EP2155071B1 - Medical devices and systems for closing perforations - Google Patents

Medical devices and systems for closing perforations Download PDF

Info

Publication number
EP2155071B1
EP2155071B1 EP08756124.7A EP08756124A EP2155071B1 EP 2155071 B1 EP2155071 B1 EP 2155071B1 EP 08756124 A EP08756124 A EP 08756124A EP 2155071 B1 EP2155071 B1 EP 2155071B1
Authority
EP
European Patent Office
Prior art keywords
medical device
distal
tubes
tissue
delivery devices
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
EP08756124.7A
Other languages
German (de)
English (en)
French (fr)
Other versions
EP2155071A1 (en
Inventor
Vihar C. Surti
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cook Medical Technologies LLC
Original Assignee
Cook Medical Technologies LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cook Medical Technologies LLC filed Critical Cook Medical Technologies LLC
Publication of EP2155071A1 publication Critical patent/EP2155071A1/en
Application granted granted Critical
Publication of EP2155071B1 publication Critical patent/EP2155071B1/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/04—Surgical instruments, devices or methods for suturing wounds; Holders or packages for needles or suture materials
    • A61B17/0469—Suturing instruments for use in minimally invasive surgery, e.g. endoscopic surgery
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/0057—Implements for plugging an opening in the wall of a hollow or tubular organ, e.g. for sealing a vessel puncture or closing a cardiac septal defect
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/04—Surgical instruments, devices or methods for suturing wounds; Holders or packages for needles or suture materials
    • A61B17/0401—Suture anchors, buttons or pledgets, i.e. means for attaching sutures to bone, cartilage or soft tissue; Instruments for applying or removing suture anchors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/04—Surgical instruments, devices or methods for suturing wounds; Holders or packages for needles or suture materials
    • A61B17/0482—Needle or suture guides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/0057—Implements for plugging an opening in the wall of a hollow or tubular organ, e.g. for sealing a vessel puncture or closing a cardiac septal defect
    • A61B2017/00637—Implements for plugging an opening in the wall of a hollow or tubular organ, e.g. for sealing a vessel puncture or closing a cardiac septal defect for sealing trocar wounds through abdominal wall
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/0057—Implements for plugging an opening in the wall of a hollow or tubular organ, e.g. for sealing a vessel puncture or closing a cardiac septal defect
    • A61B2017/00646—Type of implements
    • A61B2017/00663—Type of implements the implement being a suture
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/04—Surgical instruments, devices or methods for suturing wounds; Holders or packages for needles or suture materials
    • A61B17/0469—Suturing instruments for use in minimally invasive surgery, e.g. endoscopic surgery
    • A61B2017/0472—Multiple-needled, e.g. double-needled, instruments

