EP2040667A1 - Moisturising and sunscreen skincare composition - Google Patents
Moisturising and sunscreen skincare compositionInfo
- Publication number
- EP2040667A1 EP2040667A1 EP20070733754 EP07733754A EP2040667A1 EP 2040667 A1 EP2040667 A1 EP 2040667A1 EP 20070733754 EP20070733754 EP 20070733754 EP 07733754 A EP07733754 A EP 07733754A EP 2040667 A1 EP2040667 A1 EP 2040667A1
- Authority
- EP
- European Patent Office
- Prior art keywords
- composition
- weight
- skin
- starch
- emulsifier
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 142
- 239000000516 sunscreening agent Substances 0.000 title claims abstract description 55
- 230000000475 sunscreen effect Effects 0.000 title claims abstract description 52
- 239000003995 emulsifying agent Substances 0.000 claims abstract description 39
- 229920002472 Starch Polymers 0.000 claims abstract description 25
- 235000019698 starch Nutrition 0.000 claims abstract description 25
- 239000008107 starch Substances 0.000 claims abstract description 24
- FQUNFJULCYSSOP-UHFFFAOYSA-N bisoctrizole Chemical compound N1=C2C=CC=CC2=NN1C1=CC(C(C)(C)CC(C)(C)C)=CC(CC=2C(=C(C=C(C=2)C(C)(C)CC(C)(C)C)N2N=C3C=CC=CC3=N2)O)=C1O FQUNFJULCYSSOP-UHFFFAOYSA-N 0.000 claims abstract description 23
- 239000012071 phase Substances 0.000 claims abstract description 23
- XVAMCHGMPYWHNL-UHFFFAOYSA-N bemotrizinol Chemical compound OC1=CC(OCC(CC)CCCC)=CC=C1C1=NC(C=2C=CC(OC)=CC=2)=NC(C=2C(=CC(OCC(CC)CCCC)=CC=2)O)=N1 XVAMCHGMPYWHNL-UHFFFAOYSA-N 0.000 claims abstract description 21
- 239000000839 emulsion Substances 0.000 claims abstract description 18
- 239000003906 humectant Substances 0.000 claims abstract description 17
- 230000001804 emulsifying effect Effects 0.000 claims abstract description 16
- 239000008346 aqueous phase Substances 0.000 claims abstract description 14
- -1 compound salt Chemical class 0.000 claims abstract description 14
- 230000005855 radiation Effects 0.000 claims abstract description 12
- 125000000129 anionic group Chemical group 0.000 claims abstract description 11
- 239000012874 anionic emulsifier Substances 0.000 claims abstract description 9
- 239000012875 nonionic emulsifier Substances 0.000 claims abstract description 9
- 239000004615 ingredient Substances 0.000 claims description 33
- GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 claims description 28
- 239000003921 oil Substances 0.000 claims description 28
- 235000019198 oils Nutrition 0.000 claims description 28
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 24
- 238000000034 method Methods 0.000 claims description 19
- 229920000881 Modified starch Polymers 0.000 claims description 18
- 235000019426 modified starch Nutrition 0.000 claims description 18
- BANXPJUEBPWEOT-UHFFFAOYSA-N 2-methyl-Pentadecane Chemical compound CCCCCCCCCCCCCC(C)C BANXPJUEBPWEOT-UHFFFAOYSA-N 0.000 claims description 16
- YBGZDTIWKVFICR-JLHYYAGUSA-N Octyl 4-methoxycinnamic acid Chemical compound CCCCC(CC)COC(=O)\C=C\C1=CC=C(OC)C=C1 YBGZDTIWKVFICR-JLHYYAGUSA-N 0.000 claims description 15
- CYSGHNMQYZDMIA-UHFFFAOYSA-N 1,3-Dimethyl-2-imidazolidinon Chemical group CN1CCN(C)C1=O CYSGHNMQYZDMIA-UHFFFAOYSA-N 0.000 claims description 13
- 229960001679 octinoxate Drugs 0.000 claims description 12
- XMSXQFUHVRWGNA-UHFFFAOYSA-N Decamethylcyclopentasiloxane Chemical compound C[Si]1(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O1 XMSXQFUHVRWGNA-UHFFFAOYSA-N 0.000 claims description 11
- 241001135917 Vitellaria paradoxa Species 0.000 claims description 11
- 235000018936 Vitellaria paradoxa Nutrition 0.000 claims description 11
- 229940071160 cocoate Drugs 0.000 claims description 10
- 229940086555 cyclomethicone Drugs 0.000 claims description 10
- 229940008099 dimethicone Drugs 0.000 claims description 10
- 239000004205 dimethyl polysiloxane Substances 0.000 claims description 10
- 235000013870 dimethyl polysiloxane Nutrition 0.000 claims description 10
- GOQYKNQRPGWPLP-UHFFFAOYSA-N n-heptadecyl alcohol Natural products CCCCCCCCCCCCCCCCCO GOQYKNQRPGWPLP-UHFFFAOYSA-N 0.000 claims description 10
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 claims description 10
- 150000005846 sugar alcohols Polymers 0.000 claims description 10
- LADGBHLMCUINGV-UHFFFAOYSA-N tricaprin Chemical compound CCCCCCCCCC(=O)OCC(OC(=O)CCCCCCCCC)COC(=O)CCCCCCCCC LADGBHLMCUINGV-UHFFFAOYSA-N 0.000 claims description 10
- 229940043268 2,2,4,4,6,8,8-heptamethylnonane Drugs 0.000 claims description 8
- GUOCOOQWZHQBJI-UHFFFAOYSA-N 4-oct-7-enoxy-4-oxobutanoic acid Chemical compound OC(=O)CCC(=O)OCCCCCCC=C GUOCOOQWZHQBJI-UHFFFAOYSA-N 0.000 claims description 8
- 239000004411 aluminium Substances 0.000 claims description 8
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 claims description 8
- 229910052782 aluminium Inorganic materials 0.000 claims description 8
- 229940081733 cetearyl alcohol Drugs 0.000 claims description 8
- DLAHAXOYRFRPFQ-UHFFFAOYSA-N dodecyl benzoate Chemical compound CCCCCCCCCCCCOC(=O)C1=CC=CC=C1 DLAHAXOYRFRPFQ-UHFFFAOYSA-N 0.000 claims description 8
- KUVMKLCGXIYSNH-UHFFFAOYSA-N isopentadecane Natural products CCCCCCCCCCCCC(C)C KUVMKLCGXIYSNH-UHFFFAOYSA-N 0.000 claims description 8
- JDRSMPFHFNXQRB-CMTNHCDUSA-N Decyl beta-D-threo-hexopyranoside Chemical compound CCCCCCCCCCO[C@@H]1O[C@H](CO)C(O)[C@H](O)C1O JDRSMPFHFNXQRB-CMTNHCDUSA-N 0.000 claims description 7
- HVUMOYIDDBPOLL-XWVZOOPGSA-N Sorbitan monostearate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O HVUMOYIDDBPOLL-XWVZOOPGSA-N 0.000 claims description 7
- UBNYRXMKIIGMKK-RMKNXTFCSA-N amiloxate Chemical compound COC1=CC=C(\C=C\C(=O)OCCC(C)C)C=C1 UBNYRXMKIIGMKK-RMKNXTFCSA-N 0.000 claims description 7
- 229940073499 decyl glucoside Drugs 0.000 claims description 7
- 239000002304 perfume Substances 0.000 claims description 7
- 150000003242 quaternary ammonium salts Chemical class 0.000 claims description 7
- 229950011392 sorbitan stearate Drugs 0.000 claims description 7
- 230000000699 topical effect Effects 0.000 claims description 7
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 claims description 6
- DGSZGZSCHSQXFV-UHFFFAOYSA-N 2,3-bis(2-ethylhexanoyloxy)propyl 2-ethylhexanoate Chemical compound CCCCC(CC)C(=O)OCC(OC(=O)C(CC)CCCC)COC(=O)C(CC)CCCC DGSZGZSCHSQXFV-UHFFFAOYSA-N 0.000 claims description 6
- TYYHDKOVFSVWON-UHFFFAOYSA-N 2-butyl-2-methoxy-1,3-diphenylpropane-1,3-dione Chemical compound C=1C=CC=CC=1C(=O)C(OC)(CCCC)C(=O)C1=CC=CC=C1 TYYHDKOVFSVWON-UHFFFAOYSA-N 0.000 claims description 6
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims description 6
- 229930006000 Sucrose Natural products 0.000 claims description 6
- 229960005193 avobenzone Drugs 0.000 claims description 6
- BXWNKGSJHAJOGX-UHFFFAOYSA-N hexadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCO BXWNKGSJHAJOGX-UHFFFAOYSA-N 0.000 claims description 6
- 239000004973 liquid crystal related substance Substances 0.000 claims description 6
- 239000002480 mineral oil Substances 0.000 claims description 6
- 229940049964 oleate Drugs 0.000 claims description 6
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 claims description 6
- 230000004224 protection Effects 0.000 claims description 6
- 239000005720 sucrose Substances 0.000 claims description 6
- 150000003626 triacylglycerols Chemical class 0.000 claims description 6
- 229910019142 PO4 Inorganic materials 0.000 claims description 5
- 150000003863 ammonium salts Chemical class 0.000 claims description 5
- 239000012188 paraffin wax Substances 0.000 claims description 5
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims description 5
- 239000010452 phosphate Substances 0.000 claims description 5
- 229940012831 stearyl alcohol Drugs 0.000 claims description 5
- 235000015112 vegetable and seed oil Nutrition 0.000 claims description 5
- 239000008158 vegetable oil Substances 0.000 claims description 5
- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 claims description 4
- DBFHTTOOJDMDTI-KCMGSBMCSA-N C(CCCCCCCCCCCCCCCCC)(=O)O.CC(=O)[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO.C(CCCCCCCCCCCCCCCCC)(=O)O.C(CCCCCCCCCCCCCCCCC)(=O)O.CC(=O)[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO Chemical compound C(CCCCCCCCCCCCCCCCC)(=O)O.CC(=O)[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO.C(CCCCCCCCCCCCCCCCC)(=O)O.C(CCCCCCCCCCCCCCCCC)(=O)O.CC(=O)[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO DBFHTTOOJDMDTI-KCMGSBMCSA-N 0.000 claims description 4
- 229940075529 glyceryl stearate Drugs 0.000 claims description 4
- XUGNVMKQXJXZCD-UHFFFAOYSA-N isopropyl palmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OC(C)C XUGNVMKQXJXZCD-UHFFFAOYSA-N 0.000 claims description 4
- 229940075495 isopropyl palmitate Drugs 0.000 claims description 4
- 229940100486 rice starch Drugs 0.000 claims description 4
- 229920002545 silicone oil Polymers 0.000 claims description 4
