EP1670466A4 - Preparation d'azabenzimidazoles trisubstitues en position 1,6,7 servant d'inhibiteurs des kinases - Google Patents
Preparation d'azabenzimidazoles trisubstitues en position 1,6,7 servant d'inhibiteurs des kinasesInfo
- Publication number
- EP1670466A4 EP1670466A4 EP04794310A EP04794310A EP1670466A4 EP 1670466 A4 EP1670466 A4 EP 1670466A4 EP 04794310 A EP04794310 A EP 04794310A EP 04794310 A EP04794310 A EP 04794310A EP 1670466 A4 EP1670466 A4 EP 1670466A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- azabenzimidazoles
- trisubstituted
- preparation
- kinase inhibitors
- kinase
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 229940043355 kinase inhibitor Drugs 0.000 title 1
- 239000003757 phosphotransferase inhibitor Substances 0.000 title 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Cardiology (AREA)
- Diabetes (AREA)
- Urology & Nephrology (AREA)
- Endocrinology (AREA)
- Heart & Thoracic Surgery (AREA)
- Ophthalmology & Optometry (AREA)
- Oncology (AREA)
- Reproductive Health (AREA)
- Hospice & Palliative Care (AREA)
- Pulmonology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Psychiatry (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Communicable Diseases (AREA)
- Psychology (AREA)
- Emergency Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Gynecology & Obstetrics (AREA)
- Vascular Medicine (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US50912303P | 2003-10-06 | 2003-10-06 | |
PCT/US2004/032909 WO2005034866A2 (fr) | 2003-10-06 | 2004-10-06 | Preparation d'azabenzimidazoles trisubstitues en position 1,6,7 servant d'inhibiteurs des kinases |
Publications (2)
Publication Number | Publication Date |
---|---|
EP1670466A2 EP1670466A2 (fr) | 2006-06-21 |
EP1670466A4 true EP1670466A4 (fr) | 2007-04-25 |
Family
ID=34434944
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP04794310A Withdrawn EP1670466A4 (fr) | 2003-10-06 | 2004-10-06 | Preparation d'azabenzimidazoles trisubstitues en position 1,6,7 servant d'inhibiteurs des kinases |
Country Status (4)
Country | Link |
---|---|
US (1) | US20070004771A1 (fr) |
EP (1) | EP1670466A4 (fr) |
JP (1) | JP2007507549A (fr) |
WO (1) | WO2005034866A2 (fr) |
Families Citing this family (32)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB0206860D0 (en) * | 2002-03-22 | 2002-05-01 | Glaxo Group Ltd | Compounds |
WO2004096154A2 (fr) * | 2003-04-29 | 2004-11-11 | Smithkline Beecham Corporation | Procedes de traitement de maladies/lesions degeneratives |
US20090143453A1 (en) * | 2003-04-29 | 2009-06-04 | Connie Erickson-Miller | Methods for treating degenerative diseases/injuries |
US20090048318A1 (en) * | 2003-04-29 | 2009-02-19 | Connie Erickson-Miller | Methods for treating degenerative diseases/injuries |
US20090298179A1 (en) * | 2003-04-29 | 2009-12-03 | Connie Erickson-Miller | Methods For Treating Degenerative Diseases/Injuries |
TW200523262A (en) * | 2003-07-29 | 2005-07-16 | Smithkline Beecham Corp | Inhibitors of AKT activity |
TWI609409B (zh) * | 2003-10-28 | 2017-12-21 | 尼康股份有限公司 | 照明光學裝置、曝光裝置、曝光方法以及元件製造方法 |
PE20061378A1 (es) * | 2005-04-20 | 2006-12-03 | Smithkline Beecham Corp | INHIBIDORES DE LA ACTIVIDAD DE Akt |
US8629161B2 (en) | 2005-06-21 | 2014-01-14 | Kowa Co., Ltd. | Preventive or remedy for glaucoma |
PT1905452E (pt) | 2005-07-12 | 2013-07-16 | Kowa Co | Agente para a prevenção ou tratamento do glaucoma |
US7625890B2 (en) * | 2005-11-10 | 2009-12-01 | Smithkline Beecham Corp. | Substituted imidazo[4,5-c]pyridine compounds as Akt inhibitors |
US20090018142A9 (en) * | 2006-05-02 | 2009-01-15 | Zhengping Zhuang | Use of phosphatases to treat tumors overexpressing N-CoR |
CN101662939B (zh) * | 2007-02-06 | 2015-11-25 | 利克斯特生物技术公司 | 氧杂双环庚烷和氧杂双环庚烯,它们的制备及用途 |
UY30892A1 (es) | 2007-02-07 | 2008-09-02 | Smithkline Beckman Corp | Inhibidores de la actividad akt |
WO2009028631A1 (fr) | 2007-08-29 | 2009-03-05 | Senju Pharmaceutical Co., Ltd. | Agent pour favoriser l'adhérence cellulaire endothéliale cornéenne |
CA2700857C (fr) | 2007-10-01 | 2016-08-02 | John S. Kovach | Inhibiteurs de hdac |
WO2009154940A1 (fr) | 2008-06-18 | 2009-12-23 | Inspire Pharmaceuticals, Inc. | Processus de préparation de composés inhibiteurs de rho-kinase |
US8410147B2 (en) | 2008-06-26 | 2013-04-02 | Inspire Pharmaceuticals, Inc. | Method for treating diseases associated with alterations in cellular integrity using Rho kinase inhibitor compounds |
US8227473B2 (en) | 2008-08-01 | 2012-07-24 | Lixte Biotechnology, Inc. | Oxabicycloheptanes and oxabicycloheptenes, their preparation and use |
WO2010014220A1 (fr) | 2008-08-01 | 2010-02-04 | Lixte Biotechnology, Inc. | Agents neuroprotecteurs pour la prévention et le traitement de maladies neurodégénératives |
