EP1802374A1 - Produits de nettoyage et d'hygiene bucco-dentaire reduisant la mauvaise haleine et assurant le detartrage des dents - Google Patents

Produits de nettoyage et d'hygiene bucco-dentaire reduisant la mauvaise haleine et assurant le detartrage des dents

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Publication number
EP1802374A1
EP1802374A1 EP05785721A EP05785721A EP1802374A1 EP 1802374 A1 EP1802374 A1 EP 1802374A1 EP 05785721 A EP05785721 A EP 05785721A EP 05785721 A EP05785721 A EP 05785721A EP 1802374 A1 EP1802374 A1 EP 1802374A1
Authority
EP
European Patent Office
Prior art keywords
weight
oral
dental care
sodium
tooth surface
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP05785721A
Other languages
German (de)
English (en)
Inventor
Ullrich Bernecker
Adolf Peter Barth
Wilfried Howorka
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Henkel AG and Co KGaA
Original Assignee
Henkel AG and Co KGaA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Henkel AG and Co KGaA filed Critical Henkel AG and Co KGaA
Publication of EP1802374A1 publication Critical patent/EP1802374A1/fr
Withdrawn legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34—Alcohols
    • A61K8/345—Alcohols containing more than one hydroxy group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/25—Silicon; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses

Definitions

  • the invention relates to preparations for oral and dental care and cleaning, which act tooth smoothing due to special ingredients, have a high cleaning performance, without scratching the tooth surface or to be very abrasive and beyond the Disease of halitosis and reduce bad breath.
  • Dentifrices are in various forms on the market and serve primarily the cleaning of the tooth surface and the prevention of dental and Zahn ⁇ meat diseases. They usually contain a combination of polishing agents, humectants, surfactants, binders, flavorings and fluoride-containing and antimicrobial agents. In addition to toothpowder, which play a minor role because of their increased abrasiveness, dentifrices are mainly offered in paste, cream and translucent or transparent gel form. Liquid or liquid toothpastes and mouthwashes have also become increasingly important in recent years.
  • the present invention has for its object to provide preparations for oral and dental care and cleaning, combine the advantages in terms of cleaning performance with low abrasiveness and reduced scratching of the tooth surface.
  • the products should smooth the tooth surface and counteract bad breath.
  • the present invention relates in a first embodiment to oral and dental care and cleaning compositions comprising a) at least 10% by weight of sorbitol and / or glycerol and / or 1,2-propylene glycol; b) at least 0.25% by weight of at least one bioactive glass.
  • Oral and dental care products as well as mouth and tooth cleaning agents in the sense of the invention are mouthwashes and toothpowder, oral and toothpastes, liquid mouthwashes and toothpastes as well as oral and dental gels.
  • toothpastes and liquid dentifrices are suitable.
  • the oral and dental care and cleaning agents for example in the form of toothpastes, liquid toothpastes, tooth powders, mouthwashes or possibly also as gum, z. B. as chewing gum, present.
  • they are present as more or less flowable or plastic toothpastes, as they are used for cleaning the teeth using a toothbrush.
  • compositions of the invention contain as the first essential ingredient at least 10 wt .-% sorbitol and / or glycerol and / or 1, 2-propylene glycol, which - unless expressly stated otherwise - all wt .-% - information in the context of the present invention refer to the entire preparation.
  • Sorbitol (also referred to as glucitol) is a sugar alcohol of glucose, ie, a hexitol sorbitol can be prepared by hydrogenation of glucose, is intramolecularly relatively easy to split-one or two molecules of water, and forms cyclic ethers
  • Glycerol (1,2,3-propanetriol, 1,2,3-trihydroxypropane, glycerol, oil sweet, INCI name: Glycerin, E 422) is a colorless, clear, heavy-bodied, odorless, sweet-tasting, hygroscopic liquid that combines with water and alcohol is miscible in any ratio.
  • Glycerol can be defined by the formula
  • glycerol was originally as a by-product of fat saponification.
  • Today's technical processes are based on propene, which is processed via the intermediates allyl chloride and epichlorohydrin to glycerol.
  • Another one technical process is the hydroxylation of allyl alcohol with hydrogen peroxide at the WO 3 contact via the step of the glycide.