- 229940058015 1,3-butylene glycol Drugs 0.000 claims description 3
- PWVUXRBUUYZMKM-UHFFFAOYSA-N 2-(2-hydroxyethoxy)ethyl octadecanoate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCCOCCO PWVUXRBUUYZMKM-UHFFFAOYSA-N 0.000 claims description 3
- KWVPFECTOKLOBL-KTKRTIGZSA-N 2-[(z)-octadec-9-enoxy]ethanol Chemical compound CCCCCCCC\C=C/CCCCCCCCOCCO KWVPFECTOKLOBL-KTKRTIGZSA-N 0.000 claims description 3
- ICIDSZQHPUZUHC-UHFFFAOYSA-N 2-octadecoxyethanol Chemical compound CCCCCCCCCCCCCCCCCCOCCO ICIDSZQHPUZUHC-UHFFFAOYSA-N 0.000 claims description 3
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 3
- NWGKJDSIEKMTRX-AAZCQSIUSA-N Sorbitan monooleate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O NWGKJDSIEKMTRX-AAZCQSIUSA-N 0.000 claims description 3
- IYFATESGLOUGBX-YVNJGZBMSA-N Sorbitan monopalmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O IYFATESGLOUGBX-YVNJGZBMSA-N 0.000 claims description 3
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 claims description 3
- YPFDHNVEDLHUCE-UHFFFAOYSA-N Trimethylene glycol Natural products OCCCO YPFDHNVEDLHUCE-UHFFFAOYSA-N 0.000 claims description 3
- 239000003963 antioxidant agent Substances 0.000 claims description 3
- 235000006708 antioxidants Nutrition 0.000 claims description 3
- 235000019437 butane-1,3-diol Nutrition 0.000 claims description 3
- 229940073669 ceteareth 20 Drugs 0.000 claims description 3
- 229960000541 cetyl alcohol Drugs 0.000 claims description 3
- 239000002738 chelating agent Substances 0.000 claims description 3
- 125000002704 decyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 claims description 3
- 229940074050 glyceryl myristate Drugs 0.000 claims description 3
- 238000002156 mixing Methods 0.000 claims description 3
- NJTGANWAUPEOAX-UHFFFAOYSA-N molport-023-220-454 Chemical compound OCC(O)CO.OCC(O)CO NJTGANWAUPEOAX-UHFFFAOYSA-N 0.000 claims description 3
- 125000000913 palmityl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 3
- 229940077414 peg-12 stearate Drugs 0.000 claims description 3
- 239000003755 preservative agent Substances 0.000 claims description 3
- DCBSHORRWZKAKO-UHFFFAOYSA-N rac-1-monomyristoylglycerol Chemical compound CCCCCCCCCCCCCC(=O)OCC(O)CO DCBSHORRWZKAKO-UHFFFAOYSA-N 0.000 claims description 3
- 239000011734 sodium Substances 0.000 claims description 3
- 229910052708 sodium Inorganic materials 0.000 claims description 3
- 229950004959 sorbitan oleate Drugs 0.000 claims description 3
- 229950003429 sorbitan palmitate Drugs 0.000 claims description 3
- 229940100458 steareth-21 Drugs 0.000 claims description 3
- 125000004079 stearyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 3
- 229910021653 sulphate ion Inorganic materials 0.000 claims description 3
- JNYAEWCLZODPBN-JGWLITMVSA-N (2r,3r,4s)-2-[(1r)-1,2-dihydroxyethyl]oxolane-3,4-diol Chemical compound OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O JNYAEWCLZODPBN-JGWLITMVSA-N 0.000 claims description 2
- ZJTORAKRUDAUCS-UHFFFAOYSA-N 4,5-dihydroxy-1,3-dimethylimidazolidin-2-one 1,3-dimethylimidazolidin-2-one Chemical compound CN1C(N(CC1)C)=O.CN1C(N(C(C1O)O)C)=O ZJTORAKRUDAUCS-UHFFFAOYSA-N 0.000 claims description 2
- 239000004368 Modified starch Substances 0.000 claims description 2
- 238000006243 chemical reaction Methods 0.000 claims description 2
- 238000004040 coloring Methods 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims description 2
- 239000003002 pH adjusting agent Substances 0.000 claims description 2
- 229940114930 potassium stearate Drugs 0.000 claims description 2
- ANBFRLKBEIFNQU-UHFFFAOYSA-M potassium;octadecanoate Chemical compound [K+].CCCCCCCCCCCCCCCCCC([O-])=O ANBFRLKBEIFNQU-UHFFFAOYSA-M 0.000 claims description 2
- 238000002360 preparation method Methods 0.000 claims description 2
- 239000003814 drug Substances 0.000 claims 1
- 239000003381 stabilizer Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 32
- 230000006378 damage Effects 0.000 abstract description 9
- 210000003491 skin Anatomy 0.000 description 56
- PEDCQBHIVMGVHV-UHFFFAOYSA-N glycerol group Chemical group OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 24
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 16
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 15
- 235000011187 glycerol Nutrition 0.000 description 12
- 210000000434 stratum corneum Anatomy 0.000 description 7
- QCDWFXQBSFUVSP-UHFFFAOYSA-N 2-phenoxyethanol Chemical compound OCCOC1=CC=CC=C1 QCDWFXQBSFUVSP-UHFFFAOYSA-N 0.000 description 6
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 6
- 229920002125 Sokalan® Polymers 0.000 description 6
- 229960001631 carbomer Drugs 0.000 description 6
- 239000006071 cream Substances 0.000 description 6
- WWZKQHOCKIZLMA-UHFFFAOYSA-N octanoic acid Chemical compound CCCCCCCC(O)=O WWZKQHOCKIZLMA-UHFFFAOYSA-N 0.000 description 6
- 229960005323 phenoxyethanol Drugs 0.000 description 6
- 239000000230 xanthan gum Substances 0.000 description 6
- 229920001285 xanthan gum Polymers 0.000 description 6
- 235000010493 xanthan gum Nutrition 0.000 description 6
- 229940082509 xanthan gum Drugs 0.000 description 6
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 5
- 125000001931 aliphatic group Chemical group 0.000 description 5
- 238000009472 formulation Methods 0.000 description 5
- 150000002632 lipids Chemical class 0.000 description 5
- UZKWTJUDCOPSNM-UHFFFAOYSA-N 1-ethenoxybutane Chemical compound CCCCOC=C UZKWTJUDCOPSNM-UHFFFAOYSA-N 0.000 description 4
- RMTFNDVZYPHUEF-XZBKPIIZSA-N 3-O-methyl-D-glucose Chemical compound O=C[C@H](O)[C@@H](OC)[C@H](O)[C@H](O)CO RMTFNDVZYPHUEF-XZBKPIIZSA-N 0.000 description 4
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 4
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 4
- 125000005250 alkyl acrylate group Chemical group 0.000 description 4
- 239000003795 chemical substances by application Substances 0.000 description 4
- 229920006037 cross link polymer Polymers 0.000 description 4
- GVJHHUAWPYXKBD-UHFFFAOYSA-N d-alpha-tocopherol Natural products OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 4
- 229930182478 glucoside Natural products 0.000 description 4
- 150000008131 glucosides Chemical class 0.000 description 4
- 239000007764 o/w emulsion Substances 0.000 description 4
- 229960001295 tocopherol Drugs 0.000 description 4
- 229930003799 tocopherol Natural products 0.000 description 4
- 235000010384 tocopherol Nutrition 0.000 description 4
- 239000011732 tocopherol Substances 0.000 description 4
- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 description 4
- ALYNCZNDIQEVRV-UHFFFAOYSA-N 4-aminobenzoic acid Chemical class NC1=CC=C(C(O)=O)C=C1 ALYNCZNDIQEVRV-UHFFFAOYSA-N 0.000 description 3
- 229920002261 Corn starch Polymers 0.000 description 3
- 206010013786 Dry skin Diseases 0.000 description 3
- 150000001252 acrylic acid derivatives Chemical class 0.000 description 3
- 230000008901 benefit Effects 0.000 description 3
- 230000003750 conditioning effect Effects 0.000 description 3
- 239000008120 corn starch Substances 0.000 description 3
- 230000018044 dehydration Effects 0.000 description 3
- 238000006297 dehydration reaction Methods 0.000 description 3
- 235000014113 dietary fatty acids Nutrition 0.000 description 3
- 230000037336 dry skin Effects 0.000 description 3
- 210000002615 epidermis Anatomy 0.000 description 3
- 150000002148 esters Chemical class 0.000 description 3
- 239000000194 fatty acid Substances 0.000 description 3
- 229930195729 fatty acid Natural products 0.000 description 3
- 235000019271 petrolatum Nutrition 0.000 description 3
- 230000037067 skin hydration Effects 0.000 description 3
- HDTRYLNUVZCQOY-UHFFFAOYSA-N α-D-glucopyranosyl-α-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 description 2
- AFDXODALSZRGIH-QPJJXVBHSA-N (E)-3-(4-methoxyphenyl)prop-2-enoic acid Chemical compound COC1=CC=C(\C=C\C(O)=O)C=C1 AFDXODALSZRGIH-QPJJXVBHSA-N 0.000 description 2
- ILCOCZBHMDEIAI-UHFFFAOYSA-N 2-(2-octadecoxyethoxy)ethanol Chemical compound CCCCCCCCCCCCCCCCCCOCCOCCO ILCOCZBHMDEIAI-UHFFFAOYSA-N 0.000 description 2
- ISDGWTZFJKFKMO-UHFFFAOYSA-N 2-phenyl-1,3-dioxane-4,6-dione Chemical compound O1C(=O)CC(=O)OC1C1=CC=CC=C1 ISDGWTZFJKFKMO-UHFFFAOYSA-N 0.000 description 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 2
- 239000004264 Petrolatum Substances 0.000 description 2
- 208000000453 Skin Neoplasms Diseases 0.000 description 2
- 229920002385 Sodium hyaluronate Polymers 0.000 description 2
- HDTRYLNUVZCQOY-WSWWMNSNSA-N Trehalose Natural products O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-WSWWMNSNSA-N 0.000 description 2
- 239000004480 active ingredient Substances 0.000 description 2
- HDTRYLNUVZCQOY-LIZSDCNHSA-N alpha,alpha-trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 description 2
- 239000008163 avocado oil Substances 0.000 description 2
- 235000021302 avocado oil Nutrition 0.000 description 2