Definitions

  • the present invention relates generally to medical devices, and systems for closing perforations in tissue.
  • T-anchors also known as tissue anchors or visceral anchors.
  • An exemplary tissue anchor is disclosed in U.S. Pat. No. 5,123,914 . Such tissue anchors have been very successful in medical procedures requiring visceral wall mobilization or wall apposition.
  • U.S. Patent Application Publication No. 2001/021855 discloses a tissue fixation delivery system having the features of the preamble of claim 1.
  • the present invention provides medical devices, and systems for placing tissue fixation devices that are easy to employ, reduce procedure time, and improve spacing of the tissue fixation devices.
  • a medical device constructed in accordance with the teachings of the present invention, includes a plurality of elongate delivery devices, a plurality of elongate tubes, and a distal tip as determined by the appended claim 1.
  • the delivery devices are needles, although other devices may be used for delivering tissue fixation devices.
  • Each delivery device defines a delivery lumen sized to receive a tissue fixation device.
  • the plurality of elongate tubes extend generally parallel to a longitudinal axis, and each tube defines a tube lumen sized to receive one of the delivery devices.
  • Each tube lumen has a distal port.
  • the distal tip is connected to the plurality of elongate tubes and defines a guide surface positioned distally of the distal ports.
  • the guide surface is structured to redirect the plurality of delivery devices radially outwardly as the plurality of delivery devices are distally translated through the tube lumens and the distal ports of the plurality of elongate tubes.
  • the guide surface slopes radially outwardly, and preferably is curved.
  • the guide surface redirects the plurality of delivery devices in a direction angled relative to the longitudinal axis, preferably angled in the range of 10 to 60 degrees, and most preferably about 30 degrees.
  • the distal tip defines a hub having a plurality of pockets sized to receive the plurality of elongate tubes. An end surface of the distal tip is atraumatically shaped.
  • the delivery devices are puncture needles
  • the tissue fixation devices are tissue anchors.
  • a medical system for placing tissue fixation devices in bodily tissues includes a plurality of elongate delivery devices, a plurality of elongate tubes, a distal tip, and an endoscope.
  • the plurality of delivery devices each define a delivery lumen sized to receive a tissue fixation device.
  • the plurality of elongate tubes extend generally parallel to a longitudinal axis and each tube defines a tube lumen sized to receive one of the plurality of delivery devices.
  • Each tube lumen defines a distal port.
  • a distal tip is connected to the plurality of elongate tubes and defines a guide surface positioned distally of the distal ports and extending radially outwardly.
  • the distal tip defines a passageway.
  • the endoscope is selectively attachable to the distal tip, and the passageway is sized to receive a distal end of the endoscope therein.
  • the medical device 20 generally includes a plurality of puncture needles 30 and a plurality of tubes 32.
  • the plurality of needles 30 have at their proximal end a plurality of needle housings 34, while the proximal end of the plurality of tubes 32 includes a plurality of tube housings 36.
  • the relative positions of the needle housings 34 and the tube housings 36 control the relative positions of the needles 30 within the protective tubes 32. In this manner, the needles 30 may be operated to project from a distal end of the tubes 32, or operated to be retracted within the tubes 32, as will be described in more detail hereinbelow.
  • the distal tip 42 and plurality of tubes 32 may be interconnected through frictional engagement, adhesives, welding, soldering or any other well known means for connecting two structures.
  • the hubs 44 define distal ports 55 through which the plurality of needles 30 extend and are exposed for placement through the bodily tissue 12. It will be recognized by those skilled in the art that the distal tip 42 may simply have the plurality of tubes 32 attached to its exterior surface, thereby eliminating the hub or hubs 44 and their pockets 46. In this case, the plurality of tubes 32 themselves would define the distal ports 55 though which the needles 30 can exit.
  • the distal ports 55 are circumferentially spaced about the distal tip 42.
  • the plurality of tubes 32 each define a tube lumen 58 which slideably receives the needles 30 therein.
  • the needles 30 each define a needle lumen 52 which is sized to receive the stylet 40.
  • a distal end 31 of each needle 30 contains one or more tissue anchors 54 positioned within the needle lumen 52.
  • the distal end 31 also includes a slot 33 through which the suture 56 passes.
  • the suture 56 is connected to the tissue anchor 54 and is used to draw the perforation 16 ( FIG. 7 ) closed, as is known in the art. It can be seen in FIG. 3 that the suture 56 extends proximally through the tube lumen 58 between the needle 30 and tube 32.
  • the hubs 44 define slots 50 that open radially, and the slots 50 provide increased range of movement to the needles 30 as they flex.
  • the plurality of tubes 32 are simply attached to the exterior surface of the distal tip 42 (i.e. without the hub 44 and pockets 46) these slots 50 may be formed in the tubes 32 themselves.
  • the needles 30 enter the slots 50 defined by the hub 44 and pockets 46, thereby permitting greater range of movement and preventing excessive flexing or bending of the needles 30.
  • the distal tip 42 and its guiding surface 64 move each of the needles 30 radially outwardly away from each other and away from the longitudinal axis 14. While the figures have depicted the guide surface 64 as curved, and generally a bell-shaped curve, it will be recognized by those skilled in the art that the guiding surface 64 may take many different curvatures, or can even be flat, such as in a conical or pyramidal shape (i.e. flat in the longitudinal direction). Further, the outer diameter of the distal tip 42 at its peak 65 may also be increased or decreased to increase or decrease the amount of deflection of the plurality of needles 30. The peaks 65 are preferably spaced radially outwardly of the distal ports 50.
  • the distal tip 42 and its guiding surface 64 are structured to cause the needles 30 to be passed through the tissue 12 at an angle of about 10 to 60 degrees relative to the longitudinal axis 14.
  • the needles 30 are at an angle of about 30 degrees relative to the longitudinal axis 14.
  • the needles 30 are in paths that are circumferentially spaced apart, and preferably equidistantly spaced apart, thereby greatly improving the spacing of the tissue anchors 54 around a perforation 16 ( FIG. 7 ) and improving perforation closure.
  • the plurality of puncture needles 30 are passed through the bodily tissue 12. This may occur sequentially or simultaneously. It will be recognized by those skilled in the art that because the distance between each of the needles 30 increases in the longitudinal direction (i.e. the more distal the greater the spacing), the medical system 22 and its distal tip 42 may be placed closer to the tissue 12 to bring the placement sites closer together, or the medical system 22 may be moved further away from the tissue 12 to increase the distance between the placement sites. In devices where other types of tissue fixation devices and delivery devices are employed (e.g. a visceral staple and delivery catheter, respectively) the delivery device need only be positioned proximate the tissue 12, and need not pass through the tissue 12.
  • tissue fixation devices and delivery devices e.g. a visceral staple and delivery catheter, respectively
  • the plurality of tissue anchors 54 are delivered to a position on the distal side of the bodily tissue 12.
  • the tissue anchors 54 are connected to suture 56, and the anchors 54 are ejected from the distal end of the needles 30 through translation of the stylets 40 via depression of the plungers 38 ( FIG. 1 ).
  • the plurality of puncture needles 30 are then retracted into the plurality of tubes 30, leaving the tissue anchors 54 in place.
  • a cutting instrument 68 may then be delivered through the accessory channel 25 of the endoscope 24, and used to form an opening 16 in the tissue 12.
  • the cutting tool 68 is an electrosurgical cutting instrument, although it will be recognized by those skilled in the art that any type of cutting instrument or device may be employed.
  • the exemplary step of forming the opening 16 is performed after the exemplary step of translating the puncture needles 30 and most preferably after delivering the plurality of tissue anchors 54, thereby reducing the potential for the tissue 12 to deflect or move when placing the tissue anchors 54.
  • the plurality of tissue anchors 54 or other tissue fixation devices may be delivered after the opening 16 has already been formed in the tissue 12. In either case, the tissue 12 (and sometimes the opening 16) is preferably visualized using the endoscope 24 prior to placing the plurality of puncture needles 30 through the bodily tissue 12.
  • the medical system 22 may be retracted through the bodily lumen 10, and the endoscope 24 may be detached from the medical device 20. If desired, the endoscope 24 may then be reintroduced through the bodily lumen 10 and through the opening 16 in the bodily tissue 12. As such, various procedures may be employed with, or in conjunction with, the endoscope 24 on the distal side of the bodily tissue 12. It will also be recognized that various other medical devices may be passed through the bodily lumen 10 and through the opening 16 formed in the bodily tissue 12.
  • the one or more sutures 56 attached to the tissue anchors 54 are connected together, such as by using a suture lock. Exemplary suture locks are disclosed in U.S. Patent Application Nos. 60/941,086 and 60/956,575 now published as WO 2008/147875 and WO 2009/026078 respectively. Through fixation of the sutures 56, the perforation 16 can be easily and securely closed.