  • 1, 2-Propylene glycol (1, 2-propanediol) is a colorless and highly hygroscopic liquid which is miscible in any ratio with water and alcohols (such as methanol, ethanol, propanols, butanols).
  • Technical 1,2-propanediol is a racemate of (-) - (R) - and (+) - (S) -1, 2-propylene glycol.
  • the preparation is carried out by direct hydrolysis of propylene oxide. Because 1, 2-P. further reacted with propylene oxide, thereby forming a mixture of 1, 2 and tripropylene glycol, which must be separated by distillation.
  • 1,2-propylene glycol can also be made from renewable resources via three different routes: a) catalytic hydrogenation of sugars; b) fermentation of sugars to lactic acid and then hydrogenation of the lactic acid ester; c) direct fermentation of sugars.
  • compositions according to the invention are characterized in that they contain from 12 to 60% by weight, preferably from 15 to 50% by weight, particularly preferably from 17 to 40% by weight and in particular from 20 to 35% by weight. -% sorbitol and / or glycerol and / or 1, 2-propylene glycol.
  • sorbitol is preferred.
  • mixtures of two of the three or all three may be preferred.
  • a mixture of glycerol, sorbitol and 1,2-propylene glycol in a weight ratio of 1: (0.5-1): (0.1-0.5) has proved particularly advantageous.
  • compositions according to the invention contain at least 0.25% by weight of at least one bioactive glass.
  • biologically active glasses encompasses glasses which are biologically active and / or biologically active
  • the biological effectiveness of a glass can be demonstrated in its antimicrobial properties, for example, biologically active glass differs from conventional lime-sodium silicate - Glass by bonding living tissue, for example, a glass that forms a firm bond with body tissue, forming a hydroxyapatite layer, or a glass under bioactive glass understood that shows antimicrobial and / or anti-inflammatory activity.
  • the glass powders show a biocidal or biostatic effect against bacteria, fungi and viruses; are in contact with humans skin-friendly, toxicologically safe and especially suitable for consumption.
  • compositions of the invention contain bioactive glass or glass powder or glass ceramic powder or composite materials comprising such a bioactive glass.
  • glass powders are also understood as meaning granules and glass beads.
  • At least 0.25% by weight of at least one bioactive glass is contained in the oral and dental care and cleaning compositions.
  • Preferred oral and dental care and cleaning agents according to the invention are characterized in that they contain from 0.2 to 20% by weight, preferably from 0.4 to 14% by weight, particularly preferably from 0.5 to 3% by weight and in particular 0.6 to 2 wt .-% of at least one bioactive glass.
  • the glass powder should be particularly pure.
  • the burden of heavy metals is preferably low.
  • the maximum concentration in the range of cosmetic formulations is preferably for Pb ⁇ 20 ppm, Cd ⁇ 5 ppm, As ⁇ 5 ppm, Sb ⁇ 10 ppm, Hg ⁇ 1 ppm, Ni ⁇ 10 ppm.
  • the unfused starting glass which is directly contained in the compositions according to the invention or is optionally used for the production of a glass ceramic which can be used according to the invention, contains SiO 2 as a network former, preferably between 35-80% by weight. At lower concentrations, the spontaneous tendency to crystallize increases greatly and the chemical resistance decreases sharply. At higher SiO 2 values, the crystallization stability may decrease and the processing temperature is significantly increased, so that the hot-forming properties deteriorate. Na 2 O is used as a flux when melting the glass. At concentrations of less than 5%, the melting behavior is adversely affected.
  • Sodium is part of the at the Ceramization forming phases and, if high crystalline phase proportions are to be set by the ceramization, must be contained in correspondingly high concentrations in the glass.
  • K 2 O acts as a flux when melting the glass.
  • potassium is released in aqueous systems. If high potassium concentrations are present in the glass, potassium-containing phases such as calcium silicates are also eliminated.
  • the P 2 O 5 content of silicate glasses, glass ceramics or composites can be used to adjust the chemical resistance of the glass and thus the release of ions in aqueous media.
  • P 2 O 5 is network images.
  • the P 2 O 5 content is preferably between 0 and 80 wt .-%.
  • the glass may contain up to 25% by weight of B 2 O 3 .
  • Al 2 O 3 is used to adjust the chemical resistance of the glass.
  • the antibacterial properties of the glass-ceramic antimicrobial acting ions such as Ag, Au, I, Ce, Cu, Zn in concentrations less than 5 wt .-% may be included.
