EP2160597A2 - Verfahren zur rheologischen charakterisierung eines viskoelastischen mediums - Google Patents

Verfahren zur rheologischen charakterisierung eines viskoelastischen mediums

Info

Publication number
EP2160597A2
EP2160597A2 EP08806061A EP08806061A EP2160597A2 EP 2160597 A2 EP2160597 A2 EP 2160597A2 EP 08806061 A EP08806061 A EP 08806061A EP 08806061 A EP08806061 A EP 08806061A EP 2160597 A2 EP2160597 A2 EP 2160597A2
Authority
EP
European Patent Office
Prior art keywords
medium
deformation
rheological
excitation
parameter
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
EP08806061A
Other languages
English (en)
French (fr)
Inventor
Ralph Sinkus
Mickaël TANTER
Mathias Fink
Jeremy Bercoff
David Savery
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SuperSonic Imagine SA
Original Assignee
Centre National de la Recherche Scientifique CNRS
SuperSonic Imagine SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Centre National de la Recherche Scientifique CNRS, SuperSonic Imagine SA filed Critical Centre National de la Recherche Scientifique CNRS
Publication of EP2160597A2 publication Critical patent/EP2160597A2/de
Ceased legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N29/00—Investigating or analysing materials by the use of ultrasonic, sonic or infrasonic waves; Visualisation of the interior of objects by transmitting ultrasonic or sonic waves through the object
    • G01N29/02—Analysing fluids
    • G01N29/032—Analysing fluids by measuring attenuation of acoustic waves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/08—Detecting organic movements or changes, e.g. tumours, cysts, swellings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/48—Diagnostic techniques
    • A61B8/485—Diagnostic techniques involving measuring strain or elastic properties
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N29/00—Investigating or analysing materials by the use of ultrasonic, sonic or infrasonic waves; Visualisation of the interior of objects by transmitting ultrasonic or sonic waves through the object
    • G01N29/02—Analysing fluids
    • G01N29/024—Analysing fluids by measuring propagation velocity or propagation time of acoustic waves
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N29/00—Investigating or analysing materials by the use of ultrasonic, sonic or infrasonic waves; Visualisation of the interior of objects by transmitting ultrasonic or sonic waves through the object
    • G01N29/04—Analysing solids
    • G01N29/06—Visualisation of the interior, e.g. acoustic microscopy
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N29/00—Investigating or analysing materials by the use of ultrasonic, sonic or infrasonic waves; Visualisation of the interior of objects by transmitting ultrasonic or sonic waves through the object
    • G01N29/04—Analysing solids
    • G01N29/07—Analysing solids by measuring propagation velocity or propagation time of acoustic waves
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N29/00—Investigating or analysing materials by the use of ultrasonic, sonic or infrasonic waves; Visualisation of the interior of objects by transmitting ultrasonic or sonic waves through the object
    • G01N29/04—Analysing solids
    • G01N29/11—Analysing solids by measuring attenuation of acoustic waves
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01S—RADIO DIRECTION-FINDING; RADIO NAVIGATION; DETERMINING DISTANCE OR VELOCITY BY USE OF RADIO WAVES; LOCATING OR PRESENCE-DETECTING BY USE OF THE REFLECTION OR RERADIATION OF RADIO WAVES; ANALOGOUS ARRANGEMENTS USING OTHER WAVES
    • G01S7/00—Details of systems according to groups G01S13/00, G01S15/00, G01S17/00
    • G01S7/52—Details of systems according to groups G01S13/00, G01S15/00, G01S17/00 of systems according to group G01S15/00
    • G01S7/52017—Details of systems according to groups G01S13/00, G01S15/00, G01S17/00 of systems according to group G01S15/00 particularly adapted to short-range imaging
    • G01S7/52023—Details of receivers
    • G01S7/52036—Details of receivers using analysis of echo signal for target characterisation
    • G01S7/52038—Details of receivers using analysis of echo signal for target characterisation involving non-linear properties of the propagation medium or of the reflective target
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2203/00—Investigating strength properties of solid materials by application of mechanical stress
    • G01N2203/0058—Kind of property studied
    • G01N2203/0092—Visco-elasticity, solidification, curing, cross-linking degree, vulcanisation or strength properties of semi-solid materials
    • G01N2203/0094—Visco-elasticity
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2291/00—Indexing codes associated with group G01N29/00
    • G01N2291/02—Indexing codes associated with the analysed material
    • G01N2291/024—Mixtures
    • G01N2291/02475—Tissue characterisation
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2291/00—Indexing codes associated with group G01N29/00
    • G01N2291/02—Indexing codes associated with the analysed material
    • G01N2291/024—Mixtures
    • G01N2291/02483—Other human or animal parts, e.g. bones
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2291/00—Indexing codes associated with group G01N29/00
    • G01N2291/02—Indexing codes associated with the analysed material
    • G01N2291/024—Mixtures
    • G01N2291/02491—Materials with nonlinear acoustic properties
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2291/00—Indexing codes associated with group G01N29/00
    • G01N2291/02—Indexing codes associated with the analysed material
    • G01N2291/028—Material parameters
    • G01N2291/02827—Elastic parameters, strength or force
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01S—RADIO DIRECTION-FINDING; RADIO NAVIGATION; DETERMINING DISTANCE OR VELOCITY BY USE OF RADIO WAVES; LOCATING OR PRESENCE-DETECTING BY USE OF THE REFLECTION OR RERADIATION OF RADIO WAVES; ANALOGOUS ARRANGEMENTS USING OTHER WAVES
    • G01S15/00—Systems using the reflection or reradiation of acoustic waves, e.g. sonar systems
    • G01S15/88—Sonar systems specially adapted for specific applications
    • G01S15/89—Sonar systems specially adapted for specific applications for mapping or imaging
    • G01S15/8906—Short-range imaging systems; Acoustic microscope systems using pulse-echo techniques

