EP1786408A1 - Utilisation d'un modulateur selectif du recepteurs des oestrogenes dans la fabrication d'une preparation pharmaceutique utilisee dans une methode de traitement ou de prevention des insuffisances endrogeniques - Google Patents

Utilisation d'un modulateur selectif du recepteurs des oestrogenes dans la fabrication d'une preparation pharmaceutique utilisee dans une methode de traitement ou de prevention des insuffisances endrogeniques

Info

Publication number
EP1786408A1
EP1786408A1 EP05771627A EP05771627A EP1786408A1 EP 1786408 A1 EP1786408 A1 EP 1786408A1 EP 05771627 A EP05771627 A EP 05771627A EP 05771627 A EP05771627 A EP 05771627A EP 1786408 A1 EP1786408 A1 EP 1786408A1
Authority
EP
European Patent Office
Prior art keywords
testosterone
hypogonadism
syndrome
deficiency
estrogen receptor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP05771627A
Other languages
German (de)
English (en)
Other versions
EP1786408A4 (fr
Inventor
Taru Blom
Janne Komi
Risto Lammintausta
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hormos Medical Ltd
Original Assignee
Hormos Medical Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FI20041216A external-priority patent/FI20041216A0/fi
Application filed by Hormos Medical Ltd filed Critical Hormos Medical Ltd
Publication of EP1786408A1 publication Critical patent/EP1786408A1/fr
Publication of EP1786408A4 publication Critical patent/EP1786408A4/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/075—Ethers or acetals
    • A61K31/085—Ethers or acetals having an ether linkage to aromatic ring nuclear carbon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/095—Sulfur, selenium, or tellurium compounds, e.g. thiols
    • A61K31/10—Sulfides; Sulfoxides; Sulfones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/26—Androgens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/30—Oestrogens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/32—Antioestrogens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics

Abstract

L'invention concerne l'utilisation d'un modulateur sélectif du récepteur des oestrogènes, ou d'un isomère, d'un mélange d'isomères, d'un métabolite ou d'un sel pharmaceutiquement acceptable de celui-ci, dans la fabrication d'une préparation pharmaceutique utilisée dans une méthode de traitement ou de prévention des insuffisances androgéniques, ou des maladies ou troubles causés par les insuffisances androgéniques chez un individu mâle.
EP05771627A 2004-09-03 2005-07-20 Utilisation d'un modulateur selectif du recepteurs des oestrogenes dans la fabrication d'une preparation pharmaceutique utilisee dans une methode de traitement ou de prevention des insuffisances endrogeniques Withdrawn EP1786408A4 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US60690704P 2004-09-03 2004-09-03
FI20041216A FI20041216A0 (fi) 2004-09-21 2004-09-21 Menetelmä androgeenivajeen hoitoon tai estoon
PCT/FI2005/000333 WO2006024689A1 (fr) 2004-09-03 2005-07-20 Utilisation d'un modulateur selectif du recepteurs des oestrogenes dans la fabrication d'une preparation pharmaceutique utilisee dans une methode de traitement ou de prevention des insuffisances endrogeniques

Publications (2)

Publication Number Publication Date
EP1786408A1 true EP1786408A1 (fr) 2007-05-23
EP1786408A4 EP1786408A4 (fr) 2010-07-28

Family

ID=35999733

Family Applications (1)

Application Number Title Priority Date Filing Date
EP05771627A Withdrawn EP1786408A4 (fr) 2004-09-03 2005-07-20 Utilisation d'un modulateur selectif du recepteurs des oestrogenes dans la fabrication d'une preparation pharmaceutique utilisee dans une methode de traitement ou de prevention des insuffisances endrogeniques

Country Status (10)

