EP1856072A1 - Derives de thiazole utilises comme ligands ppar delta et processus de fabrication de ceux-ci - Google Patents

Derives de thiazole utilises comme ligands ppar delta et processus de fabrication de ceux-ci

Info

Publication number
EP1856072A1
EP1856072A1 EP06716113A EP06716113A EP1856072A1 EP 1856072 A1 EP1856072 A1 EP 1856072A1 EP 06716113 A EP06716113 A EP 06716113A EP 06716113 A EP06716113 A EP 06716113A EP 1856072 A1 EP1856072 A1 EP 1856072A1
Authority
EP
European Patent Office
Prior art keywords
formula
compound
group
atom
halogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP06716113A
Other languages
German (de)
English (en)
Other versions
EP1856072A4 (fr
Inventor
Jungyeob 123-404 Gwanak dream town HAM
Hoosang 202-ho Ilheung villa HWANG
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Seoul National University Industry Foundation
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority claimed from KR1020060018360A external-priority patent/KR100797798B1/ko
Publication of EP1856072A1 publication Critical patent/EP1856072A1/fr
Publication of EP1856072A4 publication Critical patent/EP1856072A4/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D277/26—Radicals substituted by sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)

Abstract

La présente invention concerne de nouveaux composés dérivés de thiazole qui possèdent une activité pour le récepteur d (PPARd) activé par le proliférateur de peroxisome, ainsi que leurs intermédiaires et des techniques de synthèse de ceux-ci..
EP06716113A 2005-02-25 2006-02-24 Derives de thiazole utilises comme ligands ppar delta et processus de fabrication de ceux-ci Withdrawn EP1856072A4 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
KR20050015663 2005-02-25
PCT/KR2006/000663 WO2006091047A1 (fr) 2005-02-25 2006-02-24 Derives de thiazole utilises comme ligands ppar delta et processus de fabrication de ceux-ci
KR1020060018360A KR100797798B1 (ko) 2005-02-25 2006-02-24 퍼록시솜 증식자 활성화 수용체 델타 리간드 티아졸 유도체및 그의 제조방법

Publications (2)

Publication Number Publication Date
EP1856072A1 true EP1856072A1 (fr) 2007-11-21
EP1856072A4 EP1856072A4 (fr) 2009-10-21

Family

ID=36927652

Family Applications (1)

Application Number Title Priority Date Filing Date
EP06716113A Withdrawn EP1856072A4 (fr) 2005-02-25 2006-02-24 Derives de thiazole utilises comme ligands ppar delta et processus de fabrication de ceux-ci

Country Status (3)

Country Link
EP (1) EP1856072A4 (fr)
CA (1) CA2599281C (fr)
WO (1) WO2006091047A1 (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2444514C2 (ru) * 2006-12-02 2012-03-10 Сеул Нэшнл Юниверсити Индастри Фаундейшн Арильные соединения в качестве лигандов ppar и их применение
BRPI0807023A2 (pt) * 2007-01-08 2014-04-22 Seoul Nat Univ Ind Foundation Composto de tiazol como ligante de ppard e produto farmacêutico, cosmético e alimento saudável dele composto
BR112012021515A2 (pt) * 2010-02-25 2016-07-05 Snu R&Db Foundation derivado de selenazol tendo ligantes os quais ativam o receptor ativado de proliferador de peroxissomo (ppar), método de preparação do mesmo e o uso dos compostos químicos
KR101898610B1 (ko) 2010-08-31 2018-09-14 서울대학교산학협력단 ＰＰＡＲδ 활성물질의 태자 재프로그래밍 용도

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002062774A1 (fr) * 2000-12-20 2002-08-15 Glaxo Group Limited Derives thiazole destines au traitement de troubles associes a des recepteurs ppar
WO2003072100A1 (fr) * 2002-02-25 2003-09-04 Eli Lilly And Company Modulateurs du recepteur active du proliferateur des peroxysomes
WO2003106442A1 (fr) * 2002-05-04 2003-12-24 Heonjoong Kang Procede pour l'elaboration de derive thiazole et composes intermediaires a cet effet

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUP0102470A3 (en) * 1998-07-01 2002-05-28 Takeda Chemical Industries Ltd 1,3-azole derivatives as retinoid-associated receptor regulators and their use
JP2002542218A (ja) * 1999-04-20 2002-12-10 ノボ ノルディスク アクティーゼルスカブ 新規な化合物、それらの製造および使用

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002062774A1 (fr) * 2000-12-20 2002-08-15 Glaxo Group Limited Derives thiazole destines au traitement de troubles associes a des recepteurs ppar
WO2003072100A1 (fr) * 2002-02-25 2003-09-04 Eli Lilly And Company Modulateurs du recepteur active du proliferateur des peroxysomes
WO2003106442A1 (fr) * 2002-05-04 2003-12-24 Heonjoong Kang Procede pour l'elaboration de derive thiazole et composes intermediaires a cet effet

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of WO2006091047A1 *

Also Published As

Publication number Publication date
CA2599281A1 (fr) 2006-08-31
WO2006091047A1 (fr) 2006-08-31
CA2599281C (fr) 2012-01-17
EP1856072A4 (fr) 2009-10-21

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Owner name: SEOUL NATIONAL UNIVERSITY INDUSTRY FOUNDATION

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Effective date: 20090921

RIC1 Information provided on ipc code assigned before grant

Ipc: A61P 3/10 20060101ALI20090915BHEP

Ipc: A61P 3/06 20060101ALI20090915BHEP

Ipc: A61K 31/426 20060101ALI20090915BHEP

Ipc: C07D 277/26 20060101AFI20060904BHEP

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Inventor name: HWANG, HOOSANG

Inventor name: HAM, JUNGYEOB

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