EP2131878A1 - Composition de ciment injectable à usage orthopédique et dentaire - Google Patents

Composition de ciment injectable à usage orthopédique et dentaire

Info

Publication number
EP2131878A1
EP2131878A1 EP08712858A EP08712858A EP2131878A1 EP 2131878 A1 EP2131878 A1 EP 2131878A1 EP 08712858 A EP08712858 A EP 08712858A EP 08712858 A EP08712858 A EP 08712858A EP 2131878 A1 EP2131878 A1 EP 2131878A1
Authority
EP
European Patent Office
Prior art keywords
precursor powder
powder
cao
hydration liquid
ceramic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP08712858A
Other languages
German (de)
English (en)
Other versions
EP2131878A4 (fr
Inventor
Leif Hermansson
Håkan ENGQVIST
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Doxa AB
Original Assignee
Doxa AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US11/712,413 external-priority patent/US20080214500A1/en
Application filed by Doxa AB filed Critical Doxa AB
Publication of EP2131878A1 publication Critical patent/EP2131878A1/fr
Publication of EP2131878A4 publication Critical patent/EP2131878A4/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/02—Surgical adhesives or cements; Adhesives for colostomy devices containing inorganic materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K6/00—Preparations for dentistry
    • A61K6/15—Compositions characterised by their physical properties
    • A61K6/17—Particle size
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K6/00—Preparations for dentistry
    • A61K6/70—Preparations for dentistry comprising inorganic additives
    • A61K6/71—Fillers
    • A61K6/76—Fillers comprising silicon-containing compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K6/00—Preparations for dentistry
    • A61K6/80—Preparations for artificial teeth, for filling teeth or for capping teeth
    • A61K6/802—Preparations for artificial teeth, for filling teeth or for capping teeth comprising ceramics
    • A61K6/818—Preparations for artificial teeth, for filling teeth or for capping teeth comprising ceramics comprising zirconium oxide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K6/00—Preparations for dentistry
    • A61K6/80—Preparations for artificial teeth, for filling teeth or for capping teeth
    • A61K6/849—Preparations for artificial teeth, for filling teeth or for capping teeth comprising inorganic cements
    • A61K6/853—Silicates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K6/00—Preparations for dentistry
    • A61K6/80—Preparations for artificial teeth, for filling teeth or for capping teeth
    • A61K6/849—Preparations for artificial teeth, for filling teeth or for capping teeth comprising inorganic cements
    • A61K6/86—Al-cements
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/0047—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A61L24/0052—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material with an inorganic matrix
    • A61L24/0068—Inorganic materials not covered by groups A61L24/0057 or A61L24/0063
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/0047—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A61L24/0073—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material with a macromolecular matrix
    • A61L24/0089—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material with a macromolecular matrix containing inorganic fillers not covered by groups A61L24/0078 or A61L24/0084
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/02—Inorganic materials
    • A61L27/10—Ceramics or glasses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/02—Inorganic materials
    • A61L27/10—Ceramics or glasses
    • A61L27/105—Ceramics or glasses containing Al2O3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A61L27/42—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having an inorganic matrix
    • A61L27/427—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having an inorganic matrix of other specific inorganic materials not covered by A61L27/422 or A61L27/425
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A61L27/44—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
    • A61L27/446—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix with other specific inorganic fillers other than those covered by A61L27/443 or A61L27/46
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00—Materials characterised by their function or physical properties
    • A61L2400/06—Flowable or injectable implant compositions

