EP1883465B1 - Dispositif de melange a double chambre pour substances pharmaceutiques visqueuses et procede - Google Patents
Dispositif de melange a double chambre pour substances pharmaceutiques visqueuses et procede Download PDFInfo
- Publication number
- EP1883465B1 EP1883465B1 EP06752699A EP06752699A EP1883465B1 EP 1883465 B1 EP1883465 B1 EP 1883465B1 EP 06752699 A EP06752699 A EP 06752699A EP 06752699 A EP06752699 A EP 06752699A EP 1883465 B1 EP1883465 B1 EP 1883465B1
- Authority
- EP
- European Patent Office
- Prior art keywords
- tank
- tanks
- substances
- mixing
- mixing element
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 238000002156 mixing Methods 0.000 title claims abstract description 54
- 239000000126 substance Substances 0.000 title claims abstract description 14
- 238000000034 method Methods 0.000 title claims description 16
- 238000002347 injection Methods 0.000 claims abstract description 8
- 239000007924 injection Substances 0.000 claims abstract description 8
- 230000033001 locomotion Effects 0.000 claims abstract description 8
- 239000011345 viscous material Substances 0.000 claims abstract description 6
- 230000003213 activating effect Effects 0.000 claims abstract 3
- 239000000203 mixture Substances 0.000 claims description 21
- 230000003068 static effect Effects 0.000 claims description 13
- 239000012530 fluid Substances 0.000 claims description 7
- 229910001220 stainless steel Inorganic materials 0.000 claims description 6
- 239000010935 stainless steel Substances 0.000 claims description 6
- 238000001816 cooling Methods 0.000 claims description 3
- 238000010438 heat treatment Methods 0.000 claims description 3
- 239000011261 inert gas Substances 0.000 claims description 3
- 238000005086 pumping Methods 0.000 claims description 2
- 239000004615 ingredient Substances 0.000 description 4
- 229920000642 polymer Polymers 0.000 description 3
- 241001415961 Gaviidae Species 0.000 description 2
- 230000004913 activation Effects 0.000 description 2
- 238000009529 body temperature measurement Methods 0.000 description 2
- 238000010348 incorporation Methods 0.000 description 2
- 238000005070 sampling Methods 0.000 description 2
- 229920005830 Polyurethane Foam Polymers 0.000 description 1
- 230000003416 augmentation Effects 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 230000009977 dual effect Effects 0.000 description 1
- 238000004945 emulsification Methods 0.000 description 1
- 229940082150 encore Drugs 0.000 description 1
- 230000004907 flux Effects 0.000 description 1
- 239000008240 homogeneous mixture Substances 0.000 description 1
- 238000000265 homogenisation Methods 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000006194 liquid suspension Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000010355 oscillation Effects 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 229940127557 pharmaceutical product Drugs 0.000 description 1
- 239000011496 polyurethane foam Substances 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Images
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
- B01F25/40—Static mixers
- B01F25/45—Mixers in which the materials to be mixed are pressed together through orifices or interstitial spaces, e.g. between beads
- B01F25/451—Mixers in which the materials to be mixed are pressed together through orifices or interstitial spaces, e.g. between beads characterised by means for moving the materials to be mixed or the mixture
- B01F25/4512—Mixers in which the materials to be mixed are pressed together through orifices or interstitial spaces, e.g. between beads characterised by means for moving the materials to be mixed or the mixture with reciprocating pistons
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
- B01F35/71—Feed mechanisms
- B01F35/716—Feed mechanisms characterised by the relative arrangement of the containers for feeding or mixing the components
- B01F35/7161—Feed mechanisms characterised by the relative arrangement of the containers for feeding or mixing the components the containers being connected coaxially before contacting the contents
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
- B01F35/71—Feed mechanisms
- B01F35/717—Feed mechanisms characterised by the means for feeding the components to the mixer
- B01F35/7174—Feed mechanisms characterised by the means for feeding the components to the mixer using pistons, plungers or syringes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
- B01F35/71—Feed mechanisms
- B01F35/717—Feed mechanisms characterised by the means for feeding the components to the mixer
- B01F35/71775—Feed mechanisms characterised by the means for feeding the components to the mixer using helical screws
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
- B01F35/71—Feed mechanisms
- B01F35/717—Feed mechanisms characterised by the means for feeding the components to the mixer
- B01F35/71805—Feed mechanisms characterised by the means for feeding the components to the mixer using valves, gates, orifices or openings
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
- B01F35/75—Discharge mechanisms
- B01F35/754—Discharge mechanisms characterised by the means for discharging the components from the mixer
- B01F35/7547—Discharge mechanisms characterised by the means for discharging the components from the mixer using valves, gates, orifices or openings
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
- B01F35/90—Heating or cooling systems
- B01F35/92—Heating or cooling systems for heating the outside of the receptacle, e.g. heated jackets or burners
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F2101/00—Mixing characterised by the nature of the mixed materials or by the application field
- B01F2101/22—Mixing of ingredients for pharmaceutical or medical compositions
Definitions
- the present invention relates to a dual chamber mixing device for obtaining a very good homogeneity in the case of a mixture of viscous substances, in particular in the pharmaceutical field.
