EP1778832A1 - Substrat, son procede de production et son utilisation pour la formation de culture a partir de cellules organiques - Google Patents

Substrat, son procede de production et son utilisation pour la formation de culture a partir de cellules organiques

Info

Publication number
EP1778832A1
EP1778832A1 EP05771838A EP05771838A EP1778832A1 EP 1778832 A1 EP1778832 A1 EP 1778832A1 EP 05771838 A EP05771838 A EP 05771838A EP 05771838 A EP05771838 A EP 05771838A EP 1778832 A1 EP1778832 A1 EP 1778832A1
Authority
EP
European Patent Office
Prior art keywords
pores
substrate according
substrate
microns
cell
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP05771838A
Other languages
German (de)
English (en)
Inventor
Alexander Walter
Udo Leuschner
Erich Wintermantel
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Gerresheimer Regensburg GmbH
Original Assignee
GERRESHEIMER WILDEN AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by GERRESHEIMER WILDEN AG filed Critical GERRESHEIMER WILDEN AG
Publication of EP1778832A1 publication Critical patent/EP1778832A1/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0068—General culture methods using substrates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M25/00—Means for supporting, enclosing or fixing the microorganisms, e.g. immunocoatings
    • C12M25/02—Membranes; Filters
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/13—Hollow or container type article [e.g., tube, vase, etc.]
    • Y10T428/1352—Polymer or resin containing [i.e., natural or synthetic]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/13—Hollow or container type article [e.g., tube, vase, etc.]
    • Y10T428/1352—Polymer or resin containing [i.e., natural or synthetic]
    • Y10T428/1376—Foam or porous material containing
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/249921—Web or sheet containing structurally defined element or component
    • Y10T428/249953—Composite having voids in a component [e.g., porous, cellular, etc.]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/249921—Web or sheet containing structurally defined element or component
    • Y10T428/249953—Composite having voids in a component [e.g., porous, cellular, etc.]
    • Y10T428/249954—With chemically effective material or specified gas other than air, N, or carbon dioxide in void-containing component
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/249921—Web or sheet containing structurally defined element or component
    • Y10T428/249953—Composite having voids in a component [e.g., porous, cellular, etc.]
    • Y10T428/249975—Void shape specified [e.g., crushed, flat, round, etc.]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/249921—Web or sheet containing structurally defined element or component
    • Y10T428/249953—Composite having voids in a component [e.g., porous, cellular, etc.]
    • Y10T428/249976—Voids specified as closed
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/249921—Web or sheet containing structurally defined element or component
    • Y10T428/249953—Composite having voids in a component [e.g., porous, cellular, etc.]
    • Y10T428/249976—Voids specified as closed
    • Y10T428/249977—Specified thickness of void-containing component [absolute or relative], numerical cell dimension or density
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/249921—Web or sheet containing structurally defined element or component
    • Y10T428/249953—Composite having voids in a component [e.g., porous, cellular, etc.]
    • Y10T428/249978—Voids specified as micro
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/249921—Web or sheet containing structurally defined element or component
    • Y10T428/249953—Composite having voids in a component [e.g., porous, cellular, etc.]
    • Y10T428/249978—Voids specified as micro
    • Y10T428/249979—Specified thickness of void-containing component [absolute or relative] or numerical cell dimension
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/249921—Web or sheet containing structurally defined element or component
    • Y10T428/249953—Composite having voids in a component [e.g., porous, cellular, etc.]
    • Y10T428/249987—With nonvoid component of specified composition
    • Y10T428/249991—Synthetic resin or natural rubbers

