EP1660517A4 - ANTAGONISTS OF NOGO RECEPTOR - Google Patents
ANTAGONISTS OF NOGO RECEPTORInfo
- Publication number
- EP1660517A4 EP1660517A4 EP04707073A EP04707073A EP1660517A4 EP 1660517 A4 EP1660517 A4 EP 1660517A4 EP 04707073 A EP04707073 A EP 04707073A EP 04707073 A EP04707073 A EP 04707073A EP 1660517 A4 EP1660517 A4 EP 1660517A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- nogo receptor
- nogo
- receptor antagonists
- antigen
- disclosed
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Diabetes (AREA)
- Immunology (AREA)
- Psychology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Physical Education & Sports Medicine (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Psychiatry (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Heart & Thoracic Surgery (AREA)
- Rheumatology (AREA)
- Cell Biology (AREA)
- Obesity (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Hospice & Palliative Care (AREA)
- Endocrinology (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/US2003/025004 WO2004014311A2 (en) | 2002-08-10 | 2003-08-07 | Nogo receptor antagonists |
PCT/US2004/002702 WO2005016955A2 (en) | 2003-08-07 | 2004-01-30 | Nogo receptor antagonists |
Publications (2)
Publication Number | Publication Date |
---|---|
EP1660517A2 EP1660517A2 (en) | 2006-05-31 |
EP1660517A4 true EP1660517A4 (en) | 2006-10-04 |
Family
ID=34192565
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP04707073A Withdrawn EP1660517A4 (en) | 2003-08-07 | 2004-01-30 | ANTAGONISTS OF NOGO RECEPTOR |
Country Status (11)
Country | Link |
---|---|
EP (1) | EP1660517A4 (ja) |
JP (1) | JP2007501612A (ja) |
CN (1) | CN1926147A (ja) |
AU (1) | AU2004264405A1 (ja) |
BR (1) | BRPI0413426A (ja) |
CA (1) | CA2535007A1 (ja) |
IS (1) | IS8339A (ja) |
MX (1) | MXPA06001444A (ja) |
NO (1) | NO20061081L (ja) |
PL (1) | PL380274A1 (ja) |
WO (1) | WO2005016955A2 (ja) |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7119165B2 (en) | 2000-01-12 | 2006-10-10 | Yale University | Nogo receptor-mediated blockade of axonal growth |
WO2004014311A2 (en) | 2002-08-10 | 2004-02-19 | Yale University | Nogo receptor antagonists |
ES2215470B1 (es) | 2002-09-30 | 2005-12-16 | Bsh Electrodomesticos España, S.A. | Aparato de aire acondicionado. |
ES2215469B1 (es) | 2002-09-30 | 2005-12-16 | Bsh Electrodomesticos España, S.A. | Aparato de aire acondicionado. |
ES2537015T3 (es) | 2003-03-19 | 2015-06-01 | Biogen Ma Inc. | Proteína de unión del receptor de NOGO |
BRPI0512500A (pt) | 2004-06-24 | 2008-03-11 | Biogen Idec Inc | tratamento ou condições envolvendo desmielinação |
EP1789070B1 (en) | 2004-08-03 | 2012-10-24 | Biogen Idec MA Inc. | Taj in neuronal function |
WO2006124627A2 (en) * | 2005-05-12 | 2006-11-23 | Biogen Idec Ma Inc. | Methods of treating conditions involving neuronal degeneration |
US7893032B2 (en) | 2005-07-07 | 2011-02-22 | Yale University | NgR variants and compositions thereof for suppressing axonal growth inhibition |
JP2009502123A (ja) | 2005-07-08 | 2009-01-29 | バイオジェン・アイデック・エムエイ・インコーポレイテッド | Sp35抗体およびその使用 |
WO2007039256A2 (de) | 2005-09-30 | 2007-04-12 | Abbott Gmbh & Co. Kg | Bindungsdomänen von proteinen der repulsive guidance molecule (rgm) proteinfamilie und funktionale fragmente davon sowie deren verwendung |
CN103215293B (zh) | 2006-01-27 | 2015-10-28 | 比奥根Ma公司 | Nogo受体拮抗剂 |
US8642040B2 (en) | 2006-07-24 | 2014-02-04 | Biogen Idec Ma Inc. | Methods for promoting myelination, neuronal survival and oligodendrocyte differentiation via administration of Sp35 or TrkA antagonists |
EP2081562B1 (en) | 2006-09-20 | 2016-02-24 | The Board of Regents of The University of Texas System | Methods for delivering volatile anesthetics for regional anesthesia and/or pain relief |
US7906120B2 (en) * | 2006-11-21 | 2011-03-15 | Abbott Laboratories | Neutralizing monoclonal antibodies against the Nogo-66 receptor (NgR) |
EP2244737B1 (en) | 2008-01-22 | 2019-04-10 | The Board of Regents of The University of Texas System | Volatile anesthetic compositions comprising extractive solvents for regional anesthesia and/or pain relief |