  • Coloring ions such as Mn, Cu, Fe, Cr, Co, V, may be contained individually or in combination, preferably in a total concentration less than 1 wt .-%.
  • the glass or the glass ceramic is used in powder form.
  • the ceramization can be done either with a glass block or Glasribbons or with glass powder. After ceramization, the glass ceramic blocks or ribbons must be ground to powder. If the powder has been ceramified, it may also be necessary to re-mill to remove agglomerates formed during the ceramification step.
  • the grinding can be carried out both dry and in aqueous or non-aqueous grinding media.
  • the particle sizes are less than 500 microns. As appropriate, particle sizes ⁇ 100 microns or ⁇ 20 microns have been found. Particularly suitable are particle sizes ⁇ 10 microns and less than 5 microns and less than 2 microns, see below.
  • the bioactive glasses or glass powder or glass ceramic powder or composite compositions contained in the compositions according to the invention comprise glasses which preferably comprise the following components: SiO 2 : 35-80% by weight, Na 2 O: 0-35% by weight, P 2 O 5 : 0-80% by weight, MgO: 0-5% by weight, Ag 2 O: 0-0.5% by weight, AgJ: 0-0.5% by weight, NaI: 0-5 wt.%, TiO 2 : 0-5 wt.%, K 2 O: 0-35 wt.%, ZnO: 0-10 wt.%, Al 2 O 3 : 0-25 wt % and B 2 O 3 : 0-25% by weight.
  • the base glass according to the above composition to achieve further effects such as color or UV filtering ions such as Fe, Co, Cr, V, Ce, Cu, Mn, Ni, Bi, Sn, Ag, Au, J individually or in total to be added to 10 wt .-%.
  • color or UV filtering ions such as Fe, Co, Cr, V, Ce, Cu, Mn, Ni, Bi, Sn, Ag, Au, J individually or in total to be added to 10 wt .-%.
  • a further glass composition may be as follows: SiO 2 : 35-80 wt%, Na 2 O: 0-35 wt%, P 2 O 5 : 0-80 wt%, MgO: 0-5 wt %, Ag 2 O: 0-0.5 wt%, AgJ: 0-0.5 wt%, NaJ: 0-5 wt%, TiO 2 : 0-5 wt% , K 2 O: 0-35 wt .-%, ZnO: 0-10 wt .-%, Al 2 O 3 : 0-25 wt .-%, B 2 O 3 : 0- 25 wt .-%, SnO : 0-5 wt%, CeO 2 : 0-3 wt% and Au: 0.001-0.1 wt%.
  • SiO 2 35 to 60% by weight, preferably 40 to 60% by weight
  • MgO 0 to 10% by weight, preferably 0 to 5% by weight
  • CaO 0 to 35% by weight, preferably 5 to 30% by weight
  • Al 2 O 3 0 to 25 wt .-%, preferably 0 to 5 wt .-%,
  • B 2 O 3 0 to 25 wt .-%, preferably 0 to 5 wt .-%,
  • TiO 2 O to 10 wt .-%, preferably 0.1 to 5 wt .-%.
  • the bioactive glass is preferably used in particulate form.
  • the antimicrobial glass particle sizes ⁇ 10 .mu.m, preferably from 0.5 to 4 .mu.m, more preferably from 1 to 2 microns having.
  • the oral and dental care and cleaning compositions according to the invention may contain, in addition to the aforementioned essential ingredients, other ingredients of oral cleansers, oral hygiene products, dentifrices and / or dentifrices.
  • the preferred further ingredients are described below.
  • the oral and dental care and cleaning agents according to the invention in particular the toothpastes, z. B. antimicrobial substances as preservatives or as Contain antiplaque agents.
  • Such substances may, for. B. be selected from p-Hydroxybenzoeklaremethyl-, ethyl or propyl, sodium sorbate, sodium benzoate, bromochlorophene, triclosan, phenyl salicylates, biguanides z.
  • substances may, for. B. be selected from p-Hydroxybenzoeklaremethyl-, ethyl or propyl, sodium sorbate, sodium benzoate, bromochlorophene, triclosan, phenyl salicylates, biguanides z.
  • antiplaque agents preferably p-Hydroxybenzoeklaremethyl-, ethyl or propyl esters, sodium sorbate, sodium benzoate, bromochlorophene, triclosan, phenyl Salicylic acid esters, biguanides z.
