EP1904827A2 - Structure de biodetection a cristal photonique et son procede de fabrication - Google Patents

Structure de biodetection a cristal photonique et son procede de fabrication

Info

Publication number
EP1904827A2
EP1904827A2 EP06785860A EP06785860A EP1904827A2 EP 1904827 A2 EP1904827 A2 EP 1904827A2 EP 06785860 A EP06785860 A EP 06785860A EP 06785860 A EP06785860 A EP 06785860A EP 1904827 A2 EP1904827 A2 EP 1904827A2
Authority
EP
European Patent Office
Prior art keywords
sensor
refractive index
porous
nanoporous
specific binding
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP06785860A
Other languages
German (de)
English (en)
Inventor
Brian T. Cunningham
Ian Block
Leo Li-Ying Chan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Illinois
Original Assignee
University of Illinois
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US11/177,708 external-priority patent/US7479404B2/en
Priority claimed from US11/177,707 external-priority patent/US7521769B2/en
Application filed by University of Illinois filed Critical University of Illinois
Publication of EP1904827A2 publication Critical patent/EP1904827A2/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
    • G01N21/7703—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator using reagent-clad optical fibres or optical waveguides
    • G01N21/774—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator using reagent-clad optical fibres or optical waveguides the reagent being on a grating or periodic structure
    • G01N21/7743—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator using reagent-clad optical fibres or optical waveguides the reagent being on a grating or periodic structure the reagent-coated grating coupling light in or out of the waveguide
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y20/00—Nanooptics, e.g. quantum optics or photonic crystals
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/20—Material Coatings
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/30—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration
    • C12M41/36—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration of biomass, e.g. colony counters or by turbidity measurements
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B6/00—Light guides; Structural details of arrangements comprising light guides and other optical elements, e.g. couplings
    • G02B6/10—Light guides; Structural details of arrangements comprising light guides and other optical elements, e.g. couplings of the optical waveguide type
    • G02B6/12—Light guides; Structural details of arrangements comprising light guides and other optical elements, e.g. couplings of the optical waveguide type of the integrated circuit kind
    • G02B6/122—Basic optical elements, e.g. light-guiding paths
    • G02B6/1225—Basic optical elements, e.g. light-guiding paths comprising photonic band-gap structures or photonic lattices
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
    • G01N2021/7769—Measurement method of reaction-produced change in sensor
    • G01N2021/7776—Index

Definitions

  • a grating of a photonic crystal sensor of the invention has a grating period that is small compared to the wavelength of incident light such that no diffractive orders other than the reflected and transmitted zeroth orders are allowed.
  • a photonic crystal sensor can comprise a grating, which is comprised of or coated with a high dielectric constant dielectric material, sandwiched between a substrate layer and a cover layer that fills the grating grooves. Optionally, a cover layer is not used.
  • the grating structure selectively couples light at a narrow band of wavelengths. This highly sensitive coupling condition can produce a resonant grating effect on the reflected radiation spectrum, resulting in a narrow band of reflected or transmitted wavelengths. The depth and period of the grating are less than the wavelength of the resonant grating effect.
  • the reflected or transmitted color of a photonic crystal sensor structure can be modified by the addition of molecules such as specific binding substances or binding partners or both to the upper surface of the cover layer or the grating surface.
  • the added molecules increase the optical path length of incident radiation through the sensor structure, and thus modify the wavelength at which maximum reflectance or transmittance will occur.
  • a low-k nanoporous material is an inorganic, porous, oxide-like low dielectric material, wherein the refractive index, n, is about 1.1 to about 2.2, and preferably about 1.1 to about 1.5.
  • a low-k nanoporous material can be, for example, porous silica xerogels and aerogels (about 1.1- about 2.2); porous HSQ (about 1.7- about 2.2); porous SiLKTM (a B staged polymer) (about 1.5- about 2.0); porous MSQ (about 1.8- about 2.2); porous PAE (about 1.8- about 2.2).
  • the nanoporous material is NANOGLASS®, which is porous SiO 2 . Porosity is created in the SiO 2 thereby reducing the dielectric constant from about 3.9 to as low as 1.9.
  • the PDMS replicas are then used to imprint a thin film of uncured NANOGLASS ⁇ (Honeywell Elec. Mat.), a low-index sol-gel glass, spun-on to a glass substrate. Once the low-index dielectric becomes rigid, the flexible PDMS mold is removed and the sol-gel glass is fully cured by further baking.
  • the sensor structure is completed by evaporating 175nm of TiO 2 onto the patterned surface. A subsequent surface treatment with dimethyldichlorosilane encourages bio-adsorption and promotes sensor stability.
  • a schematic illustrating the cross-section of the device is shown in Figure 7.
  • the polymer devices were provided as an array of sensors aligned and attached to bottomless 96-well standard microtiter plates (SRU Biosystems).
  • the porous glass devices are fabricated on 75mm x 25mm x lmm glass microscope slides.
  • Adhesive rubber wells (Research International Corp.) are attached to the glass surface to provide liquid containment for 5-6 sensors on each slide.
  • FIG. 11 gives a spatial profile of PWV shift versus polymer thickness, where each PWV shift was measured in buffer after the wash step.
  • Each monolayer of polyelectrolyte is approximately 4.4 nm thick and has a refractive index of 1.49. See, e.g., Picart et al., Determination of structural parameters characterizing thin films by optical methods: A comparison between scanning angle reflectometry and optical waveguide lightmode spectroscopy. Journal of Chemical Physics, 2001. 115(2): p. 1086-1094.
  • the porous glass sensor exhibits an average surface sensitivity ⁇ 1.5x that of the polymer sensor.

