EP1926709A4 - Verfahren zur herstellung einer chiralen 3-hydroxypyrrolidinverbindung und derivaten davon mit hoher optischer reinheit - Google Patents

Verfahren zur herstellung einer chiralen 3-hydroxypyrrolidinverbindung und derivaten davon mit hoher optischer reinheit

Info

Publication number
EP1926709A4
EP1926709A4 EP06783728A EP06783728A EP1926709A4 EP 1926709 A4 EP1926709 A4 EP 1926709A4 EP 06783728 A EP06783728 A EP 06783728A EP 06783728 A EP06783728 A EP 06783728A EP 1926709 A4 EP1926709 A4 EP 1926709A4
Authority
EP
European Patent Office
Prior art keywords
chiral
derivatives
preparation
optical purity
high optical
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP06783728A
Other languages
English (en)
French (fr)
Other versions
EP1926709A1 (de
Inventor
Chung-Woo Lim
Chang Jin Boo
Ki Hyun Kim
Seong-Jin Kim
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
RSTECH Corp
Original Assignee
RSTECH CORP
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by RSTECH CORP filed Critical RSTECH CORP
Priority claimed from KR1020060080184A external-priority patent/KR100743617B1/ko
Publication of EP1926709A1 publication Critical patent/EP1926709A1/de
Publication of EP1926709A4 publication Critical patent/EP1926709A4/de
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/12—Oxygen or sulfur atoms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pyrrole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
EP06783728A 2005-08-25 2006-08-24 Verfahren zur herstellung einer chiralen 3-hydroxypyrrolidinverbindung und derivaten davon mit hoher optischer reinheit Withdrawn EP1926709A4 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
KR20050078199 2005-08-25
KR1020060080184A KR100743617B1 (ko) 2005-08-25 2006-08-24 고광학순도를 갖는 키랄 3-히드록시 피롤리딘 및 그유도체를 제조하는 방법
PCT/KR2006/003341 WO2007024113A1 (en) 2005-08-25 2006-08-24 Process for the preparation of chiral 3-hydroxy pyrrolidine compound and derivatives thereof having high optical purity

Publications (2)

Publication Number Publication Date
EP1926709A1 EP1926709A1 (de) 2008-06-04
EP1926709A4 true EP1926709A4 (de) 2009-06-24

Family

ID=37771815

Family Applications (1)

Application Number Title Priority Date Filing Date
EP06783728A Withdrawn EP1926709A4 (de) 2005-08-25 2006-08-24 Verfahren zur herstellung einer chiralen 3-hydroxypyrrolidinverbindung und derivaten davon mit hoher optischer reinheit

Country Status (2)

Country Link
EP (1) EP1926709A4 (de)
WO (1) WO2007024113A1 (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2361244B1 (de) 2008-11-24 2013-07-10 Council of Scientific & Industrial Research Verfahren zur herstellung optisch aktiver n-benzyl-3-hydroxypyrrolidine
CN111518015A (zh) * 2020-05-20 2020-08-11 上海合全药物研发有限公司 一种叔丁基-8-氧亚基-2-氮杂螺[4.5]癸烷-2-甲酸基酯的制备方法
CN111763228A (zh) * 2020-08-03 2020-10-13 连云港宏业化工有限公司 （3s）-4-氯-3-[（三甲基甲硅烷基）氧基]丁腈合成方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0269258A2 (de) * 1986-10-27 1988-06-01 A.H. Robins Company, Incorporated Verfahren zur Herstellung einer Pyrrolidinolverbindung

