EP1844105A1 - Procede de production d'un elastomere et elastomere correspondant - Google Patents

Procede de production d'un elastomere et elastomere correspondant

Info

Publication number
EP1844105A1
EP1844105A1 EP06705874A EP06705874A EP1844105A1 EP 1844105 A1 EP1844105 A1 EP 1844105A1 EP 06705874 A EP06705874 A EP 06705874A EP 06705874 A EP06705874 A EP 06705874A EP 1844105 A1 EP1844105 A1 EP 1844105A1
Authority
EP
European Patent Office
Prior art keywords
elastomer
sio
stamp
pdms
structured
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP06705874A
Other languages
German (de)
English (en)
Inventor
Rudolf Merkel
Bernd Hoffmann
Claudia M. Cesa
Nils Hersch
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Forschungszentrum Juelich GmbH
Original Assignee
Forschungszentrum Juelich GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Forschungszentrum Juelich GmbH filed Critical Forschungszentrum Juelich GmbH
Publication of EP1844105A1 publication Critical patent/EP1844105A1/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G03—PHOTOGRAPHY; CINEMATOGRAPHY; ANALOGOUS TECHNIQUES USING WAVES OTHER THAN OPTICAL WAVES; ELECTROGRAPHY; HOLOGRAPHY
    • G03F—PHOTOMECHANICAL PRODUCTION OF TEXTURED OR PATTERNED SURFACES, e.g. FOR PRINTING, FOR PROCESSING OF SEMICONDUCTOR DEVICES; MATERIALS THEREFOR; ORIGINALS THEREFOR; APPARATUS SPECIALLY ADAPTED THEREFOR
    • G03F7/00—Photomechanical, e.g. photolithographic, production of textured or patterned surfaces, e.g. printing surfaces; Materials therefor, e.g. comprising photoresists; Apparatus specially adapted therefor
    • G03F7/0015—Production of aperture devices, microporous systems or stamps
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y10/00—Nanotechnology for information processing, storage or transmission, e.g. quantum computing or single electron logic
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y40/00—Manufacture or treatment of nanostructures
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L83/00—Compositions of macromolecular compounds obtained by reactions forming in the main chain of the macromolecule a linkage containing silicon with or without sulfur, nitrogen, oxygen or carbon only; Compositions of derivatives of such polymers
    • C08L83/04—Polysiloxanes
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09D—COATING COMPOSITIONS, e.g. PAINTS, VARNISHES OR LACQUERS; FILLING PASTES; CHEMICAL PAINT OR INK REMOVERS; INKS; CORRECTING FLUIDS; WOODSTAINS; PASTES OR SOLIDS FOR COLOURING OR PRINTING; USE OF MATERIALS THEREFOR
    • C09D183/00—Coating compositions based on macromolecular compounds obtained by reactions forming in the main chain of the macromolecule a linkage containing silicon, with or without sulfur, nitrogen, oxygen, or carbon only; Coating compositions based on derivatives of such polymers
    • C09D183/04—Polysiloxanes
    • G—PHYSICS
    • G03—PHOTOGRAPHY; CINEMATOGRAPHY; ANALOGOUS TECHNIQUES USING WAVES OTHER THAN OPTICAL WAVES; ELECTROGRAPHY; HOLOGRAPHY
    • G03F—PHOTOMECHANICAL PRODUCTION OF TEXTURED OR PATTERNED SURFACES, e.g. FOR PRINTING, FOR PROCESSING OF SEMICONDUCTOR DEVICES; MATERIALS THEREFOR; ORIGINALS THEREFOR; APPARATUS SPECIALLY ADAPTED THEREFOR
    • G03F7/00—Photomechanical, e.g. photolithographic, production of textured or patterned surfaces, e.g. printing surfaces; Materials therefor, e.g. comprising photoresists; Apparatus specially adapted therefor
    • G03F7/0002—Lithographic processes using patterning methods other than those involving the exposure to radiation, e.g. by stamping