- the invention also relates to the method of implementation of the device.
- the document US 3,353,918 A discloses an apparatus for mixing the polyurethane foam manufacturing ingredients, comprising: a mixing apparatus containing two chambers having adjacent ends interconnected by a wall having through-holes and two pistons, each slidably mounted in one of the respective two chambers, means for causing oscillation of the two pistons within the chambers so as to force the ingredients into the mixing apparatus in a back-and-forth movement through the orifices and to mix them, said wall comprising a discharge passage provided with a control valve and communicating with the orifices, the mixed ingredients being able to be unloaded, once the pistons converge towards the wall, provided that the valve is open.
- the wall also comprises means provided with valves and communicating with the orifices, for loading the ingredients into the mixing apparatus.
- the document US 3,035,820 A discloses apparatus for emulsification and homogenization of a viscous solid or liquid suspension in a liquid (eg water / oil), wherein the suspension or mixture is forced through a high speed restriction and / or high pressure.
- the apparatus has a pair of opposed cylindrical syringes each having a piston slidably mounted in its cylinder, and operable to repetitively transfer the fluid reciprocally from one syringe to the other through the restriction which communicates the two cylinders.
- the document US 6,062,722 A discloses a method of mixing a fluid in which one or two separate fluid reservoirs communicating with a static propeller mixer are used as the mixing apparatus. The fluid is forced from the tank to the static mixer and vice versa.
- the present invention aims to provide a solution that makes it possible to overcome the disadvantages of the state of the art.
- the present invention aims to provide a device and a mixing process that allow to obtain a perfectly homogeneous mixture of viscous pharmaceutical substances.
- the invention also aims to allow the mixture of heat-sensitive pharmaceutical substances.
- the invention aims to provide a mixing device for the complete emptying of the tanks used.
- a first object of the present invention is to provide an automated process for mixing at least two viscous substances.
- a second object of the present invention is to provide a device for mixing at least two viscous substances.
- the figure 1 is a sectional view of the mixing device according to a preferred embodiment of the present invention.
- the figure 2 schematically represents the different steps of the method of implementation of the device according to the figure 1 .
- the figure 3 schematically represents the step of emptying the mixing device of the invention, which occurs once the desired homogeneity.
- the present invention relates to a mixing unit which allows the incorporation and the automated and closed-loop mixing of pharmaceutical products to obtain a final mixture of high viscosity.
- the invented mixing unit generally consists of two communicating tanks, vertical cylindrical, of the same axis and symmetrical with respect to a median horizontal plane (image of the tanks one of the other as in a mirror). These tanks are equipped with sealed pistons whose actuation by a hydraulic system allows the passage in successive cycles of the components to be mixed through a baffle mixing device.
- the assembly is fully automated using a PLC and can be thermostatically controlled for mixtures of heat-sensitive substances that require it.
- the mixing process whose steps (a) to (e) are represented on the figure 2 is carried out by pumping, in the form of successive cycles, the components to be mixed from the upper tank 1 to the lower tank 2 by passing through the static mixer 5 and vice versa.
- the number of cycles required is set by the type and viscosity of the components to be mixed.
- this process is carried out between 5 and 10 cycles of about 30 seconds, which corresponds to a total process time of between 2 minutes and 5 minutes. According to the state of the art, a typical mixing time is 60 minutes.
- the components of the mixture are introduced into the upper tank 1 before starting the mixing process by removing the lid 12 or are injected into the system being mixed by means of a sealed worm gear (not shown in FIG. the figures) which can be positioned indifferently on the upper tank 1 or on the central mixing element 5.
