EP2012796A4 - USE OF GLUCOCORTICOID TYPE II RECEPTOR ANTAGONISTS TO TREAT PATIENT DEPRESSION WITH IL-2 - Google Patents

USE OF GLUCOCORTICOID TYPE II RECEPTOR ANTAGONISTS TO TREAT PATIENT DEPRESSION WITH IL-2

Info

Publication number
EP2012796A4
EP2012796A4 EP07783115A EP07783115A EP2012796A4 EP 2012796 A4 EP2012796 A4 EP 2012796A4 EP 07783115 A EP07783115 A EP 07783115A EP 07783115 A EP07783115 A EP 07783115A EP 2012796 A4 EP2012796 A4 EP 2012796A4
Authority
EP
European Patent Office
Prior art keywords
antagonist
glucocorticoid receptor
patients taking
treat depression
depression
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP07783115A
Other languages
German (de)
English (en)
French (fr)
Other versions
EP2012796A2 (en
Inventor
Joseph K Belanoff
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Corcept Therapeutics Inc
Original Assignee
Corcept Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Corcept Therapeutics Inc filed Critical Corcept Therapeutics Inc
Publication of EP2012796A2 publication Critical patent/EP2012796A2/en
Publication of EP2012796A4 publication Critical patent/EP2012796A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pain & Pain Management (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
EP07783115A 2006-05-02 2007-05-02 USE OF GLUCOCORTICOID TYPE II RECEPTOR ANTAGONISTS TO TREAT PATIENT DEPRESSION WITH IL-2 Withdrawn EP2012796A4 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US79726506P 2006-05-02 2006-05-02
PCT/US2007/068044 WO2007131041A2 (en) 2006-05-02 2007-05-02 The use of a glucocorticoid receptor ii antagonist to treat depression in patients taking il-2

Publications (2)

Publication Number Publication Date
EP2012796A2 EP2012796A2 (en) 2009-01-14
EP2012796A4 true EP2012796A4 (en) 2010-08-11

Family

ID=38668513

Family Applications (1)

Application Number Title Priority Date Filing Date
EP07783115A Withdrawn EP2012796A4 (en) 2006-05-02 2007-05-02 USE OF GLUCOCORTICOID TYPE II RECEPTOR ANTAGONISTS TO TREAT PATIENT DEPRESSION WITH IL-2

Country Status (5)

Country Link
EP (1) EP2012796A4 (https=)
JP (1) JP2009535430A (https=)
AU (1) AU2007248059A1 (https=)
CA (1) CA2649894A1 (https=)
WO (1) WO2007131041A2 (https=)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HRP20110702T1 (hr) 2007-02-02 2011-10-31 Pfizer Products Inc. Triciklički spojevi i njihova uporaba kao modulatora glukokortikoidnih receptora
EP2114888B1 (en) * 2007-02-02 2010-11-10 Pfizer Products Inc. Tricyclic compounds and their use as glucocorticoid receptor modulators
ES2865334T3 (es) 2015-08-13 2021-10-15 Corcept Therapeutics Inc Método de diagnóstico diferencial de síndrome de Cushing dependiente de ACTH
EP4406611A3 (en) * 2016-01-11 2024-10-23 Dignity Health Modulators of zinc activated cation channel
CN115053861A (zh) * 2022-06-30 2022-09-16 南方医科大学南方医院 一种基于免疫激活的精神分裂症动物模型的构建方法和应用

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999017779A1 (en) * 1997-10-06 1999-04-15 The Board Of Trustees Of Leland Stanford Jr. University Methods for treating psychosis associated with glucocorticoid related dysfunction
WO2003043640A2 (en) * 2001-11-23 2003-05-30 Akzo Nobel N.V. Treatment of major depressive disorder using glucocorticoid receptor antagonists

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20050038580A (ko) * 2001-10-26 2005-04-27 악조 노벨 엔.브이. 주요 우울 장애의 치료에 사용되는(11β,17β)-11-(1,3-벤조디옥솔-5-일)-17-히드록시-17-(1-프로피닐)-에스트라-4,9-디엔-3-온의 용도
JP2006508951A (ja) * 2002-11-05 2006-03-16 コーセプト セラピューティクス， インコーポレイテッド 片頭痛を処置するための方法

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999017779A1 (en) * 1997-10-06 1999-04-15 The Board Of Trustees Of Leland Stanford Jr. University Methods for treating psychosis associated with glucocorticoid related dysfunction
WO2003043640A2 (en) * 2001-11-23 2003-05-30 Akzo Nobel N.V. Treatment of major depressive disorder using glucocorticoid receptor antagonists

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
BELANOFF JOSEPH K ET AL: "An open label trial of C-1073 (mifepristone) for psychotic major depression.", 1 September 2002, BIOLOGICAL PSYCHIATRY 1 SEP 2002 LNKD- PUBMED:12242054, VOL. 52, NR. 5, PAGE(S) 386 - 392, ISSN: 0006-3223, XP002588309 *
CAPURON L ET AL: "Early depressive symptoms in cancer patients receiving interleukin 2 and/or interferon alfa-2b therapy.", May 2000, JOURNAL OF CLINICAL ONCOLOGY : OFFICIAL JOURNAL OF THE AMERICAN SOCIETY OF CLINICAL ONCOLOGY MAY 2000 LNKD- PUBMED:10811680, VOL. 18, NR. 10, PAGE(S) 2143 - 2151, ISSN: 0732-183X, XP002588310 *
CAPURON LUCILE ET AL: "Baseline mood and psychosocial characteristics of patients developing depressive symptoms during interleukin-2 and/or interferon-alpha cancer therapy.", May 2004, BRAIN, BEHAVIOR, AND IMMUNITY MAY 2004 LNKD- PUBMED:15050647, VOL. 18, NR. 3, PAGE(S) 205 - 213, ISSN: 0889-1591, XP002588311 *
MAES M ET AL: "Lowered serum dipeptidyl peptidase IV activity is associated with depressive symptoms and cytokine production in cancer patients receiving interleukin-2-based immunotherapy.", February 2001, NEUROPSYCHOPHARMACOLOGY : OFFICIAL PUBLICATION OF THE AMERICAN COLLEGE OF NEUROPSYCHOPHARMACOLOGY FEB 2001 LNKD- PUBMED:11120395, VOL. 24, NR. 2, PAGE(S) 130 - 140, ISSN: 0893-133X, XP002588312 *

Also Published As

Publication number Publication date
WO2007131041A2 (en) 2007-11-15
JP2009535430A (ja) 2009-10-01
AU2007248059A1 (en) 2007-11-15
EP2012796A2 (en) 2009-01-14
CA2649894A1 (en) 2007-11-15
WO2007131041A3 (en) 2008-10-09

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