Landscapes

  • Health & Medical Sciences (AREA)
  • Surgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medical Informatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Rheumatology (AREA)
  • Cardiology (AREA)
  • Surgical Instruments (AREA)
  • Endoscopes (AREA)
EP08756124.7A 2007-05-25 2008-05-22 Medical devices and systems for closing perforations Active EP2155071B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US94024607P 2007-05-25 2007-05-25
PCT/US2008/064508 WO2008147871A1 (en) 2007-05-25 2008-05-22 Medical devices, systems and methods for closing perforations

Publications (2)

Publication Number Publication Date
EP2155071A1 EP2155071A1 (en) 2010-02-24
EP2155071B1 true EP2155071B1 (en) 2014-07-16

Family

ID=39689461

Family Applications (1)

Application Number Title Priority Date Filing Date
EP08756124.7A Active EP2155071B1 (en) 2007-05-25 2008-05-22 Medical devices and systems for closing perforations

Country Status (6)

Country Link
US (1) US9155532B2 (enExample)
EP (1) EP2155071B1 (enExample)
JP (1) JP5443341B2 (enExample)
AU (1) AU2008256823B2 (enExample)
CA (1) CA2688261C (enExample)
WO (1) WO2008147871A1 (enExample)

Families Citing this family (57)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8758400B2 (en) 2000-01-05 2014-06-24 Integrated Vascular Systems, Inc. Closure system and methods of use
US6391048B1 (en) 2000-01-05 2002-05-21 Integrated Vascular Systems, Inc. Integrated vascular device with puncture site closure component and sealant and methods of use
US9579091B2 (en) 2000-01-05 2017-02-28 Integrated Vascular Systems, Inc. Closure system and methods of use
AU2001288009B2 (en) 2000-09-08 2005-07-07 Abbott Vascular Inc Surgical stapler
US6626918B1 (en) 2000-10-06 2003-09-30 Medical Technology Group Apparatus and methods for positioning a vascular sheath
US6623510B2 (en) 2000-12-07 2003-09-23 Integrated Vascular Systems, Inc. Closure device and methods for making and using them
US8690910B2 (en) 2000-12-07 2014-04-08 Integrated Vascular Systems, Inc. Closure device and methods for making and using them
US7905900B2 (en) * 2003-01-30 2011-03-15 Integrated Vascular Systems, Inc. Clip applier and methods of use
US6749621B2 (en) 2002-02-21 2004-06-15 Integrated Vascular Systems, Inc. Sheath apparatus and methods for delivering a closure device
US7850709B2 (en) 2002-06-04 2010-12-14 Abbott Vascular Inc. Blood vessel closure clip and delivery device
US8398656B2 (en) 2003-01-30 2013-03-19 Integrated Vascular Systems, Inc. Clip applier and methods of use
US8202293B2 (en) 2003-01-30 2012-06-19 Integrated Vascular Systems, Inc. Clip applier and methods of use
US8905937B2 (en) 2009-02-26 2014-12-09 Integrated Vascular Systems, Inc. Methods and apparatus for locating a surface of a body lumen
US9713465B1 (en) * 2004-04-19 2017-07-25 Granit Medical Innovation Llc Surgical closure device and associated method
US8926633B2 (en) 2005-06-24 2015-01-06 Abbott Laboratories Apparatus and method for delivering a closure element
US8313497B2 (en) 2005-07-01 2012-11-20 Abbott Laboratories Clip applier and methods of use
US8556930B2 (en) 2006-06-28 2013-10-15 Abbott Laboratories Vessel closure device
US8893947B2 (en) 2007-12-17 2014-11-25 Abbott Laboratories Clip applier and methods of use
US9282965B2 (en) 2008-05-16 2016-03-15 Abbott Laboratories Apparatus and methods for engaging tissue
EP2344045A1 (en) * 2008-09-16 2011-07-20 Ventralfix, Inc. Method and apparatus for minimally invasive delivery, tensioned deployment and fixation of secondary material prosthetic devices in patient body tissue, including hernia repair within the patient's herniation site
WO2010042402A1 (en) * 2008-10-06 2010-04-15 Wilson-Cook Medical, Inc. Endcap for safely deploying tissue anchors
