EP1734931A2 - Formulations de ramipril - Google Patents

Formulations de ramipril

Info

Publication number
EP1734931A2
EP1734931A2 EP05718970A EP05718970A EP1734931A2 EP 1734931 A2 EP1734931 A2 EP 1734931A2 EP 05718970 A EP05718970 A EP 05718970A EP 05718970 A EP05718970 A EP 05718970A EP 1734931 A2 EP1734931 A2 EP 1734931A2
Authority
EP
European Patent Office
Prior art keywords
amount
ramipril
tablet formulation
compactrol
hydrogen carbonate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP05718970A
Other languages
German (de)
English (en)
Inventor
Eyjolfsson Reynir
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Actavis Group hf
Original Assignee
Actavis Group hf
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from IS7196A external-priority patent/IS2197B/is
Application filed by Actavis Group hf filed Critical Actavis Group hf
Priority claimed from IS7772A external-priority patent/IS2204B/is
Publication of EP1734931A2 publication Critical patent/EP1734931A2/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/549—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame having two or more nitrogen atoms in the same ring, e.g. hydrochlorothiazide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2009—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin

Definitions

  • the present invention relates to stable pharmaceutical formulations of ramipril, optionally in combination with a diuretic.
  • Ramipril, (2S,3aS,6aS)-1[(S) ⁇ /V-[(S)-1-carboxy-3-phenylpropyl] alanyl] octahydrocyclopenta[ ⁇ ]pyrrole-2-carboxylic acid, 1 -ethyl ester is an angiotensin converting enzyme (ACE) inhibitor.
  • ACE angiotensin converting enzyme
  • Ramipril can undergo cyclization via internal nucleophilic attack to form substituted diketopiperazines and also degrade via hydrolysis and oxidation.
  • EP 1 501 546 A1 describes stable pharmaceutical formulation for combinations of a statin and an ACE inhibitor.
  • the problem underlying the invention is that if an ACE inhibior is in the presence of a stabilised statin, the ACE inhibitor decomposes to such extent that even after short storage period the content of decomposition products exceeds the permissible limit of degratation.
  • EP 1 501 546 A1 provides a formulation wherein the statin and the ACE inhibitor are separated by physiologically acceptable inert material. Calcium sulfate is mentioned as a possible inorganic filler in the formulation but it is neither claimed nor mentioned in any example. In fact all the examples are concerned with three-layer tablet, wherein the statin layer and ACE inhibitor layer are seperated by a layer of microcrystalline cellulose. Combinations of the ACE inhibitor with a diuretic are not mentioned.
  • US 2003/0215526 claims formulations of ACE inhibitor a pharmaceutical composition
  • a pharmaceutical composition comprising a therapeutically effective amount of an ACE inhibitor which is susceptible to degradation or its salt; a greater than stoichiometric amount of an alkali or alkaline earth metal carbonate, relative to the amount of ACE inhibitor or its salt, and a pharmaceutically acceptable carrier.
  • the excipient calcium sulphate is not mentioned.
  • EP 0 317 878 B1 claims a stable, compressed pharmaceutical formulation containing a compound of a defined formula (i.e. ramipril) wherein, for stabilization before compression, a compound of the formula is a) coated with a polymeric, physiologically tolerated protective coating, or b) mixed with a physiologically tolerated buffer which ensures that a pH in the weakly acidic to weakly alkaline range is set up in a pharmaceutical formulation in the presence of moisture, where sodium bicarbonate is excepted as buffer, or c) mixed with a physilogically tolerated buffer which ensures that a pH in the weakly acid to weakly alkaline range is set up in a pharmaceutical formulation in the presence of moisture, and is coated with a polymeric, physiologically tolerated protective coating, where, in the case of stabilization according to b) with alkali metal or alkaline earth metal carbonate, the formulation is free of sugar.
  • a compound of a defined formula i.e. ramipril
  • WO 93/17685 claims combinations of ACE inhibitors and diuretics such as hydrochlorothiazide.
  • Sodium hydrogen carbonate, pregelatinised starch and magnesium stearate are mentioned as excipients.
  • Calicium sulphate is not mentioned.
  • Compositons of ramipril and piretanide is described in EP 215 357 B1.
  • Calcium sulfate is not mentioned in this patent.
  • WO 03/028707 claims a formulation containing ramipril and lactose monohydrate. Calcium sulfate is mentioned in the specification as a possible diluent. Calcium sufate is not included in any example.
  • Calcium sulphate dihydrate is known as an inert diluent in compressed tablets. However, it was surprising that the stability of the tablets proved to be very satisfying.
  • the invention provides a pharmaceutical formulation comprising ramipril,
  • the pharmaceutical formulation of the present invention comprises typically: a) 0.1 - 5.0% w/w of ramipril; b) 50 - 95% w/w of Compactrol; c) 0.1 - 5.0% w/w of sodium hydrogen carbonate; and optionally disintegrant (e.g. starch), binder and/or lubricant (e.g. sodium stearyl fumarate).
  • disintegrant e.g. starch
  • binder and/or lubricant e.g. sodium stearyl fumarate
  • the formulation optionally also includes a diuretic, such as hydrochlorothiazide or piretanide.
  • a diuretic such as hydrochlorothiazide or piretanide.
  • the preferred amount of ramipril is 0.5-1.5% w/w
  • the amount of Compactrol is 85-90% w/w
  • the amount of sodium hydrogen carbonate is 0.5-1.5% w/w
  • the amount of starch pregelatinised is 7-13% w/w
  • the amount of sodium stearyl fumarate is 0.5-1.5% w/w.
  • the preferred amount of ramipril is 1.4-2.5% w/w
  • the amount of Compactrol is 78- 95% w/w
  • the amount of sodium hydrogen carbonate is 1.4-2.5% w/w
  • the amount of starch pregelatinised is 7-13% w/w
  • the amount of sodium stearyl fumarate is 0.5-1.5% w/w.
  • ramipril is 1.4-2.5% w/w
  • hydrochlorothiazide is 8.5- 10.5% w/w
  • the amount of Compactrol is 65-75% w/w
  • the amount of sodium hydrogen carbonate is 1.0-2.5% w/w
  • the amount of starch pregelatinised is 12-18% w/w
  • the amount of sodium stearyl fumarate is 0.5-1.5% w/w.
  • the preferred amount of ramipril is 1.5 - 2.5% w/w
  • the amount of piretanide is 1.8 - 3.0% w/w
  • the amount of Compactrol is 65-85% w/w
  • the amount of sodium hydrogen carbonate is 3.0-5.0% w/w
  • the amount of starch pregelatinised is 10-20% w/w
  • the amount of sodium stearyl fumarate is 0.5-1.5% w/w.
  • ramipril is susceptible to certain types of degradation, there are several impurities formed during the manufacturing process and storing of the tablet. It is of high importance to minimize this degradation. The strength of different exipients was adjusted until a useful formulation was found.
  • Ramipril diketopiperazine is one of the compounds formed via degradation.
  • the present formulation proved to be especially stable with regard to formation of the diketopiperazine.
  • the example demonstates a very good stability with regard to ramipril diketopiperazine formation.

