EP1841424A4 - SYNTHESIS OF ARYL PYRROLIDONES - Google Patents

SYNTHESIS OF ARYL PYRROLIDONES

Info

Publication number
EP1841424A4
EP1841424A4 EP06719887A EP06719887A EP1841424A4 EP 1841424 A4 EP1841424 A4 EP 1841424A4 EP 06719887 A EP06719887 A EP 06719887A EP 06719887 A EP06719887 A EP 06719887A EP 1841424 A4 EP1841424 A4 EP 1841424A4
Authority
EP
European Patent Office
Prior art keywords
synthesis
pyrrolidones
aryl
aryl pyrrolidones
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP06719887A
Other languages
German (de)
English (en)
French (fr)
Other versions
EP1841424A2 (en
Inventor
Yun He
David Woodmanse
Ha-Soon Choi
Zhicheng Wang
Baogen Wu
Nguyen Truc Ngoc
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
IRM LLC
Original Assignee
IRM LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by IRM LLC filed Critical IRM LLC
Publication of EP1841424A2 publication Critical patent/EP1841424A2/en
Publication of EP1841424A4 publication Critical patent/EP1841424A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C07D207/263—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms
    • C07D207/27—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Virology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
EP06719887A 2005-01-28 2006-01-30 SYNTHESIS OF ARYL PYRROLIDONES Withdrawn EP1841424A4 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US64803905P 2005-01-28 2005-01-28
PCT/US2006/003240 WO2006081562A2 (en) 2005-01-28 2006-01-30 Synthesis of aryl pyrrolidones

Publications (2)

Publication Number Publication Date
EP1841424A2 EP1841424A2 (en) 2007-10-10
EP1841424A4 true EP1841424A4 (en) 2010-01-27

Family

ID=36741151

Family Applications (1)

Application Number Title Priority Date Filing Date
EP06719887A Withdrawn EP1841424A4 (en) 2005-01-28 2006-01-30 SYNTHESIS OF ARYL PYRROLIDONES

Country Status (10)

Country Link
EP (1) EP1841424A4 (https=)
JP (1) JP2008528625A (https=)
KR (1) KR100890696B1 (https=)
CN (1) CN101111246A (https=)
AU (1) AU2006209241B2 (https=)
BR (1) BRPI0607294A2 (https=)
CA (1) CA2593816A1 (https=)
MX (1) MX2007008974A (https=)
RU (1) RU2007132260A (https=)
WO (1) WO2006081562A2 (https=)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2012013197A (es) 2010-05-12 2013-04-03 Abbvie Inc Inhibidores de indazol de cinasa.
CN101979378B (zh) * 2010-10-13 2012-06-27 中国科学院上海有机化学研究所 一种手性γ-内酰胺化合物的合成方法
RU2485100C1 (ru) * 2012-02-07 2013-06-20 Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Пермский государственный национальный исследовательский университет" 1-арил-4-бензоил-3-гидрокси-5-метоксикарбонил-2,5-дигидро-1н-пиррол-2-оны, проявляющие анальгетическую активность, и способ их получения
US11589583B2 (en) 2013-12-03 2023-02-28 Fmc Corporation Pyrrolidinones herbicides
MX2016007259A (es) 2013-12-03 2016-08-04 Du Pont Pirrolidinonas como herbicidas.
US9944602B2 (en) 2014-07-02 2018-04-17 E. I. Du Pont De Nemours And Company Piperidinone herbicides
EP3230264B1 (en) 2014-12-08 2019-09-11 FMC Corporation 3-oxo-3-(arylamino)propanoates, a process for their preparation, and their use in preparing pyrrolidinones
EP3280709B1 (en) 2015-04-10 2021-05-26 FMC Corporation Substituted cyclic amides as herbicides
CN107531658B (zh) 2015-04-27 2021-07-27 Fmc公司 作为除草剂的丁内酯
PL3294743T3 (pl) 2015-05-12 2020-03-31 Fmc Corporation Podstawione arylem związki bicykliczne jako środki chwastobójcze
WO2016196019A1 (en) 2015-05-29 2016-12-08 E I Du Pont De Nemours And Company Substituted cyclic amides as herbicides
CN107709310B (zh) 2015-06-02 2021-09-24 Fmc公司 取代的环酰胺及其作为除草剂的用途
CN108137512B (zh) 2015-07-31 2022-05-31 Fmc公司 用作除草剂的环状n-酰胺化合物
CA3047724A1 (en) 2016-12-21 2018-06-28 Fmc Corporation Nitrone herbicides
WO2018175231A1 (en) 2017-03-21 2018-09-27 Fmc Corporation Herbicidal mixture, composition and method
CA3057297A1 (en) 2017-03-21 2018-09-27 Fmc Corporation Pyrrolidinones and a process to prepare them
AR111839A1 (es) 2017-05-30 2019-08-21 Fmc Corp Lactamas 3-sustituidas herbicidas
AR111967A1 (es) 2017-05-30 2019-09-04 Fmc Corp Amidas herbicidas
MX2023003841A (es) * 2020-10-06 2023-06-23 De Shaw Res Llc Compuestos lactámicos como bloqueadores del canal agitador de potasio kv1.3.