- 230000004888 barrier function Effects 0.000 description 2
- 239000004202 carbamide Substances 0.000 description 2
- 229940085262 cetyl dimethicone Drugs 0.000 description 2
- 229920001577 copolymer Polymers 0.000 description 2
- 210000004207 dermis Anatomy 0.000 description 2
- 239000003974 emollient agent Substances 0.000 description 2
- 235000008524 evening primrose extract Nutrition 0.000 description 2
- 150000004665 fatty acids Chemical class 0.000 description 2
- 230000036074 healthy skin Effects 0.000 description 2
- 230000036571 hydration Effects 0.000 description 2
- 238000006703 hydration reaction Methods 0.000 description 2
- 229930195733 hydrocarbon Natural products 0.000 description 2
- 150000002430 hydrocarbons Chemical class 0.000 description 2
- 239000008172 hydrogenated vegetable oil Substances 0.000 description 2
- 238000010348 incorporation Methods 0.000 description 2
- 229940119170 jojoba wax Drugs 0.000 description 2
- 239000011159 matrix material Substances 0.000 description 2
- 239000012528 membrane Substances 0.000 description 2
- LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 description 2
- OQILCOQZDHPEAZ-UHFFFAOYSA-N octyl palmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OCCCCCCCC OQILCOQZDHPEAZ-UHFFFAOYSA-N 0.000 description 2
- 229940066842 petrolatum Drugs 0.000 description 2
- 230000000144 pharmacologic effect Effects 0.000 description 2
- 229920001296 polysiloxane Polymers 0.000 description 2
- 230000002035 prolonged effect Effects 0.000 description 2
- QELSKZZBTMNZEB-UHFFFAOYSA-N propylparaben Chemical compound CCCOC(=O)C1=CC=C(O)C=C1 QELSKZZBTMNZEB-UHFFFAOYSA-N 0.000 description 2
- 150000003839 salts Chemical class 0.000 description 2
- 239000003352 sequestering agent Substances 0.000 description 2
- 229940057910 shea butter Drugs 0.000 description 2
- 229940010747 sodium hyaluronate Drugs 0.000 description 2
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 description 2
- CRPCXAMJWCDHFM-UHFFFAOYSA-M sodium;5-oxopyrrolidine-2-carboxylate Chemical compound [Na+].[O-]C(=O)C1CCC(=O)N1 CRPCXAMJWCDHFM-UHFFFAOYSA-M 0.000 description 2
- PRAKJMSDJKAYCZ-UHFFFAOYSA-N squalane Chemical compound CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 description 2
- 229940098760 steareth-2 Drugs 0.000 description 2
- 239000002562 thickening agent Substances 0.000 description 2
- 239000004408 titanium dioxide Substances 0.000 description 2
- 239000007762 w/o emulsion Substances 0.000 description 2
- 239000001993 wax Substances 0.000 description 2
- WQKLGQXWHKQTPO-UXRZSMILSA-N (2r,3s,4s,5r,6r)-2-(hydroxymethyl)-6-methoxyoxane-3,4,5-triol;2-(2-hydroxypropoxy)propan-1-ol Chemical compound CC(O)COC(C)CO.CC(O)COC(C)CO.CC(O)COC(C)CO.CC(O)COC(C)CO.CO[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O WQKLGQXWHKQTPO-UXRZSMILSA-N 0.000 description 1
- DSEKYWAQQVUQTP-XEWMWGOFSA-N (2r,4r,4as,6as,6as,6br,8ar,12ar,14as,14bs)-2-hydroxy-4,4a,6a,6b,8a,11,11,14a-octamethyl-2,4,5,6,6a,7,8,9,10,12,12a,13,14,14b-tetradecahydro-1h-picen-3-one Chemical compound C([C@H]1[C@]2(C)CC[C@@]34C)C(C)(C)CC[C@]1(C)CC[C@]2(C)[C@H]4CC[C@@]1(C)[C@H]3C[C@@H](O)C(=O)[C@@H]1C DSEKYWAQQVUQTP-XEWMWGOFSA-N 0.000 description 1
- DSSYKIVIOFKYAU-XCBNKYQSSA-N (R)-camphor Chemical class C1C[C@@]2(C)C(=O)C[C@@H]1C2(C)C DSSYKIVIOFKYAU-XCBNKYQSSA-N 0.000 description 1
- CUAJPFGLNDCFAH-UHFFFAOYSA-N 1,1-di(propan-2-yl)cyclohexane Chemical compound CC(C)C1(C(C)C)CCCCC1 CUAJPFGLNDCFAH-UHFFFAOYSA-N 0.000 description 1
- JLHMJWHSBYZWJJ-UHFFFAOYSA-N 1,2-thiazole 1-oxide Chemical compound O=S1C=CC=N1 JLHMJWHSBYZWJJ-UHFFFAOYSA-N 0.000 description 1
- ZQCIPRGNRQXXSK-UHFFFAOYSA-N 1-octadecoxypropan-2-ol Chemical compound CCCCCCCCCCCCCCCCCCOCC(C)O ZQCIPRGNRQXXSK-UHFFFAOYSA-N 0.000 description 1
- RZRNAYUHWVFMIP-KTKRTIGZSA-N 1-oleoylglycerol Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OCC(O)CO RZRNAYUHWVFMIP-KTKRTIGZSA-N 0.000 description 1
- LSHGMOIQPURPAK-UHFFFAOYSA-N 2-benzylidene-1,4,7,7-tetramethylbicyclo[2.2.1]heptan-3-one Chemical compound CC1(C)C(C2=O)(C)CCC1(C)C2=CC1=CC=CC=C1 LSHGMOIQPURPAK-UHFFFAOYSA-N 0.000 description 1
- OPJWPPVYCOPDCM-UHFFFAOYSA-N 2-ethylhexyl octadecanoate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(CC)CCCC OPJWPPVYCOPDCM-UHFFFAOYSA-N 0.000 description 1
- GTJOHISYCKPIMT-UHFFFAOYSA-N 2-methylundecane Chemical compound CCCCCCCCCC(C)C GTJOHISYCKPIMT-UHFFFAOYSA-N 0.000 description 1
- LEACJMVNYZDSKR-UHFFFAOYSA-N 2-octyldodecan-1-ol Chemical compound CCCCCCCCCCC(CO)CCCCCCCC LEACJMVNYZDSKR-UHFFFAOYSA-N 0.000 description 1
- VOZACBAWQWTUID-UHFFFAOYSA-N 3-methylbut-3-enyl 3-(4-methoxyphenyl)prop-2-enoate Chemical compound COC1=CC=C(C=CC(=O)OCCC(C)=C)C=C1 VOZACBAWQWTUID-UHFFFAOYSA-N 0.000 description 1
- HIQIXEFWDLTDED-UHFFFAOYSA-N 4-hydroxy-1-piperidin-4-ylpyrrolidin-2-one Chemical compound O=C1CC(O)CN1C1CCNCC1 HIQIXEFWDLTDED-UHFFFAOYSA-N 0.000 description 1
- AMEMLELAMQEAIA-UHFFFAOYSA-N 6-(tert-butyl)thieno[3,2-d]pyrimidin-4(3H)-one Chemical compound N1C=NC(=O)C2=C1C=C(C(C)(C)C)S2 AMEMLELAMQEAIA-UHFFFAOYSA-N 0.000 description 1
- XZOYHFBNQHPJRQ-UHFFFAOYSA-N 7-methyloctanoic acid Chemical compound CC(C)CCCCCC(O)=O XZOYHFBNQHPJRQ-UHFFFAOYSA-N 0.000 description 1
- KGKQNDQDVZQTAG-UHFFFAOYSA-N 8-methylnonyl 2,2-dimethylpropanoate Chemical compound CC(C)CCCCCCCOC(=O)C(C)(C)C KGKQNDQDVZQTAG-UHFFFAOYSA-N 0.000 description 1
- UOFXSBOAZYCBAV-UHFFFAOYSA-N 8-methylnonyl dodecanoate Chemical compound CCCCCCCCCCCC(=O)OCCCCCCCC(C)C UOFXSBOAZYCBAV-UHFFFAOYSA-N 0.000 description 1
- 229920000936 Agarose Polymers 0.000 description 1
- LSNNMFCWUKXFEE-UHFFFAOYSA-M Bisulfite Chemical compound OS([O-])=O LSNNMFCWUKXFEE-UHFFFAOYSA-M 0.000 description 1
- LVDKZNITIUWNER-UHFFFAOYSA-N Bronopol Chemical compound OCC(Br)(CO)[N+]([O-])=O LVDKZNITIUWNER-UHFFFAOYSA-N 0.000 description 1
- 229920002134 Carboxymethyl cellulose Polymers 0.000 description 1
- 102000008186 Collagen Human genes 0.000 description 1
- 108010035532 Collagen Proteins 0.000 description 1
- QXNVGIXVLWOKEQ-UHFFFAOYSA-N Disodium Chemical compound [Na][Na] QXNVGIXVLWOKEQ-UHFFFAOYSA-N 0.000 description 1
- 102000016942 Elastin Human genes 0.000 description 1
- 108010014258 Elastin Proteins 0.000 description 1
- 240000002024 Gossypium herbaceum Species 0.000 description 1
- 235000004341 Gossypium herbaceum Nutrition 0.000 description 1
- 244000020551 Helianthus annuus Species 0.000 description 1
- 235000003222 Helianthus annuus Nutrition 0.000 description 1
- 239000004354 Hydroxyethyl cellulose Substances 0.000 description 1
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 description 1
- SGVYKUFIHHTIFL-UHFFFAOYSA-N Isobutylhexyl Natural products CCCCCCCC(C)C SGVYKUFIHHTIFL-UHFFFAOYSA-N 0.000 description 1
- 239000004166 Lanolin Substances 0.000 description 1
- 235000004496 Oenothera biennis Nutrition 0.000 description 1
- 240000008916 Oenothera biennis Species 0.000 description 1
- 240000007817 Olea europaea Species 0.000 description 1
- 235000002725 Olea europaea Nutrition 0.000 description 1
- WYWZRNAHINYAEF-UHFFFAOYSA-N Padimate O Chemical compound CCCCC(CC)COC(=O)C1=CC=C(N(C)C)C=C1 WYWZRNAHINYAEF-UHFFFAOYSA-N 0.000 description 1
- 235000019482 Palm oil Nutrition 0.000 description 1
- 244000025272 Persea americana Species 0.000 description 1
- 235000011236 Persea americana var americana Nutrition 0.000 description 1
- 229920002413 Polyhexanide Polymers 0.000 description 1
- 244000044822 Simmondsia californica Species 0.000 description 1
- 235000004433 Simmondsia californica Nutrition 0.000 description 1
- 239000004288 Sodium dehydroacetate Substances 0.000 description 1
- 206010042496 Sunburn Diseases 0.000 description 1
- 235000019486 Sunflower oil Nutrition 0.000 description 1
- 244000299461 Theobroma cacao Species 0.000 description 1
- 235000009470 Theobroma cacao Nutrition 0.000 description 1
- 244000141804 Theobroma grandiflorum Species 0.000 description 1
- 235000002424 Theobroma grandiflorum Nutrition 0.000 description 1
- PHYFQTYBJUILEZ-UHFFFAOYSA-N Trioleoylglycerol Natural products CCCCCCCCC=CCCCCCCCC(=O)OCC(OC(=O)CCCCCCCC=CCCCCCCCC)COC(=O)CCCCCCCC=CCCCCCCCC PHYFQTYBJUILEZ-UHFFFAOYSA-N 0.000 description 1
- 230000006750 UV protection Effects 0.000 description 1
- LPGFSDGXTDNTCB-UHFFFAOYSA-N [3-(16-methylheptadecanoyloxy)-2,2-bis(16-methylheptadecanoyloxymethyl)propyl] 16-methylheptadecanoate Chemical compound CC(C)CCCCCCCCCCCCCCC(=O)OCC(COC(=O)CCCCCCCCCCCCCCC(C)C)(COC(=O)CCCCCCCCCCCCCCC(C)C)COC(=O)CCCCCCCCCCCCCCC(C)C LPGFSDGXTDNTCB-UHFFFAOYSA-N 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- 125000000217 alkyl group Chemical group 0.000 description 1
- 229960004050 aminobenzoic acid Drugs 0.000 description 1
- 239000012164 animal wax Substances 0.000 description 1
- BTFJIXJJCSYFAL-UHFFFAOYSA-N arachidyl alcohol Natural products CCCCCCCCCCCCCCCCCCCCO BTFJIXJJCSYFAL-UHFFFAOYSA-N 0.000 description 1
