EP1929305A2 - Reactifs pour la detection de la phosphorylation des proteines dans des processus de signalisation de la leucemie - Google Patents

Reactifs pour la detection de la phosphorylation des proteines dans des processus de signalisation de la leucemie

Info

Publication number
EP1929305A2
EP1929305A2 EP06802749A EP06802749A EP1929305A2 EP 1929305 A2 EP1929305 A2 EP 1929305A2 EP 06802749 A EP06802749 A EP 06802749A EP 06802749 A EP06802749 A EP 06802749A EP 1929305 A2 EP1929305 A2 EP 1929305A2
Authority
EP
European Patent Office
Prior art keywords
rows
corresponding column
protein
phosphorylated
column
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP06802749A
Other languages
German (de)
English (en)
Inventor
Roberto Polakiewicz
Valerie Goss
Kimberly Lee
Ting-Lei Gu
Albrecht Moritz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cell Signaling Technology Inc
Original Assignee
Cell Signaling Technology Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cell Signaling Technology Inc filed Critical Cell Signaling Technology Inc
Publication of EP1929305A2 publication Critical patent/EP1929305A2/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407—Specifically defined cancers
    • G01N33/57426—Specifically defined cancers leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/008—Peptides; Proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3061—Blood cells
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/44—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material not provided for elsewhere, e.g. haptens, metals, DNA, RNA, amino acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6842—Proteomic analysis of subsets of protein mixtures with reduced complexity, e.g. membrane proteins, phosphoproteins, organelle proteins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/91—Transferases (2.)
    • G01N2333/912—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • G01N2333/91205—Phosphotransferases in general
    • G01N2333/9121—Phosphotransferases in general with an alcohol group as acceptor (2.7.1), e.g. general tyrosine, serine or threonine kinases

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Physics & Mathematics (AREA)
  • Urology & Nephrology (AREA)
  • Medicinal Chemistry (AREA)
  • Cell Biology (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Hospice & Palliative Care (AREA)
  • Oncology (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

L'invention porte sur environ 480 nouveaux sites de phosphorylation identifiés dans des protéines et des processus de transduction du signal impliqués dans la leucémie chez l'homme, cette invention portant également sur des anticorps spécifiques d'un site de phosphorylation et sur des peptides marqués par un isotope lourd (peptides AQUA) utiles dans la détection et la quantification sélectives de ces sites/protéines phosphorylés, ainsi que sur des méthodes d'utilisation de ces réactifs. Parmi les sites de phosphorylation identifiés, il existe des sites apparaissant dans les types de protéines suivants : protéines adaptatrices/support, acétyltransférases, protéines se liant à l'actine, protéines d'adhésion, protéines de l'apoptose, protéines se liant au calcium, protéines de régulation du cycle cellulaire, protéines de surface cellulaires, protéines de canal, protéines chaperones, protéines contractiles, protéines des cytokines, protéines cytosquelettiques, régulateurs des protéines G et protéines d'activation de GTPase, facteurs d'échange nucléotidiques de la guanine, protéines de l'hélicase, protéines de la superfamille des immunoglobulines, protéines inhibitrices, protéines kinases, kinases lipidiques, ligases, protéines de liaison aux lipides, méthyltransférases, protéines moteurs, oxydoréductases, phosphotases, phosphodiestérases, phospholipases, protéases, protéines réceptrices, facteurs de transcription, transférases, protéines de translation/transporteurs, et protéines du système de conjugaison à l'ubiquitine.
EP06802749A 2005-08-31 2006-08-30 Reactifs pour la detection de la phosphorylation des proteines dans des processus de signalisation de la leucemie Withdrawn EP1929305A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US71277605P 2005-08-31 2005-08-31
PCT/US2006/034126 WO2007027957A2 (fr) 2005-08-31 2006-08-30 Reactifs pour la detection de la phosphorylation des proteines dans des processus de signalisation de la leucemie

Publications (1)

