EP1883465B1 - Dispositif de melange a double chambre pour substances pharmaceutiques visqueuses et procede - Google Patents

Dispositif de melange a double chambre pour substances pharmaceutiques visqueuses et procede Download PDF

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Publication number
EP1883465B1
EP1883465B1 EP06752699A EP06752699A EP1883465B1 EP 1883465 B1 EP1883465 B1 EP 1883465B1 EP 06752699 A EP06752699 A EP 06752699A EP 06752699 A EP06752699 A EP 06752699A EP 1883465 B1 EP1883465 B1 EP 1883465B1
Authority
EP
European Patent Office
Prior art keywords
tank
tanks
substances
mixing
mixing element
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
EP06752699A
Other languages
German (de)
English (en)
French (fr)
Other versions
EP1883465A1 (fr
Inventor
Eric Bonnard
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Odyssea Pharma SPRL
Original Assignee
Uteron Pharma Technologies SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Uteron Pharma Technologies SA filed Critical Uteron Pharma Technologies SA
Priority to PL06752699T priority Critical patent/PL1883465T3/pl
Priority to SI200630625T priority patent/SI1883465T1/sl
Publication of EP1883465A1 publication Critical patent/EP1883465A1/fr
Application granted granted Critical
Publication of EP1883465B1 publication Critical patent/EP1883465B1/fr
Priority to CY20101100310T priority patent/CY1109930T1/el
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/40—Static mixers
    • B01F25/45—Mixers in which the materials to be mixed are pressed together through orifices or interstitial spaces, e.g. between beads
    • B01F25/451—Mixers in which the materials to be mixed are pressed together through orifices or interstitial spaces, e.g. between beads characterised by means for moving the materials to be mixed or the mixture
    • B01F25/4512—Mixers in which the materials to be mixed are pressed together through orifices or interstitial spaces, e.g. between beads characterised by means for moving the materials to be mixed or the mixture with reciprocating pistons
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/71—Feed mechanisms
    • B01F35/716—Feed mechanisms characterised by the relative arrangement of the containers for feeding or mixing the components
    • B01F35/7161—Feed mechanisms characterised by the relative arrangement of the containers for feeding or mixing the components the containers being connected coaxially before contacting the contents
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/71—Feed mechanisms
    • B01F35/717—Feed mechanisms characterised by the means for feeding the components to the mixer
    • B01F35/7174—Feed mechanisms characterised by the means for feeding the components to the mixer using pistons, plungers or syringes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/71—Feed mechanisms
    • B01F35/717—Feed mechanisms characterised by the means for feeding the components to the mixer
    • B01F35/71775—Feed mechanisms characterised by the means for feeding the components to the mixer using helical screws
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/71—Feed mechanisms
    • B01F35/717—Feed mechanisms characterised by the means for feeding the components to the mixer
    • B01F35/71805—Feed mechanisms characterised by the means for feeding the components to the mixer using valves, gates, orifices or openings
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/75—Discharge mechanisms
    • B01F35/754—Discharge mechanisms characterised by the means for discharging the components from the mixer
    • B01F35/7547—Discharge mechanisms characterised by the means for discharging the components from the mixer using valves, gates, orifices or openings
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/90—Heating or cooling systems
    • B01F35/92—Heating or cooling systems for heating the outside of the receptacle, e.g. heated jackets or burners
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F2101/00—Mixing characterised by the nature of the mixed materials or by the application field
    • B01F2101/22—Mixing of ingredients for pharmaceutical or medical compositions