Definitions

  • the present invention relates to ceramic precursor powder compositions and chemically bonded ceramic (CBC) materials, calcium aluminate- and/or calcium silicate-based ones, and composite biomaterials suitable for orthopaedic applications with improved injectability.
  • CBC chemically bonded ceramic
  • Chemically bonded ceramics are formed from mixing ceramic precursor powder compositions with a water containing liquid.
  • the CBC precursor powders originate from the calcium silicate, calcium aluminate, calcium phosphate or calcium sulphate systems.
  • the CBC precursor powder can be mixed with inert particles, so-called fillers, for various reasons, e.g. increased strength and dimensional stability.
  • CBC systems intended for use in orthopaedic and dental applications are described e.g. in the Ph. D. thesis by M. Nilsson "Injectable calcium sulphate and calcium phosphate bone substitutes", Lund University 2003, and the Ph. D. thesis by L. Kraft “Calcium aluminate-based cement as dental restoratives materials", Uppsala University, 2002.
  • the CBC precursor powder materials react with water to form the final CBC material.
  • the hydrated material is described as being hydraulic, meaning that it is not further reactive to water. Being reactive to water or water vapour in the precursor powder form, also means that the humidity in the air potentially can be harmful to the powder, leading to that a pre-reacted or partly pre-reacted powder, which subsequently in the process may not be formed and used in the intended way. Such powder exhibits short shelf life and is difficult to mix and handle, and may not have the proper setting properties.
  • the final strength of the hardened CBC material may also be negatively influenced by a prematurely reacted powder. This problem is well-known in the cement industry, and where it is known that a relative humidity (RH) of above 70% results in a sub-optimal product.
  • RH relative humidity
  • Injectable ceramics for orthopaedic applications are formed from mixing ceramic precursor powder compositions with a water-containing liquid.
  • the precursor powders originate from the calcium phosphate cement system.
  • Calcium phosphate cements (CPC) are used as injectable orthopaedic cements.
  • CPC Calcium phosphate cements
  • the injectability of an orthopaedic material is very important since it gives the surgeon the possibility to choose needle size depending on the voids to be filled and also to have enough time for injection, i.e. how to control the time available for injection, the so-called working . This is especially important when working with minimally invasive techniques, where a thin needle results in a less invasive operation.
  • the CPC suffers from phase separation (between ceramic powder and hydration liquid) due to the shear force situation within the cement. This results in a paste which cannot be extruded through needles thinner than 11 gauge without extreme caution.
  • radio-opacity during injection is, as mentioned above, very important.
  • radio-opacity achieved by adding a an additive imparting radio-opacity to the precursor powder is barium sulphate powder. Adding such powders to CPC results in problems with viscosity of the mix and in greater difficulties to inject the material through thin needles.
  • the present invention relates to a ceramic bone replacement material that possesses all of the above-mentioned properties, and which may suitably be used in orthopaedic applications, such as vertebroplasty.
  • the present invention also relates to the manufacturing, packaging and storage conditions for hydraulic precursor powders upon which said ceramic bone replacement material is based.
  • the present invention describes a ceramic system that comprises a ceramic precursor powder and a hydration liquid, that when mixed,
  • the proposed ceramic precursor powder may also comprise additives that impart of radio-opacity.
  • a ceramic system comprising a hydraulic ceramic precursor powder which is mixed with a specific hydration liquid, resulting in a paste that exhibits an increased handling and injectability (without phase-separation) compared to that of the CPC systems.
  • said paste When cured, said paste forms a ceramic material exhibiting a high strength.
  • the ceramic precursor powder may optionally comprise additives (a high-density additive) imparting a high radio-opacity that improves the X-ray visibility for a user during injection.
  • the injectability can be controlled, not just by the added water through the hydration liquid, but by the water content in the precursor powder. If during manufacturing, said precursor powder contains too much water, as well as experience too high humidity during packaging, the subsequent handling properties are negatively affected, resulting in a decreased working time and setting time. In addition, the injectability is negatively influenced by such water content.
  • the amount of water in the precursor powder is according to the present invention controlled as regards the relative humidity during manufacturing and packaging of the powder.