Definitions

  • the present invention relates to rheological characterization methods of a viscoelastic medium.
  • the invention relates to a method for the rheological characterization of a viscoelastic medium, comprising the following steps:
  • a particularly important application of this method is the imaging of the soft tissues of the human body, for example for the purpose of detecting cancers.
  • WO-A-04 / 21,038 describes an example of such a method.
  • the object of the present invention is to further improve the methods of this type, so as to improve the reliability and sensitivity of detection.
  • a method of the kind in question is characterized in that during the characterization step, a non-zero power parameter y such that said parameter is determined in said plurality of middle points.
  • one or more of the following provisions may also be used: during the characterization step, the parameter of scale b in said plurality of points of the medium; said rheological parameter x is an attenuation coefficient of the mechanical waves in the medium; said rheological parameter x is a coefficient of propagation of mechanical waves in the medium; said excitation generates a shear wave in the medium; said rheological parameter is the real part of the complex shear modulus G * of the medium; said rheological parameter is the imaginary part of the complex shear modulus G * of the medium; said excitation is generated locally by a mechanical vibrator which produces the shear wave from a point of contact between said vibrator and the medium; said shear wave is generated at a distance by emitting in the medium ultrasonic compression waves adapted to locally move the medium; during the step (b) of deformation measurement, an image of the deformation generated by the excitation is produced on a region with at least two dimensions belonging to said medium; during the step (b) of deformation measurement, an image of the de
  • FIG. 1 is a two-dimensional MRI view of a breast of a patient with infiltrating ductal carcinoma, sectioned in a sagittal plane
  • FIGS. 2-5 show cartographies of several rheological parameters of the breast of Figure 1, in the plane of Figure 1.
  • the invention relates to a process for the rheological characterization of a viscoelastic medium 1, for example the soft tissues of an organ of the human body, especially for the purpose of identifying abnormalities such as cancers, from the analysis of the rheological parameters. in question.
  • FIG. 1 represents an MRI section of a breast (constituting the aforementioned medium 1) of a patient suffering from invasive ductal carcinoma 2, corresponding to the area surrounded by a solid line in Figure 1.
  • the diseased portion 2 of the medium 1 is not clearly distinguishable from the healthy portions on the MRI section.
  • rheological parameters at least one point, or preferably over an entire region to obtain a map of this rheological parameter
  • the vibratory excitation can for example generate a shear wave in the medium: either locally by an external mechanical vibrator which produces the shear wave from a point of contact between said vibrator and the medium (as described by example in WO-A-2000/55616), said vibrator then inducing an excitation whose spectrum can be monofrequential or wide, included for example in a frequency band between 0 and 10000 Hz, or remotely by emitting in the medium compressional ultrasonic waves adapted to locally move the medium (WO-A-2004/021038), these waves ultrasound can be of frequency for example between 0.1 and 50 MHz, focused or not, created by a network of independent transducers or a mono-element transducer.
  • step (b) of deformation measurement said deformation is measured by a method chosen in particular from ultrasound and MRI, as illustrated for example in documents WO-A-2000/55616, WO-A -2004/021038, WO-A-2006/010213 mentioned above.
  • step (b) of measuring deformation it is advantageous to carry out an image of the deformation (amplitude of deformation) generated by the excitation, on a region with at least two dimensions belonging to the medium 1, and during in step (c) of rheological characterization, it is advantageous to determine a cartography of the rheological parameter of the medium in said region.
  • the imaginary part ex of k represents the attenuation of the wave whereas its real part ⁇ represents the propagation: these parameters are part of the parameters characterizing the rheology of the medium 1.
  • at least one of the rheological parameters of the medium varies according to a power law of the frequency f.
  • the power is generally between 0 and 2 for mechanical waves in biological tissues.
  • r fo is a reference frequency
  • the power law can concern one of the following rheological parameters:
  • the estimation of the spatial variations of the rheological parameter (s) selected can be done by analyzing the spatio-temporal response of the medium to the mechanical excitation over the entire imagined zone, and in particular:
  • shear waves have been propagated in the breast 1, the propagation of which has been observed by MRI by measuring the displacements u of the medium 1, then we used a rheological model based on a power law for attenuation of shear waves:
  • the causality determines the fréguentiel behavior of the real part of the wave vector (the coefficient of propagation):
  • a monochromatic external vibration (that is to say with a single vibrational frequency) was applied to the breast 1 of the patient by a mechanical vibrator.
  • the displacement field u was measured by MRI and the complex shear modulus G * was deduced from these measurements:
  • Figures 2 and 3 show such mappings of y and a () , obtained with a monochromatic excitation of frequency 80 Hz. These two mappings make it possible to locate with a great precision and with a strong contrast, the invasive ductal carcinoma of which the patient. Similar results can be obtained with Y and ⁇ 0 .