  • chlorhexidine thymol, preferably in amounts of 0.1 to 5 wt.%, Preferably from 0.25 to 2.5 wt.% And in particular from 0.5 to 1, 5 wt.%, Each based on the total Means, included.
  • ingredients that may be included in the compositions of the invention are the anti-caries agents. These may be selected, for example, from organic or inorganic fluorides, for. Example of sodium fluoride, potassium fluoride, sodium monofluorophosphate and sodium fluorosilicate. Also zinc fluoride, stannous fluoride are preferred. An amount of 0.01-0.2% by weight of fluorine should preferably be present in the form of the compounds mentioned.
  • Oral and dental care and cleaning compositions according to the invention which additionally anti-caries agents, preferably fluorine compound (s), in particular sodium fluoride, potassium fluoride, sodium monofluorophosphate, zinc fluoride, stannous fluoride and sodium fluorosilicate, preferably in amounts of 0.01 to 5 wt.%, Preferably from 0.1 to 2.5 wt.% And in particular from 0.2 to 1, 1 wt.%, Each based on the total agent, are preferred according to the invention.
  • fluorine compound (s) in particular sodium fluoride, potassium fluoride, sodium monofluorophosphate, zinc fluoride, stannous fluoride and sodium fluorosilicate
  • fluorine compound s
  • sodium fluoride potassium fluoride
  • sodium monofluorophosphate sodium fluoride
  • zinc fluoride stannous fluoride
  • sodium fluorosilicate preferably in amounts of 0.01 to 5 wt.%, Preferably from 0.1 to 2.5 wt.% And
  • the oral and dental care and cleaning agents may also contain substances that are effective against tartar.
  • substances may be, for example, chelating agents such.
  • pyrophosphate salts such as the water-soluble dialkali or Tetraalkalimetallpyrophosphat- salts
  • z. B. Na 4 P 2 O 7 , K 4 P 2 O 7 , Na 2 K 2 P 2 O 7 , Na 2 H 2 P 2 O 7 and K 2 H 2 P 2 O 7 or polyphosphate salts
  • the z. B. from water-soluble Alkalimethalltripolyphosphaten as sodium tripolyphosphate and potassium tripolyphosphate can be selected.
  • preferred oral and dental care and cleaning agents are characterized in that they additionally phosphate (s), preferably alkali metal phosphate (s) and in particular sodium tripolyphosphate, preferably in amounts of 1 to 10 wt .-%, particularly preferably from 2 to 8 wt .-% and in particular from 3 to 7 wt .-%, each based on the total agent included.
  • phosphate preferably alkali metal phosphate (s) and in particular sodium tripolyphosphate
  • compositions according to the invention in particular toothpastes or liquid toothpastes, preferably contain one or more polishing agents, usually in an amount of from 5 to 50% by weight.
  • polishing agent are in principle all known for toothpastes friction body, in particular those that do not contain calcium ions.
  • suitable polishing agent components are therefore silicic acids, aluminum hydroxide, aluminum oxide, sodium aluminum silicates, organic polymers or mixtures of such friction bodies.
  • Calcium containing polishing components such as e.g. However, chalk, calcium pyrophosphate, dicalcium phosphate dihydrate can be present in amounts of up to 5% by weight.
  • the total content of polishing agents is preferably in the range of 5 to 50% by weight of the dentifrice.
  • Suitable silicas are e.g. Gel silicas, hydrogel silicas and precipitated silicas.
  • Gel silicas are prepared by reacting sodium silicate solutions with strong, aqueous mineral acids to form a hydrosol, aging to the hydrogel, washing and drying. If the drying is carried out under mild conditions to a water content of 15 to 35 wt .-%, the so-called hydrogel silicic acids are obtained. Drying to water contents below 15% by weight results in an irreversible shrinkage of the previously loose structure of the hydrogel to the dense structure of the so-called xerogel.
  • a second, preferably suitable group of silica polishing agents are the precipitated silicas. These are obtained by precipitation of silica from dilute alkali silicate solutions by addition of strong acids under conditions in which aggregation to the sol and gel can not occur. Suitable methods for preferably suitably a precipitated silica having a BET surface area of 15 - 110 m2 / g, a particle size of 0.5-20 microns, wherein at least 80 wt .-% of the primary particles should be below 5 microns, and a viscosity in 30% glycerol water (1: 1) dispersion of 30 - 60 Pa. s (20 0 C) in an amount of 10 to 20 wt .-% of the toothpaste.