  • the present inventors have surprisingly found that if the amount of water exceeds a certain limit in the precursor powder, the described properties are negatively affected.
  • the allowable water content may be measured by controlling the water content in the packaged precursor powder.
  • the measured relative humidity in the precursor powder or water content (measured as loss on ignition) may then be used to determine the status of the precursor powder, and if the precursor powder is still "fit" for obtaining optimal properties. This discovery enables a user to determine if properties such as correct working time, setting time, and final strength of the ceramic material is still achievable.
  • the present invention also relates to a method of manufacturing said cured material, bioelements, implants, or drug delivery carrier materials based on said precursor powder or said cured material, a kit comprising the ceramic precursor powder and hydration liquid, as well as the use of said ceramic precursor powder and hydration liquid, or said cured material, for orthopaedic and dental applications.
  • the present ceramic material allows a) the material to be delivered through thin needles, b) possesses high radio-opacity, and c) makes it possible to inject the material via an injection device or system.
  • the orthopaedic surgeon needs to follow the injection of the material into the body under live-fluoroscopy. This is especially important for vertebroplasty, injection of material into a fractured vertebrae via a minimally invasive procedure, where possible leakage of material into the spinal column can be very dangerous for the patient. Injection is often performed with the surgeon ' s hand also under the fluoroscope, resulting in a high X-ray dose for the surgeon. In such a situation, the ceramic paste may be injecting using an injection system such as for example described in the co-pending provisional US application No. 60/784,085, which allows the surgeon to stand outside the fluoroscope while injecting the material into a defect.
  • an injection system such as for example described in the co-pending provisional US application No. 60/784,085, which allows the surgeon to stand outside the fluoroscope while injecting the material into a defect.
  • such injection systems combined with the overall difficulty of injecting materials through thin needles, put high demands on the biomaterial, and thus pose a problem.
  • the ceramic biomaterial comprises a powder and a hydration liquid, which are mixed just before usage.
  • the mixing can be done manually, but is preferably performed using a mixing device.
  • the formed paste can be transferred to an injection device via a transfer device.
  • Said precursor powder are mixed with the hydration liquid according to the invention, which comprises: mixed with, LiCl and
  • the components of the precursor powder have the following characteristics:
  • the calcium aluminate may have a grain size of below 30 micrometer, preferably below 20 micrometer, and more preferably below 15 micrometer.
  • the grain size is determined as d99 ( 99 % ⁇ stated value) using laser diffraction and calculated from the volume distribution, i.e. 1% of the powder may be of greater grain size.
  • the calcium aluminate is to more than 70 atomic% comprised of CaO(AIaOs) and to less than 30 atomic% comprised of one or more of the phases (CaO) 12(AbOa) 7 , (CaO) 3 Al 2 O 3 , CaO(Al 2 Os) 2 , CaO(Al 2 OsJe, and CaO(Al 2 O 3 ) glass.
  • the calcium aluminate constitutes 55-65 wt-%, preferably 57-63 wt-%, of the total amount of precursor powder.
  • the calcium aluminate is the reactive phase (binder phase).
  • the micro-silica (SiO 2 ) may have a grain size of below 30, preferably below 20 nm.
  • the micro-silica is added in an amount of 0.5-5 wt-%, preferably 0.7-1.3 wt-%, of the total amount of the precursor powder.
  • the nano-size silica (SiO 2 ) could also be included in the hydration liquid.
  • Zirconium dioxide may optionally be added as an inert precursor additive for increased radio-opacity.
  • the zirconium dioxide (ZrO 2 ) may have a grain size of below 10 micrometer, preferably below 5 micrometer, determined as d99 (99 % ⁇ stated vaue) using laser diffraction.
  • the zirconium dioxide is added to achieve extra radio- opacity and is considered as a non-reacting, inert phase.
  • the ZrO 2 is added in an amount of 35-45 wt-%, preferably 38-42 wt-%, of the total amount of the precursor powder. If radio-opacity is not required for a certain application, the ZrO 2 may also be mixed with or replaced by another inert filler material, in the same amounts and grain sizes.
  • Calcium silicate may also be added to the precursor powder as an additional hydrating phase (also a reactive phase), in the form of C 3 S or C 2 S or combinations thereof, in the amount of below 10 wt-%. of the total amount of the precursor powder.
  • the grain size should be below 40 micrometer, preferably below 20 micrometer.
  • the calcium silicate may also replace the calcium aluminate phase.
