EP1844426A4 - Blood analysis using a flow imaging cytometer - Google Patents

Blood analysis using a flow imaging cytometer

Info

Publication number
EP1844426A4
EP1844426A4 EP06720094.9A EP06720094A EP1844426A4 EP 1844426 A4 EP1844426 A4 EP 1844426A4 EP 06720094 A EP06720094 A EP 06720094A EP 1844426 A4 EP1844426 A4 EP 1844426A4
Authority
EP
European Patent Office
Prior art keywords
imageur
cytometer
flux
blood
cell analysis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP06720094.9A
Other languages
German (de)
English (en)
French (fr)
Other versions
EP1844426A2 (en
Inventor
William Ortyn
David Basiji
Thaddeous George
Philip Morrissey
Brian Hall
David Perry
Cathleen Zimmerman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Amnis LLC
Original Assignee
Amnis LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amnis LLC filed Critical Amnis LLC
Publication of EP1844426A2 publication Critical patent/EP1844426A2/en
Publication of EP1844426A4 publication Critical patent/EP1844426A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1468—Optical investigation techniques, e.g. flow cytometry with spatial resolution of the texture or inner structure of the particle
    • G01N15/147—Optical investigation techniques, e.g. flow cytometry with spatial resolution of the texture or inner structure of the particle the analysis being performed on a sample stream
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1429—Signal processing
    • G01N15/1433—Signal processing using image recognition
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06V—IMAGE OR VIDEO RECOGNITION OR UNDERSTANDING
    • G06V20/00—Scenes; Scene-specific elements
    • G06V20/60—Type of objects
    • G06V20/69—Microscopic objects, e.g. biological cells or cellular parts
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N2015/1497—Particle shape

Landscapes

  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Molecular Biology (AREA)
  • Theoretical Computer Science (AREA)
  • Multimedia (AREA)
  • Biomedical Technology (AREA)
  • Signal Processing (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
EP06720094.9A 2005-02-01 2006-02-01 Blood analysis using a flow imaging cytometer Withdrawn EP1844426A4 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US64937305P 2005-02-01 2005-02-01
PCT/US2006/003573 WO2006083969A2 (en) 2005-02-01 2006-02-01 Blood analysis using a flow imaging cytometer

Publications (2)

Publication Number Publication Date
EP1844426A2 EP1844426A2 (en) 2007-10-17
EP1844426A4 true EP1844426A4 (en) 2016-09-07

Family

ID=36777881

Family Applications (1)

Application Number Title Priority Date Filing Date
EP06720094.9A Withdrawn EP1844426A4 (en) 2005-02-01 2006-02-01 Blood analysis using a flow imaging cytometer

Country Status (3)

Country Link
EP (1) EP1844426A4 (enExample)
JP (1) JP4982385B2 (enExample)
WO (1) WO2006083969A2 (enExample)