Definitions

  • the invention relates to a process for producing an elastomer and to an elastomer produced in this way.
  • Elastomers are polymers with rubber-elastic behavior, which can be stretched repeatedly in their length and, after removing the force required for the elongation, return to their original dimensions. Elastomers are wide-meshed, high-polymer materials which do not flow viscously at the service temperature due to the linkage of the individual polymer chains at the crosslinking points.
  • a photoresist is applied to a silicon substrate in a first process step.
  • a structure is generated by means of a stencil mask and exposure to the photosensitive photoresist.
  • positive photoresists arise after removal of the exposed areas with developer free areas on the silicon surface.
  • a stamp with the desired structure in the photoresist is created as the surface of the stamp.
  • the structured surface of the photoresist is then overcoated with the uncrosslinked elastomer.
  • a mixture of vinyl-terminated siloxane as the basic substance of the elastomer and a methylhydrosiloxane Dimethylsiloxane copolymer as cross-linking agent is z. B. suitable.
  • the cross-linking of the two components is usually carried out with the aid of a platinum catalyst by an incubation step at elevated temperatures. This results in cured polydimethylsiloxane (PDMS) on the photoresist.
  • PDMS polydimethylsiloxane
  • the elasticity of the PDMS is regulated by the mixing ratio to the cross-linking agent.
  • the photoresist surface of the stamp and the elastomer are separated from each other.
  • the adhesive properties of the PDMS must be overcome.
  • the elastomer then has an impression of the structure applied by the stamp.
  • microstructured PDMS PDMS
  • the mixing ratio of base substance to crosslinker ranges according to the prior art from about 5: 1 for the production of low elasticities or high Young's modulus (> 1 MPa) up to a maximum of a mixing ratio of about 50: 1 for producing high elasticities or mean Young Modulus ( ⁇ 15 kPa).
  • the method according to the prior art is also disadvantageous for the stamp itself.
  • a residual PDMS remains on the surface of the photoresist. This must therefore be cleaned before it can be used again for the production of microstructured surfaces. The cleaning is due to the low resistance or. good solubility of photoresists over PDMS solvents is difficult.
  • the prior art method is therefore laborious and expensive.
  • the fine structure of the photoresist is often destroyed next to that of the elastomer when the elastomer is dissolved.
  • the object of the invention is to provide a reusable stamp and a method for structuring elastomers, in particular highly deformable elastomers by means of this stamp.
  • the process for producing a patterned elastomer on a substrate provides the elastomer on a patterned SiO 2 surface as a stamp to apply and polymerize, that is to cure. According to the invention, therefore, structured SiO 2 is used as nanostamp.
  • the SiO 2 can be structured by means of lithographic processes. The dimensions are primarily dependent on the structuring process.
  • a silicon substrate can be selected in a first step and oxidized to SiO 2 .
  • up to 5 micrometers of the Si surface can be oxidized to SiO 2 .
  • a photoresist is applied to the SiO 2 and z. B. structured lithographically. In this case, free areas are generated in the photoresist, which extend down to the SiO 2 surface. The structure of the photoresist is then transferred to the SiO 2 .
  • a stamp having such a structured SiO 2 surface is very well suited for minimizing the occurring adhesion forces between the stamp surface and the cross-linked PDMS elastomer.
  • An elastomer applied to the SiO 2 surface and polymerized is advantageous even at very high levels Mixing ratios between the base substance and cross-linking agent of> 40: 1 and in particular> 50: 1 detachable from the SiO 2 surface, without the structure of the SiO 2 stamp or the elastomer is destroyed.
  • Polymerized elastomers having a Young's Modulus ⁇ 15 kPa and even ⁇ 10 kPa are readily manufacturable.
  • the SiO 2 surface of the stamp can be cleaned very well.
  • the stamp is thus reusable. As a result, a significant cost reduction occurs.
  • Structured SiO 2 is therefore particularly well suited for use as a stamp in the production of highly deformable elastomers but also of elastomers in general.
  • a mixture of base substance and cross-linking agent is generally applied to the structure of the SiO 2 stamp and cured by means of PI tine catalysis.
  • the elastomer is separated from the SiO 2 .
  • It can, for. B. vinyl-terminated siloxane can be used as the base substance of the elastomer and methylhydrosiloxane-dimethyl siloxane copolymer as a cross-linking agent.
  • SiO 2 as a stamp, however, it is by no means restricted to these reactants. Rather, any other siloxane can be used.
  • Sioxan are advantageous in comparison to the likewise known acrylamides non-toxic. It is conceivable to apply other elastomers to SiO 2 and harden them.
  • a mixing ratio of base substance to cross-linking agent of> 40: 1 and in particular one of> 50: 1 is set.
  • the SiO 2 stamp can be reused immediately because the structure is retained here. In this way, it is possible to provide elastomers with lateral structures of a few mm to about 500 nm at depth structures of about 10 nm to 4 ⁇ m with a Young's modulus ⁇ 10 kPa. Of course, the stamp can also be used to produce stronger elastomers. After curing, the PDMS is produced in the desired elasticity.
  • the elastomer is made of SiO 2 reduces the surface tension of SiO 2 prior to separation.
  • silanes for. B. Trichloro-perfluorooctylsilane, carried on the surface of the SiO 2 .