Definitions

  • the present invention relates to a dual chamber mixing device for obtaining a very good homogeneity in the case of a mixture of viscous substances, in particular in the pharmaceutical field.
  • the invention also relates to the method of implementation of the device.
  • the document US 3,353,918 A discloses an apparatus for mixing the polyurethane foam manufacturing ingredients, comprising: a mixing apparatus containing two chambers having adjacent ends interconnected by a wall having through-holes and two pistons, each slidably mounted in one of the respective two chambers, means for causing oscillation of the two pistons within the chambers so as to force the ingredients into the mixing apparatus in a back-and-forth movement through the orifices and to mix them, said wall comprising a discharge passage provided with a control valve and communicating with the orifices, the mixed ingredients being able to be unloaded, once the pistons converge towards the wall, provided that the valve is open.
  • the wall also comprises means provided with valves and communicating with the orifices, for loading the ingredients into the mixing apparatus.
  • the document US 3,035,820 A discloses apparatus for emulsification and homogenization of a viscous solid or liquid suspension in a liquid (eg water / oil), wherein the suspension or mixture is forced through a high speed restriction and / or high pressure.
  • the apparatus has a pair of opposed cylindrical syringes each having a piston slidably mounted in its cylinder, and operable to repetitively transfer the fluid reciprocally from one syringe to the other through the restriction which communicates the two cylinders.
  • the document US 6,062,722 A discloses a method of mixing a fluid in which one or two separate fluid reservoirs communicating with a static propeller mixer are used as the mixing apparatus. The fluid is forced from the tank to the static mixer and vice versa.
  • the present invention aims to provide a solution that makes it possible to overcome the disadvantages of the state of the art.
  • the present invention aims to provide a device and a mixing process that allow to obtain a perfectly homogeneous mixture of viscous pharmaceutical substances.
  • the invention also aims to allow the mixture of heat-sensitive pharmaceutical substances.
  • the invention aims to provide a mixing device for the complete emptying of the tanks used.
  • a first object of the present invention is to provide an automated process for mixing at least two viscous substances.
  • a second object of the present invention is to provide a device for mixing at least two viscous substances.
  • the figure 1 is a sectional view of the mixing device according to a preferred embodiment of the present invention.
  • the figure 2 schematically represents the different steps of the method of implementation of the device according to the figure 1 .
  • the figure 3 schematically represents the step of emptying the mixing device of the invention, which occurs once the desired homogeneity.
  • the present invention relates to a mixing unit which allows the incorporation and the automated and closed-loop mixing of pharmaceutical products to obtain a final mixture of high viscosity.
  • the invented mixing unit generally consists of two communicating tanks, vertical cylindrical, of the same axis and symmetrical with respect to a median horizontal plane (image of the tanks one of the other as in a mirror). These tanks are equipped with sealed pistons whose actuation by a hydraulic system allows the passage in successive cycles of the components to be mixed through a baffle mixing device.
  • the assembly is fully automated using a PLC and can be thermostatically controlled for mixtures of heat-sensitive substances that require it.
  • the mixing process whose steps (a) to (e) are represented on the figure 2 is carried out by pumping, in the form of successive cycles, the components to be mixed from the upper tank 1 to the lower tank 2 by passing through the static mixer 5 and vice versa.
  • the number of cycles required is set by the type and viscosity of the components to be mixed.
  • this process is carried out between 5 and 10 cycles of about 30 seconds, which corresponds to a total process time of between 2 minutes and 5 minutes. According to the state of the art, a typical mixing time is 60 minutes.
  • the components of the mixture are introduced into the upper tank 1 before starting the mixing process by removing the lid 12 or are injected into the system being mixed by means of a sealed worm gear (not shown in FIG. the figures) which can be positioned indifferently on the upper tank 1 or on the central mixing element 5.
  • the mixing process is complete, the system allows a complete emptying of it as represented on the figure 3 .
  • the mixture is transferred for this purpose completely into the upper tank 1 or lower 2 and then drained outwards.

Landscapes

  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dispersion Chemistry (AREA)
  • Accessories For Mixers (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Nozzles (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Mixers Of The Rotary Stirring Type (AREA)
  • Processing And Handling Of Plastics And Other Materials For Molding In General (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
EP06752699A 2005-05-24 2006-05-23 Dispositif de melange a double chambre pour substances pharmaceutiques visqueuses et procede Active EP1883465B1 (fr)

Priority Applications (3)

Application Number Priority Date Filing Date Title
PL06752699T PL1883465T3 (pl) 2005-05-24 2006-05-23 Dwukomorowe urządzenie mieszające do lepkich substancji farmaceutycznych oraz sposób
SI200630625T SI1883465T1 (sl) 2005-05-24 2006-05-23 Dvokomorna mešalna naprava za viskozne farmacevtske snovi in postopek
CY20101100310T CY1109930T1 (el) 2005-05-24 2010-03-31 Διαταξη αναμιξης διπλου θαλαμου για πυκνορρευστες φαρμακευτικες ουσιες και μεθοδος

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US68433805P 2005-05-24 2005-05-24
PCT/BE2006/000058 WO2006125284A1 (fr) 2005-05-24 2006-05-23 Dispositif de melange a double chambre pour substances pharmaceutiques visqueuses

Publications (2)

Publication Number Publication Date
EP1883465A1 EP1883465A1 (fr) 2008-02-06
EP1883465B1 true EP1883465B1 (fr) 2010-01-20

Family

ID=36747276

Family Applications (1)

Application Number Title Priority Date Filing Date
EP06752699A Active EP1883465B1 (fr) 2005-05-24 2006-05-23 Dispositif de melange a double chambre pour substances pharmaceutiques visqueuses et procede

Country Status (13)