- the mixing process is complete, the system allows a complete emptying of it as represented on the figure 3 .
- the mixture is transferred for this purpose completely into the upper tank 1 or lower 2 and then drained outwards.
Landscapes
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Dispersion Chemistry (AREA)
- Accessories For Mixers (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
- Nozzles (AREA)
- Medicines Containing Plant Substances (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- Mixers Of The Rotary Stirring Type (AREA)
- Processing And Handling Of Plastics And Other Materials For Molding In General (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PL06752699T PL1883465T3 (pl) | 2005-05-24 | 2006-05-23 | Dwukomorowe urządzenie mieszające do lepkich substancji farmaceutycznych oraz sposób |
SI200630625T SI1883465T1 (sl) | 2005-05-24 | 2006-05-23 | Dvokomorna mešalna naprava za viskozne farmacevtske snovi in postopek |
CY20101100310T CY1109930T1 (el) | 2005-05-24 | 2010-03-31 | Διαταξη αναμιξης διπλου θαλαμου για πυκνορρευστες φαρμακευτικες ουσιες και μεθοδος |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US68433805P | 2005-05-24 | 2005-05-24 | |
PCT/BE2006/000058 WO2006125284A1 (fr) | 2005-05-24 | 2006-05-23 | Dispositif de melange a double chambre pour substances pharmaceutiques visqueuses |
Publications (2)
Publication Number | Publication Date |
---|---|
EP1883465A1 EP1883465A1 (fr) | 2008-02-06 |
EP1883465B1 true EP1883465B1 (fr) | 2010-01-20 |
Family
ID=36747276
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP06752699A Active EP1883465B1 (fr) | 2005-05-24 | 2006-05-23 | Dispositif de melange a double chambre pour substances pharmaceutiques visqueuses et procede |
Country Status (13)
Country | Link |
---|---|
US (1) | US7878704B2 (da) |
EP (1) | EP1883465B1 (da) |
AT (1) | ATE455588T1 (da) |
CA (1) | CA2609438C (da) |
CY (1) | CY1109930T1 (da) |
DE (1) | DE602006011876D1 (da) |
DK (1) | DK1883465T3 (da) |
EA (1) | EA012125B1 (da) |
ES (1) | ES2339384T3 (da) |
PL (1) | PL1883465T3 (da) |
PT (1) | PT1883465E (da) |
SI (1) | SI1883465T1 (da) |
WO (1) | WO2006125284A1 (da) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2322132B1 (en) * | 2008-09-05 | 2016-07-13 | OncoTherapy Science Inc | Device and method for automatically preparing emulsion drug |
ITMI20090102A1 (it) * | 2009-01-29 | 2010-07-30 | Marina Scremin | Miscelatore |
CN103517726B (zh) * | 2011-04-05 | 2016-08-17 | 优势医疗 | 用于改善脑损伤后影响脑血流的结果的脑室内药物递送系统 |
NL2006787C2 (en) * | 2011-05-16 | 2012-11-19 | Avantium Holding B V | COMPOUNDER AND METHOD FOR MIXING ONE OR MORE VISCOUS FLUIDS. |
US9604184B2 (en) | 2013-03-06 | 2017-03-28 | Orthovita, Inc. | Mixing system and valve assembly |
US10596069B2 (en) * | 2015-12-22 | 2020-03-24 | Ethicon, Inc. | Syringes with mixing chamber in a removable cap |
RU170178U1 (ru) * | 2016-11-25 | 2017-04-18 | Общество с ограниченной ответственностью "Тунег" | Смеситель для приготовления смесей из сыпучих материалов |
RU2656319C2 (ru) * | 2016-11-25 | 2018-06-04 | Общество с ограниченной ответственностью "Тунег" | Способ смешения сыпучих материалов и автоматическое устройство для его осуществления |
CN111729532B (zh) * | 2020-08-03 | 2020-12-18 | 山东明福染业有限公司 | 一种天然植物染料混匀装置 |
CN113230958A (zh) * | 2021-05-10 | 2021-08-10 | 深圳杰明纳微电子科技有限公司 | 一种均匀混合氧化铈泥浆的装置 |
Family Cites Families (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2477598A (en) * | 1948-02-16 | 1949-08-02 | George M Hain | Microworker for lubricating greases |