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3956314A (en) * 1970-07-24 1976-05-11 U.C.B., Societe Anonyme Derivatives of 2-pyrrolidinone
WO2004037784A2 (en) * 2002-10-21 2004-05-06 Irm Llc Pyrrolidones with anti-hiv activity
WO2006081554A2 (en) * 2005-01-28 2006-08-03 Irm Llc Phenyl-substituted pyrrolidones

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3058986A (en) * 1962-10-16 N-ammoalkyl-x-phenyl-x-lower alkyl-z-
US3956914A (en) * 1974-11-14 1976-05-18 The Marison Company Spin lathe
JP2002363160A (ja) * 2001-06-05 2002-12-18 Sumitomo Chem Co Ltd 光学活性４−アリール−２−ピペリジノン類の製造方法
JP4351859B2 (ja) * 2003-04-14 2009-10-28 三菱レイヨン株式会社 光学活性β−アリ−ル化合物の製造法

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3956314A (en) * 1970-07-24 1976-05-11 U.C.B., Societe Anonyme Derivatives of 2-pyrrolidinone
WO2004037784A2 (en) * 2002-10-21 2004-05-06 Irm Llc Pyrrolidones with anti-hiv activity
WO2006081554A2 (en) * 2005-01-28 2006-08-03 Irm Llc Phenyl-substituted pyrrolidones

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
KEITH FAGNOU AND MARK LAUTENS: "Rhodium-catalyzed carbon-carbon bond forming reactions of organometallic compounds", CHEMICAL REVIEWS, vol. 103, no. 1, 2003, pages 169 - 196, XP002559949 *
MARK LAUTENS ET AL: "Rhodium-catalyzed Heck-type coupling of boronic acids with activated alkenes in an aqueous emulsion", SYNTHESIS, no. 12, 2004, pages 2006 - 2014, XP001205153, ISSN: 0039-7881 *
RYO SHINTANI ET AL: "Chiral norbornadienes as efficient ligands for the rhodium-catalyzed asymmetric 1,4-addition of arylboronic acids to fumaric and maleic compounds", ORGANIC LETTERS, vol. 6, no. 19, 2004, pages 3425 - 3427, XP002559905 *
TAICHI SENDA ET AL: "Rhodium-catalyzed asymmetric 1,4-addition of organoboron reagents to 5,6-dihydro-2(1H)-pyridinones. Asymmetric synthesis of 4-aryl-2-piperidinones", JOURNAL OF ORGANIC CHEMISTRY, vol. 66, no. 21, 2001, pages 6852 - 6856, XP002977097, ISSN: 0022-3263 *
TAMIO HAYASHI AND KAORI YAMASAKI: "Rhodium-catalyzed asymmetric 1,4-addition and its related asymmetric reactions", CHEMICAL REVIEWS, vol. 103, no. 8, 2003, pages 2829 - 2844, XP002559950 *

Also Published As

Publication number Publication date
WO2006081562A3 (en) 2006-10-19
KR20070097555A (ko) 2007-10-04
CN101111246A (zh) 2008-01-23
JP2008528625A (ja) 2008-07-31
WO2006081562A2 (en) 2006-08-03
AU2006209241A1 (en) 2006-08-03
AU2006209241B2 (en) 2009-10-22
EP1841424A2 (en) 2007-10-10
MX2007008974A (es) 2007-09-18
RU2007132260A (ru) 2009-03-10
BRPI0607294A2 (pt) 2009-08-25
CA2593816A1 (en) 2006-08-03
KR100890696B1 (ko) 2009-03-26

Similar Documents

Publication Publication Date Title
PT1778618E (pt) Síntese de trietilenotetraminas
GB0504994D0 (en) Novel compounds
EP1841424A4 (en) SYNTHESIS OF ARYL PYRROLIDONES
GB0517414D0 (en) Chemical synthesis
PL2468724T3 (pl) Synteza związków pirolidynowych
IL185439A0 (en) Synthesis of oligonucleotides
EP1711484A4 (en) SYNTHESIS OF CYANOIMINO-BENZOIMIDAZOLES
GB0516469D0 (en) Novel compounds
GB0504314D0 (en) Novel polymorph
IL189547A0 (en) Synthesis of 1??-fluoro-25-hydroxy
IL187856A0 (en) ??-lactam synthesis
GB0614245D0 (en) Synthesis process
TWI368621B (en) Stereoselective synthesis of β-nucleosides
GB0618703D0 (en) Synthesis of leikotriene compounds
EP1869026A4 (en) NEW CONNECTIONS
IL178184A0 (en) Synthesis of pyrrole-2-carbonitriles
GB0614246D0 (en) Synthesis process
HK1108386A (en) Synthesis of aryl pyrrolidones
PT1899354E (pt) Síntese de desoxibiotinil-hexametilenodiaminadota
PL2076521T3 (pl) Sposób otrzymywania sililopodstawionych 1,2 alkinów
TWM291553U (en) Improved structure of fan-free mini-computer
SI1709057T1 (sl) Sinteza spongozina
GB0514321D0 (en) Synthesis
GB0510013D0 (en) Interaction of SNEV
HUP0500461A3 (en) Pyperazine derivatives of alkyl-oxindoles

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 20070727

AK Designated contracting states

Kind code of ref document: A2

Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR

DAX Request for extension of the european patent (deleted)
REG Reference to a national code

Ref country code: HK

Ref legal event code: DE

Ref document number: 1108386

Country of ref document: HK

RIC1 Information provided on ipc code assigned before grant

Ipc: C07D 207/27 20060101AFI20091217BHEP

A4 Supplementary search report drawn up and despatched

Effective date: 20100104

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 20100401

REG Reference to a national code

Ref country code: HK

Ref legal event code: WD

Ref document number: 1108386

Country of ref document: HK