- 235000013871 bee wax Nutrition 0.000 description 1
- 239000012166 beeswax Substances 0.000 description 1
- 229960004101 bemotrizinol Drugs 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000012965 benzophenone Substances 0.000 description 1
- 150000008366 benzophenones Chemical class 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 229960003168 bronopol Drugs 0.000 description 1
- 235000014121 butter Nutrition 0.000 description 1
- 239000000828 canola oil Substances 0.000 description 1
- 235000019519 canola oil Nutrition 0.000 description 1
- 239000001768 carboxy methyl cellulose Substances 0.000 description 1
- 235000010948 carboxy methyl cellulose Nutrition 0.000 description 1
- 229920003090 carboxymethyl hydroxyethyl cellulose Polymers 0.000 description 1
- 239000004203 carnauba wax Substances 0.000 description 1
- 235000013869 carnauba wax Nutrition 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- CMDKPGRTAQVGFQ-RMKNXTFCSA-N cinoxate Chemical compound CCOCCOC(=O)\C=C\C1=CC=C(OC)C=C1 CMDKPGRTAQVGFQ-RMKNXTFCSA-N 0.000 description 1
- 229940110456 cocoa butter Drugs 0.000 description 1
- 235000019868 cocoa butter Nutrition 0.000 description 1
- 239000003240 coconut oil Substances 0.000 description 1
- 235000019864 coconut oil Nutrition 0.000 description 1
- 229920001436 collagen Polymers 0.000 description 1
- 230000002844 continuous effect Effects 0.000 description 1
- 210000000736 corneocyte Anatomy 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
- 235000012343 cottonseed oil Nutrition 0.000 description 1
- 239000002385 cottonseed oil Substances 0.000 description 1
- SOROIESOUPGGFO-UHFFFAOYSA-N diazolidinylurea Chemical compound OCNC(=O)N(CO)C1N(CO)C(=O)N(CO)C1=O SOROIESOUPGGFO-UHFFFAOYSA-N 0.000 description 1
- 229960001083 diazolidinylurea Drugs 0.000 description 1
- NZZIMKJIVMHWJC-UHFFFAOYSA-N dibenzoylmethane Chemical class C=1C=CC=CC=1C(=O)CC(=O)C1=CC=CC=C1 NZZIMKJIVMHWJC-UHFFFAOYSA-N 0.000 description 1
- RNPXCFINMKSQPQ-UHFFFAOYSA-N dicetyl hydrogen phosphate Chemical compound CCCCCCCCCCCCCCCCOP(O)(=O)OCCCCCCCCCCCCCCCC RNPXCFINMKSQPQ-UHFFFAOYSA-N 0.000 description 1
- 229940093541 dicetylphosphate Drugs 0.000 description 1
- TVWTZAGVNBPXHU-FOCLMDBBSA-N dioctyl (e)-but-2-enedioate Chemical compound CCCCCCCCOC(=O)\C=C\C(=O)OCCCCCCCC TVWTZAGVNBPXHU-FOCLMDBBSA-N 0.000 description 1
- KCIDZIIHRGYJAE-YGFYJFDDSA-L dipotassium;[(2r,3r,4s,5r,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl] phosphate Chemical compound [K+].[K+].OC[C@H]1O[C@H](OP([O-])([O-])=O)[C@H](O)[C@@H](O)[C@H]1O KCIDZIIHRGYJAE-YGFYJFDDSA-L 0.000 description 1
- GLCJMPWWQKKJQZ-UHFFFAOYSA-L disodium;2-[4-(4,6-disulfonato-1h-benzimidazol-2-yl)phenyl]-1h-benzimidazole-4,6-disulfonate;hydron Chemical compound [Na+].[Na+].C1=C(S(O)(=O)=O)C=C2NC(C3=CC=C(C=C3)C3=NC4=C(C=C(C=C4N3)S(=O)(=O)O)S([O-])(=O)=O)=NC2=C1S([O-])(=O)=O GLCJMPWWQKKJQZ-UHFFFAOYSA-L 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- WSDISUOETYTPRL-UHFFFAOYSA-N dmdm hydantoin Chemical compound CC1(C)N(CO)C(=O)N(CO)C1=O WSDISUOETYTPRL-UHFFFAOYSA-N 0.000 description 1
- HUVYTMDMDZRHBN-UHFFFAOYSA-N drometrizole trisiloxane Chemical compound C[Si](C)(C)O[Si](C)(O[Si](C)(C)C)CC(C)CC1=CC(C)=CC(N2N=C3C=CC=CC3=N2)=C1O HUVYTMDMDZRHBN-UHFFFAOYSA-N 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 229920002549 elastin Polymers 0.000 description 1
- UVCJGUGAGLDPAA-UHFFFAOYSA-N ensulizole Chemical compound N1C2=CC(S(=O)(=O)O)=CC=C2N=C1C1=CC=CC=C1 UVCJGUGAGLDPAA-UHFFFAOYSA-N 0.000 description 1
- 229940045761 evening primrose extract Drugs 0.000 description 1
- 229940089020 evening primrose oil Drugs 0.000 description 1
- 239000010475 evening primrose oil Substances 0.000 description 1
- 210000000245 forearm Anatomy 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- ZUVCYFMOHFTGDM-UHFFFAOYSA-N hexadecyl dihydrogen phosphate Chemical compound CCCCCCCCCCCCCCCCOP(O)(O)=O ZUVCYFMOHFTGDM-UHFFFAOYSA-N 0.000 description 1
- 229920006007 hydrogenated polyisobutylene Polymers 0.000 description 1
- 229920001477 hydrophilic polymer Polymers 0.000 description 1
- 230000002209 hydrophobic effect Effects 0.000 description 1
- 239000001341 hydroxy propyl starch Substances 0.000 description 1
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 description 1
- 235000013828 hydroxypropyl starch Nutrition 0.000 description 1
- 230000001771 impaired effect Effects 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 229940040923 isodecyl laurate Drugs 0.000 description 1
- VKPSKYDESGTTFR-UHFFFAOYSA-N isododecane Natural products CC(C)(C)CC(C)CC(C)(C)C VKPSKYDESGTTFR-UHFFFAOYSA-N 0.000 description 1
- 229940033357 isopropyl laurate Drugs 0.000 description 1
- 235000019388 lanolin Nutrition 0.000 description 1
- 229940039717 lanolin Drugs 0.000 description 1
- 229940057995 liquid paraffin Drugs 0.000 description 1
- 239000006210 lotion Substances 0.000 description 1
- 239000000314 lubricant Substances 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 150000001455 metallic ions Chemical class 0.000 description 1
- 235000010270 methyl p-hydroxybenzoate Nutrition 0.000 description 1
- 239000004292 methyl p-hydroxybenzoate Substances 0.000 description 1
- 229960002216 methylparaben Drugs 0.000 description 1
- 230000000813 microbial effect Effects 0.000 description 1
- 230000003278 mimic effect Effects 0.000 description 1
- 235000010446 mineral oil Nutrition 0.000 description 1
- 229940042472 mineral oil Drugs 0.000 description 1
- 239000012184 mineral wax Substances 0.000 description 1
- JXTPJDDICSTXJX-UHFFFAOYSA-N n-Triacontane Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCC JXTPJDDICSTXJX-UHFFFAOYSA-N 0.000 description 1
- 229960003921 octisalate Drugs 0.000 description 1
- FMJSMJQBSVNSBF-UHFFFAOYSA-N octocrylene Chemical group C=1C=CC=CC=1C(=C(C#N)C(=O)OCC(CC)CCCC)C1=CC=CC=C1 FMJSMJQBSVNSBF-UHFFFAOYSA-N 0.000 description 1
- 229960000601 octocrylene Drugs 0.000 description 1
- WCJLCOAEJIHPCW-UHFFFAOYSA-N octyl 2-hydroxybenzoate Chemical compound CCCCCCCCOC(=O)C1=CC=CC=C1O WCJLCOAEJIHPCW-UHFFFAOYSA-N 0.000 description 1
- 239000004006 olive oil Substances 0.000 description 1
- 235000008390 olive oil Nutrition 0.000 description 1
- DXGLGDHPHMLXJC-UHFFFAOYSA-N oxybenzone Chemical compound OC1=CC(OC)=CC=C1C(=O)C1=CC=CC=C1 DXGLGDHPHMLXJC-UHFFFAOYSA-N 0.000 description 1
- 229960001173 oxybenzone Drugs 0.000 description 1
- 239000002540 palm oil Substances 0.000 description 1
- 230000000149 penetrating effect Effects 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- 230000000737 periodic effect Effects 0.000 description 1
- 230000002085 persistent effect Effects 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 229940057874 phenyl trimethicone Drugs 0.000 description 1
- 229920002401 polyacrylamide Polymers 0.000 description 1
- 229940078491 ppg-15 stearyl ether Drugs 0.000 description 1
- 229940116393 ppg-20 methyl glucose ether Drugs 0.000 description 1
- VZKNAUXVJXVEAG-UHFFFAOYSA-N propan-2-yl hexadecanoate;propan-2-yl tetradecanoate Chemical compound CCCCCCCCCCCCCC(=O)OC(C)C.CCCCCCCCCCCCCCCC(=O)OC(C)C VZKNAUXVJXVEAG-UHFFFAOYSA-N 0.000 description 1
- 235000010232 propyl p-hydroxybenzoate Nutrition 0.000 description 1
- 239000004405 propyl p-hydroxybenzoate Substances 0.000 description 1
- 229960003415 propylparaben Drugs 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 239000001944 prunus armeniaca kernel oil Substances 0.000 description 1
- 150000003254 radicals Chemical class 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 238000007665 sagging Methods 0.000 description 1
- 150000003902 salicylic acid esters Chemical class 0.000 description 1
- 230000037075 skin appearance Effects 0.000 description 1
- 230000008591 skin barrier function Effects 0.000 description 1
- 201000000849 skin cancer Diseases 0.000 description 1
- 210000004927 skin cell Anatomy 0.000 description 1
- 229940083542 sodium Drugs 0.000 description 1
- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 description 1
- 235000010234 sodium benzoate Nutrition 0.000 description 1
- 239000004299 sodium benzoate Substances 0.000 description 1
- 229960003885 sodium benzoate Drugs 0.000 description 1
- 235000019259 sodium dehydroacetate Nutrition 0.000 description 1
- 229940079839 sodium dehydroacetate Drugs 0.000 description 1
- RYYKJJJTJZKILX-UHFFFAOYSA-M sodium octadecanoate Chemical compound [Na+].CCCCCCCCCCCCCCCCCC([O-])=O RYYKJJJTJZKILX-UHFFFAOYSA-M 0.000 description 1
- DSOWAKKSGYUMTF-GZOLSCHFSA-M sodium;(1e)-1-(6-methyl-2,4-dioxopyran-3-ylidene)ethanolate Chemical compound [Na+].C\C([O-])=C1/C(=O)OC(C)=CC1=O DSOWAKKSGYUMTF-GZOLSCHFSA-M 0.000 description 1
- 239000003549 soybean oil Substances 0.000 description 1
- 235000012424 soybean oil Nutrition 0.000 description 1
- 229940032094 squalane Drugs 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000036561 sun exposure Effects 0.000 description 1