US8398676B2 (en) 2008-10-30 2013-03-19 Abbott Vascular Inc. Closure device
US9089311B2 (en) 2009-01-09 2015-07-28 Abbott Vascular Inc. Vessel closure devices and methods
US20100179589A1 (en) 2009-01-09 2010-07-15 Abbott Vascular Inc. Rapidly eroding anchor
US9173644B2 (en) 2009-01-09 2015-11-03 Abbott Vascular Inc. Closure devices, systems, and methods
US9414820B2 (en) * 2009-01-09 2016-08-16 Abbott Vascular Inc. Closure devices, systems, and methods
US9486191B2 (en) 2009-01-09 2016-11-08 Abbott Vascular, Inc. Closure devices
US20100185234A1 (en) 2009-01-16 2010-07-22 Abbott Vascular Inc. Closure devices, systems, and methods
US8382776B2 (en) * 2009-04-03 2013-02-26 Cook Medical Technologies Llc Medical devices, systems and methods for rapid deployment and fixation of tissue anchors
US20110054492A1 (en) 2009-08-26 2011-03-03 Abbott Laboratories Medical device for repairing a fistula
US20150335320A1 (en) * 2010-04-13 2015-11-26 neoSurgical Ltd. Suture delivery system
US9855031B2 (en) 2010-04-13 2018-01-02 Neosurgical Limited Suture delivery system
GB2486497B (en) * 2010-12-17 2013-06-19 Neosurgical Ltd Laparoscopic trocar system
EP3305209B1 (en) 2010-06-09 2025-01-08 C.R. Bard Inc. Instruments for delivering transfascial sutures and transfascial suture assemblies.
ITPI20100099A1 (it) * 2010-08-18 2012-02-19 Enrico Gervasi Innovativo dispositivo a uso chirurgico da impiegare nei trapianti muscolo/tendinei eseguiti in artroscopia
JP5615112B2 (ja) * 2010-09-21 2014-10-29 日本コヴィディエン株式会社 臓器固定具及び臓器固定具の導入具
GB2495534B (en) * 2011-10-13 2014-04-23 Neosurgical Ltd Laparoscopic system
US9826972B2 (en) 2011-10-24 2017-11-28 C.R. Bard, Inc. Instruments for delivering transfascial sutures, transfascial suture assemblies and methods of transfascial suturing
US9924938B2 (en) 2011-11-07 2018-03-27 C.R. Bard, Inc. Instruments for delivering transfascial sutures and methods of transfascial suturing
US9078648B2 (en) 2011-11-07 2015-07-14 C.R. Bard, Inc. Instruments for delivering transfascial sutures and methods of transfascial suturing
US9039721B2 (en) 2011-11-07 2015-05-26 C.R. Bard, Inc. Instruments for delivering transfascial sutures and methods of transfascial suturing
US9332976B2 (en) 2011-11-30 2016-05-10 Abbott Cardiovascular Systems, Inc. Tissue closure device
WO2013119630A1 (en) * 2012-02-06 2013-08-15 Cook Medical Technologies Llc Artificial device deployment apparatus
US9364209B2 (en) 2012-12-21 2016-06-14 Abbott Cardiovascular Systems, Inc. Articulating suturing device
JP6117160B2 (ja) * 2014-09-18 2017-04-19 本田技研工業株式会社 車両制動制御装置
US9668725B2 (en) * 2015-03-24 2017-06-06 Richard B. Beaven Laparoscopic wound closure device
US10639020B2 (en) 2015-09-28 2020-05-05 M-V Arterica AB Vascular closure device
US20190142403A1 (en) 2017-11-16 2019-05-16 M-V Arterica AB Tissue closure device
US11179145B2 (en) 2017-11-16 2021-11-23 M-V Arterica AB Collapsible tube for hemostasis
US11344292B2 (en) * 2018-06-14 2022-05-31 Covidien Lp Trans-vaginal cuff anchor and method of deploying same
US12108945B2 (en) * 2018-10-24 2024-10-08 Arterica Inc. Self-expanding hemostatic devices and methods for fascia and vessel passages
US11375994B2 (en) 2019-07-12 2022-07-05 Abbot Cardiovascular Systems, Inc. Methods, systems, and devices for positioning sutures for closing an opening in tissue
CA3144517A1 (en) * 2019-09-06 2021-03-11 Boston Scientific Scimed, Inc. Systems device
EP4061244A4 (en) 2019-11-19 2024-06-19 Arterica Inc. Vascular closure devices and methods
US12383246B2 (en) 2020-10-12 2025-08-12 Abbott Cardiovascular Systems, Inc. Vessel closure device with improved safety and tract hemostasis
WO2023114840A1 (en) * 2021-12-16 2023-06-22 Hologic, Inc. Colpotomy cup for faciliting suturing of vaginal cuff
CN120241153B (zh) * 2025-06-04 2025-09-30 浙江省肿瘤医院 一种用于十二指肠内镜治疗术后穿孔的缝合装置