Abstract

L'invention concerne un substrat servant à former des cultures à partir de cellules organiques, présentant les caractéristiques suivantes: un corps en trois dimensions; la section transversale du corps présente une pluralité au moins de premiers pores dont une majorité présente une taille = 1000 µm, de préférence de 10 à 500 µm, mieux encore de 10 à 200 µm, idéalement de 10 à 100 µm; les premiers pores sont en liaison fluidique les uns avec les autres, au moins les premiers pores présentant une taille de 10 à 500 µm possèdent une propriété favorisant la croissance de cellules ; au moins une partie des premiers pores placés à proximité d'au moins une surface libre du corps sont ouverts vers l'environnement extérieur. Ce substrat se présente de préférence sous la forme d'un corps en mousse à pores ouverts constitué d'une matière plastique. Ce substrat permet la formation de cultures de cellules en trois dimensions.
EP05771838A 2004-08-17 2005-08-17 Substrat, son procede de production et son utilisation pour la formation de culture a partir de cellules organiques Withdrawn EP1778832A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE200410039762 DE102004039762A1 (de) 2004-08-17 2004-08-17 Substrat, Verfahren zu seiner Herstellung und Verwendung für die Bildung von Kulturen aus organischen Zellen
PCT/EP2005/008927 WO2006018298A1 (fr) 2004-08-17 2005-08-17 Substrat, son procede de production et son utilisation pour la formation de culture a partir de cellules organiques

Publications (1)

Publication Number Publication Date
EP1778832A1 true EP1778832A1 (fr) 2007-05-02

Family

ID=35429149

Family Applications (1)

Application Number Title Priority Date Filing Date
EP05771838A Withdrawn EP1778832A1 (fr) 2004-08-17 2005-08-17 Substrat, son procede de production et son utilisation pour la formation de culture a partir de cellules organiques

Country Status (4)

Country Link
US (1) US8105684B2 (fr)
EP (1) EP1778832A1 (fr)
DE (2) DE202004021077U1 (fr)
WO (1) WO2006018298A1 (fr)

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5266476A (en) * 1985-06-18 1993-11-30 Yeda Research & Development Co., Ltd. Fibrous matrix for in vitro cell cultivation
JPH03175973A (ja) * 1989-09-26 1991-07-31 Kirin Brewery Co Ltd 動物細胞培養用担体およびその製造法
JP3071969B2 (ja) * 1992-10-28 2000-07-31 日本車輌製造株式会社 多孔質セラミックスからなる増殖微生物用担持体
US7022522B2 (en) * 1998-11-13 2006-04-04 Limin Guan Macroporous polymer scaffold containing calcium phosphate particles
CA2364570A1 (fr) * 1999-04-09 2000-10-19 The Regents Of The University Of Michigan Preparation de produits a base d'hydrogel
US6103255A (en) * 1999-04-16 2000-08-15 Rutgers, The State University Porous polymer scaffolds for tissue engineering
EP1317526B1 (fr) * 2000-09-13 2008-05-21 Csir Dispositif bioreacteur
EP1379287A1 (fr) * 2001-04-12 2004-01-14 Therics, Inc. Procede et appareil destines a des biostructures de regeneration techniques
US20030072790A1 (en) * 2001-10-16 2003-04-17 Industrial Technology Research Institute Biodegradable porous devices for tissue engineering
US20040063206A1 (en) * 2002-09-30 2004-04-01 Rowley Jon A. Programmable scaffold and method for making and using the same
CN101193623A (zh) * 2003-05-15 2008-06-04 柏尔迈瑞克斯公司 可植入的网状弹性基质的制造和应用
DE10326744B4 (de) * 2003-06-13 2006-03-23 Gerlach, Jörg, Dr.med. Modul zur Züchtung und zur Nutzung der Stoffwechselleistung und/oder zum Erhalt von Mikroorganismen, Verfahren zu dessen Herstellung und Verwendung

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See references of WO2006018298A1 *

Also Published As

Publication number Publication date
US20080107853A1 (en) 2008-05-08
WO2006018298A1 (fr) 2006-02-23
DE202004021077U1 (de) 2006-10-19
DE102004039762A1 (de) 2006-03-02
US8105684B2 (en) 2012-01-31

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Inventor name: WALTER, ALEXANDER

Inventor name: WINTERMANTEL, ERICH

Inventor name: LEUSCHNER, UDO

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Owner name: GERRESHEIMER WILDEN GMBH

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Owner name: GERRESHEIMER REGENSBURG GMBH

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