  • isopropanol is used to lower the surface tension.
  • Base substance is cross-linked by the low concentration of the copolymer.
  • Unincorporated ground substance adversely affects the elastic properties of the PDMS.
  • An inventive elastomer with high elasticity can be advantageously used as a force sensor.
  • novel applications can be developed by the very soft elastomers, z. B. the examination of heart muscle cells in the course of a drug screening.
  • a silicon substrate is first oxidized. This is done by wet oxidation of the silicon at a temperature of HOO 0 C for a period of 20 to 40 min. As a result, about 300 to 500 nm of the silicon surface are oxidized in depth to silica.
  • a photoresist is applied to the silicon dioxide layer and exposed by means of a shadow mask with the structure of interest (optical lithography). After removal of the mask, the exposed areas of the photoresist are removed (positive photoresists) and the remaining photoresist is on the surface by means of a temperature of 150 0 C for about 30 min. hardened.
  • freely accessible silicon dioxide regions are removed in a subsequent step at a rate of about 45 nm per minute by means of reactive ion etching. This is done by using a mixture of trifluoromethane (CHF3) and tetrafluoromethane (CF4). The structure of the photoresist is transferred into the SiO 2 surface.
  • CHF3 trifluoromethane
  • CF4 tetrafluoromethane
  • the result is a structure in which both the photoresist and in the underlying silicon dioxide layer laterally the same areas were removed.
  • the depth of the structure in the SiO 2 depends on the type and duration of the etching process used.
  • the remaining photoresist areas are finally removed by means of oxygen plasma.
  • the SiO 2 stamp also includes unoxidized silicon below the SiO 2 .
  • trichloro-perfluorooctylsilane is applied to the silicon dioxide surface in vacuo by passive vapor deposition at mixing ratios of> 50: 1 between the base substance and cross-linking agent prior to the application of the elastomer. Due to the highly hydrophobic properties of trichloro-perfluorooctylsilane, the surface tension of the SiO 2 stamp is reduced.
  • the subsequently applied PDMS as a base substance with cross-linking agent is applied in the present embodiment in the ratio of 55: 1 to the SiO 2 surface and polymerized. It adheres to the surface of the stamp due to the low-intensity siliconization. As a result, both can be separated from each other easier in the following.
  • the silane is thus incorporated to reduce the adhesion forces between the silica surface and cross-linked PDMS.
  • FIG. 1 a structured SiO 2 surface is produced (FIG. 1).
  • Each round survey 1 has dimensions of 1, 7 microns in diameter and 300 nm in height.
  • the distance between two elevations 1 in the present example is 1, 6 microns.
  • a highly elastic, microstructured PDMS elastomer is formed (FIG. 2), in which each elevation of the SiO 2 stamp causes a depression 2 of the same dimension.
  • the distance from a recessed center of the microstructure in Elastomer to the next corresponds to 3, 3 microns.
  • the pits are indicated as dark spots in FIG. 2 recognizable.
  • the elastomer has a Young's modulus of about 10 kPa.
  • isopropanol is used as the solvent.
  • the isopropanol serves as a solvent for unpolymerized PDMS and at the same time reduces the surface tension of the PDMS and SiO 2 and the stickiness of the PDMS.
  • Isopropanol is introduced for this purpose in the space between silicon dioxide and polymerized PDMS.
  • Isopropanol is also used for this purpose.
  • the isopropanol diffuses into fully polymerized PDMS regions and releases unpolymerized components out of the network.
  • this process is completed after an incubation period of 10 h.
  • the treatment leads to an approximately 10 to 50% volume reduction and at the same time to fully transparent PDMS elastomer layers, which are then available for further experiments, in particular also for microscopic applications.
  • the invention is not limited thereto.
  • the elastomer produced in this way can be used as a highly sensitive force sensor.
  • z. B Forces of adherent or migrating cells are analyzed.
  • the development of sol cher sensors is z. B. important for the analysis of cell adhesion, cancer cell research and analysis of cardiac muscle therapeutics.
  • the sensors and elastomers according to the invention are proposed.
  • the sensitivity of the elastomer surface is significantly lower than necessary for the mechanical force measurement of myocytes.
  • the elastomer according to the invention thus represents a highly suitable system for the fine analysis of the myocyte function with the addition of therapeutics.
  • the elastomer surfaces are coated with natural, specific proteins, such as extracellular matrix molecules (ECMs), eg. B. with 2 ⁇ g / cm 2 fibronectin.
  • ECMs extracellular matrix molecules
  • the adhesion of myocytes to elastomer surfaces, as well as to glass or plastic surfaces allows.
  • rat heart muscle cells are incubated for 24 hours on ultrathin PDMS elastomer surfaces at a 55: 1 mixing ratio (Young's modulus: 10 kPa).
  • Spontaneously contra-dividing myocardial cells are analyzed by video microscopy using phase contrast and reflection-interference contrast microscopy.
  • FIG. 3 left
  • FIG. 3 right Deformations of the PDMS microstructure around resp. below the L-shaped cell 3 at rest and during impact serve as a basis for the analysis of the forces described above.
  • the dark inclusions in the left half of FIG. 3 represent the cell organelles.
  • elastomers having a Young modulus ⁇ 40 kPa with structures ⁇ 10 ⁇ m are provided by the process according to the invention. Such elastomers are also very relevant for drug screening.