  • Preferred precipitated silicas of this type also have rounded corners and edges and are available under the trade name Sident12 DS (DEGUSSA).
  • polishing agent component e.g. Aluminum oxide in the form of weakly calcined clay containing - and -Aluminiumoxid in an amount of about 1-5 wt .-%.
  • Aluminum oxide in the form of weakly calcined clay containing - and -Aluminiumoxid in an amount of about 1-5 wt .-% is available under the trade designation "Polianton earth P10 finest" (Giulini Chemie).
  • polishing agent As a polishing agent are all further known for toothpastes friction body such.
  • oral and dental care and cleansing compositions according to the invention are preferred which additionally have cleaning bodies, preferably silicic acids, aluminum hydroxide, aluminum oxide, calcium pyrophosphate, chalk, dicalcium phosphate dihydrate (CaHPO 4 .2H 2 O), sodium aluminum silicates, in particular zeolite A, organic Polymers, in particular polymethacrylates or mixtures of these Reib stresses.vorzugieri preferably in amounts of 1 to 30 wt.%, Preferably from 2.5 to 25 wt.% And in particular from 5 to 20 wt.%, Each based on the total agent.
  • cleaning bodies preferably silicic acids, aluminum hydroxide, aluminum oxide, calcium pyrophosphate, chalk, dicalcium phosphate dihydrate (CaHPO 4 .2H 2 O), sodium aluminum silicates, in particular zeolite A, organic Polymers, in particular polymethacrylates or mixtures of these Reib stresses.vorzugieri preferably in amounts of 1 to 30 wt.%, Preferably
  • a carrier for the toothpastes which allows the setting of a suitable consistency for the dosage from tubes, dispensing containers or flexible bottles, is for example a combination of humectants, binders and water.
  • Humectants are, for example, the sorbitol or glycerol or 1,2-propylene glycol contained in the compositions according to the invention.
  • suitable humectants are preferably alcohols having at least 2 OH groups, preferably mannitol, xylitol, polyethylene glycol, polypropylene glycol and mixtures thereof.
  • the (n, n + 1) or (n, n + 2) -diols with non-terminal OH groups can also be used.
  • polyhydroxy compounds having 2 OH groups are also the polyethylene and polypropylene glycols.
  • humectants z B. xylitol, propylene glycols, polyethylene glycols, especially those having average molecular weights of 200-800 are used.
  • the additional humectant (s) may be employed in the compositions of the invention in varying amounts. While depending on the rest optional ingredients amounts of a few% (for example, 1, 2, 3, 4, 5, 6, 7, 8, 9, 10 wt.%, Each based on the total agent) may be included, there are also formulations that significantly higher humectants -Contents have.
  • the total moisture content (including the sorbitol, glycerol and 1,2-propylene glycols contained in the agents according to the invention) is, for example, 50, 55, 60, 65, 70, 75% by weight, in each case based on the total agent.
  • agents according to the invention which contain (including the sorbitol, glycerol and 1,2-propylene glycols contained in the agents according to the invention) between 10 and 75% by weight of humectant. Contents between 15 and 70, preferably between 20 and 60 wt.%, In each case based on the total agent, may be preferred.
  • a consistency regulator serve z.
  • natural and / or synthetic water-soluble polymers such as alginates, carrageenan, tragacanth, starch and starch ethers, cellulose ethers such.
  • Carboxymethylcellulose Na-SaIz
  • hydroxyethylcellulose methylhydroxypropylcellulose, guar, acacia
  • agar xanthan gum
  • succinoglycan gum locust bean gum
  • pectins water-soluble carboxyvinyl polymers
  • polyvinyl alcohol polyvinylpyrrolidone
  • Polyethylene glycols in particular those having molecular weights of 1 500-1 000 000.
  • z. B phyllosilicates
  • montmorillonite clays colloidal thickened silicas such.
  • airgel silicas fumed silicas or finely ground precipitated silicas.