Family Cites Families (108)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2199025A (en) * 1936-06-08 1940-04-30 Carl E Conn Means and method of closing surgical incisions
US3556079A (en) * 1967-05-16 1971-01-19 Haruo Omizo Method of puncturing a medical instrument under guidance of ultrasound
US4235238A (en) * 1978-05-11 1980-11-25 Olympus Optical Co., Ltd. Apparatus for suturing coeliac tissues
US5417691A (en) * 1982-05-20 1995-05-23 Hayhurst; John O. Apparatus and method for manipulating and anchoring tissue
US5123914A (en) * 1986-05-19 1992-06-23 Cook Incorporated Visceral anchor for visceral wall mobilization
ES2074130T3 (es) * 1989-08-09 1995-09-01 Bard Inc C R Sistema de cateteres guia y mandriles para intercambio rapido de cateteres.
US5203787A (en) * 1990-11-19 1993-04-20 Biomet, Inc. Suture retaining arrangement
US5366480A (en) * 1990-12-24 1994-11-22 American Cyanamid Company Synthetic elastomeric buttressing pledget
US5333624A (en) * 1992-02-24 1994-08-02 United States Surgical Corporation Surgical attaching apparatus
DE4235506A1 (de) * 1992-10-21 1994-04-28 Bavaria Med Tech Katheter zur Injektion von Arzneimitteln
IL103737A (en) * 1992-11-13 1997-02-18 Technion Res & Dev Foundation Stapler device particularly useful in medical suturing
US5403348A (en) * 1993-05-14 1995-04-04 Bonutti; Peter M. Suture anchor
IT1269443B (it) * 1994-01-19 1997-04-01 Stefano Nazari Protesi vascolare per la sostituzione o il rivestimento interno di vasi sanguigni di medio e grande diametro e dispositivo per la sua applicazione senza interruzione del flusso ematico
GB2298368B (en) * 1995-02-22 1999-01-20 John Francis Cockburn Medical needle assembly for use in ultrasound imaging
US5807304A (en) * 1995-03-09 1998-09-15 Cockburn; John F. Medical needle for use in ultrasound imaging
US6132438A (en) * 1995-06-07 2000-10-17 Ep Technologies, Inc. Devices for installing stasis reducing means in body tissue
US5690656A (en) * 1995-06-27 1997-11-25 Cook Incorporated Method and apparatus for creating abdominal visceral anastomoses
US5810848A (en) * 1996-08-21 1998-09-22 Hayhurst; John O. Suturing system
US6053871A (en) * 1997-01-21 2000-04-25 William Cook Australia Pty. Ltd Calibrated hollow probe for use with ultrasound imaging
US5891159A (en) * 1997-05-02 1999-04-06 Cardiothoratic Systems, Inc. Automatic purse string suture device
US5908428A (en) * 1997-05-27 1999-06-01 United States Surgical Corporation Stitching devices for heart valve replacement surgery
US6071292A (en) * 1997-06-28 2000-06-06 Transvascular, Inc. Transluminal methods and devices for closing, forming attachments to, and/or forming anastomotic junctions in, luminal anatomical structures
US5954732A (en) * 1997-09-10 1999-09-21 Hart; Charles C. Suturing apparatus and method
US6078831A (en) * 1997-09-29 2000-06-20 Scimed Life Systems, Inc. Intravascular imaging guidewire
AU736964B2 (en) * 1998-12-09 2001-08-09 Cook Medical Technologies Llc Hollow, curved, superelastic medical needle
US6110183A (en) * 1998-12-22 2000-08-29 Cook Incorporated Suture anchor device
US7416554B2 (en) * 2002-12-11 2008-08-26 Usgi Medical Inc Apparatus and methods for forming and securing gastrointestinal tissue folds
US6398796B2 (en) * 1999-07-13 2002-06-04 Scion Cardio-Vascular, Inc. Suture with toggle and delivery system
JP4108882B2 (ja) * 1999-08-04 2008-06-25 オリンパス株式会社 内視鏡用壁固定具
US6358197B1 (en) * 1999-08-13 2002-03-19 Enteric Medical Technologies, Inc. Apparatus for forming implants in gastrointestinal tract and kit for use therewith
US6231561B1 (en) * 1999-09-20 2001-05-15 Appriva Medical, Inc. Method and apparatus for closing a body lumen
US6635073B2 (en) * 2000-05-03 2003-10-21 Peter M. Bonutti Method of securing body tissue
EP1261282B1 (en) 2000-03-03 2013-09-25 C. R. Bard, Inc. Endoscopic tissue apposition device with multiple suction ports
US6572629B2 (en) * 2000-08-17 2003-06-03 Johns Hopkins University Gastric reduction endoscopy