Landscapes

  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Physics & Mathematics (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Nanotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Sustainable Development (AREA)
  • Optics & Photonics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pathology (AREA)
  • Microelectronics & Electronic Packaging (AREA)
  • Plasma & Fusion (AREA)
  • Biophysics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Clinical Laboratory Science (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Photometry And Measurement Of Optical Pulse Characteristics (AREA)

Abstract

L'invention concerne des compositions de détection et un procédé de fabrication de détecteurs.
EP06785860A 2005-07-08 2006-06-29 Structure de biodetection a cristal photonique et son procede de fabrication Withdrawn EP1904827A2 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US11/177,708 US7479404B2 (en) 2005-07-08 2005-07-08 Photonic crystal biosensor structure and fabrication method
US11/177,707 US7521769B2 (en) 2005-07-08 2005-07-08 Photonic crystal biosensor structure and fabrication method
PCT/US2006/025400 WO2007008440A2 (fr) 2005-07-08 2006-06-29 Structure de biodetection a cristal photonique et son procede de fabrication

Publications (1)

Publication Number Publication Date
EP1904827A2 true EP1904827A2 (fr) 2008-04-02

Family

ID=37637689

Family Applications (2)

Application Number Title Priority Date Filing Date
EP06851538A Withdrawn EP1920235A2 (fr) 2005-07-08 2006-06-29 Structure de biocapteur à cristaux photoniques et procédé de fabrication
EP06785860A Withdrawn EP1904827A2 (fr) 2005-07-08 2006-06-29 Structure de biodetection a cristal photonique et son procede de fabrication

Family Applications Before (1)

Application Number Title Priority Date Filing Date
EP06851538A Withdrawn EP1920235A2 (fr) 2005-07-08 2006-06-29 Structure de biocapteur à cristaux photoniques et procédé de fabrication

Country Status (6)

Country Link
EP (2) EP1920235A2 (fr)
JP (2) JP2009510391A (fr)
AU (2) AU2006269532B2 (fr)
CA (2) CA2614556A1 (fr)
NZ (2) NZ565682A (fr)
WO (2) WO2007008440A2 (fr)