US2724383A (en) * | 1951-06-28 | 1955-11-22 | Compule Corp | Combined mixing container structure and hypodermic syringe for segregated ingredients of hypodermically injectable preparations |
US2798488A (en) * | 1954-09-15 | 1957-07-09 | Merck & Co Inc | Syringe unit |
US3035820A (en) * | 1960-03-23 | 1962-05-22 | Allergy Section Of The Res Fou | Emulsification apparatus |
US3010705A (en) * | 1960-09-26 | 1961-11-28 | Brown Ethan Allan | Emulsifiers |
GB1052971A (da) * | 1962-10-25 | |||
US3190619A (en) * | 1963-05-27 | 1965-06-22 | Union Carbide Corp | Fluid mixing container assembly |
US3700215A (en) * | 1970-10-21 | 1972-10-24 | Hardman Inc | Mixing and dispensing device |
CH542699A (de) * | 1972-02-18 | 1973-10-15 | P Huerlimann Hans | Vorrichtung zum Behandeln von Stoffen |
US4350650A (en) * | 1979-01-09 | 1982-09-21 | Euro-Linea S.N.C. Di Colombo & C. | Method for admixing at least two liquids and feeding them to a shaping mould |
SU895160A1 (ru) * | 1979-01-16 | 1983-12-23 | Среднеазиатский научно-исследовательский институт природного газа | Устройство дл приготовлени бурового раствора |
US4463875A (en) * | 1982-06-14 | 1984-08-07 | Robert W. Mann | Method and apparatus for preparing and applying a two-component cement |
GB8516344D0 (en) * | 1985-06-28 | 1985-07-31 | Brunold C R | Mixing apparatus & processes |
US5425580A (en) * | 1990-12-28 | 1995-06-20 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Dosage form for micro-bubble echo contrast agents |
US6062722A (en) | 1997-10-21 | 2000-05-16 | Micron Communications, Inc. | Fluid mixing and withdrawing methods |
SE9904539D0 (sv) * | 1999-12-10 | 1999-12-10 | Alphahelix Ab | Method and device for the handling of samples and reagents |
US6592251B2 (en) * | 2001-01-26 | 2003-07-15 | Howmedica Osteonics Corp. | Cement mixing and dispensing device |
US6799884B2 (en) * | 2002-12-23 | 2004-10-05 | The Goodyear Tire And Rubber Company | Dual chamber orifice mixer and method of use |
US7748892B2 (en) * | 2004-06-02 | 2010-07-06 | Mccoy William | Method and apparatus for compounding medications |
-
2006
- 2006-05-23 DE DE602006011876T patent/DE602006011876D1/de active Active
- 2006-05-23 PL PL06752699T patent/PL1883465T3/pl unknown
- 2006-05-23 DK DK06752699.6T patent/DK1883465T3/da active
- 2006-05-23 EP EP06752699A patent/EP1883465B1/fr active Active
- 2006-05-23 EA EA200702272A patent/EA012125B1/ru unknown
- 2006-05-23 ES ES06752699T patent/ES2339384T3/es active Active
- 2006-05-23 AT AT06752699T patent/ATE455588T1/de active
- 2006-05-23 CA CA2609438A patent/CA2609438C/en active Active
- 2006-05-23 PT PT06752699T patent/PT1883465E/pt unknown
- 2006-05-23 US US11/915,118 patent/US7878704B2/en active Active
- 2006-05-23 SI SI200630625T patent/SI1883465T1/sl unknown
- 2006-05-23 WO PCT/BE2006/000058 patent/WO2006125284A1/fr not_active Application Discontinuation
-
2010
- 2010-03-31 CY CY20101100310T patent/CY1109930T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
DE602006011876D1 (de) | 2010-03-11 |
EA200702272A1 (ru) | 2008-04-28 |
US7878704B2 (en) | 2011-02-01 |
ES2339384T3 (es) | 2010-05-19 |
DK1883465T3 (da) | 2010-05-17 |
EA012125B1 (ru) | 2009-08-28 |
SI1883465T1 (sl) | 2010-05-31 |
PT1883465E (pt) | 2010-04-14 |
ATE455588T1 (de) | 2010-02-15 |
CA2609438C (en) | 2014-07-08 |
CA2609438A1 (en) | 2006-11-30 |
WO2006125284A1 (fr) | 2006-11-30 |
PL1883465T3 (pl) | 2010-06-30 |
CY1109930T1 (el) | 2014-04-09 |
US20080212399A1 (en) | 2008-09-04 |
EP1883465A1 (fr) | 2008-02-06 |
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