Abstract

Cette invention se rapporte à des formulations de comprimés stables de ramipril, éventuellement associées à un diurétique.
EP05718970A 2004-03-24 2005-03-23 Formulations de ramipril Withdrawn EP1734931A2 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IS7196A IS2197B (is) 2004-03-24 2004-03-24 Ramipríl lyfjasamsetningar
PCT/IS2005/000008 WO2005067887A2 (fr) 2004-03-24 2005-03-23 Formulations de ramipril
IS7772A IS2204B (is) 2005-03-23 2005-03-23 Lyfjasamsetningar af ramipríli og píretaníði

Publications (1)

Publication Number Publication Date
EP1734931A2 true EP1734931A2 (fr) 2006-12-27

Family

ID=34796871

Family Applications (1)

Application Number Title Priority Date Filing Date
EP05718970A Withdrawn EP1734931A2 (fr) 2004-03-24 2005-03-23 Formulations de ramipril

Country Status (4)

Country Link
US (2) US20080234353A1 (fr)
EP (1) EP1734931A2 (fr)
EA (1) EA011862B1 (fr)
WO (1) WO2005067887A2 (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013121233A1 (fr) 2012-02-17 2013-08-22 Egis Gyógyszergyár Nyilvánosan Működö Részvénytársaság Formule pharmaceutique à stabilité améliorée
WO2015022560A1 (fr) 2013-08-16 2015-02-19 Egis Gyógyszergyár Zrt. Composition pharmaceutique stable contenant du bisoprolol et du ramipril

Families Citing this family (12)

* Cited by examiner, † Cited by third party
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EA011862B1 (ru) 2004-03-24 2009-06-30 Актавис Груп Хф. Композиции рамиприла
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RU2479310C2 (ru) * 2011-02-09 2013-04-20 Открытое акционерное общество "Химико-фармацевтический комбинат "АКРИХИН" (ОАО "АКРИХИН") Фармацевтическая композиция для лечения артериальной гипертензии и застойной сердечной недостаточности и способ ее получения
RU2618471C2 (ru) * 2012-12-03 2017-05-03 Закрытое Акционерное Общество "Вертекс" Пероральная фармацевтическая композиция диуретика и ингибитора АПФ в микронизированной форме, лекарственное средство и его применение

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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013121233A1 (fr) 2012-02-17 2013-08-22 Egis Gyógyszergyár Nyilvánosan Működö Részvénytársaság Formule pharmaceutique à stabilité améliorée
EP3501501A1 (fr) 2012-02-17 2019-06-26 Egis Gyógyszergyár Zrt. Formule pharmaceutique à stabilité améliorée
WO2015022560A1 (fr) 2013-08-16 2015-02-19 Egis Gyógyszergyár Zrt. Composition pharmaceutique stable contenant du bisoprolol et du ramipril

Also Published As

Publication number Publication date
EA011862B1 (ru) 2009-06-30
WO2005067887A3 (fr) 2005-11-03
EA200601759A1 (ru) 2007-04-27
US20080234353A1 (en) 2008-09-25
US7589064B2 (en) 2009-09-15
WO2005067887A2 (fr) 2005-07-28
US20070254030A1 (en) 2007-11-01

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