Landscapes

  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Acoustics & Sound (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Radar, Positioning & Navigation (AREA)
  • Veterinary Medicine (AREA)
  • Biophysics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Remote Sensing (AREA)
  • Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Computer Networks & Wireless Communication (AREA)
  • Nonlinear Science (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Investigating Strength Of Materials By Application Of Mechanical Stress (AREA)
EP08806061A 2007-06-25 2008-06-23 Verfahren zur rheologischen charakterisierung eines viskoelastischen mediums Ceased EP2160597A2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0704535A FR2917831B1 (fr) 2007-06-25 2007-06-25 Procede de caracterisation rheologique d'un milieu viscoelastique
PCT/FR2008/051129 WO2009007582A2 (fr) 2007-06-25 2008-06-23 Procede de caracterisation rheologique d'un milieu viscoelastique

Publications (1)

Publication Number Publication Date
EP2160597A2 true EP2160597A2 (de) 2010-03-10

Family

ID=38935903

Family Applications (1)

Application Number Title Priority Date Filing Date
EP08806061A Ceased EP2160597A2 (de) 2007-06-25 2008-06-23 Verfahren zur rheologischen charakterisierung eines viskoelastischen mediums

Country Status (9)

Country Link
US (1) US8347692B2 (de)
EP (1) EP2160597A2 (de)
JP (2) JP2010531183A (de)
KR (2) KR20150023945A (de)
CN (2) CN101918828A (de)
CA (1) CA2692296A1 (de)
FR (1) FR2917831B1 (de)
IL (1) IL202962A (de)
WO (1) WO2009007582A2 (de)

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FR2899336B1 (fr) 2006-03-29 2008-07-04 Super Sonic Imagine Procede et dispositif pour l'imagerie d'un milieu viscoelastique
US8741663B2 (en) * 2008-03-11 2014-06-03 Drexel University Enhanced detection sensitivity with piezoelectric sensors
AU2009246115A1 (en) * 2008-05-16 2009-11-19 Drexel University System and method for evaluating tissue
CA2732334C (en) * 2008-07-30 2017-05-23 Centre Hospitalier De L'universite De Montreal A system and method for detection, characterization and imaging of heterogeneity using shear wave induced resonance
FR2940444B1 (fr) * 2008-12-24 2014-03-07 Areva Np Procede de caracterisation non destructif et sans contact d'une structure multi-couche sensiblement spherique et dispositif associe
US20100286520A1 (en) * 2009-05-11 2010-11-11 General Electric Company Ultrasound system and method to determine mechanical properties of a target region
US10368843B2 (en) * 2009-11-25 2019-08-06 Koninklijke Philips N.V. Ultrasonic shear wave imaging with focused scanline beamforming
CA2797262C (en) 2010-04-20 2016-12-13 Centre National De La Recherche Scientifique - Cnrs Imaging method and apparatus using shear waves
WO2013105987A2 (en) 2011-02-15 2013-07-18 Hemosonics, Llc Characterization of blood hemostasis and oxygen transport parameters
CN105188556B (zh) * 2013-02-25 2017-11-07 皇家飞利浦有限公司 对声学分散元素的浓度分布的确定
WO2014201020A1 (en) * 2013-06-10 2014-12-18 Mayo Foundation For Medical Education And Research System and method for acoustic radiation force creep-recovery and shear wave propagation for elasticity imaging
US9726647B2 (en) 2015-03-17 2017-08-08 Hemosonics, Llc Determining mechanical properties via ultrasound-induced resonance
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CN114280030B (zh) * 2021-12-24 2023-07-21 中国科学院近代物理研究所 基于激光诱导击穿光谱的软物质粘弹性表征方法

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Also Published As

Publication number Publication date
CN101918828A (zh) 2010-12-15
WO2009007582A2 (fr) 2009-01-15
KR20150023945A (ko) 2015-03-05
IL202962A (en) 2014-08-31
CA2692296A1 (fr) 2009-01-15
KR101633804B1 (ko) 2016-06-27
US20100170342A1 (en) 2010-07-08
KR20100050469A (ko) 2010-05-13
US8347692B2 (en) 2013-01-08
CN102830163A (zh) 2012-12-19
JP5864680B2 (ja) 2016-02-17
JP2015006405A (ja) 2015-01-15
WO2009007582A3 (fr) 2009-03-12
FR2917831B1 (fr) 2009-10-30
FR2917831A1 (fr) 2008-12-26
JP2010531183A (ja) 2010-09-24

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