  • viscosity-stabilizing additives from the group of cationic, zwitterionic or ampholytic nitrogenous surfactants, hydroxypropyl-substituted hydrocolloids or polyethylene glycol / polypropylene glycol copolymers having an average molecular weight of 1000 to 5000 or a combination of the compounds mentioned in the toothpastes.
  • Surface-active substances are also present in the toothpastes in support of the cleaning action and, if desired, also for the development of foam in brushing teeth and for stabilizing the polishing body dispersion in the carrier in an amount of 0.1-5% by weight.
  • Suitable surfactants are, for. B. linear sodium alkyl sulfates having 12-18 C atoms in the alkyl group. These substances additionally have an enzyme-inhibiting effect on the bacterial metabolism of the dental plaque.
  • Other suitable surfactants are Alkali metal salts, preferably sodium salts of Alkylpolyglycolethersulfat with 12-16 C atoms in the linear alkyl group and 2-6 glycol ether groups in the molecule, of linear alkane (C 2 - C 18) sulfonate, esters of -Ci ⁇ J-SulfobernsteinklamonoalkyKC ⁇ , of sulfated fatty acid monoglycerides, sulfated fatty acid alkanolamides, sulfoacetic acid alkyl (C 12 -C 16 ) esters, acylsarcosines, acyl taurides and acyl isothionates each having 8-18 C atoms in the acyl group
  • zwitterionic, ampholytic and nonionic surfactants are suitable, for.
  • the oral and dental care products may also contain the insensitivity of the teeth-enhancing substances, such as potassium salts such as potassium nitrate, potassium citrate, potassium chloride, potassium bicarbonate and potassium oxalate.
  • potassium salts such as potassium nitrate, potassium citrate, potassium chloride, potassium bicarbonate and potassium oxalate.
  • compositions according to the invention can also additionally other wound-healing and anti-inflammatory substances, eg. B. agents for gingivitis included.
  • B. agents for gingivitis included Such substances may, for. B. be selected from allantoin, azulen, chamomile extracts, tocopherol, panthenol, bisabolol, sage extracts.
  • non-cationic, bactericidal component e.g. Phenols, resorcinols, bisphenols, salicylanilides and their halogenated derivatives, halogenated carbanilides and p-hydroxybenzoic acid esters.
  • Particularly preferred antimicrobial components are halogenated diphenyl ethers, e.g. 2,4-dichloro-2'-hydroxydiphenyl ether, 4,4'-dichloro-2'-hydroxydiphenyl ether, 2,4,4'-tribromo-2'-hydroxydiphenyl ether and 2,4,4'-trichloro-2'-hydroxydiphenyl ether (triclosan). They are preferably used in amounts of from 0.01 to 1% by weight in the dentifrices according to the invention. Triclosan is particularly preferably used in an amount of 0.01-0.3% by weight.
  • D-panthenol D - (+) - 2,4-dihydroxy-N- (3-hydroxypropyl) -3,3-dimethyl-butyramide exhibits a biological activity corresponding to pantothenic acid.
  • the pantothenic acid (R - (+) - N - (2,4-dihydroxy-3,3-dimethylbutyryl- ⁇ -alanine) is a precursor in the biosynthesis of coenzyme A and is counted to the vitamin B complex (B3).
  • B3 vitamin B complex
  • the dentifrices according to the invention preferably contain 0.05-5% by weight of panthenol or a salt of pantothenic acid.
  • Retinol (3,7-dimethyl-9- (2,6,6-trimethyl-1-cyclohexenyl) -2,4,6,8-nonatetraen-1-ol is the international common name for vitamin A1, but may also be used instead of retinol one of its derivatives having similar biological activity, for example an ester or the retinoic acid (tretinoin), one of its salts or its esters is preferably used, preferably a retinol ester, in particular a fatty acid ester of a fatty acid having 12-22 carbon atoms if retinol palmitate is used, an amount of 0.001 to 0.1% by weight is preferred when using a retinol ester, for example retinol palmitate with an activity of 1.710 6 IU per g When other retinol derivatives are used It is recommended to use at a concentration of 10 3 to 10 6 IU (international units) per 100 g.
  • Preferred dentifrices according to the present invention preferably contain, in addition to polishing agents, fluorine compounds, humectants and binders
  • panthenol or a salt of pantothenic acid 0.05 - 5 wt .-% panthenol or a salt of pantothenic acid
  • a retinol ester preferably retinol palmitate.