- 239000002600 sunflower oil Substances 0.000 description 1
- 235000020238 sunflower seed Nutrition 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 230000002459 sustained effect Effects 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 150000003918 triazines Chemical class 0.000 description 1
- LINXHFKHZLOLEI-UHFFFAOYSA-N trimethyl-[phenyl-bis(trimethylsilyloxy)silyl]oxysilane Chemical compound C[Si](C)(C)O[Si](O[Si](C)(C)C)(O[Si](C)(C)C)C1=CC=CC=C1 LINXHFKHZLOLEI-UHFFFAOYSA-N 0.000 description 1
- 229940099259 vaseline Drugs 0.000 description 1
- 239000012178 vegetable wax Substances 0.000 description 1
- 239000003981 vehicle Substances 0.000 description 1
- 239000008307 w/o/w-emulsion Substances 0.000 description 1
- 230000037303 wrinkles Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/04—Dispersions; Emulsions
- A61K8/06—Emulsions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/347—Phenols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
- A61K8/496—Triazoles or their condensed derivatives, e.g. benzotriazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
- A61K8/4966—Triazines or their condensed derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/731—Cellulose; Quaternized cellulose derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/732—Starch; Amylose; Amylopectin; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/54—Polymers characterized by specific structures/properties
- A61K2800/542—Polymers characterized by specific structures/properties characterized by the charge
- A61K2800/5426—Polymers characterized by specific structures/properties characterized by the charge cationic
Definitions
- the present invention relates to a composition for topical application which protects the skin from the effects of sunlight, in particular to a skincare composition in the form of an emulsion which provides a moisturising and sunscreen effect.
- UVB rays are responsible for causing sunburn where significant damage and dehydration of the skin occurs, and also may lead to skin cancers.
- UVA rays may also contribute to skin cancer but additionally lead to a photoageing effect where the skin loses its healthy and youthful appearance.
- the collagen and elastin fibres which provide the skin with strength, structure and elasticity, are broken down by exposure to UV radiation, leading to wrinkles and sagging skin. The UV damage may occur at any time of year as the UVA rays, which penetrate more deeply into the skin than UVB rays, pass though glass.
- lipids in the outer layer of the skin may affect lipids in the outer layer of the skin causing the cells in the stratum corneum to adhere poorly to each other, providing that the new skin continuously being formed has an impaired skin barrier.
- destruction of the lipids which generally form a strong protective barrier acting to preserve the moisture in the body, may also cause the skin cells to lose the water they need to stay healthy and supple.
- a healthy stratum corneum comprises about 30% water, giving the skin resilience and elasticity. Accordingly, it is desired to moisturise skin exposed to UV light to retain its healthy function.
- the present invention seeks to provide an improved suncare formulation. It has now been found that by providing a stable composition in which an effective sunscreen component can be combined with a particular moisturising system, advantages in the protection and overall appearance of the skin are achieved.
- Patent application WO2006/061661 published 15 June 2006, concerns a skincare composition comprising a starch (or starch derivative) and a polymeric quaternary ammonium salt having humectant properties, said composition being useful for moisturising the skin. It is disclosed that sunscreening agents are among conventional ingredients that may be incorporated in the subject composition.
- an improved skincare emulsion composition which enhances the combined moisturisation and sunscreen effect on the skin of a user. It has been found that the selection of particular sunscreens formulated as an emulsion with a particular moisturising system provides advantageous protection for the skin from the effects of sunlight.
- the present invention provides a skincare composition in the form of an emulsion
- a skincare composition in the form of an emulsion
- an organic sunscreen component comprising at least one sunscreen selected from the group consisting of bis-ethylhexyloxyphenol methoxyphenyl triazine and methylene bis-benzotriazolyl tetramethylbutylphenol
- a moisturising system comprising starch or a derivative thereof and a polymeric quaternary compound salt having humectant properties
- a carrier comprising an oil phase, an aqueous phase and an emulsifying system, said emulsifying system comprising at least one emulsifier selected from an anionic or non-ionic emulsifier.
- the present invention has allowed the formation of a stable sunscreen system in a composition which is able to provide a continuous moisturisation effect.
- the emulsion can contain a relatively high proportion of water, especially up to 50% or even 60% by weight or more.
- the moisturisation effect of the composition may be maintained at continuous levels for a period of 12 hours or more.
- a continuous moisturisation effect is particularly desirable as it significantly reduces the dehydration of the skin on exposure to sunlight and maximises the rehydration and moisturisation of the skin. It has been found that a healthy skin with a properly functioning outer barrier layer exposed to the environment is better able to withstand the effects of exposure to sunlight than dehydrated, damaged skin.
- compositions according to the invention prevent substantial moisture loss, through the continuous addition of moisture over a period of up to 12 hours or more, the epidermal layer of the skin is healthier and is better able to withstand the effects of UV radiation. Accordingly, an advantageous UV protection effect may be obtained.
- the compositions are advantageously used daily to maximize their effect.
- the compositions may be used by any person to obtain a moisturisation effect during exposure to sunlight, preferably also in advance of exposure to sunlight.
- a particular advantage of the present invention is that it provides a stable and effective sunscreen composition which is effective when the user has dry skin or a dry skin condition where the effect of a poorly moisturised skin can have a more marked effect on the UV damage caused to the skin.
- the present composition not only reduces the effect of sunlight on the skin from UV damage, it also improves the moisturisation levels to help protect the skin from the effects of UV radiation.
- the skincare composition is suitable for topical application to the skin to provide a continuous moisturisation and sunscreen effect over a number of hours, ie there is a continuous and regular hydration effect to support the effect of the sunscreen component. Accordingly, the composition provides a sustained moisurisation and sunscreen effect which achieves an enhanced and persistent treatment of the skin when exposed to sunlight, especially UV radiation. The prolonged effects of the composition and constant effect of the composition is particularly valuable.
- the sunscreen component useful in accordance with the present invention comprises an organic sunscreen component comprising at least one sunscreen selected from the group consisting of bis-ethylhexyloxyphenol methoxyphenyl triazine and methylene bis-benzotriazolyl tetramethylbutylphenol.
- sunscreens are known as broad spectrum UV agents, but are particularly effective as UV-A sunscreens, and hence serve to reduce the effect of UV radiation on the skin.
- UV-A sunscreens have been found to be particularly effective in combination with the present moisturisation system and may be used singly or in combination.
- Additional organic sunscreen agents may also be combined with said sunscreens, including p-aminobenzoic acids, esters and derivatives thereof, for example, 2-ethylhexyl p-dimethylaminobenzoate, and the octyl ester of p-aminobenzoic acid; methoxycinnamate esters such as 2-ethylhexyl p-methoxycinnamate, 2-ethoxyethyl p-methoxycinnamate, isopentenyl-4-methoxycinnamate or ⁇ , ⁇ -di-(p- methoxycinnamoyl)- ⁇ '-(2-ethylhexanoyl)-glycerin; dibenzoylmethanes such as butyl methoxydibenzoylmethane; benzophenones such as oxybenzone; 2- phenylbenzimidazole-5-sulfonic acid and disodium phenyl dibenz
- the organic sunscreen component comprises bis- ethylhexyloxyphenol methoxyphenyl triazine in combination with one or more of methylene bis-benzotriazolyl tetramethylbutylphenol, ethylhexyl methoxycinnamate, isoamyl p-methoxycinnamate and butyl methoxydibenzoylmethane.