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CN101403742B (zh) * 2008-10-29 2012-05-23 东南大学 利用光电镊对微纳米生物粒子进行介电表征的方法
US9213000B2 (en) 2009-10-16 2015-12-15 Opalux, Incorporated Photonic crystal combinatorial sensor
US8437965B2 (en) * 2010-03-01 2013-05-07 Empire Technology Development Llc Sensing chemicals in aqueous environments
JP5149321B2 (ja) * 2010-03-24 2013-02-20 株式会社東芝 電磁場シミュレーション方法、電磁場シミュレーション装置、半導体装置の製造方法
JP2012098272A (ja) * 2010-08-23 2012-05-24 Nsk Ltd 標的物質濃度測定装置および標的物質濃度測定方法
EP2500314A1 (fr) 2011-03-14 2012-09-19 Nederlandse Organisatie voor toegepast -natuurwetenschappelijk onderzoek TNO Capteur de cristal photonique
JP6553735B2 (ja) * 2015-03-13 2019-07-31 ダウ グローバル テクノロジーズ エルエルシー ナノ構造材料の方法及び素子
CN105655719B (zh) * 2016-01-07 2017-11-17 内蒙古科技大学 电磁波透射增强装置
WO2017151582A1 (fr) * 2016-02-29 2017-09-08 The University Of North Carolina At Chapel Hill Réseau de micro-éléments pour imagerie haute densité et haute résolution et tri cellulaire
WO2018155556A1 (fr) * 2017-02-23 2018-08-30 デンカ株式会社 Cristal photonique
CN112313501A (zh) * 2018-07-31 2021-02-02 积水化学工业株式会社 检测方法、检测用器具和检测装置
NL2023516B1 (en) * 2019-05-28 2020-12-08 Illumina Inc Manufacturing a flowcell with a planar waveguide
WO2021076154A1 (fr) * 2019-10-18 2021-04-22 California Institute Of Technology Capteurs d'image couleur cmos à division de couleur de métamatériau
RU2725011C1 (ru) * 2019-12-24 2020-06-29 Самсунг Электроникс Ко., Лтд. Сенсорное устройство для распознавания смесей летучих соединений и способ его изготовления
JP7264134B2 (ja) * 2020-08-26 2023-04-25 横河電機株式会社 分光分析装置、光学系、及び方法
US20220252779A1 (en) * 2021-02-08 2022-08-11 Applied Materials, Inc. Method for amorphous, high-refractive-index encapsulation of nanoparticle imprint films for optical devices
CN113744767A (zh) * 2021-08-31 2021-12-03 广东工业大学 一种利用dvd光盘制备具有光栅结构二氧化钛薄膜的方法及其制成的薄膜和应用

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US6270846B1 (en) * 2000-03-02 2001-08-07 Sandia Corporation Method for making surfactant-templated, high-porosity thin films
US7264973B2 (en) * 2000-10-30 2007-09-04 Sru Biosystems, Inc. Label-free methods for performing assays using a colorimetric resonant optical biosensor
US7306827B2 (en) * 2000-10-30 2007-12-11 Sru Biosystems, Inc. Method and machine for replicating holographic gratings on a substrate
US7070987B2 (en) * 2000-10-30 2006-07-04 Sru Biosystems, Inc. Guided mode resonant filter biosensor using a linear grating surface structure
US7101660B2 (en) * 2000-10-30 2006-09-05 Sru Biosystems, Inc. Method for producing a colorimetric resonant reflection biosensor on rigid surfaces
CA2473825A1 (fr) * 2002-07-11 2004-01-22 Sumitomo Electric Industries, Ltd. Semiconducteur poreux et procede de production correspondant
JP4054718B2 (ja) * 2003-05-28 2008-03-05 キヤノン株式会社 センサ装置
JP2005016963A (ja) * 2003-06-23 2005-01-20 Canon Inc 化学センサ、化学センサ装置

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Also Published As

Publication number Publication date
NZ565681A (en) 2009-11-27
NZ565682A (en) 2009-11-27
AU2006269532B2 (en) 2011-06-30
AU2006269532A1 (en) 2007-01-18
AU2006344709B2 (en) 2012-01-19
WO2007008440A2 (fr) 2007-01-18
WO2008027025A3 (fr) 2008-05-08
JP2009520947A (ja) 2009-05-28
AU2006344709A1 (en) 2008-03-06
JP2009510391A (ja) 2009-03-12
CA2614556A1 (fr) 2007-01-18
WO2008027025A2 (fr) 2008-03-06
WO2007008440A3 (fr) 2007-04-05
CA2615417A1 (fr) 2007-01-08
EP1920235A2 (fr) 2008-05-14

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