Landscapes

  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Nanotechnology (AREA)
  • General Physics & Mathematics (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Manufacturing & Machinery (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • Theoretical Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Mathematical Physics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Materials Engineering (AREA)
  • Wood Science & Technology (AREA)
  • Micromachines (AREA)
  • Application Of Or Painting With Fluid Materials (AREA)
  • Materials For Medical Uses (AREA)

Abstract

L'invention concerne un procédé permettant de produire nu élastomère structuré. Ledit procédé se caractérise en ce que l'élastomère est appliqué directement sur une surface SiO<SUB>2</SUB> structurée, puis est durci. L'invention permet d'obtenir des élastomères microstructurés à grande capacité de déformation pour capteurs de force, qui s'utilisent dans le cadre de la caractérisation d'agents thérapeutiques.
EP06705874A 2005-02-04 2006-02-01 Procede de production d'un elastomere et elastomere correspondant Withdrawn EP1844105A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102005005121A DE102005005121A1 (de) 2005-02-04 2005-02-04 Verfahren zur Herstellung eines Elastomers und Elastomer
PCT/DE2006/000144 WO2006081798A1 (fr) 2005-02-04 2006-02-01 Procede de production d'un elastomere et elastomere correspondant

Publications (1)

Publication Number Publication Date
EP1844105A1 true EP1844105A1 (fr) 2007-10-17

Family

ID=36572020

Family Applications (1)

Application Number Title Priority Date Filing Date
EP06705874A Withdrawn EP1844105A1 (fr) 2005-02-04 2006-02-01 Procede de production d'un elastomere et elastomere correspondant

Country Status (5)

Country Link
US (1) US20090022896A1 (fr)
EP (1) EP1844105A1 (fr)
JP (1) JP2008529016A (fr)
DE (1) DE102005005121A1 (fr)
WO (1) WO2006081798A1 (fr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010230599A (ja) * 2009-03-28 2010-10-14 Tokyo Univ Of Agriculture & Technology 圧力センサ
DE102009049454A1 (de) 2009-10-14 2011-04-21 Forschungszentrum Jülich GmbH Vorrichtung zur Untersuchung von Zellen mit einem Elastomer sowie Verwendung der Vorrichtung
US8733702B1 (en) 2009-12-02 2014-05-27 The Boeing Company Reduced solar absorptivity applique
US8739169B2 (en) 2010-04-20 2014-05-27 International Business Machines Corporation Method for monitoring operating experiences of images to improve workload optimization in cloud computing environments
DE102010026490A1 (de) * 2010-07-07 2012-01-12 Basf Se Verfahren zur Herstellung von feinstrukturierten Oberflächen
DE102011050490B4 (de) * 2011-05-19 2020-08-13 Ludwig-Maximilians-Universität München Kraftsensor und dessen Verwendung zur Bestimmung von Zellkräften
US20140326400A1 (en) * 2013-05-01 2014-11-06 Ismail Emre ARACI Robust monolithic micromechanical valves for high density microfluidic very large scale integration
JP6418446B2 (ja) * 2013-12-27 2018-11-07 国立大学法人大阪大学 接触物体が発生する力を可視化および／または定量化するための表面改質方法およびこれを用いたスクリーニング方法、ならびにこれら方法に用いるキット