US6638275B1 (en) * 2000-10-05 2003-10-28 Medironic, Inc. Bipolar ablation apparatus and method
ATE443476T1 (de) * 2001-05-18 2009-10-15 Ucl Business Plc Flexibles gerät zum durchstechen und zusammenfügen von gewebe
JP4351458B2 (ja) * 2002-03-18 2009-10-28 オリンパス株式会社 内視鏡挿入システム
US6699263B2 (en) * 2002-04-05 2004-03-02 Cook Incorporated Sliding suture anchor
US7494496B2 (en) * 2002-05-17 2009-02-24 Ucl Biomedica Plc Device for transfixing and joining tissue
JP4373146B2 (ja) * 2002-07-11 2009-11-25 オリンパス株式会社 内視鏡用縫合装置
US20060015125A1 (en) * 2004-05-07 2006-01-19 Paul Swain Devices and methods for gastric surgery
US9314235B2 (en) * 2003-02-05 2016-04-19 Smith & Nephew, Inc. Tissue anchor and insertion tool
WO2006002417A2 (en) * 2004-06-22 2006-01-05 Yeung Jeffrey E Disc shunt for treating back pain
US7431694B2 (en) * 2003-05-16 2008-10-07 Ethicon Endo-Surgery, Inc. Method of guiding medical devices
JP4145200B2 (ja) * 2003-06-06 2008-09-03 オリンパス株式会社 縫合器
US8216252B2 (en) 2004-05-07 2012-07-10 Usgi Medical, Inc. Tissue manipulation and securement system
US7481826B2 (en) * 2003-09-30 2009-01-27 Ethicon, Inc. Fluid emitting suture needle
US7217279B2 (en) * 2003-11-14 2007-05-15 Ethicon, Inc. Suture loop anchor
JP4217587B2 (ja) 2003-11-26 2009-02-04 オリンパス株式会社 内視鏡用キャップ
US7361180B2 (en) * 2004-05-07 2008-04-22 Usgi Medical, Inc. Apparatus for manipulating and securing tissue
WO2005065554A1 (ja) 2004-01-08 2005-07-21 Olympus Corporation 吻合器および生体内管腔器官壁部の切除方法
US20050154401A1 (en) * 2004-01-08 2005-07-14 Scimed Life Systems, Inc. Suturing device for implantable device
JP3799612B2 (ja) * 2004-03-22 2006-07-19 有限会社エスアールジェイ 超音波内視鏡装置
JP4643328B2 (ja) * 2004-04-07 2011-03-02 オリンパス株式会社 医療用結紮縫合装置
JP4923231B2 (ja) * 2004-04-15 2012-04-25 クック メディカル テクノロジーズ エルエルシー 内視鏡手術用アクセス器具及び外付け式付属品チャネルを関節運動させる方法
US8444657B2 (en) 2004-05-07 2013-05-21 Usgi Medical, Inc. Apparatus and methods for rapid deployment of tissue anchors
US7390329B2 (en) * 2004-05-07 2008-06-24 Usgi Medical, Inc. Methods for grasping and cinching tissue anchors
EP1750595A4 (en) * 2004-05-07 2008-10-22 Valentx Inc DEVICES AND METHOD FOR FIXING AN ENDOLUMINAL GASTROINTESTINAL IMPLANT
US7736374B2 (en) 2004-05-07 2010-06-15 Usgi Medical, Inc. Tissue manipulation and securement system
US20060004409A1 (en) * 2004-05-14 2006-01-05 Nobis Rudolph H Devices for locking and/or cutting a suture
US7785348B2 (en) * 2004-05-14 2010-08-31 Ethicon Endo-Surgery, Inc. Devices and methods of locking and cutting a suture in a medical procedure
US8475476B2 (en) * 2004-06-01 2013-07-02 Cook Medical Technologies Llc System and method for accessing a body cavity
US7678135B2 (en) * 2004-06-09 2010-03-16 Usgi Medical, Inc. Compressible tissue anchor assemblies
US8206417B2 (en) 2004-06-09 2012-06-26 Usgi Medical Inc. Apparatus and methods for optimizing anchoring force
US7931661B2 (en) 2004-06-14 2011-04-26 Usgi Medical, Inc. Apparatus and methods for performing transluminal gastrointestinal procedures
US20060020274A1 (en) * 2004-07-23 2006-01-26 Usgi Medical Inc. Manipulatable grasping needle
WO2006101610A2 (en) * 2005-02-08 2006-09-28 Aspire Medical, Inc. System and method for percutaneous glossoplasty
JP4592007B2 (ja) * 2005-02-15 2010-12-01 Ｈｏｙａ株式会社 対象物内部処置装置及び対象物内部処置システム
JP2006288755A (ja) 2005-04-11 2006-10-26 Olympus Medical Systems Corp 医療処置装置
US20060237023A1 (en) * 2005-04-26 2006-10-26 Usgi Medical Inc. Transgastric tubal ligation
US8663236B2 (en) * 2005-04-26 2014-03-04 Usgi Medical Inc. Transgastric abdominal access
US9585651B2 (en) 2005-05-26 2017-03-07 Usgi Medical, Inc. Methods and apparatus for securing and deploying tissue anchors
US8628541B2 (en) 2005-05-26 2014-01-14 Usgi Medical, Inc. Methods and apparatus for securing and deploying tissue anchors
EP2135560B1 (en) * 2005-06-02 2011-08-10 Cordis Corporation Medical device for deploying a mechanical closure devcie
