAL OF EXPERIMENTAL MEDICINE, TOKYO, JP, vol. 183, no. 2, February 1996 (1996-02-01), pages 599 - 609, XP009011302, ISSN: 0022-1007 *
FERREIRA F ET AL: "Modulation of IgE reactivity of allergens by site-directed mutagenesis: potential use of hypoallergenic variants for immunotherapy", FASEB JOURNAL, FED. OF AMERICAN SOC. FOR EXPERIMENTAL BIOLOGY, BETHESDA, MD, US, vol. 12, no. 2, February 1998 (1998-02-01), pages 231 - 242, XP002085249, ISSN: 0892-6638 *
HOLM JENS ET AL: "Allergy vaccine engineering: Epitope modulation of recombinant Bet v 1 reduces IgE binding but retains protein folding pattern for induction of protective blocking-antibody responses", JOURNAL OF IMMUNOLOGY, vol. 173, no. 8, 15 October 2004 (2004-10-15), pages 5258 - 5267, XP002577739, ISSN: 0022-1767 *

Also Published As

Publication number Publication date
WO2007073907A1 (fr) 2007-07-05
NO20082881L (no) 2008-09-25
EP2172215B1 (fr) 2013-10-16
JP2009521910A (ja) 2009-06-11
CA2634955A1 (fr) 2007-07-05
EP1973567B1 (fr) 2010-02-17
DK1973567T3 (da) 2010-05-31
DE602006012376D1 (de) 2010-04-01
EP2172215A2 (fr) 2010-04-07
CN101351224A (zh) 2009-01-21
EA200801463A1 (ru) 2008-12-30
MX2008008578A (es) 2008-09-26
US8945574B2 (en) 2015-02-03
UA93894C2 (ru) 2011-03-25
ITMI20052517A1 (it) 2007-06-30
CA2634955C (fr) 2017-02-28
ES2341367T3 (es) 2010-06-18
CN101351224B (zh) 2013-04-03
ATE457738T1 (de) 2010-03-15
US20090304752A1 (en) 2009-12-10
ES2441217T3 (es) 2014-02-03
BRPI0620749A2 (pt) 2011-11-22
DK2172215T3 (da) 2014-01-20
PT1973567E (pt) 2010-05-12
EP1973567A1 (fr) 2008-10-01
AU2006331005A1 (en) 2007-07-05
AU2006331005B2 (en) 2012-02-02
EA015446B1 (ru) 2011-08-30

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