EP1713819A4 - Verfahren und zusammensetzungen zur kombination von rnai-therapeutika - Google Patents

Verfahren und zusammensetzungen zur kombination von rnai-therapeutika

Info

Publication number
EP1713819A4
EP1713819A4 EP05713043A EP05713043A EP1713819A4 EP 1713819 A4 EP1713819 A4 EP 1713819A4 EP 05713043 A EP05713043 A EP 05713043A EP 05713043 A EP05713043 A EP 05713043A EP 1713819 A4 EP1713819 A4 EP 1713819A4
Authority
EP
European Patent Office
Prior art keywords
compositions
methods
rnai therapeutics
combination rnai
combination
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP05713043A
Other languages
English (en)
French (fr)
Other versions
EP1713819A2 (de
Inventor
Bao-Jian Li
Patrick Y Lu
Martin C Woodle
Frank Y Xie
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Silence Therapeutics PLC
Original Assignee
Intradigm Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Intradigm Corp filed Critical Intradigm Corp
Publication of EP1713819A2 publication Critical patent/EP1713819A2/de
Publication of EP1713819A4 publication Critical patent/EP1713819A4/de
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/111—General methods applicable to biologically active non-coding nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1131—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against viruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering N.A.
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/17—Immunomodulatory nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
    • C12N2310/315—Phosphorothioates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2320/00—Applications; Uses
    • C12N2320/30—Special therapeutic applications
    • C12N2320/31—Combination therapy

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Virology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
EP05713043A 2004-02-05 2005-02-07 Verfahren und zusammensetzungen zur kombination von rnai-therapeutika Withdrawn EP1713819A4 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US54177604P 2004-02-05 2004-02-05
PCT/US2005/003858 WO2005076999A2 (en) 2004-02-05 2005-02-07 Methods and compositions for combination rnai therapeutics

Publications (2)

Publication Number Publication Date
EP1713819A2 EP1713819A2 (de) 2006-10-25
EP1713819A4 true EP1713819A4 (de) 2007-11-14

Family

ID=34860217

Family Applications (1)

Application Number Title Priority Date Filing Date
EP05713043A Withdrawn EP1713819A4 (de) 2004-02-05 2005-02-07 Verfahren und zusammensetzungen zur kombination von rnai-therapeutika

Country Status (5)

Country Link
EP (1) EP1713819A4 (de)
CN (1) CN101044152A (de)
AU (1) AU2005213485A1 (de)
CA (1) CA2555531A1 (de)
WO (1) WO2005076999A2 (de)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8491914B2 (en) * 2004-02-13 2013-07-23 Ibc Pharmaceuticals, Inc. Dock-and-lock (DNL) complexes for delivery of interference RNA
EP1817416A2 (de) * 2004-11-05 2007-08-15 Intradigm Corporation Zusammensetzungen zur behandlung viraler atemwegsinfektionen und deren verwendung
KR101169668B1 (ko) 2005-01-07 2012-08-07 알닐람 파마슈티칼스 인코포레이티드 ＲＳＶ의 ＲＮＡｉ 조절 및 이를 위한 약제학적 조성물
JP2008537752A (ja) * 2005-04-12 2008-09-25 イントラディグム コーポレイション がんおよび他の新血管形成疾患を処置するためのＲＮＡｉ治療用の組成物および方法
WO2007025254A2 (en) * 2005-08-26 2007-03-01 Henry Ford Health System Investigation and treatment of cancer using a g-protien coupled eicosnoid receptor
EP1970078A4 (de) * 2006-01-11 2010-11-17 Kyowa Hakko Kirin Co Ltd Zusammensetzung zur hemmung eines target-gens in einem augapfel und heilmittel für eine augapfel-erkrankung
TW200836762A (en) * 2006-11-27 2008-09-16 Enzon Pharmaceuticals Inc Polymeric short interfering RNA conjugates
CN101583715A (zh) * 2006-12-21 2009-11-18 因特拉迪格姆公司 用于治疗癌症的抑制性多核苷酸组合物和方法
WO2008118013A2 (en) 2007-03-23 2008-10-02 To-Bbb Holding B.V. Targeted intracellular delivery of antiviral agents
CA2701128A1 (en) 2007-10-01 2009-04-09 Isis Pharmaceuticals, Inc. Antisense modulation of fibroblast growth factor receptor 4 expression
US8735567B2 (en) 2007-11-06 2014-05-27 Patrick Y. Lu Multi-targeted RNAi therapeutics for scarless wound healing of skin
WO2009151539A1 (en) 2008-05-24 2009-12-17 Sirnaomics, Inc. COMPOSITIONS AND METHODS USING siRNA MOLECULES FOR TREATMENT OF GLIOMAS
WO2010078517A2 (en) 2008-12-31 2010-07-08 Sirnaomics, Inc. Compositions and methods using sirna molecules and sirna cocktails for the treatment of breast cancer
US9642873B2 (en) 2010-05-04 2017-05-09 Sirnaomics, Inc. Combinations of TGFβ and COX-2 inhibitors and methods for their therapeutic application
WO2012016139A2 (en) 2010-07-29 2012-02-02 Sirnaomics, Inc. Sirna compositions and methods for treatment of hpv and other infections
EP2721156B1 (de) 2011-06-16 2016-12-21 Ionis Pharmaceuticals, Inc. Antisense-modulierung der expression des fibroblastenwachstumsfaktor-rezeptors 4
CN103007291B (zh) * 2011-09-26 2015-04-29 苏州圣诺生物医药技术有限公司 双靶标/多靶标小核酸治疗眼部疾病的组合物及应用
CN102399820B (zh) * 2011-09-27 2013-06-12 天津佰思普生物科技有限公司 针对hpv16 e7基因的小干扰rna及其应用
US9868952B2 (en) 2012-07-08 2018-01-16 Sirnaomics, Inc. Compositions and methods for “resistance-proof” SiRNA therapeutics for influenza
AU2016226414B2 (en) 2015-03-02 2021-09-09 180 Therapeutics Lp Method of treating a localized fibrotic disorder using an IL-33 antagonist
EP4035659A1 (de) 2016-11-29 2022-08-03 PureTech LYT, Inc. Exosome zur ausgabe von therapeutischen wirkstoffen
CN106771252A (zh) * 2017-01-13 2017-05-31 福建医科大学 Amacr蛋白在制备肝癌术后预后评估试剂盒中的应用及试剂盒
CN111620939B (zh) * 2019-10-25 2021-01-01 南京市妇幼保健院 一种用于治疗或辅助治疗卵巢癌的多肽zyx36-58
EP4093511A4 (de) * 2020-01-23 2023-10-18 Sirnaomics, Inc. Zusammensetzung und verfahren von rnai-prophylaktika und -therapeutika zur behandlung schwerer akuter atemwegsinfektionen, verursacht durch das neue coronavirus 2019 (2019-ncov)
CN114196785A (zh) * 2020-09-18 2022-03-18 北京大学人民医院 异基因造血干细胞移植后巨细胞病毒对巨核细胞易感性的生物标记物及其应用
CN114452393A (zh) * 2022-02-22 2022-05-10 南方科技大学 Pinch-1蛋白作为靶点在制备治疗肺纤维化的药物中的应用
CN116421616A (zh) * 2022-03-17 2023-07-14 圣诺生物医药技术(苏州)有限公司 一种核酸干扰药物组合物及用于治疗结直肠癌、胃癌、前列腺癌的药物