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3823187A (en) 1972-06-19 1974-07-09 Bristol Myers Co Production of l(-)-gamma-amino-alpha-hydroxybutyric acid
JPS6163652A (ja) 1984-09-04 1986-04-01 Yamanouchi Pharmaceut Co Ltd （ｓ）−（−）−１−ベンジル−３−ヒドロキシピロリジンの製造法
JP2703768B2 (ja) 1987-11-28 1998-01-26 鐘淵化学工業株式会社 光学活性３−ヒドロキシピロリジン誘導体の製造法
IE62338B1 (en) 1988-06-22 1995-01-25 Kanegafuchi Chemical Ind Process for preparing 3-pyrrolidinol
US5233053A (en) 1989-03-17 1993-08-03 Pfizer Inc. Pyrrolidine derivatives
JP2735326B2 (ja) 1989-12-02 1998-04-02 鐘淵化学工業株式会社 ３‐ピロリジノールの製造法
GB8928042D0 (en) 1989-12-12 1990-02-14 Pfizer Ltd Muscarinic receptor antagonists
JPH0776209B2 (ja) 1990-04-11 1995-08-16 高砂香料工業株式会社 光学活性３―ヒドロキシピロリジン誘導体の製造方法
JPH04131093A (ja) 1990-09-19 1992-05-01 Denki Kagaku Kogyo Kk 混合物の製造法
US5237088A (en) 1992-03-25 1993-08-17 E. I. Du Pont De Nemours And Company Transfer hydrogenation of nitriles using amine donors
JP3159800B2 (ja) 1992-08-28 2001-04-23 ダイセル化学工業株式会社 光学異性体の分離法
JPH06141876A (ja) 1992-11-10 1994-05-24 Kyowa Hakko Kogyo Co Ltd 光学活性なｎ−ベンジル−３−ピロリジノールの製造法
JPH06211782A (ja) 1993-01-19 1994-08-02 Denki Kagaku Kogyo Kk アルコールとその誘導体の分離法
BE1007297A3 (nl) 1993-07-19 1995-05-09 Dsm Nv Werkwijze voor de bereiding van optisch aktieve alcoholen en esters, en alcoholen en esters toegepast en bereid in dergelijke werkwijzen.
JP3346852B2 (ja) 1993-10-26 2002-11-18 松下電工株式会社 脈拍検出装置
CN1082389C (zh) 1993-12-28 2002-04-10 罗纳布朗克化学公司 用于将腈催化加氢为胺的催化剂及其制备方法和用途
EP1002871A1 (de) * 1998-11-17 2000-05-24 Eidgenössische Technische Hochschule (ETH) Zürich Verfahren zur Herstellung von optisch aktiven 3-hydroxy-pyrrolidinderivaten durch enzymatische Hydroxylierung
KR100461569B1 (ko) * 2002-05-20 2004-12-14 삼성정밀화학 주식회사 광학적으로 순수한 3-히드록시-피롤리딘의 제조방법
KR100523321B1 (ko) * 2002-12-27 2005-10-24 한국화학연구원 4-히드록시-2-피롤리디논의 제조방법
KR100572687B1 (ko) * 2004-05-25 2006-04-24 주식회사 알에스텍 광학적으로 순수한 4-하이드록시-2-옥소-1-피롤리딘아세트아미드의 제조방법

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0269258A2 (de) * 1986-10-27 1988-06-01 A.H. Robins Company, Incorporated Verfahren zur Herstellung einer Pyrrolidinolverbindung

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
HARRIS B D ET AL: "SYNTHESIS OF 3S-PYRROLIDINOL FROM L-GLUTAMIC ACID", SYNTHETIC COMMUNICATIONS, TAYLOR & FRANCIS GROUP, PHILADELPHIA, PA, vol. 16, no. 14, 1 January 1986 (1986-01-01), pages 1815 - 1822, XP008075594, ISSN: 0039-7911 *
MURAHASHI S-I ET AL: "Synthesis of (R)- and (S)-3-(tert-butyldimethylsilyloxy)-1-pyrroline N-oxides -- chiral nitrones for synthesis of biologically active pyrrolidine derivative, Geissman-Waiss lactone", TETRAHEDRON LETTERS, ELSEVIER, AMSTERDAM, vol. 39, no. 18, 30 April 1998 (1998-04-30), pages 2765 - 2766, XP004113343, ISSN: 0040-4039 *
PELLEGATA R ET AL: "AN IMPROVED SYNTHESIS OF GAMMA-, DELTA-, AND EPSILON-LACTAMS", SYNTHESIS, GEORG THIEME VERLAG, STUTTGART, DE, 1 August 1978 (1978-08-01), pages 614 - 616, XP000673066, ISSN: 0039-7881 *
See also references of WO2007024113A1 *

Also Published As

Publication number Publication date
WO2007024113A1 (en) 2007-03-01
EP1926709A1 (de) 2008-06-04

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