Publication Number Publication Date
EP1929305A2 true EP1929305A2 (fr) 2008-06-11

Family

ID=37809538

Family Applications (1)

Application Number Title Priority Date Filing Date
EP06802749A Withdrawn EP1929305A2 (fr) 2005-08-31 2006-08-30 Reactifs pour la detection de la phosphorylation des proteines dans des processus de signalisation de la leucemie

Country Status (2)

Country Link
EP (1) EP1929305A2 (fr)
WO (1) WO2007027957A2 (fr)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE60230482D1 (de) 2001-01-17 2009-02-05 Intreat Pty Ltd Antikörper gegen nichtfunktionelle p 2 x 7 rezeptoren, diagnose und behandlung von krebs und anderen leiden
CN101802182A (zh) 2007-08-21 2010-08-11 诺达利蒂公司 用于诊断、预后和治疗方法的方法
AU2008299593B2 (en) 2007-09-14 2013-04-18 Biosceptre International Limited Novel P2X7 epitopes
JP5624885B2 (ja) 2007-09-14 2014-11-12 バイオセプター・インターナショナル・リミテッド 細胞外体液中のプリン作動性（ｐ２ｘ）受容体
EP2304439A4 (fr) 2008-05-29 2012-07-04 Nuclea Biotechnologies Llc Anticorps anti-phospho-akt
WO2010000041A1 (fr) 2008-07-04 2010-01-07 Biosceptre International Limiited Peptides et épitopes anti-p2x<sb>7</sb>
US8399206B2 (en) 2008-07-10 2013-03-19 Nodality, Inc. Methods for diagnosis, prognosis and methods of treatment
WO2010006291A1 (fr) 2008-07-10 2010-01-14 Nodality, Inc. Procédés de diagnostic, pronostic et traitement
CN104725512A (zh) * 2009-04-27 2015-06-24 诺华股份有限公司 增加肌肉生长的组合物和方法
ES2704711T3 (es) 2009-08-20 2019-03-19 Biosceptre Aust Pty Ltd Anticuerpos anti-receptor P2X7 y fragmentos de los mismos
ES2667003T3 (es) 2009-12-24 2018-05-09 Biosceptre (Aust) Pty Ltd Anticuerpos para receptores P2X7 oligoméricos no funcionales
US9562094B2 (en) 2010-09-10 2017-02-07 Biosceptre (Aust) Pty Ltd Companion animal treatments
JP6305920B2 (ja) 2011-07-01 2018-04-04 バイオセプター・（オーストラリア）・ピーティーワイ・リミテッド 併用療法
KR101478826B1 (ko) * 2011-10-28 2015-01-08 전남대학교산학협력단 신규한 대장암 진단용 마커 및 이를 이용한 대장암 진단 키트
PT2878306T (pt) * 2012-07-13 2019-02-06 Proteimax Biotecnologia Ltda Péptido modificado, ligando do recetor cb, kit, processo in vitro para avaliação das ligações do recetor cb, utilizações, composição farmacêutica para modular a atividade do recetor cb
KR20230152153A (ko) 2016-03-10 2023-11-02 악셀레론 파마 인코포레이티드 액티빈 타입 2 수용체 결합 단백질 및 이의 용도

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7300753B2 (en) * 1998-09-04 2007-11-27 John Rush Immunoaffinity isolation of modified peptides from complex mixtures
US20030190689A1 (en) * 2002-04-05 2003-10-09 Cell Signaling Technology,Inc. Molecular profiling of disease and therapeutic response using phospho-specific antibodies
US7052916B2 (en) * 2002-05-24 2006-05-30 Immunex Corporation Polypeptide analyses using stable isotope labeling

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See references of WO2007027957A3 *

Also Published As

Publication number Publication date
WO2007027957A3 (fr) 2009-01-29
WO2007027957A9 (fr) 2007-05-31
WO2007027957A2 (fr) 2007-03-08

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Inventor name: MORITZ, ALBRECHT

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Inventor name: GOSS, VALERIE

Inventor name: POLAKIEWICZ, ROBERTO

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