US20070038232A1 (en) * 2005-08-12 2007-02-15 Kraemer Stefan J M Apparatus and method for securing the stomach to the diaphragm for use, for example, in treating hiatal hernias and gastroesophageal reflux disease
US20070060929A1 (en) 2005-09-13 2007-03-15 Norio Onishi Treating implement cartridge of living body tissue
US8758375B2 (en) * 2005-09-28 2014-06-24 Olympus Medical Systems Corp Method for suturing perforation
US20070123840A1 (en) * 2005-10-18 2007-05-31 Usgi Medical, Inc. Instrument assisted abdominal access
US20070112362A1 (en) * 2005-11-14 2007-05-17 Olympus Medical Systems Corp. Perforation suturing method
US8728121B2 (en) * 2006-01-13 2014-05-20 Olympus Medical Systems Corp. Puncture needle and medical procedure using puncture needle that is performed via natural orifice
US20080255422A1 (en) * 2006-01-13 2008-10-16 Olympus Medical Systems Corp. Medical device
US8721657B2 (en) * 2006-01-13 2014-05-13 Olympus Medical Systems Corp. Medical instrument
US20070219411A1 (en) * 2006-01-13 2007-09-20 Olympus Medical Systems Corp. Overtube and endoscopic treatment system
ITMI20060443A1 (it) * 2006-03-13 2007-09-14 Ethicon Endo Surgery Inc Dispositivo per la manipolazione di tessuto corporeo
US7951161B2 (en) 2006-05-09 2011-05-31 Medrad, Inc. Atherectomy system having a variably exposed cutter
BRPI0711615A2 (pt) 2006-05-18 2011-12-06 Aponos Medical Corp introdutor para acessar um local no corpo de um mamìfero, e método de elaboração de um introdutor tubular dobrável e com alta força de torção
US7758598B2 (en) 2006-05-19 2010-07-20 Ethicon Endo-Surgery, Inc. Combination knotting element and suture anchor applicator
US7736376B2 (en) 2006-07-05 2010-06-15 Olympus Medical Systems Corp. Living body wall fixing tool used in endoscope
US8870916B2 (en) * 2006-07-07 2014-10-28 USGI Medical, Inc Low profile tissue anchors, tissue anchor systems, and methods for their delivery and use
US20080097152A1 (en) * 2006-07-20 2008-04-24 David Stefanchik Braided endoscope accessories
US7837455B2 (en) * 2006-07-28 2010-11-23 Ethicon, Inc. Apparatus and method for making suture packages
US8007432B2 (en) * 2007-01-26 2011-08-30 Ethicon Endo-Surgery, Inc. Endoscopic accessory control mechanism
US20080208214A1 (en) * 2007-02-26 2008-08-28 Olympus Medical Systems Corp. Applicator and tissue fastening method through natural orifice
US8460314B2 (en) * 2007-02-26 2013-06-11 Olympus Medical Systems Corp. Application of procedure through natural orifice
US8308766B2 (en) * 2007-02-27 2012-11-13 Olympus Medical Systems Corp. Endoscopic treatment instrument
US7780702B2 (en) * 2007-02-27 2010-08-24 Olympus Medical Systems Corp. Suture tool
US8128657B2 (en) * 2007-02-27 2012-03-06 Olympus Medical Systems Corp. Suture instrument
US7815662B2 (en) * 2007-03-08 2010-10-19 Ethicon Endo-Surgery, Inc. Surgical suture anchors and deployment device
US20080228203A1 (en) * 2007-03-15 2008-09-18 Minos Medical System and method for translumenal closure in natural orifice surgery
US20080262525A1 (en) * 2007-04-17 2008-10-23 Usgi Medical, Inc. Tissue penetration and grasping apparatus
US7967741B2 (en) 2007-05-01 2011-06-28 Ethicon Endo-Surgery, Inc. Endoscopic guide device
US7967842B2 (en) 2007-06-01 2011-06-28 Ethicon Endo-Surgery, Inc. Integrated securement and closure apparatus
US8088062B2 (en) * 2007-06-28 2012-01-03 Ethicon Endo-Surgery, Inc. Interchangeable endoscopic end effectors
US8992569B2 (en) * 2007-06-29 2015-03-31 Ethicon Endo-Surgery, Inc. Insertion device and method of use
US8128592B2 (en) * 2007-07-11 2012-03-06 Apollo Endosurgery, Inc. Methods and systems for performing submucosal medical procedures
US8771314B2 (en) * 2007-09-28 2014-07-08 Ethicon, Inc. Surgical anchor device
US7998150B2 (en) * 2007-09-28 2011-08-16 Olympus Medical Systems Corp. Suturing device
US20090149714A1 (en) * 2007-12-05 2009-06-11 Frank Bonadio Surgical devices and methods