  • the components of the hydration liquid have the following characteristics :
  • the polycarboxylic compound may have a molecular weight within the interval 10000-50000, and constitutes 3-5 wt-%, preferably 3.7-4.3 wt-% of the hydration liquid,.
  • the compound is added to control the viscosity of the paste.
  • the methyl cellulose constitutes 1-5 wt-% of the hydration liquid, preferably 2.5-3.5 wt-%.
  • the compound is added to control viscosity and cohesion of a paste.
  • Lithium chloride constitutes less than 0.2 wt-%, normally 0.05-0.2 wt-%, of the hydration liquid. LiCl is added to control the setting time.
  • the precursor powder and the hydration liquid may form a paste or a thick slurry depending on the water-to-cement (liquid-to-powder) ratio.
  • the powder- to-liquid (p/1) ratio should be kept within 3,75-5, preferably 4-4.5.
  • the components added to the liquid promote a high cohesiveness of the paste. This means that the paste is easily kept together during injection, thus avoiding e.g. phase separation. This reduces also the risk of uncontrolled spread of the paste into undesired voids, e.g. the spinal column.
  • the precursor powder may be kept at a relative humidity of below 60%, preferably below 50 %, during manufacturing and packaging. If not the reactive calcium aluminate and/ or calcium silicates start to react with the water in the air and the function of the powder is negatively affected. However, according to the present invention, it is also possible to measure if a ceramic precursor powder has experienced too high humidity during manufacturing and/ or packing. This can be measured as the ignition loss, i.e. the amount of water evaporated from the powder if heated above a certain temperature, where the chemically bonded water is decomposed, typically at temperatures above 300 0 C. The critical ignition loss has been measured to 0.08 % of the precursor powder weight. However, it is preferred that is 0.05 % of the precursor powder weight. This ignition loss is related to the relative humidity of ⁇ 60 %.
  • temperatures of less than 25 0 C may preferably be used, since this under normal conditions will not involve detrimental levels of relative humidity.
  • the present invention provides a precursor powder that is packaged and stored under vacuum and/or inert gas, e.g. nitrogen and/or argon. Said powder may feature a loss on ignition less than 0.08, even less than 0.05 %. Such a powder may also be provided in a kit comprising the hydration liquid (stored separately)
  • Tests were conducted to test the shelf life of precursor powder compositions as function of the relative humidity during packaging. The shelf life was evaluated according to working time and setting time measurements as described below.
  • the precursor powder see Table 1 , was packaged in capsules in clean room facilities with controlled RH.
  • the hydration liquid was also filled in syringes in clean room facilities, under controlled RH.
  • the precursor powder was homogenised using tumbling, and the hydration liquid was homogenised through mixing. Table 1. Composition of the precursor powder and hydration liquid
  • the precursor powder and hydration liquid were packaged under 30%, 40%, 50%, 60% and 70% RH and stored under room temperature and normal RH for 3, 6 and 12 months. 12 capsules and syringes for each RH-package condition and time period were tested regarding working time and setting time.
  • Mixing of the precursor powder and liquid was performed using a machine mixer and a powder to liquid ratio of 4.2.
  • the working time was evaluated as ejection time through 11 Gauge syringes at RT and setting time as the time at peak temperature during setting. The aim was to have a constant working time and setting time throughout the test period. This is important to the reproducibility in the handling of the material.
  • Packaging at 60% RH or below assures a shelf-life of more than 12 months.
  • Packaging at 70% RH prolongs the working time and setting time directly, i.e. already at packaging.
  • the calcium aluminate-based precursor powder had the composition as described in Table 1 above.
  • the calcium phosphate-based precursor powder had the precursor powder composition (in wt.%): ⁇ -TCP (71%), Mg 3 (PO 4 )2 (10%), MgHPO 4 (3.8%), SrCO 3 (3.6%) and ZrO 2 (10%) and the hydration liquid H 2 O, (NH 4 J 2 HPO 4 (3.5M).
  • a calcium aluminate precursor powder and hydration liquid were mixed using machine vibrator in a powder- to-liquid ratio of 4.2.
  • the calcium phosphate powder and hydration liquid were mixed using machine vibrator in a powder-to-liquid ratio of 3.
  • the calcium aluminate-based paste was possible to inject through both 11 and 13 Gauge needles.
  • the calcium phosphate paste was not possible to inject through neither of the needle sizes.
  • the radio- opacity for the calcium aluminate-based discs was considerably higher than for the calcium phosphate-based discs but lower than for the 2 mm thick Al discs.
  • the calcium aluminate-based paste has a higher radio-opacity than the calcium phosphate-based paste, and considerably improved injectability.