Country Link
EP (1) EP1786408A4 (fr)
JP (1) JP2008511615A (fr)
KR (1) KR20070059110A (fr)
AU (1) AU2005279178A1 (fr)
BR (1) BRPI0514701A (fr)
CA (1) CA2578852A1 (fr)
MX (1) MX2007002606A (fr)
NO (1) NO20071160L (fr)
RU (1) RU2007112114A (fr)
WO (1) WO2006024689A1 (fr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101636372B (zh) 2007-02-14 2013-03-27 霍尔莫斯医疗有限公司 有治疗价值的三苯基丁烯衍生物的制备方法
US20080312239A1 (en) * 2007-06-13 2008-12-18 Quatrx Pharmaceuticals Company Methods for the treatment of erectile dysfunction using fispemifene
CN102939287B (zh) 2010-06-10 2016-01-27 塞拉根制药公司 雌激素受体调节剂及其用途
US9193714B2 (en) 2011-12-14 2015-11-24 Seragon Pharmaceuticals, Inc. Fluorinated estrogen receptor modulators and uses thereof
US9744177B2 (en) * 2014-03-10 2017-08-29 Endorecherche, Inc. Treatment of male androgen deficiency symptoms or diseases with sex steroid precursor combined with SERM
EP3240771B1 (fr) 2014-12-29 2019-02-20 OLON S.p.A. Procédé de préparation d'ospémifène et de fispémifène
WO2023175010A1 (fr) * 2022-03-15 2023-09-21 Centre D'etude Des Cellules Souches (Cecs) Utilisation du bazedoxifene pour augmenter la survie musculaire

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001036360A1 (fr) * 1999-11-16 2001-05-25 Hormos Medical Corporation Derives de triphenylalcene et leur utilisation comme modulateurs selectifs des recepteurs aux oestrogenes

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL120262A (en) * 1996-02-28 2001-01-28 Pfizer Droloxifene and derivatives thereof for use in increasing serum testosterone levels
US6632447B1 (en) * 1998-05-07 2003-10-14 The University Of Tennessee Research Corporation Method for chemoprevention of prostate cancer
CO5271697A1 (es) * 2000-01-12 2003-04-30 Pfizer Prod Inc Composiciones y procedimientos para el tratamiento de afecciones que responden a un aumento de testosterona
JP2003534375A (ja) * 2000-05-26 2003-11-18 フィッチ，ハリー 選択性抗エストロゲン薬を用いた男性におけるアンドロゲン欠乏症の治療法
US7067557B2 (en) * 2000-05-26 2006-06-27 Harry Fisch Methods of treating androgen deficiency in men using selective antiestrogens
EP1666033B1 (fr) * 2001-11-29 2008-12-31 GTX, Inc. Prevention et traitement de l'osteoporose induite par la privation d'androgene

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001036360A1 (fr) * 1999-11-16 2001-05-25 Hormos Medical Corporation Derives de triphenylalcene et leur utilisation comme modulateurs selectifs des recepteurs aux oestrogenes

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
DUSCHEK ERIK J J ET AL: "Effects of raloxifene on gonadotrophins, sex hormones, bone turnover and lipids in healthy elderly men" EUROPEAN JOURNAL OF ENDOCRINOLOGY, vol. 150, no. 4, April 2004 (2004-04), pages 539-546, XP002586475 ISSN: 0804-4643 *
See also references of WO2006024689A1 *
STEINER MITCHELL S ET AL: "Phase IIA clinical trial to test the efficacy and safety of Toremifene in men with high-grade prostatic intraepithelial neoplasia." CLINICAL PROSTATE CANCER JUN 2003 LNKD- PUBMED:15046680, vol. 2, no. 1, June 2003 (2003-06), pages 24-31, XP009134590 ISSN: 1540-0352 *

Also Published As

Publication number Publication date
MX2007002606A (es) 2007-05-15
JP2008511615A (ja) 2008-04-17
KR20070059110A (ko) 2007-06-11
AU2005279178A1 (en) 2006-03-09
BRPI0514701A (pt) 2008-06-24
CA2578852A1 (fr) 2006-03-09
EP1786408A4 (fr) 2010-07-28
WO2006024689A1 (fr) 2006-03-09
RU2007112114A (ru) 2008-10-10
NO20071160L (no) 2007-05-25

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Inventor name: KOMI, JANNE

Inventor name: BLOM, TARU

Inventor name: LAMMINTAUSTA, RISTO

RIC1 Information provided on ipc code assigned before grant

Ipc: A61K 31/085 20060101AFI20100615BHEP

Ipc: A61K 31/10 20060101ALI20100615BHEP

Ipc: A61P 5/32 20060101ALI20100615BHEP

Ipc: A61K 31/135 20060101ALI20100615BHEP

Ipc: A61K 31/395 20060101ALI20100615BHEP

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