- the sunscreen component comprises methylene bis-benzotriazolyl tetramethylbutylphenol in combination with one or more of bis-ethylhexyloxyphenol methoxyphenyl triazine, ethylhexylmethoxy cinnamate, isoamyl p-methoxycinnamate and butyl methoxydibenzoylmethane.
- the sunscreen component comprises a combination of bis-ethylhexyloxyphenol methoxyphenyl triazine, methylene bis- benzotriazolyl tetramethylbutylphenol and ethylhexylmethoxy cinnamate, optionally including isoamyl p-methoxycinnamate.
- a composition according to the invention comprises an organic sunscreen component in an amount greater than 2.5% by weight of the composition, more preferably greater than 5% by weight and most preferably greater than 10% by weight.
- the sunscreen agent is present in the composition in an amount less than 25% by weight, more preferably less than 20% by weight and most preferably less than 15% by weight.
- the sunscreen component is present in the composition in the range from 2.5% to 25% by weight, more preferably in the range from 5% to 20% by weight and most preferably in the range from 10% to 15% by weight.
- the organic sunscreen component is present in an amount of from 15% to 60% by weight of the oil phase, more preferably from 25% to 50% by weight and most preferably from 30% to 45% by weight.
- a composition according to the present invention may also comprise an inorganic sunscreen agent, preferably titanium dioxide. Said inorganic sunscreen agent, if present, is preferably used in the range from 1 % to 10% by weight, more preferably in the range from 2% to 8% by weight and most preferably in the range from 3% to 7% by weight.
- a composition according to the invention comprises a moisturising system comprising starch or a derivative thereof and a polymeric quaternary compound salt having humectant properties.
- the moisturising system reduces the effect of sunlight, including UV radiation, in dehydrating the skin.
- the moisturising system is present in an amount of from 0.1 % to 16% by weight of the composition, more preferably from 1 % to 6% by weight and most preferably from 2.25% to 3.75% by weight.
- the moisturising system used in accordance with present invention has a continuous effect in moisturising the skin over a period of 12 hours or more. This is particularly effective where a person may be exposed to the sun for long periods and accordingly the provision of a continuous moisturising system helps to combat the continuous dehydrating effect of the sun and to protect the skin against the effects of the sun.
- the starch or starch derivative employed in the moisturing system is preferably a chemically or physically modified starch. Most preferably, the starch is modified so as to render it heat-stable and/or non-swelling.
- a preferred form of starch derivative is a dimethyl imidazolidinone starch derivative, ie a product obtained by reaction of 1 ,3-dimethyl-4,5-dihydroxy-2-imidazolidinone (dimethyl imidazolidinone) with starch.
- Particular starches that may be used include corn starch but, more preferably, the starch is rice starch.
- the dimethyl imidazolidinone starch derivative may thus be dimethylimidazolidinone corn starch or, more preferably, dimethylimidazolidinone rice starch.
- a suitable form of dimethylimidazolidinone rice starch is available from Agrana u. Staerke AG, Conrathstr. 7, A-3950 Gmuend, Austria, under the trade name Rice NS. Another supplier is Dr Hauser, Reintalstrasse 8, D-82467 Garmisch- Partenmaschinen, Germany.
- the starch or starch derivative is preferably present in the composition according to the invention at a level of less than 15% by weight, preferably less than 10% by weight, and more preferably less than 5% by weight.
- the concentration of starch derivative is preferably greater than 0.1 % by weight, and more preferably greater than 1 % by weight.
- the concentration of starch derivative is therefore preferably in the range from 0.1 % to 15% by weight, and more preferably in the range from 1 % to 5% by weight, particularly in the range from 2.25% to 3.75% by weight.
- the polymeric quaternary ammonium salt is most preferably the material known as Polyquaternium-51 , ie the polymeric quaternary ammonium salt that conforms generally to the formula:
- polyquaternium-51 is available from NOF Corporation, 4-20-3, Ebisu, Shibuya-ku, Tokyo 150, Japan, under the trade name Lipidure-PMB.
- the ammonium salt is preferably present in the composition according to the invention at a level of less than 1 % by weight, more preferably less than 0.1 % by weight.
- the concentration of ammonium salt is preferably greater than 0.0001% by weight, and more preferably greater than 0.001 % by weight.
- the concentration of ammonium salt is therefore preferably in the range from 0.0001 % to 1 % by weight, and more preferably in the range from 0.001 % to 0.1 % by weight.
- the ratio of moisturising system to sunscreen component is in the range 1 :1 to 1 :20 parts by weight, more preferably 1 :2 to 1 :10 parts by weight, most preferably 1 :4 to 1 :6 parts by weight.
- composition according to the invention may comprise one or more additional moisturising or humectant ingredients, ie moisturising or humectant ingredients that are additional to the starch derivative and the ammonium salt.
- the additional moisturising or humectant ingredient is a relatively low molecular weight polyalcohol, eg a C2-6 aliphatic polyalcohol.
- polyalcohols include glycerin (1 ,2,3-trihydroxypropane), 1 ,3-butylene glycol and propylene glycol.
- the most preferred additional moisturising or humectant ingredient is glycerin.
- the additional moisturising or humectant ingredient(s) are preferably present in the composition at a level of up to 25% by weight or more, more preferably up to 20% by weight.
- the concentration of additional moisturising or humectant ingredient(s) is preferably greater than 1% by weight, more preferably greater than 5% by weight, and most preferably greater than 10% by weight.
- the concentration of additional moisturising or humectant ingredient(s) is therefore preferably in the range from 1 % to 25% by weight, and more preferably in the range from 5% to 20% by weight.
- the concentration of glycerin is preferably in the range from 1 % to 20% by weight, more preferably in the range from 10% to 20% by weight, and in particular in the range from 10% to 15% by weight.
- the composition may comprise more than one aliphatic polyalcohol. In some embodiments, the composition comprises both glycerin and propylene glycol.
- compositions comprising one or more aliphatic polyalcohols have been found to be particularly beneficial.
- the invention thus provides a composition for topical application to the skin, which composition comprises a starch or starch derivative, a polymeric quaternary ammonium salt having humectant properties, and from 10% to 20% by weight of one or more aliphatic polyalcohols.
- the polyalcohols are preferably C2-6 aliphatic polyalcohols, most preferably selected from the group consisting of glycerin (1 ,2,3-trihydroxypropane), 1 ,3-butylene glycol and propylene glycol.
- the composition comprises glycerin.
- the composition is free of any additional moisturising agents other than the low molecular weight polyalcohols.
- the composition is preferably free of sodium PCA, urea, trehalose and sodium hyaluronate.
- the carrier provided in accordance with the present invention comprises an oil component and an aqueous component. Both components are required to be topically acceptable to a user, especially both cosmetically and dermatologically acceptable.
- the present compositions may be applied to healthy skin and to diseased skin.
- a composition according to the present invention is in the form of an emulsion, such as water-in-oil or oil-in-water emulsion, in which one of the phases is dispersed in the other phase with the aid of said emulsifying system.
- the emulsion may have an aqueous continuous phase or an oily continuous phase.
- the emulsion is an oil-in-water emulsion in which the aqueous component provides the continuous phase.
- the carrier provides a suitable stable topical vehicle for the sunscreen component, the moisturising component and any other desired ingredients. Elements of the carrier may be chosen so that they also have a pharmacological effect in the formulation, especially the oils.
- the carrier comprises at least 50% by weight of the composition, more preferably at least 65% by weight of the composition. Further preferably, the carrier comprises from 50% to 98% by weight of the composition, more preferably from 65% to 95% by weight and most preferably from 75% to 90% by weight of the composition.
- the organic sunscreen component is contained in the oil phase and the moisturising system is in the aqueous phase.
- a portion of the sunscreen component is contained in the oil phase and another portion of the sunscreen component is dispersed in the aqueous phase.
- bis-ethylhexyloxyphenol methoxyphenyl triazine is contained in the oil phase.
- methylene bis- benzotriazolyl tetramethylbutylphenol is dispersed in the aqueous phase.
- the oil component comprises: hydrocarbons, silicone oils, triglycerides, waxes, glycerin, fatty acids, fatty acid alcohols and esters thereof, mineral oils, vegetable oils and hydrogenated vegetable oils, lanolin or mixtures thereof.
- hydrocarbons examples include paraffins (for example paraffinum liquidum and white soft paraffin), petrolatum, hydrogenated polyisobutene, alkyl benzoates, isohexadecane, isododecane, isononyl isonanoate, diisopropylcyclohexane;
- silicone oils include dimethicone, cyclomethicone, cetyldimethicone or stearyl dimethicone,
- examples of triglycerides include natural triglycerides and synthetic or semi-synthetic triglycerides including triethylhexanoin and caprilic/capric triglyceride;
- waxes include vegetable waxes such as carnauba wax, animal waxes such as beeswax,and mineral waxes such as paraffin wax, ozokerite;
- esters of fatty acids or alcohols include isopropyl palmitate, isopropyl myristate
- the oil chosen for any composition may depend on the type of composition desired.
- the oil will be topically acceptable for cosmetic and/or dermatological use. Conveniently, the oil will have a pharmacological effect on the skin, such as providing an emollient effect.
- Preferred classes of oils include silicone oils, mineral oils, vegetable oils and triglycerides, especially mineral oils and vegetable oils.
- oils are butyrospermum parkii, caprilic/capric triglyceride, C12-15 alkyl benzoate, isohexadecane, triethylhexanoin, cyclomethicone, dimethicone, cetearyl alcohol, isopropylpalmitate, stearyl alcohol, cetyl alcohol, stearyl dimethicone, glyceryl myristate, paraffinum liquidum, aluminium starch octenylsuccinate and decyl cocoate or mixtures thereof.
- C12-15 alkyl benzoate Especially preferred is a combination of C12-15 alkyl benzoate, caprilic/capric triglyceride, cyclomethicone and aluminium starch octenylsuccinate, optionally in combination with either isopropylpalmitate and/or isohexadecane, butyrospermum parkii.
- said oil is present in an amount in the range from 4% to 50% by weight of the composition, more preferably in the range from 6% to 30% by weight and most preferably in the range from 8% to 20% by weight.
- water is present in the composition in the range from 20% to 80% by weight of the composition, more preferably in the range from 25% to 75% by weight and most preferably in the range from 35% to 55% by weight.