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3415850B2 (ja) * 1995-08-04 2003-06-09 インターナシヨナル・ビジネス・マシーンズ・コーポレーシヨン リソグラフィによる表面または薄層の改変
US7144616B1 (en) * 1999-06-28 2006-12-05 California Institute Of Technology Microfabricated elastomeric valve and pump systems
EP1194693B1 (fr) * 1999-06-28 2006-10-25 California Institute Of Technology Obturateur elastomere micro-usine et systemes de pompe
DE19930782A1 (de) * 1999-07-03 2001-01-04 Bosch Gmbh Robert Verfahren zum selektiven Beschichten keramischer Oberflächenbereiche
US20030086333A1 (en) * 2001-11-05 2003-05-08 Constantinos Tsouris Electrohydrodynamic mixing on microfabricated devices
JP2003178642A (ja) * 2001-12-11 2003-06-27 Polymatech Co Ltd キーパッド及びその架橋硬化性樹脂層の分離方法
DE10206420A1 (de) * 2002-02-15 2003-08-28 Infineon Technologies Ag Bedruckter Probenträger, ein Verfahren zu dessen Herstellung sowie dessen Verwendung
SE0403091D0 (sv) * 2004-12-20 2004-12-20 Amo Groningen Bv New composition for injectable ophtalmic lenses

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See references of WO2006081798A1 *

Also Published As

Publication number Publication date
WO2006081798A1 (fr) 2006-08-10
US20090022896A1 (en) 2009-01-22
DE102005005121A1 (de) 2006-08-17
JP2008529016A (ja) 2008-07-31

Similar Documents

Publication Publication Date Title
WO2006081798A1 (fr) Procede de production d&#39;un elastomere et elastomere correspondant
DE69013764T2 (de) Kontrolle der Zellanordnung.
DE3687790T2 (de) Immobilisierte enzym-membrane fuer einen halbleiterdetektor und deren herstellungsverfahren.
DE602004013338T2 (de) Stempel für die sanfte Lithographie, insbesondere für das Mikro-Kontaktdruckverfahren und Verfahren zu seiner Herstellung
DE69524247T2 (de) Stempel für lithographie-verfahren
EP0546427B1 (fr) Microsoupape et son procédé de fabrication
DE68905784T2 (de) Verfahren zur Herstellung eines mehrfachen, ionenselektiven Membransensors.
EP1786572A1 (fr) Substrats a surface structuree et production desdits substrats
EP0727639B1 (fr) Procédé de représentation de différences chimiques à l&#39;aide d&#39;un microscope à force atomique
DE3337303C2 (de) Verfahren zur photolithographischen Erzeugung von feinen Resistmustern und hierfür verwendbare lichtempfindliche Gemische
DE69127796T2 (de) Verfahren zur Modifizierung von Oberflächen
DE69400675T2 (de) Verfahren zur Herstellung von Resiststrukturen
DE2446930A1 (de) Verfahren zur herstellung einer negativen aetzmaske durch polymerisation mittels energiereicher strahlung
EP0920618B1 (fr) Nouveaux types de films minces pour la technique des microsystemes et la microstructuration, et leur utilisation
WO2017092859A1 (fr) Corps polymère microstructuré, microbioréacteur et procédés pour les réaliser
WO1997027608A1 (fr) Matrice noire (black matrix) pour tubes image couleur et son procede de production
DE102008035866A1 (de) Verfahren zur Herstellung von einer Replik einer funktionalen Oberfläche
BE1030374B1 (de) Verfahren zur herstellung von kohlenstoffnanomaterialmustern auf substrat mit oberflächenmikrostruktur und flexiblem leitfähigen material
DE102022117029B3 (de) Dehnbare photonische Kristallplatte und Verfahren zu deren Herstellung
DE102018127812B4 (de) Kontaktlinse mit einer Oberflächenbeschichtung und Herstellungsverfahren
EP1430361B1 (fr) Carl en bioelectronique : liaison a un substrat au moyen d&#39;une couche conductrice
WO2005038525A1 (fr) Dispositif tampon pour lithographie douce et procede de fabrication associe
DE102019001137B3 (de) Gemusterte, dendrimere Substratoberflächen sowie deren Herstellung und Verwendung
WO2024160783A1 (fr) Production d&#39;électrodes tridimensionnelles au moyen d&#39;un dépôt électrochimique assisté par gabarit
DE102023102257A1 (de) Herstellung dreidimensional strukturierten elektrodenlagen, insbesondere im kirigami-prinzip

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 20070711

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR

RIN1 Information on inventor provided before grant (corrected)

Inventor name: CESA, CLAUDIA, M.

Inventor name: HOFFMANN, BERND

Inventor name: HERSCH, NILS

Inventor name: MERKEL, RUDOLF

17Q First examination report despatched

Effective date: 20080122

DAX Request for extension of the european patent (deleted)
STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION HAS BEEN WITHDRAWN

18W Application withdrawn

Effective date: 20110209