EP1968559A2 - Entzündungshemmende botanische produkte zur behandlung des metabolischen syndroms und diabetes - Google Patents

Entzündungshemmende botanische produkte zur behandlung des metabolischen syndroms und diabetes

Info

Publication number
EP1968559A2
EP1968559A2 EP06844984A EP06844984A EP1968559A2 EP 1968559 A2 EP1968559 A2 EP 1968559A2 EP 06844984 A EP06844984 A EP 06844984A EP 06844984 A EP06844984 A EP 06844984A EP 1968559 A2 EP1968559 A2 EP 1968559A2
Authority
EP
European Patent Office
Prior art keywords
acacia
insulin
acids
hops
derived
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP06844984A
Other languages
English (en)
French (fr)
Other versions
EP1968559A4 (de
Inventor
Matthew L. Tripp
John G. Babish
Jeff Bland
Amy Jennae Hall
Veera Konda
Linda Pacioretty
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
MetaProteomics LLC
Original Assignee
MetaProteomics LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by MetaProteomics LLC filed Critical MetaProteomics LLC
Priority to EP14000382.3A priority Critical patent/EP2737897A3/de
Publication of EP1968559A2 publication Critical patent/EP1968559A2/de
Publication of EP1968559A4 publication Critical patent/EP1968559A4/de
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/282—Artemisia, e.g. wormwood or sagebrush
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/01—Hydrocarbons
    • A61K31/015—Hydrocarbons carbocyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/235—Foeniculum (fennel)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/31—Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/80—Scrophulariaceae (Figwort family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Microbiology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Biotechnology (AREA)
  • Botany (AREA)
  • Medical Informatics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Mycology (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Plant Substances (AREA)
EP06844984.2A 2005-12-09 2006-12-07 Entzündungshemmende botanische produkte zur behandlung des metabolischen syndroms und diabetes Withdrawn EP1968559A4 (de)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP14000382.3A EP2737897A3 (de) 2005-12-09 2006-12-07 Botanische entzündungshemmende Produkte zur Behandlung des metabolischen Syndroms und von Diabetes

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US74890705P 2005-12-09 2005-12-09
PCT/US2006/046770 WO2007070355A2 (en) 2005-12-09 2006-12-07 Anti-inflammatory botanical products for the treatment of metabolic syndrome and diabetes

Related Child Applications (1)

Application Number Title Priority Date Filing Date
EP14000382.3A Division EP2737897A3 (de) 2005-12-09 2006-12-07 Botanische entzündungshemmende Produkte zur Behandlung des metabolischen Syndroms und von Diabetes

Publications (2)

Publication Number Publication Date
EP1968559A2 true EP1968559A2 (de) 2008-09-17
EP1968559A4 EP1968559A4 (de) 2013-08-07

Family

ID=38163414

Family Applications (2)

Application Number Title Priority Date Filing Date
EP06844984.2A Withdrawn EP1968559A4 (de) 2005-12-09 2006-12-07 Entzündungshemmende botanische produkte zur behandlung des metabolischen syndroms und diabetes
EP14000382.3A Withdrawn EP2737897A3 (de) 2005-12-09 2006-12-07 Botanische entzündungshemmende Produkte zur Behandlung des metabolischen Syndroms und von Diabetes

Family Applications After (1)

Application Number Title Priority Date Filing Date
EP14000382.3A Withdrawn EP2737897A3 (de) 2005-12-09 2006-12-07 Botanische entzündungshemmende Produkte zur Behandlung des metabolischen Syndroms und von Diabetes

Country Status (5)