Country Link
US (1) US7878704B2 (da)
EP (1) EP1883465B1 (da)
AT (1) ATE455588T1 (da)
CA (1) CA2609438C (da)
CY (1) CY1109930T1 (da)
DE (1) DE602006011876D1 (da)
DK (1) DK1883465T3 (da)
EA (1) EA012125B1 (da)
ES (1) ES2339384T3 (da)
PL (1) PL1883465T3 (da)
PT (1) PT1883465E (da)
SI (1) SI1883465T1 (da)
WO (1) WO2006125284A1 (da)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2322132B1 (en) * 2008-09-05 2016-07-13 OncoTherapy Science Inc Device and method for automatically preparing emulsion drug
ITMI20090102A1 (it) * 2009-01-29 2010-07-30 Marina Scremin Miscelatore
CN103517726B (zh) * 2011-04-05 2016-08-17 优势医疗 用于改善脑损伤后影响脑血流的结果的脑室内药物递送系统
NL2006787C2 (en) * 2011-05-16 2012-11-19 Avantium Holding B V COMPOUNDER AND METHOD FOR MIXING ONE OR MORE VISCOUS FLUIDS.
US9604184B2 (en) 2013-03-06 2017-03-28 Orthovita, Inc. Mixing system and valve assembly
US10596069B2 (en) * 2015-12-22 2020-03-24 Ethicon, Inc. Syringes with mixing chamber in a removable cap
RU170178U1 (ru) * 2016-11-25 2017-04-18 Общество с ограниченной ответственностью "Тунег" Смеситель для приготовления смесей из сыпучих материалов
RU2656319C2 (ru) * 2016-11-25 2018-06-04 Общество с ограниченной ответственностью "Тунег" Способ смешения сыпучих материалов и автоматическое устройство для его осуществления
CN111729532B (zh) * 2020-08-03 2020-12-18 山东明福染业有限公司 一种天然植物染料混匀装置
CN113230958A (zh) * 2021-05-10 2021-08-10 深圳杰明纳微电子科技有限公司 一种均匀混合氧化铈泥浆的装置

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2477598A (en) * 1948-02-16 1949-08-02 George M Hain Microworker for lubricating greases
US2724383A (en) * 1951-06-28 1955-11-22 Compule Corp Combined mixing container structure and hypodermic syringe for segregated ingredients of hypodermically injectable preparations
US2798488A (en) * 1954-09-15 1957-07-09 Merck & Co Inc Syringe unit
US3035820A (en) * 1960-03-23 1962-05-22 Allergy Section Of The Res Fou Emulsification apparatus
US3010705A (en) * 1960-09-26 1961-11-28 Brown Ethan Allan Emulsifiers
GB1052971A (da) * 1962-10-25
US3190619A (en) * 1963-05-27 1965-06-22 Union Carbide Corp Fluid mixing container assembly
US3700215A (en) * 1970-10-21 1972-10-24 Hardman Inc Mixing and dispensing device
CH542699A (de) * 1972-02-18 1973-10-15 P Huerlimann Hans Vorrichtung zum Behandeln von Stoffen
US4350650A (en) * 1979-01-09 1982-09-21 Euro-Linea S.N.C. Di Colombo & C. Method for admixing at least two liquids and feeding them to a shaping mould
SU895160A1 (ru) * 1979-01-16 1983-12-23 Среднеазиатский научно-исследовательский институт природного газа Устройство дл приготовлени бурового раствора
US4463875A (en) * 1982-06-14 1984-08-07 Robert W. Mann Method and apparatus for preparing and applying a two-component cement
GB8516344D0 (en) * 1985-06-28 1985-07-31 Brunold C R Mixing apparatus & processes
US5425580A (en) * 1990-12-28 1995-06-20 Byk Gulden Lomberg Chemische Fabrik Gmbh Dosage form for micro-bubble echo contrast agents
US6062722A (en) 1997-10-21 2000-05-16 Micron Communications, Inc. Fluid mixing and withdrawing methods
SE9904539D0 (sv) * 1999-12-10 1999-12-10 Alphahelix Ab Method and device for the handling of samples and reagents
US6592251B2 (en) * 2001-01-26 2003-07-15 Howmedica Osteonics Corp. Cement mixing and dispensing device
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US7748892B2 (en) * 2004-06-02 2010-07-06 Mccoy William Method and apparatus for compounding medications

Also Published As

Publication number Publication date
DE602006011876D1 (de) 2010-03-11
EA200702272A1 (ru) 2008-04-28
US7878704B2 (en) 2011-02-01
ES2339384T3 (es) 2010-05-19
DK1883465T3 (da) 2010-05-17
EA012125B1 (ru) 2009-08-28
SI1883465T1 (sl) 2010-05-31
PT1883465E (pt) 2010-04-14
ATE455588T1 (de) 2010-02-15
CA2609438C (en) 2014-07-08
CA2609438A1 (en) 2006-11-30
WO2006125284A1 (fr) 2006-11-30
PL1883465T3 (pl) 2010-06-30
CY1109930T1 (el) 2014-04-09
US20080212399A1 (en) 2008-09-04
EP1883465A1 (fr) 2008-02-06

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