- the ratio of water to oil is in the range 10:1 to 1 :10 parts by weight, more preferably 5:1 to 1 :1 parts by weight and most preferably 5:1 to 3:1 parts by weight.
- An emulsifying system useful in accordance with the present invention comprises at least one emulsifier comprising an anionic or non-ionic emulsifier. Typical representatives of these classes of emulsifiers are known to those skilled in the art.
- the emulsifier may be combined with a thickening agent.
- a further preferred effect is achieved in accordance with the present invention by the incorporation of liquid crystal forming emulsifiers in the composition. Accordingly, in one embodiment the composition comprises an emulsifying system comprising a liquid crystal forming system.
- Emulsifiers that form lamellar liquid crystals are believed to mimic the multi-lamellar lipid structure of the stratum corneum which comprises corneocytes surrounded by a matrix of hydrophobic lipid membranes arranged in multiple lamellar sheets; the sheets of the lamellar membranes may have a crystal-like periodic arrangement and readily slide over one another thus keeping the stratum corneum pliant and elastic.
- Liquid crystals may provide advantageous skincare characteristics, for example in terms of skin penetration and hydration. It is believed that this may occur as the liquid crystals are formed into similar self-organising structure as natural stratum corneum lipids and thus show a high affinity to the skin.
- the emulsifying system comprises a combination of emulsifiers with different HLB values, more preferably at least one emulsifier with a high HLB value and at least one emulsifier with a low-medium HLB value, especially preferably at least one emulsifier with a high HLB value and at least one emulsifier with a low HLB value.
- high HLB emulsifiers have a HLB value above 20.
- low-medium HLB emulsifiers have a HLB below 20, for example 3-20.
- the non-ionic emulsifier has a HLB value in the range 3-20.
- the anionic emulsifier has a HLB value above 20.
- the mixture of emulsifiers may comprise a combination of one or more anionic emulsifiers with one or more non-ionic emulsifiers.
- the mixture may comprise a combination of anionic emulsifiers.
- the mixture may comprise a combination of non-ionic emulsifiers.
- the emulsifying system is preferably present in the composition in an amount in the range from 0.01 % to 20% by weight of the composition, preferably from 0.1% to 15% by weight, most preferably from 1 % to 10% by weight.
- high HLB anionic emulsifiers include: methylglucose sesquistearate, sucrose cocoate, decyl glucoside, potassium stearate, sodium cetearyl sulphate, isolaureth-4 phosphate and polyglyceryl-3 methylglucose distearate.
- high HLB non-ionic emulsifiers include: steareth-21 , steareth-10, ceteareth-12, ceteareth-20, oleth-10, PEG-12 oleate, PEG-12 stearate or PEG-80 sorbitan.
- the high HLB emulsifier is present in an amount in the range 0.01 % to 10% by weight, more preferably in the range 0.1 % to 5% by weight.
- low-medium HLB anionic emulsifiers examples include steareth-2, ceteareth-5, PEG-2 stearate and cetyl PEG/PPG/-19/1 dimethicone.
- low-medium HLB non-ionic emulsifiers include stearyl alcohol, sorbitan stearate, cetearyl alcohol, glyceryl stearate, polyglyceryl-3 oleate, sorbitan oleate and sorbitan palmitate.
- a low-medium HLB emulsifier may be present in the composition in an amount in the range 0.1% to 10% by weight, more preferably in the range 0.5% to 5% by weight.
- the emulsifiers used may be selected from one or more of sorbitan stearate, stearyl alcohol, sucrose cocoate, methyl glucose sesquistearate, cetyl phosphate, dicetylphosphate, ceteth-10 phosphate, cetearyl alcohol, glyceryl stearate, cetearyl glucoside, especially a combination of a high HLB anionic emulsifier with a low HLB non-ionic emulsifier.
- the emulsifiers are selected from methylglucose sesquistearate, stearyl alcohol, sucrose cocoate, sorbitan stearate, glyceryl stearate, cetearyl glucoside and acrylates/C 10-30 alkyl acrylate cross-polymer.
- the combinations of methylglucose sesquistearate/stearyl alcohol or sucrose cocoate/ sorbitan stearate are particularly preferred.
- compositions according to the invention including steareth-2, steareth-21 , steareth-10, ceteareth-5, ceteareth-12, ceteareth-20, oleth-10, polyglyceryl-3 oleate, polyglyceryl-3 methylglucose distearate, sodium cetearyl sulphate, sodium stearate, PEG-12 Oleate, PEG-2 stearate, PEG-12 stearate, sorbitan oleate, sorbitan palmitate and cetyl PEG/PPG-10/1 dimethicone.
- thickeners include hydrophilic polymers and derivatives thereof, eg agarose, carbomer, polyacrylamide, alkyl acrylate crosspolymer, carboxymethyl hydroxyethylcellulose, hydroxyethyl cellulose, xanthan gum, cellulose gum, and hydroxypropyl starch.
- hydrophilic polymers and derivatives thereof eg agarose, carbomer, polyacrylamide, alkyl acrylate crosspolymer, carboxymethyl hydroxyethylcellulose, hydroxyethyl cellulose, xanthan gum, cellulose gum, and hydroxypropyl starch.
- compositions in accordance with the invention may be formulated in any one of numerous different forms. Suitable types of composition, and methods by which they may be prepared, will generally be evident to those skilled in the art.
- compositions according to the invention are formulated as emulsions.
- the emulsions may be o/w, w/o, o/w/o or w/o/w emulsions.
- Preferred emulsion compositions are o/w emulsions.
- Such emulsion-type compositions may be described inter alia as creams or lotions.
- Other emulsion compositions are w/o emulsions.
- additional ingredients that contribute to improved skin-feel are preferably present.
- additional ingredients may include skin conditioning agents.
- Suitable skin conditioning agents include ingredients having emollient properties, ie ingredients which help to maintain the soft, smooth and pliable appearance of the skin, and which function by their ability to remain on the skin surface or in the stratum corneum to act as lubricants, to reduce flaking and to improve the skin's appearance.
- Suitable skin conditioning ingredients will be evident to those skilled in the art, but examples include PPG-15 stearyl ether, ethylhexyl stearate, cetyl dimethicone, octyldodecanol, PPG-20 methyl glucose ether, isopropyl myristate isopropyl palmitate, isopropyl laurate isodecyl laurate, isodecyl neopentanoate, isohexadecane, pentaerythrityl tetraisostearate, caprylic/capric triglyceride, canola oil, sunflower oil (Helianthus annuus), olive oil (Olea europea), cottonseed oil (Gossypium herbaceum), jojoba oil (Simmondsia chinensis), shea butter (Butyrospermum parkii), cocoa butter (Theobroma cacao), cupuacu butter (Theo
- composition will generally also comprise other ingredients or excipients which constitute or form part of a dermatologically acceptable carrier and will be well known to those skilled in the art. These include, for example:
- Chelating agents or sequestering agents (sequestrants) - ingredients that have the ability to complex with and inactivate metallic ions in order to prevent their adverse effects on the stability or appearance of the composition.
- chelating agents are ethylenediamine tetraacetic acid and its salts, notably the dipotassium and especially the disodium or tetrasodium salt.
- Preservatives - ingredients which prevent or retard microbial growth and thus protect the composition from spoilage.
- preservatives include DMDM hydantoin, propylparaben, methylparaben, phenoxyethanol, sodium benzoate, bronopol, sodium dehydroacetate, polyhexamethylenebiguanide hydrochloride, isothiazolone and diazolidinylurea.
- composition wherein the starch or starch derivative is a corn starch derivative and the polymeric quaternary ammonium salt is polyquaternium-51 , glycerin, sodium PCA, urea, trehalose and sodium hyaluronate.
- surfactants which are not emulsifiers.
- the compositions according to the invention are useful in that they enhance the moisturisation of the skin. Accordingly, in another aspect the invention provides methods for protecting the skin or for regulating the condition of the skin, which method comprises the topical application to the skin of a composition as herein described.
- the above methods protect the skin from the effects of sunlight and/or improve the appearance of the skin following exposure to sunlight.
- the skin to which the composition is applied will most commonly be human skin, the composition generally being applied by the user to his or her own skin.
- the composition will be applied to areas of skin that are normally exposed, eg the face and/or neck, the arms, hands or legs.
- a composition according to the invention is applied to the skin for example by rubbing or massaging into the skin, preferably before exposure to the sun for example 20-30 minutes before sun exposure.
- a moisturising system comprising starch or a derivative thereof and a polymeric quaternary compound salt having humectant properties in the preparation of a skincare composition in the form of an emulsion having an emulsifying system comprising an anionic or non-ionic emulsifier and a sunscreen component comprising at least one organic sunscreen selected from the group consisting of bis- ethylhexyloxyphenol methoxyphenyl triazine and methylene bis-benzotriazolyl tetramethylbutylphenol .
- the present invention also provides a process to prepare a composition as previously described comprising combining said sunscreen component (or at least one ingredient of the sunscreen component) with an oily phase and homogenously mixing with an aqueous phase.
- the moisturising component is incorporated in the aqueous phase, further preferably it is incorporated in the aqueous phase before combining with the oil phase.
- further ingredients may be incorporated into the oil phase/ aqueous phase before and/or after mixing at least one of thesunscreen components.
- One or more active ingredients may be added at different stages of the process. Either or both the oil and aqueous phases may be heated before being combined, for example to a temperature in the range 50-100 0 C.
- Methylene Bis-benzotriazolyl Tetramethylbutylphenol and Bis- Ethylhexyloxyphenol Methoxyphenyl Triazine are available from Ciba Speciality Chemicals, D-79630 Grenzach-Wyhlen, Germany, under the trade names Tinosorb M and Tinosorb S respectively; Ethylhexyl Methoxycinnamate and lsoamyl p- Methoxycinnamate are available from Symrise, D20354 Hamburg , Germany under the trade names Parsol MCX and Neo Heliopan E 1000, respectively; the Dimethylimidazolidinone Rice Starch is available from Agrana u.
- the sunscreens excepting Methylene Bis-benzotriazolyl Tetramethylbutylphenol, the emulsifiers (Methyl Glucose Sesquistearate and stearyl alcohol) and other oily ingredients were combined to form an oil phase.
- the moisturising system Dimethylimidazolidinone Rice Starch and Polyquaternium-51 ) was combined with the water and water-soluble ingredients to form an aqueous phase.
- the oil and water phases were independently heated to 70 -80 0 C and the oil phase admixed with the water phase.