  • the agents according to the invention may also contain substances for increasing the mineralizing potential, for example calcium-containing substances such as, for example, Calcium chloride, calcium acetate and dicalcium phosphate dihydrate.
  • concentration of the calcium-containing substance depends on the solubility of the substance and the interaction with other substances contained in the oral and dental care products.
  • the dentifrices according to the invention may contain further adjuvants and additives known per se.
  • An additive which has been known for a long time as a toothpaste component is particularly effective in the dentifrices according to the invention: calcium glycerophosphate, the calcium salt of glycerol-1-phosphoric acid or glycerol-2-phosphoric acid or of the glycerol-1-phosphoric acid enantiomer Glycerol-3-phosphoric acid - or a mixture of these acids.
  • the compound has one in dentifrices remineralizing effect since it provides both calcium and phosphate ions.
  • the dentifrices according to the invention calcium glycerophosphate is preferably used in amounts of 0.01 to 1 wt .-%. Overall, the dentifrices according to the invention may contain customary auxiliaries and additives in amounts of up to 10% by weight.
  • the dentifrices according to the invention may e.g. be improved by the addition of aromatic oils and sweeteners in their organoleptic properties.
  • aroma oils all the natural and synthetic flavors customary for oral and dental care products can be used. Natural flavors can be contained both in the form of the natural essential oils isolated from drugs and the individual components isolated therefrom.
  • Suitable flavors are e.g. Peppermint oil, spearmint oil, eucalyptus oil, aniseed oil, fennel oil, caraway oil, menthyl acetate, cinnamic aldehyde, anethole, vanillin, thymol and mixtures of these components.
  • Suitable sweeteners are e.g. Saccharin sodium, sodium cyclamate, sucrose, lactose, meltose, fructose.
  • Solvents and solubilizers e.g. lower monovalent or multivalent
  • Alcohols or ethers e.g. Ethanol, 1,2-propylene glycol, diethylene glycol or
  • Titanium dioxide e.g. Titanium dioxide
  • Buffer substances e.g. primary, secondary or tertiary alkali metal phosphates or
  • Citric acid / Na citrate other wound healing or antiinflammatory agents, e.g. allantoin,
  • compositions according to the invention are outstandingly suitable for tooth cleaning and care. They gently cleanse the teeth and have the added benefit of smoothing the tooth surface.
  • the compositions according to the invention have distinct advantages: they scratch the tooth surface significantly less than corresponding compositions containing no or less than 0.25 wt % of at least one bioactive glass and / or no or less than 10% by weight of sorbitol and / or glycerine, ⁇ / ⁇ , ⁇ , 2r, propylene glycol.
  • compositions containing no or less than 0.25% by weight of bioactive glass have been compared to compositions containing and containing no or less than 10% by weight of sorbitol and / or glycerol and / or 1,2-propylene glycol
  • compositions containing either no or less than 0.25% by weight of bioactive glass and no or less than 10% by weight of sorbitol and / or glycerol and / or 1,2-propylene glycol have been found to significantly reduce the presence of halitosis.
  • compositions of the invention compared to the comparative compositions more effectively prevent the emergence of new halitosis or that the intensity of the newly developed halitosis after a defined time at the compositions of the invention compared to the comparison compositions is significantly lower.
  • compositions according to the invention are also distinguished by the fact that they combine a high cleaning performance with little damage to the tooth surface.
  • Further objects of the present invention are therefore the use of bioactive glasses to prevent and / or reduce the scratching of the tooth surface and the use of bioactive glasses to reduce abrasion from the tooth surface.
  • the use of bioactive glasses to smooth the tooth surface and / or to prevent and / or reduce halitosis and / or to prevent and / or reduce scratching of the tooth surface and / or to reduce abrasion from the tooth surface is preferably accomplished with glasses, such as described in detail above.
  • Particularly preferred uses according to the invention are therefore characterized in that a bioactive glass is used which, based on its weight, has the following composition:
  • SiO 2 35 to 60% by weight, preferably 40 to 60% by weight
  • MgO 0 to 10% by weight, preferably 0 to 5% by weight
  • TiO 2 O to 10 wt .-%, preferably 0.1 to 5 wt .-%.