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US11243494B2 (en) 2002-07-31 2022-02-08 Abs Global, Inc. Multiple laminar flow-based particle and cellular separation with laser steering
US9164037B2 (en) 2007-01-26 2015-10-20 Palo Alto Research Center Incorporated Method and system for evaluation of signals received from spatially modulated excitation and emission to accurately determine particle positions and distances
JP5013410B2 (ja) * 2007-03-14 2012-08-29 独立行政法人産業技術総合研究所 微粒子測定方法及び装置
DK2156370T3 (da) * 2007-05-14 2012-01-23 Historx Inc Kompartmentadskillelse ved pixelkarakterisering under anvendelse af billeddata-clustering
US7907271B2 (en) 2007-06-15 2011-03-15 Historx, Inc. Method and system for standardizing microscope instruments
CA2604317C (en) 2007-08-06 2017-02-28 Historx, Inc. Methods and system for validating sample images for quantitative immunoassays
CA2596204C (en) 2007-08-07 2019-02-26 Historx, Inc. Method and system for determining an optimal dilution of a reagent
US7782452B2 (en) * 2007-08-31 2010-08-24 Kla-Tencor Technologies Corp. Systems and method for simultaneously inspecting a specimen with two distinct channels
US7978258B2 (en) 2007-08-31 2011-07-12 Historx, Inc. Automatic exposure time selection for imaging tissue
US7817254B2 (en) * 2008-01-30 2010-10-19 Palo Alto Research Center Incorporated Obtaining information from time variation of sensing results
US8629981B2 (en) 2008-02-01 2014-01-14 Palo Alto Research Center Incorporated Analyzers with time variation based on color-coded spatial modulation
FR2935802B1 (fr) * 2008-09-05 2012-12-28 Horiba Abx Sas Procede et dispositif de classification, de visualisation et d'exploration de donnees biologiques
EP2335221B8 (en) 2008-09-16 2016-05-25 Novartis AG Reproducible quantification of biomarker expression
JP5438962B2 (ja) * 2008-12-25 2014-03-12 シスメックス株式会社 細胞画像表示装置
US9129371B2 (en) 2010-06-25 2015-09-08 Cireca Theranostics, Llc Method for analyzing biological specimens by spectral imaging
BR112012033200A2 (pt) * 2010-06-25 2016-12-06 Cellmark Theranostics Llc método para análise de espécimes biológicos por meio de imagem espectral
US9025850B2 (en) 2010-06-25 2015-05-05 Cireca Theranostics, Llc Method for analyzing biological specimens by spectral imaging
US10908066B2 (en) 2010-11-16 2021-02-02 1087 Systems, Inc. Use of vibrational spectroscopy for microfluidic liquid measurement
WO2012135201A1 (en) * 2011-03-31 2012-10-04 Gnubio, Inc. Scalable spectroscopic detection and measurement
CN103649717B (zh) * 2011-06-27 2016-09-07 希森美康株式会社 细胞分析装置
WO2013033271A2 (en) * 2011-08-29 2013-03-07 Derren Barken Method to augment immune system in response to disease or injury
BR112015000018B1 (pt) * 2012-07-05 2021-11-09 Beckman Coulter, Inc Sistema e método automatizado para determinar uma condição de células brancas do sangue em uma amostra biológica
US9690976B2 (en) * 2013-03-11 2017-06-27 Roche Diagnostics Hematology, Inc. Imaging blood cells
CA2907504C (en) * 2013-03-27 2023-01-17 Theranos, Inc. Methods, devices, and systems for sample analysis
EP4027132A1 (en) * 2013-05-28 2022-07-13 ChemoMetec A/S Image cytometer
US8961904B2 (en) 2013-07-16 2015-02-24 Premium Genetics (Uk) Ltd. Microfluidic chip
US11796449B2 (en) 2013-10-30 2023-10-24 Abs Global, Inc. Microfluidic system and method with focused energy apparatus
KR20170039250A (ko) * 2014-08-28 2017-04-10 시스멕스 가부시키가이샤 입자 촬상 장치 및 입자 촬상 방법
EP3259579B1 (en) * 2015-02-19 2022-09-14 1087 Systems, Inc. Scanning infrared measurement system
US10460439B1 (en) 2015-08-12 2019-10-29 Cireca Theranostics, Llc Methods and systems for identifying cellular subtypes in an image of a biological specimen
EP3455789A1 (en) 2016-06-10 2019-03-20 Amnis Corporation A method to combine brightfield and fluorescent channels for cell image segmentation and morphological analysis using images obtained from imaging flow cytometer (ifc)
CN107356515B (zh) * 2017-07-20 2020-04-03 上海睿钰生物科技有限公司 一种荧光图像的荧光强度确定方法和系统
US11314994B2 (en) 2018-01-30 2022-04-26 Riken Mask structure optimization device, mask structure optimization method, and program
FR3078777B1 (fr) * 2018-03-07 2020-11-13 Alain Rousseau Procede d’analyse d’un echantillon biologique contenant des cellules biologiques, et appareil d’analyse pour la mise en œuvre du procede d’analyse
JP7109229B2 (ja) * 2018-03-30 2022-07-29 シスメックス株式会社 フローサイトメーター及び粒子検出方法
JP7678424B2 (ja) 2018-05-10 2025-05-16 学校法人順天堂 画像解析方法、装置、コンピュータプログラム、及び深層学習アルゴリズムの生成方法
BR112020023607A2 (pt) 2018-05-23 2021-02-17 Abs Global, Inc. sistemas e métodos para focalização de partículas em microcanais
EP4245140A3 (en) 2019-04-18 2024-01-17 ABS Global, Inc. System and process for continuous addition of cryoprotectant
JP7381003B2 (ja) * 2019-04-26 2023-11-15 学校法人順天堂 疾患解析を支援する方法、装置、及びコンピュータプログラム、並びにコンピュータアルゴリズムを訓練する方法、装置、及びプログラム
US11628439B2 (en) 2020-01-13 2023-04-18 Abs Global, Inc. Single-sheath microfluidic chip
WO2022024564A1 (ja) * 2020-07-30 2022-02-03 浜松ホトニクス株式会社 判別装置、判別方法、判別プログラム及び記録媒体
JP7633402B2 (ja) 2020-11-23 2025-02-19 エイビーエス グローバル、インコーポレイテッド モジュール式フロー・サイトメトリ・システム及びサンプル処理方法

Citations (4)

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US6259807B1 (en) * 1997-05-14 2001-07-10 Applied Imaging Corp. Identification of objects of interest using multiple illumination schemes and finding overlap of features in corresponding multiple images
US20040021868A1 (en) * 1999-01-25 2004-02-05 Ortyn William E. Imaging and analyzing parameters of small moving objects such as cells
WO2004088574A1 (en) * 2003-04-02 2004-10-14 Amersham Biosciences Uk Limited Method of, and computer software for, classification of cells into subpopulations
US20040229210A1 (en) * 1999-05-14 2004-11-18 Cytokinetics, Inc. Method and apparatus for predictive cellular bioinformatics

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JPS62134559A (ja) * 1985-12-07 1987-06-17 Japan Spectroscopic Co 血液細胞自動分析方法および装置
WO2002101339A2 (en) * 2000-10-12 2002-12-19 Amnis Corporation Imaging and analyzing parameters of small moving objects such as cells

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6259807B1 (en) * 1997-05-14 2001-07-10 Applied Imaging Corp. Identification of objects of interest using multiple illumination schemes and finding overlap of features in corresponding multiple images
US20040021868A1 (en) * 1999-01-25 2004-02-05 Ortyn William E. Imaging and analyzing parameters of small moving objects such as cells
US20040229210A1 (en) * 1999-05-14 2004-11-18 Cytokinetics, Inc. Method and apparatus for predictive cellular bioinformatics
WO2004088574A1 (en) * 2003-04-02 2004-10-14 Amersham Biosciences Uk Limited Method of, and computer software for, classification of cells into subpopulations

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
KORST ET AL: "Nucleated red blood cells: An update on the marker for fetal asphyxia", AMERICAN JOURNAL OF OBSTETRICS & GYNECOLOGY, MOSBY, ST LOUIS, MO, US, vol. 175, no. 4, 1 October 1996 (1996-10-01), pages 843 - 846, XP005453639, ISSN: 0002-9378, DOI: 10.1016/S0002-9378(96)80010-X *

Also Published As

Publication number Publication date
JP2008533440A (ja) 2008-08-21
WO2006083969A2 (en) 2006-08-10
JP4982385B2 (ja) 2012-07-25
WO2006083969A3 (en) 2008-06-26
EP1844426A2 (en) 2007-10-17

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