Also Published As

Publication number Publication date
AU2008256823A1 (en) 2008-12-04
CA2688261C (en) 2013-04-30
JP2010527744A (ja) 2010-08-19
US20080294001A1 (en) 2008-11-27
AU2008256823B2 (en) 2013-09-12
WO2008147871A1 (en) 2008-12-04
CA2688261A1 (en) 2008-12-04
JP5443341B2 (ja) 2014-03-19
EP2155071A1 (en) 2010-02-24
US9155532B2 (en) 2015-10-13

Similar Documents

Publication Publication Date Title
EP2155071B1 (en) Medical devices and systems for closing perforations
US12376846B2 (en) Suturing devices and methods for suturing an anatomic structure
US5876411A (en) Device and method for locating and sealing a blood vessel
EP2230987B1 (en) Medical systems for endoscopically suturing perforations
EP2311394B1 (en) Cannulated arthroscopic knife
US5997555A (en) Device and method for suturing blood vessels
US8142448B2 (en) Endoscopic instruments for suturing tissues in a body cavity
EP1379180B1 (en) Apparatus for the insertion of a medical device
EP1880681B1 (en) Combination knotting element and suture anchor applicator
EP3597115B1 (en) Suturing devices for suturing an anatomic structure
US8317679B2 (en) Endcap for safely deploying tissue anchors
US20030004544A1 (en) Endoscopic instruments
KR20080112316A (ko) 경피적 확장 장치
JP2010527744A5 (enExample)
WO2010027843A1 (en) Access needle for natural orifice translumenal endoscopic surgery
US20100121140A1 (en) Endoscope endcap for suturing tissue
US20170281176A1 (en) Medical clip device, method for producing medical clip device and method for operating thereof
US7727251B2 (en) Low profile dilator for arteriotomy closure system
US8857441B2 (en) Biological tissue transfer method and biological tissue treatment method
CN111787864B (zh) 倾斜的活检针装置
EP2830511A1 (en) Inserts for dividing a medical device lumen
HK1208793B (en) Suturing devices for suturing an anatomic structure

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 20091215

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MT NL NO PL PT RO SE SI SK TR

AX Request for extension of the european patent

Extension state: AL BA MK RS

DAX Request for extension of the european patent (deleted)
RAP1 Party data changed (applicant data changed or rights of an application transferred)

Owner name: COOK MEDICAL TECHNOLOGIES LLC

RAP1 Party data changed (applicant data changed or rights of an application transferred)

Owner name: COOK MEDICAL TECHNOLOGIES LLC

17Q First examination report despatched

Effective date: 20120206

GRAP Despatch of communication of intention to grant a patent

Free format text: ORIGINAL CODE: EPIDOSNIGR1

INTG Intention to grant announced

Effective date: 20140319

GRAS Grant fee paid

Free format text: ORIGINAL CODE: EPIDOSNIGR3

GRAA (expected) grant

Free format text: ORIGINAL CODE: 0009210

AK Designated contracting states

Kind code of ref document: B1

Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MT NL NO PL PT RO SE SI SK TR

REG Reference to a national code

Ref country code: GB

Ref legal event code: FG4D

REG Reference to a national code

Ref country code: CH

Ref legal event code: EP

REG Reference to a national code

Ref country code: IE

Ref legal event code: FG4D

REG Reference to a national code

Ref country code: AT

Ref legal event code: REF

Ref document number: 677054

Country of ref document: AT

Kind code of ref document: T

Effective date: 20140815

REG Reference to a national code

Ref country code: DE

Ref legal event code: R096

Ref document number: 602008033329

Country of ref document: DE

Effective date: 20140828

REG Reference to a national code

Ref country code: NL

Ref legal event code: VDEP

Effective date: 20140716

REG Reference to a national code

Ref country code: AT

Ref legal event code: MK05

Ref document number: 677054

Country of ref document: AT

Kind code of ref document: T

Effective date: 20140716

REG Reference to a national code

Ref country code: LT

Ref legal event code: MG4D

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: GR

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20141017

Ref country code: SE

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20140716

Ref country code: BG

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20141016

Ref country code: NO

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20141016

Ref country code: PT

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20141117

Ref country code: FI

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20140716

Ref country code: ES

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20140716

Ref country code: LT

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20140716

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: NL

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20140716

Ref country code: IS

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20141116

Ref country code: AT

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20140716

Ref country code: LV

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20140716

Ref country code: PL

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20140716

Ref country code: CY

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20140716

REG Reference to a national code

Ref country code: DE

Ref legal event code: R097

Ref document number: 602008033329

Country of ref document: DE

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: EE

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20140716

Ref country code: DK

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20140716

Ref country code: RO

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20140716

Ref country code: SK

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20140716

Ref country code: IT

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20140716

Ref country code: CZ

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20140716

PLBE No opposition filed within time limit

Free format text: ORIGINAL CODE: 0009261

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: NO OPPOSITION FILED WITHIN TIME LIMIT

26N No opposition filed

Effective date: 20150417

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: SI

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20140716

REG Reference to a national code

Ref country code: CH

Ref legal event code: PL

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: LI

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20150531

Ref country code: LU

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20150522

Ref country code: CH

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20150531

Ref country code: MC

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20140716

REG Reference to a national code

Ref country code: FR

Ref legal event code: ST

Effective date: 20160129

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: FR

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20150601

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: BE

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20140716

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: MT

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20140716

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: HU

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT; INVALID AB INITIO

Effective date: 20080522

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: HR

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20140716

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: TR

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20140716

P01 Opt-out of the competence of the unified patent court (upc) registered

Effective date: 20230602

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: DE

Payment date: 20250528

Year of fee payment: 18

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: GB

Payment date: 20250520

Year of fee payment: 18

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: IE

Payment date: 20250520

Year of fee payment: 18