  • a composition according to the invention is particularly preferably used in order to achieve the stated advantages. With regard to the other ingredients of such compositions, reference is made to the above statements. Another object of the present invention is therefore the use of a composition according to the invention for smoothing the tooth surface and / or for preventing and / or reducing bad breath and / or for preventing and / or reducing the scratching of the tooth surface and / or for reducing the abrasion of the tooth surface.
  • sorbitol eg Neosorb 70/70 B ®;. 70 wt .-% in water
  • silica z. B. Sident ® 8 and / or Sident ® 22
  • polyethylene glycol MW 1550 (eg poly wax 1550)
  • dye solution eg Brilliant Blue FCF, 1% by weight in water
  • compositions A, B, C and D according to the invention are outstandingly suitable for tooth cleaning and care. They gently cleanse the teeth and have the added benefit of smoothing the tooth surface. They scratch the tooth surface significantly lower than corresponding compositions containing no bioactive glass and / or sorbitol.
  • compositions containing no bioactive glass have been found to have a marked reduction in halitosis over compositions containing no sorbitol and compositions containing both no bioactive glass and sorbitol.
  • the subjects have also agreed that the compositions of the invention over the
  • Comparative compositions prevent the emergence of new halitosis more effective or that the intensity of the newly developed halitosis after a defined time at which the compositions of the invention compared to the comparison compositions is significantly lower.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Inorganic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Emergency Medicine (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Cosmetics (AREA)

Abstract

L'invention concerne des produits de nettoyage et d'hygiène bucco-dentaire qui assurent un bon nettoyage et un détartrage de la surface des dents, sans effet abrasif, et qui sont en outre efficaces contre la mauvaise haleine. Ces produits contiennent au moins 10 % en poids de sorbitol et/ou de glycérine et/ou de 1,2-propylèneglycol ainsi qu'au moins 0,25 % en poids d'au moins un verre bioactif.
EP05785721A 2004-10-18 2005-08-31 Produits de nettoyage et d'hygiene bucco-dentaire reduisant la mauvaise haleine et assurant le detartrage des dents Withdrawn EP1802374A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE200410050954 DE102004050954A1 (de) 2004-10-18 2004-10-18 Zahnglättende und mundgeruchsreduzierende Mund- und Zahnpflege- und reinigungsmittel
PCT/EP2005/009364 WO2006042582A1 (fr) 2004-10-18 2005-08-31 Produits de nettoyage et d'hygiene bucco-dentaire reduisant la mauvaise haleine et assurant le detartrage des dents

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EP1802374A1 true EP1802374A1 (fr) 2007-07-04

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EP (1) EP1802374A1 (fr)
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DE102006060946A1 (de) * 2006-12-20 2008-06-26 Henkel Kgaa Mund- und Zahnpflege- und -reinigungsmittel mit verbesserter Fluoriddeposition
US9386783B2 (en) 2007-07-31 2016-07-12 Südzucker Aktiengesellschaft Mannheim/Ochsenfurt Confectionery products and process for obtaining them
US20090035227A1 (en) * 2007-07-31 2009-02-05 Stephan Hausmanns Confectionery products comprising a tooth-friendly sweetener
AR076178A1 (es) 2009-04-01 2011-05-26 Colgate Palmolive Co Composiciones dentifricas de accion doble para prevenir la hipersensibilidad y promover la remineralizacion
AR076179A1 (es) 2009-04-01 2011-05-26 Colgate Palmolive Co Composicion dentifrica no acuosa con vidrio bioaceptable y bioactivo y metodos de uso y fabricacion de la misma
US20110206749A1 (en) * 2010-02-19 2011-08-25 J.M. Huber Corporation Silica materials for reducing oral malador

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JP3057773B2 (ja) 1991-02-05 2000-07-04 不二製油株式会社 パイの製造方法
GB9502253D0 (en) 1995-02-06 1995-03-29 Giltech Ltd The effects of antibacterial agents on the behaviour of mouse fibroblasts in vitro
IL125560A0 (en) * 1996-01-29 1999-03-12 Univ Maryland A bioactive glass composition and a composition for treating teeth comprising the glass composition
IN191261B (fr) * 1997-09-18 2003-10-18 Univ Maryland
GB0027405D0 (en) * 2000-11-09 2000-12-27 S P A Composition

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Title
See references of WO2006042582A1 *

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DE102004050954A1 (de) 2006-04-20
WO2006042582A1 (fr) 2006-04-27

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