EP2012796A4 - The use of a glucocorticoid receptor ii antagonist to treat depression in patients taking il-2 - Google Patents

The use of a glucocorticoid receptor ii antagonist to treat depression in patients taking il-2

Info

Publication number
EP2012796A4
EP2012796A4 EP07783115A EP07783115A EP2012796A4 EP 2012796 A4 EP2012796 A4 EP 2012796A4 EP 07783115 A EP07783115 A EP 07783115A EP 07783115 A EP07783115 A EP 07783115A EP 2012796 A4 EP2012796 A4 EP 2012796A4
Authority
EP
European Patent Office
Prior art keywords
antagonist
glucocorticoid receptor
patients taking
treat depression
depression
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP07783115A
Other languages
German (de)
French (fr)
Other versions
EP2012796A2 (en
Inventor
Joseph K Belanoff
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Corcept Therapeutics Inc
Original Assignee
Corcept Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Corcept Therapeutics Inc filed Critical Corcept Therapeutics Inc
Publication of EP2012796A2 publication Critical patent/EP2012796A2/en
Publication of EP2012796A4 publication Critical patent/EP2012796A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pain & Pain Management (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
EP07783115A 2006-05-02 2007-05-02 The use of a glucocorticoid receptor ii antagonist to treat depression in patients taking il-2 Withdrawn EP2012796A4 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US79726506P 2006-05-02 2006-05-02
PCT/US2007/068044 WO2007131041A2 (en) 2006-05-02 2007-05-02 The use of a glucocorticoid receptor ii antagonist to treat depression in patients taking il-2

Publications (2)

Publication Number Publication Date
EP2012796A2 EP2012796A2 (en) 2009-01-14
EP2012796A4 true EP2012796A4 (en) 2010-08-11

Family

ID=38668513

Family Applications (1)

Application Number Title Priority Date Filing Date
EP07783115A Withdrawn EP2012796A4 (en) 2006-05-02 2007-05-02 The use of a glucocorticoid receptor ii antagonist to treat depression in patients taking il-2

Country Status (5)

Country Link
EP (1) EP2012796A4 (en)
JP (1) JP2009535430A (en)
AU (1) AU2007248059A1 (en)
CA (1) CA2649894A1 (en)
WO (1) WO2007131041A2 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008093236A1 (en) * 2007-02-02 2008-08-07 Pfizer Products Inc. Tricyclic compounds and their use as glucocorticoid receptor modulators
EA016494B1 (en) 2007-02-02 2012-05-30 Пфайзер Продактс Инк. (2R,4αS,10αR)-4α-BENZYL-7-((2-METHYLPIRIDIN-3-YL)CARBAMOYL)-2-(TRIFLUOROMETHYL)-1,2,3,4α,9,10,10α-OCTAHYDROPHENANTREN-2-YLDIHYDROPHOSPHATE OR A SALT THEREOF
JP6768789B2 (en) 2015-08-13 2020-10-14 コーセプト セラピューティクス， インコーポレイテッド Method for differential diagnosis of ACTH-dependent Cushing's syndrome
CA3042631A1 (en) * 2016-01-11 2017-07-20 Dignity Health Modulators of zinc activated cation channel
CN115053861A (en) * 2022-06-30 2022-09-16 南方医科大学南方医院 Construction method and application of animal model of schizophrenia based on immune activation

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999017779A1 (en) * 1997-10-06 1999-04-15 The Board Of Trustees Of Leland Stanford Jr. University Methods for treating psychosis associated with glucocorticoid related dysfunction
WO2003043640A2 (en) * 2001-11-23 2003-05-30 Akzo Nobel N.V. Treatment of major depressive disorder using glucocorticoid receptor antagonists

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4647909B2 (en) * 2001-10-26 2011-03-09 ナームローゼ・フエンノートチヤツプ・オルガノン (11β, 17β) -11- (1,3-benzodioxol-5-yl) -17-hydroxy-17- (1-propynyl) estradi-4,9-diene- in the treatment of major depressive disorder Use of 3-on
US8450379B2 (en) * 2002-11-05 2013-05-28 Corcept Therapeutics, Inc. Methods for treating migraine

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999017779A1 (en) * 1997-10-06 1999-04-15 The Board Of Trustees Of Leland Stanford Jr. University Methods for treating psychosis associated with glucocorticoid related dysfunction
WO2003043640A2 (en) * 2001-11-23 2003-05-30 Akzo Nobel N.V. Treatment of major depressive disorder using glucocorticoid receptor antagonists

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
BELANOFF JOSEPH K ET AL: "An open label trial of C-1073 (mifepristone) for psychotic major depression.", 1 September 2002, BIOLOGICAL PSYCHIATRY 1 SEP 2002 LNKD- PUBMED:12242054, VOL. 52, NR. 5, PAGE(S) 386 - 392, ISSN: 0006-3223, XP002588309 *
CAPURON L ET AL: "Early depressive symptoms in cancer patients receiving interleukin 2 and/or interferon alfa-2b therapy.", May 2000, JOURNAL OF CLINICAL ONCOLOGY : OFFICIAL JOURNAL OF THE AMERICAN SOCIETY OF CLINICAL ONCOLOGY MAY 2000 LNKD- PUBMED:10811680, VOL. 18, NR. 10, PAGE(S) 2143 - 2151, ISSN: 0732-183X, XP002588310 *
CAPURON LUCILE ET AL: "Baseline mood and psychosocial characteristics of patients developing depressive symptoms during interleukin-2 and/or interferon-alpha cancer therapy.", May 2004, BRAIN, BEHAVIOR, AND IMMUNITY MAY 2004 LNKD- PUBMED:15050647, VOL. 18, NR. 3, PAGE(S) 205 - 213, ISSN: 0889-1591, XP002588311 *
MAES M ET AL: "Lowered serum dipeptidyl peptidase IV activity is associated with depressive symptoms and cytokine production in cancer patients receiving interleukin-2-based immunotherapy.", February 2001, NEUROPSYCHOPHARMACOLOGY : OFFICIAL PUBLICATION OF THE AMERICAN COLLEGE OF NEUROPSYCHOPHARMACOLOGY FEB 2001 LNKD- PUBMED:11120395, VOL. 24, NR. 2, PAGE(S) 130 - 140, ISSN: 0893-133X, XP002588312 *

Also Published As

Publication number Publication date
EP2012796A2 (en) 2009-01-14
AU2007248059A1 (en) 2007-11-15
WO2007131041A2 (en) 2007-11-15
CA2649894A1 (en) 2007-11-15
WO2007131041A3 (en) 2008-10-09
JP2009535430A (en) 2009-10-01

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