- the two phases were homogenised and cooled with careful stirring.
- Ingredients sensitive on temperature including Methylene Bis- benzotriazolyl Tetramethylbutylphenol, were then added to the emulsion at room temperature and the pH adjusted.
- Example 2 The composition of Example 2 was prepared in a similar manner to that described in Example 1.
- Example 3 The composition of Example 3 was prepared in a similar manner to that described in Example 1.
- Decyl Glucoside 0.36 Acrylates/C 10-30 Alkyl Acrylate Crosspolymer 0.2
- Example 4 The composition of Example 4 was prepared in a similar manner to that described in Example 1.
- Example 5 The composition of Example 5 was prepared in a similar manner to that described in Example 1.
- the continuous moisturisation effect of Examples 1 and 2 was measured using a Standard Corneometer CM 825.
- the method by which moisturisation is measured is based on the dielectric constant of water. Due to the high dielectric constant of water, the dielectric characteristics of the stratum corneum are related to the water content. Assuming constant frequency, temperature and structure of the skin surface, an increase of capacitance correlates with an increase in skin hydration.
- the study was conducted double blind on 30 female volunteers with dry skin. The investigation sites were localised at the inner sides of both forearms. The skin hydration was measured immediately before product application (t zero), after 2 hours , 4 hours, 6 hours , 8 hours and 12 hours. The results below represent the skin hydration relative to t zero ( 1 ) and how it changes over time.
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Emergency Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Dispersion Chemistry (AREA)
- Cosmetics (AREA)
Abstract
Description
Claims
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB0611743A GB2439618A (en) | 2006-06-14 | 2006-06-14 | Skincare composition |
PCT/GB2007/050333 WO2007144670A1 (en) | 2006-06-14 | 2007-06-13 | Moisturising and sunscreen skincare composition |
Publications (1)
Publication Number | Publication Date |
---|---|
EP2040667A1 true EP2040667A1 (en) | 2009-04-01 |
Family
ID=36775606
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP20070733754 Withdrawn EP2040667A1 (en) | 2006-06-14 | 2007-06-13 | Moisturising and sunscreen skincare composition |
Country Status (3)
Country | Link |
---|---|
EP (1) | EP2040667A1 (en) |
GB (1) | GB2439618A (en) |
WO (1) | WO2007144670A1 (en) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2013114004A1 (en) | 2012-01-31 | 2013-08-08 | Pierre Fabre Dermo-Cosmetique | Composition and combination of photostabilising bmdbm sunscreens |
CA2880772C (en) * | 2012-08-06 | 2020-11-17 | Unilever Plc | A photostable sunscreen composition |
EP2853255B1 (en) * | 2013-09-27 | 2018-11-28 | HallStar Beauty and Personal Care Innovations Company | Method of formulating a personal care product with substantially no whitening effect when applied on wet skin and compositions thereof |
AU2015202610A1 (en) * | 2014-05-30 | 2015-12-17 | Johnson & Johnson Consumer Companies, Inc. | Deodorant antiperspirant compositions |
WO2017220254A1 (en) * | 2016-06-21 | 2017-12-28 | Unilever N.V. | Skin care composition |
CN108670905B (en) * | 2018-07-17 | 2021-02-05 | 唯美爱科技(中国)有限公司 | Liquid crystal type emulsion with sun-screening and after-sun repairing functions and preparation method thereof |
CN109512682B (en) * | 2018-12-29 | 2022-03-25 | 浙江大学华南工业技术研究院 | Multiple emulsion with function of protecting natural water-soluble pigment, preparation method and application thereof |
US20220151893A1 (en) * | 2019-02-27 | 2022-05-19 | Lg Household & Health Care Ltd. | Cosmetic composition for uv-protection that increases uv protection efficiency by means of uv light |
FR3102672B1 (en) * | 2019-11-05 | 2021-10-29 | Thorel Jean Noel | Water resistant solar composition with a high content of triazines |
CN111265459B (en) * | 2020-03-12 | 2022-07-15 | 广东袋鼠妈妈生物科技有限公司 | Sunscreen lotion for children and preparation method thereof |
CN112516022B (en) * | 2020-12-03 | 2022-08-12 | 深圳市琉璃光生物科技有限公司 | Sun-screening lotion and preparation method thereof |
CN112791004A (en) * | 2021-01-28 | 2021-05-14 | 上海好肌茵生物科技有限公司 | Coated sunscreen composition and sunscreen emulsion composed of same |
CN115487103B (en) * | 2021-11-02 | 2024-02-23 | 上海丽舒丹医药科技有限公司 | Plant-derived sun-screening synergistic agent composition and application thereof |
CN116035924B (en) * | 2023-03-07 | 2023-06-16 | 广州华淼生物科技研究院有限公司 | Oil-in-water emulsion suitable for spraying, preparation method thereof and spraying |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5013763A (en) * | 1987-11-30 | 1991-05-07 | The Andrew Jergens Company | Wash-off-resistant skin preparation |
GB9403451D0 (en) * | 1994-02-23 | 1994-04-13 | Ciba Geigy Ag | Sunscreen compositions |
DE19543730A1 (en) * | 1995-11-23 | 1997-05-28 | Ciba Geigy Ag | Until resorcinyl-triazines |
US20030215471A1 (en) * | 2001-01-31 | 2003-11-20 | Wilmott James M. | Surfactant free topical compositions and method for rapid preparation thereof |
DE10140536A1 (en) * | 2001-08-17 | 2003-02-27 | Beiersdorf Ag | Cosmetic and dermatological light protection formulations containing benzotriazoles and iminodisuccinic acid and / or their salts |
DE10226353A1 (en) * | 2002-06-13 | 2003-12-24 | Beiersdorf Ag | Cosmetic and dermatological light protection preparations containing a synergistic combination of UV absorbers, inorganic pigments and organic dyes |
DE10238649A1 (en) * | 2002-08-23 | 2004-03-11 | Beiersdorf Ag | Low-viscosity cosmetic or dermatological preparations of the oil-in-water type |
DE102004025357B4 (en) * | 2004-05-19 | 2007-03-29 | Beiersdorf Ag | Emulsion concentrate with water-soluble and oil-soluble polymers and cosmetic preparation containing emulsion concentrate and a process for its preparation and its use |
WO2006061661A1 (en) * | 2004-12-11 | 2006-06-15 | Reckitt & Coleman (Overseas) Limited | Skincare compositions |
-
2006
- 2006-06-14 GB GB0611743A patent/GB2439618A/en not_active Withdrawn
-
2007
- 2007-06-13 EP EP20070733754 patent/EP2040667A1/en not_active Withdrawn
- 2007-06-13 WO PCT/GB2007/050333 patent/WO2007144670A1/en active Application Filing
Non-Patent Citations (1)
Title |
---|
See references of WO2007144670A1 * |
Also Published As
Publication number | Publication date |
---|---|
GB0611743D0 (en) | 2006-07-26 |
GB2439618A (en) | 2008-01-02 |
WO2007144670A1 (en) | 2007-12-21 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
WO2007144670A1 (en) | Moisturising and sunscreen skincare composition | |
US7416719B2 (en) | Sunscreen compositions | |
JP2002501014A (en) | Cosmetic or dermatological preparations with low lipid flow | |
JP2003113020A (en) | Cosmetic and dermatological composition in form of water-oil emulsion containing amino-substituted hydroxybenzophenone | |
US6858200B2 (en) | Sunscreen formulations | |
JP2003095850A (en) | Cosmetic and dermatological preparation in form of o/w emulsion comprising amino-substituted hydroxybenzophenone | |
US20160067166A1 (en) | Cosmetic composition comprising a natural organic oil and polymethylmethacrylate particles | |
KR102490647B1 (en) | Cosmetic Composition for UV and Bule-light Protection | |
US11497942B2 (en) | Cosmetic or dermatological preparation comprising a combination of a dye and an anti-inflammatory active ingredient | |
DE10064818A1 (en) | Use of chroman derivatives in cosmetic or dermatological preparations | |
KR20200055589A (en) | UV protection cosmetic composition comprising waterborne polyurethane | |
KR102451738B1 (en) | Cosmetic composition for sunscreen comprising polysaccharide thickener and method for preparing same | |
JP2003526602A (en) | Cosmetic and dermatological preparations comprising an effective amount of bile acids, their salts and / or their derivatives | |
KR20120007075A (en) | Topical compositions comprising an alkoxylated diphenylacrylate compound and an aryl carboxylic ester | |
US20040197354A1 (en) | Use of electrolytes for reinforcing the barrier function of the skin | |
DE10128910A1 (en) | Combination of arginine and ascorbic acid is used in the production of cosmetic or dermatological compositions for tightening and/or strengthening the skin, especially in cellulite treatment | |
EP4061319A1 (en) | Sunscreen compositions with multiple photoprotecting uv filters | |
KR102122720B1 (en) | Cosmetic Composition for UV and Bule-light Protection | |
WO2006061661A1 (en) | Skincare compositions | |
US20210145722A1 (en) | Active substance combinations of n-(4-amino-2-methylquinolin-6-yl)-2-((4-ethylphenoxy)methyl)benzamide and one or more cosmetically or dermatologically acceptable fragrances | |
KR20220002298A (en) | Cosmetic composition in the form of oil-in-water emulsion | |
US20210186838A1 (en) | Active substance combinations of n-(4-amino-2-methylquinolin-6-yl)-2-((4-ethylphenoxy)methyl)benzamide and one or more cosmetically or dermatologically acceptable preservatives and/or preservative auxiliaries | |
DE10002725A1 (en) | Treatment and prevention of undesired skin pigmentation, e.g. to prevent tanning or to remove freckles, using an ectoin compound, especially ectoin or hydroxyectoin | |
CN111132650A (en) | Cosmetic or dermatological water-in-oil emulsions | |
EP1834631A1 (en) | Cosmetic or dermatological preparations containing glycyrrhetin and/or glycyrrhizin and glucose derivatives or glycerin ethers |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
17P | Request for examination filed |
Effective date: 20090114 |
|
AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC MT NL PL PT RO SE SI SK TR |
|
AX | Request for extension of the european patent |
Extension state: AL BA HR MK RS |
|
17Q | First examination report despatched |
Effective date: 20090922 |
|
R17C | First examination report despatched (corrected) |
Effective date: 20090928 |
|
DAX | Request for extension of the european patent (deleted) | ||
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
|
18D | Application deemed to be withdrawn |
Effective date: 20151201 |