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Inorganic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Ceramic Engineering (AREA)
  • Transplantation (AREA)
  • Medicinal Chemistry (AREA)
  • Dermatology (AREA)
  • Materials Engineering (AREA)
  • Composite Materials (AREA)
  • Surgery (AREA)
  • Plastic & Reconstructive Surgery (AREA)
  • Materials For Medical Uses (AREA)

Abstract

L'invention concerne des compositions de poudre de précurseur de céramique, des matériaux de céramique liés chimiquement (CBC), de l'aluminate et/ou du silicate de calcium et un biomatériau composite dont la durée de vie du précurseur est prolongée, appropriés pour des applications orthopédiques à injectabilité améliorée. L'invention concerne également un procédé de production du matériau durci, des bioéléments, des implants ou des excipients pour distribuer des médicaments produits au moyen du matériau durci, un kit comprenant une poudre de précurseur de céramique et un liquide d'hydratation et leur utilisation, ou le matériau durci, pour des applications orthopédiques et dentaires.
EP08712858A 2007-03-01 2008-02-29 Composition de ciment injectable à usage orthopédique et dentaire Withdrawn EP2131878A4 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US11/712,413 US20080214500A1 (en) 2007-03-01 2007-03-01 Injectable cement composition for orthopaedic and dental use
SE0700543 2007-03-01
PCT/SE2008/050231 WO2008105738A1 (fr) 2007-03-01 2008-02-29 Composition de ciment injectable à usage orthopédique et dentaire

Publications (2)

Publication Number Publication Date
EP2131878A1 true EP2131878A1 (fr) 2009-12-16
EP2131878A4 EP2131878A4 (fr) 2012-12-26

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Family Applications (1)

Application Number Title Priority Date Filing Date
EP08712858A Withdrawn EP2131878A4 (fr) 2007-03-01 2008-02-29 Composition de ciment injectable à usage orthopédique et dentaire

Country Status (2)

Country Link
EP (1) EP2131878A4 (fr)
WO (1) WO2008105738A1 (fr)

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KR101751906B1 (ko) 2009-03-04 2017-06-29 엠플리큐어 아베 새로운 오용 방지 배합물
MX2011011829A (es) 2009-05-08 2012-02-21 Orexo Ab Composicion para suministro sostenido de farmaco que comprende un aglutinante geopolimerico.
WO2011040851A1 (fr) * 2009-10-02 2011-04-07 Doxa Ab Pâte à base d'aluminate de calcium pour stabiliser des implants dentaires et restaurer un attachement de tissu après une chirurgie, et procédés pour celle-ci
BR112012008230A2 (pt) * 2009-10-09 2019-07-30 Doxa Ab composição, pasta, kit, uso da pasta, e , métodos de selar um implante a um outro implante e/ou ao dente ou tecido ósseo, e de cimentar uma faceta a um dente
ES2658913T3 (es) 2010-09-07 2018-03-12 Emplicure Ab Dispositivo de administración transdérmica de un fármaco

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WO2000021489A1 (fr) * 1998-10-12 2000-04-20 Doxa Certex Aktiebolag Systemes d'agents liants possedant une stabilite dimensionnelle
WO2003055450A1 (fr) * 2001-12-27 2003-07-10 Cerbio Tech Ab Materiau ceramique et son procede de fabrication
WO2004028577A1 (fr) * 2002-09-30 2004-04-08 Cerbio Tech Ab Materiaux ceramiques thermogenerateurs biocompatibles

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