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003106630A2 (en) * 2002-06-12 2003-12-24 Ambion, Inc. Methods and compositions relating to polypeptides with rnase iii domains that mediate rna interference
WO2005019410A2 (en) * 2003-04-25 2005-03-03 Intradigm Corporation Rnai agents for anti-sars coronavirus therapy

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003106630A2 (en) * 2002-06-12 2003-12-24 Ambion, Inc. Methods and compositions relating to polypeptides with rnase iii domains that mediate rna interference
WO2005019410A2 (en) * 2003-04-25 2005-03-03 Intradigm Corporation Rnai agents for anti-sars coronavirus therapy

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
HAASNOOT P C JOOST ET AL: "Inhibition of virus replication by RNA interference.", JOURNAL OF BIOMEDICAL SCIENCE. 2003, vol. 10, no. 6 Pt 1, 2003, pages 607 - 616, XP002413217, ISSN: 1021-7770 *
HE M-L ET AL: "INHIBITION OF SARS-ASSOCIATED CORONAVIRUS INFECTION AND REPLICATION BY RNA INTERFERENCE", JAMA THE JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, CHICAGO,IL, US, vol. 290, no. 20, 26 November 2003 (2003-11-26), pages 2665 - 2666, XP009041436, ISSN: 0098-7484 *
JI J ET AL: "Enhanced gene silencing by the application of multiple specific small interfering RNAs", FEBS LETTERS, ELSEVIER, AMSTERDAM, NL, vol. 552, no. 2-3, 25 September 2003 (2003-09-25), pages 247 - 252, XP004460905, ISSN: 0014-5793 *
LEE N S ET AL: "Expression of small interfering RNAs targeted against HIV-1 rev transcripts in human cells", NATURE BIOTECHNOLOGY, NATURE PUBLISHING GROUP, NEW YORK, NY, US, vol. 19, May 2002 (2002-05-01), pages 500 - 505, XP002965489, ISSN: 1087-0156 *
YU JENN-YAH ET AL: "Simultaneous inhibition of GSK3alpha and GSK3beta using hairpin siRNA expression vectors.", MOLECULAR THERAPY : THE JOURNAL OF THE AMERICAN SOCIETY OF GENE THERAPY. FEB 2003, vol. 7, no. 2, February 2003 (2003-02-01), pages 228 - 236, XP002413216, ISSN: 1525-0016 *
ZHANG RENLI ET AL: "Inhibiting severe acute respiratory syndrome-associated coronavirus by small interfering RNA", CHINESE MEDICAL JOURNAL / ZHONGHUA YIXUE ZAZHI YINGWEN BAN, CHINESE MEDICAL ASSOCIATION, BEIJING, CN, vol. 116, no. 8, August 2003 (2003-08-01), pages 1262 - 1264, XP002310170, ISSN: 0366-6999 *

Also Published As

Publication number Publication date
WO2005076999A2 (en) 2005-08-25
AU2005213485A1 (en) 2005-08-25
CN101044152A (zh) 2007-09-26
EP1713819A2 (de) 2006-10-25
CA2555531A1 (en) 2005-08-25
WO2005076999A3 (en) 2006-07-06

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