SG172926A1 (en) * | 2009-01-30 | 2011-08-29 | Glaxosmithkline Llc | Crystalline n-{(1-s)-2-amino-1-[(3-fluorophenyl)methyl]ethyl}-5-chloro-4-(4-chloro-1-methyl-1h-pyrazol-5-yl)-2-thiophenecarboxamide hydrochloride |
RS58526B1 (sr) | 2011-12-06 | 2019-04-30 | Astellas Inst For Regenerative Medicine | Postupak usmerene diferencijacije koja proizvodi kornealne endotelijalne ćelije |
EP2799537B1 (fr) | 2011-12-28 | 2021-09-22 | Kyoto Prefectural Public University Corporation | Normalisation d'une culture de cellules endothéliales de la cornée |
EA201591931A1 (ru) | 2013-04-09 | 2016-05-31 | Ликсте Байотекнолоджи, Инк. | Композиции оксабициклогептанов и оксабициклогептенов |
US10908161B2 (en) | 2013-07-30 | 2021-02-02 | Kyoto Prefectural Public University Corporation | Corneal endothelial cell marker |
EP3064222B1 (fr) | 2013-10-31 | 2020-10-21 | Kyoto Prefectural Public University Corporation | Médicament thérapeutique contenant un inhibiteur de tgf-beta signal pour des maladies associées à la mort cellulaire du réticulum endoplasmique dans l'endothélium de la cornée |
US11624053B2 (en) | 2013-11-27 | 2023-04-11 | Kyoto Prefectural Public University Corporation | Application of laminin to corneal endothelial cell culture |
PL3416658T3 (pl) | 2016-02-15 | 2023-09-04 | Kyoto Prefectural Public University Corporation | Funkcjonalna ludzka komórka śródbłonka rogówki i jej zastosowanie |
JPWO2020045642A1 (ja) | 2018-08-31 | 2021-08-12 | 学校法人同志社 | 眼細胞を保存または培養するための組成物および方法 |
KR20210069640A (ko) | 2018-10-02 | 2021-06-11 | 학교법인 도시샤 | 각막 내피 세포를 보존하기 위한 방법 및 용기 |
BR112022017180A2 (pt) | 2020-02-27 | 2022-10-18 | Kyoto Prefectural Public Univ Corp | Células endoteliais da córnea humanas funcionais e aplicação das mesmas |
CA3216719A1 (fr) | 2021-05-03 | 2022-11-10 | Astellas Institute For Regenerative Medicine | Procedes de generation de cellules endotheliales corneennes matures |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2003066629A2 (fr) * | 2002-02-06 | 2003-08-14 | Vertex Pharmaceuticals Incorporated | Composes heteroaryles utiles en tant qu'inhibiteurs de gsk-3 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3722992A1 (de) * | 1987-07-11 | 1989-01-19 | Thomae Gmbh Dr K | Neue imidazo-pyridine und purine, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung |
DE60211317T2 (de) * | 2001-03-23 | 2007-04-12 | Bayer Corp. | Rho-kinase inhibitoren |
GB0206860D0 (en) * | 2002-03-22 | 2002-05-01 | Glaxo Group Ltd | Compounds |
-
2004
- 2004-10-06 US US10/574,652 patent/US20070004771A1/en not_active Abandoned
- 2004-10-06 JP JP2006534285A patent/JP2007507549A/ja active Pending
- 2004-10-06 WO PCT/US2004/032909 patent/WO2005034866A2/fr active Application Filing
- 2004-10-06 EP EP04794310A patent/EP1670466A4/fr not_active Withdrawn
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2003066629A2 (fr) * | 2002-02-06 | 2003-08-14 | Vertex Pharmaceuticals Incorporated | Composes heteroaryles utiles en tant qu'inhibiteurs de gsk-3 |
Also Published As
Publication number | Publication date |
---|---|
JP2007507549A (ja) | 2007-03-29 |
EP1670466A2 (fr) | 2006-06-21 |
US20070004771A1 (en) | 2007-01-04 |
WO2005034866A3 (fr) | 2005-07-28 |
WO2005034866A2 (fr) | 2005-04-21 |
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Legal Events
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PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
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17P | Request for examination filed |
Effective date: 20060411 |
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AK | Designated contracting states |
Kind code of ref document: A2 Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PL PT RO SE SI SK TR |
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AX | Request for extension of the european patent |
Extension state: HR LT LV |
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RAX | Requested extension states of the european patent have changed |
Extension state: LV Payment date: 20060411 Extension state: LT Payment date: 20060411 Extension state: HR Payment date: 20060411 |
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A4 | Supplementary search report drawn up and despatched |
Effective date: 20070327 |
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RIC1 | Information provided on ipc code assigned before grant |
Ipc: A61P 25/00 20060101ALI20070321BHEP Ipc: C07D 471/04 20060101ALI20070321BHEP Ipc: A61K 31/437 20060101AFI20050815BHEP |
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17Q | First examination report despatched |
Effective date: 20080114 |
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STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
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18D | Application deemed to be withdrawn |
Effective date: 20080527 |