Country Link
EP (2) EP1968559A4 (de)
JP (1) JP2009518429A (de)
AU (1) AU2006326658A1 (de)
CA (1) CA2632607A1 (de)
WO (1) WO2007070355A2 (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008115163A (ja) * 2006-10-10 2008-05-22 Kikkoman Corp アディポネクチン産生増強・促進剤
AU2009248057B2 (en) * 2008-05-13 2013-02-21 Genmedica Therapeutics Sl Salicylate conjugates useful for treating metabolic disorders
TWI492755B (zh) * 2009-12-30 2015-07-21 Metal Ind Res & Dev Ct 抗糖尿病及抗新陳代謝疾病之香椿超臨界萃取物、製備方法及用途
AU2011320140C1 (en) 2010-10-30 2019-12-12 Kindex Pharmaceuticals, Inc. Cis 3,4-dihydroxy-2-(3-methylbutanoyl)-5-(-3-methylbutyl)-4-(4-methylpentanoyl)cyclopent-2-en-1-one derivatives, substantially enantiomerically pure compositions and methods
CN102821771B (zh) * 2010-12-28 2015-01-14 高雄医学大学 抗糖尿病及抗新陈代谢疾病的香椿超临界萃取物、制备方法及用途
SG11202100264YA (en) 2018-08-10 2021-02-25 Suntory Holdings Ltd Composition and method for suppressing increase in blood glucose level
US20230040395A1 (en) * 2019-12-20 2023-02-09 Daicel Corporation Composition for suppressing obesity

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002003996A1 (en) * 2000-07-12 2002-01-17 RAJKUMAR, Sujatha Use of dammarane-type tritepenoid saporins
US6451355B1 (en) * 2000-07-17 2002-09-17 Howard M. Reisner Composition to treat diabetes
US6511683B1 (en) * 1999-09-30 2003-01-28 Factors R & D Technologies Ltd. Enchinacea supplement and method of manufacture
US20050074447A1 (en) * 2003-10-01 2005-04-07 Papas Andreas M. Treatment for diabetic microvascular and macrovascular complications

Family Cites Families (17)

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Publication number Priority date Publication date Assignee Title
JP4497566B2 (ja) * 1998-09-02 2010-07-07 株式会社 日本薬用食品研究所 アルドース還元酵素阻害剤並びに新規サポニン及び新規サポゲノール
US6586438B2 (en) * 1999-11-03 2003-07-01 Bristol-Myers Squibb Co. Antidiabetic formulation and method
US7205151B2 (en) * 2001-06-20 2007-04-17 Metaproteomics, Llc Complex mixtures exhibiting selective inhibition of cyclooxygenase-2
US20040115290A1 (en) * 2001-06-20 2004-06-17 Tripp Matthew L. Modulation of inflammation by hops fractions and derivatives
US7279185B2 (en) * 2001-10-26 2007-10-09 Metaproteonics, Llc Curcuminoid compositions exhibiting synergistic inhibition of the expression and/or activity of cyclooxygenase-2
WO2003057232A1 (en) * 2002-01-10 2003-07-17 Biosynergen, Inc. A pharmaceutical composition and functional foods for prevention and treatment of diabetes millitus
KR100993113B1 (ko) * 2002-02-14 2010-11-08 기린 홀딩스 가부시키가이샤 지질대사 개선용 조성물 및 식품
WO2004037180A2 (en) * 2002-10-21 2004-05-06 Metaproteomics, Llc Compositions that treat or inhibit pathological conditions associated with inflammatory response
JPWO2004045632A1 (ja) * 2002-11-12 2006-03-16 株式会社カネカ ペルオキシソーム増殖剤応答性受容体リガンド剤
EP1596877A4 (de) * 2003-02-26 2007-07-25 Unigen Pharmaceuticals Inc Formulierung zur verwendung bei der prävention und behandlung von durch kohlenhydrate verursachten erkrankungen und zuständen
CN1805738A (zh) * 2003-06-16 2006-07-19 兰贝克赛实验室有限公司 持续释放的二甲双胍片剂
JP4472282B2 (ja) * 2003-07-30 2010-06-02 金印株式会社 高血糖に起因する腎炎または神経障害抑制剤
EP1510208A1 (de) * 2003-08-22 2005-03-02 Fournier Laboratories Ireland Limited Metformin-Statin-Kombination enthaltende pharmazeutische Zusammensetzungen
CN1272048C (zh) * 2003-10-21 2006-08-30 陈钟 一种治疗糖尿病的胶囊
US20050192356A1 (en) * 2004-02-27 2005-09-01 Babish John G. Synergistic anti-inflammatory pharmaceutical compositions and methods of use
KR100772980B1 (ko) * 2004-04-01 2007-11-02 한미약품 주식회사 메트포르민의 경구투여용 서방성 제제
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Publication number Priority date Publication date Assignee Title
US6511683B1 (en) * 1999-09-30 2003-01-28 Factors R & D Technologies Ltd. Enchinacea supplement and method of manufacture
WO2002003996A1 (en) * 2000-07-12 2002-01-17 RAJKUMAR, Sujatha Use of dammarane-type tritepenoid saporins
US6451355B1 (en) * 2000-07-17 2002-09-17 Howard M. Reisner Composition to treat diabetes
US20050074447A1 (en) * 2003-10-01 2005-04-07 Papas Andreas M. Treatment for diabetic microvascular and macrovascular complications

Non-Patent Citations (10)

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Title
AGGARWAL BHARAT B ET AL: "Suppression of the nuclear factor-kappa B activation pathway by spice-derived phytochemicals - Reasoning for seasoning", ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, WILEY-BLACKWELL PUBLISHING, INC, US, vol. 1030, 1 December 2004 (2004-12-01), pages 434-441, XP009097664, ISSN: 0077-8923, DOI: 10.1196/ANNALS.1329.054 *
ARORA DEEPA ET AL: "Immunomodulating effects of rasayana drugs in diabetics - a clinical study.", ANCIENT SCIENCE OF LIFE OCT 2002, vol. 22, no. 2, October 2002 (2002-10), pages 42-48, XP18015455, ISSN: 0257-7941 *
DATABASE WPI Week 200519 Thomson Scientific, London, GB; AN 2005-176026 XP002699141, & JP 2005 047822 A (KIN SIRUSI MASABI KK) 24 February 2005 (2005-02-24) *
DATABASE WPI Week 200560 Thomson Scientific, London, GB; AN 2005-583447 XP002699140, & CN 1 608 644 A (CHEN Z) 27 April 2005 (2005-04-27) *
HOU C C ET AL: "Bacopaside III, bacopasaponin G, and bacopasides A, B, and C from Bacopa monniera", MEDICINAL & AROMATIC PLANTS ABSTRACTS, SCIENTIFIC PUBLISHERS, SCIENTIFIC PUBLISHERS, NEW DELHI - INDIA, vol. 25, no. 4, 1 August 2003 (2003-08-01) , XP018007587, ISSN: 0250-4367 *
OOMAH B DAVE ET AL: "Characteristics of raspberry (Rubus idaeus L.) seed oil", FOOD CHEMISTRY, vol. 69, no. 2, March 2000 (2000-03), pages 187-193, XP002699143, ISSN: 0308-8146 *
RANA T S ET AL: "Studies on indigenous herbal remedies for diabetes mellitus in India", BIOSIS,, 15 September 1990 (1990-09-15), XP002572903, *
See also references of WO2007070355A2 *
SUBRAMONIAM A ET AL: "EFFECTS OF ARTEMISIA PALLENS WALL. ON BLOOD GLUCOSE LEVELS IN NORMAL AND ALLOXAN-INDUCED DIABETIC RATS", JOURNAL OF ETHNOPHARMACOLOGY, ELSEVIER SCIENTIFIC PUBLISHERS LTD, IE, vol. 50, no. 1, 1 January 1996 (1996-01-01), pages 13-17, XP002038211, ISSN: 0378-8741, DOI: 10.1016/0378-8741(95)01329-6 *
WANG X-S ET AL: "Study on hypoglycemic polysaccharide from Centalla asiatica", CHINESE PHARMACEUTICAL JOURNAL NOVEMBER 2005 CHINESE MEDICAL ASSOCIATION CN, vol. 40, no. 22, November 2005 (2005-11), pages 1697-1700, XP009170472, *

Also Published As

Publication number Publication date
WO2007070355A3 (en) 2008-07-03
AU2006326658A1 (en) 2007-06-21
EP2737897A3 (de) 2014-10-01
EP1968559A4 (de) 2013-08-07
CA2632607A1 (en) 2007-06-21
EP2737897A2 (de) 2014-06-04
JP2009518429A (ja) 2009-05-07
WO2007070355A2 (en) 2007-06-21

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Ipc: A61K 36/73 20060101ALI20130627BHEP

Ipc: A61K 36/235 20060101ALI20130627BHEP

Ipc: A61K 36/80 20060101ALI20130627BHEP

Ipc: A61K 36/31 20060101ALI20130627BHEP

Ipc: A61K 36/23 20060101ALI20130627BHEP

Ipc: A61P 5/48 20060101ALI20130627BHEP

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