US8962803B2 (en) | 2008-02-29 | 2015-02-24 | AbbVie Deutschland GmbH & Co. KG | Antibodies against the RGM A protein and uses thereof |
AU2009269099B2 (en) | 2008-07-09 | 2016-03-10 | Biogen Ma Inc. | Compositions comprising antibodies to LINGO or fragments thereof |
EP2510001B1 (en) | 2009-12-08 | 2015-12-02 | AbbVie Deutschland GmbH & Co KG | Monoclonal antibodies against the rgm a protein for use in the treatment of retinal nerve fiber layer degeneration |
PE20142168A1 (es) | 2012-01-27 | 2015-01-17 | AbbVie Deutschland GmbH and Co KG | Composicion y metodo para el diagnostico y el tratamiento de las enfermedades asociadas a la degeneracion de las neuritas |
EP2849787A4 (en) | 2012-05-14 | 2016-06-15 | Biogen Ma Inc | LINGO-2 ANTAGONISTS FOR THE TREATMENT OF DISORDERS INVOLVING ENGINE NEURONS |
WO2016112270A1 (en) | 2015-01-08 | 2016-07-14 | Biogen Ma Inc. | Lingo-1 antagonists and uses for treatment of demyelinating disorders |
CN110488007A (zh) * | 2019-09-26 | 2019-11-22 | 天津华科泰生物技术有限公司 | 一种快速检测神经胶质纤维酸性蛋白的免疫层析检测卡及其制备方法 |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6475753B1 (en) * | 1998-06-16 | 2002-11-05 | Human Genome Sciences, Inc. | 94 Human Secreted Proteins |
WO2003035687A1 (en) * | 2001-10-22 | 2003-05-01 | Novartis Ag | Nogo receptor homologues and their use |
-
2004
- 2004-01-30 MX MXPA06001444A patent/MXPA06001444A/es unknown
- 2004-01-30 PL PL380274A patent/PL380274A1/pl not_active Application Discontinuation
- 2004-01-30 JP JP2006522535A patent/JP2007501612A/ja active Pending
- 2004-01-30 BR BRPI0413426-5A patent/BRPI0413426A/pt not_active IP Right Cessation
- 2004-01-30 AU AU2004264405A patent/AU2004264405A1/en not_active Abandoned
- 2004-01-30 CN CNA2004800294122A patent/CN1926147A/zh active Pending
- 2004-01-30 EP EP04707073A patent/EP1660517A4/en not_active Withdrawn
- 2004-01-30 CA CA002535007A patent/CA2535007A1/en not_active Abandoned
- 2004-01-30 WO PCT/US2004/002702 patent/WO2005016955A2/en active Application Filing
-
2006
- 2006-03-06 NO NO20061081A patent/NO20061081L/no not_active Application Discontinuation
- 2006-03-07 IS IS8339A patent/IS8339A/is unknown
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6475753B1 (en) * | 1998-06-16 | 2002-11-05 | Human Genome Sciences, Inc. | 94 Human Secreted Proteins |
WO2003035687A1 (en) * | 2001-10-22 | 2003-05-01 | Novartis Ag | Nogo receptor homologues and their use |
Non-Patent Citations (2)
Title |
---|
GRANDPRE T ET AL: "Nogo-66 receptor antagonist peptide promotes axonal regeneration", NATURE, NATURE PUBLISHING GROUP, LONDON, GB, vol. 417, 30 May 2002 (2002-05-30), pages 547 - 551, XP002963387, ISSN: 0028-0836 * |
See also references of WO2005016955A2 * |
Also Published As
Publication number | Publication date |
---|---|
NO20061081L (no) | 2006-04-18 |
PL380274A1 (pl) | 2007-01-22 |
WO2005016955A2 (en) | 2005-02-24 |
CN1926147A (zh) | 2007-03-07 |
BRPI0413426A (pt) | 2006-10-17 |
CA2535007A1 (en) | 2005-02-24 |
WO2005016955A3 (en) | 2006-07-20 |
MXPA06001444A (es) | 2006-05-15 |
IS8339A (is) | 2006-03-07 |
EP1660517A2 (en) | 2006-05-31 |
JP2007501612A (ja) | 2007-02-01 |
AU2004264405A1 (en) | 2005-02-24 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
17P | Request for examination filed |
Effective date: 20060306 |
|
AK | Designated contracting states |
Kind code of ref document: A2 Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT RO SE SI SK TR |
|
AX | Request for extension of the european patent |
Extension state: AL LT LV MK |
|
RIN1 | Information on inventor provided before grant (corrected) |
Inventor name: SAH, DINAH, W.Y. Inventor name: STRITTMATTER, STEPHEN, M. Inventor name: WORLEY, DANE S. Inventor name: RELTON, JANE K. Inventor name: RABACCHI, SYLVIA A. Inventor name: LI, WEIWEI355 BARD AVENUE APT. 1H Inventor name: PEPINSKY, R. BLAKE Inventor name: LEE, DANIEL H.S. |
|
PUAK | Availability of information related to the publication of the international search report |
Free format text: ORIGINAL CODE: 0009015 |
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A4 | Supplementary search report drawn up and despatched |
Effective date: 20060905 |
|
RIC1 | Information provided on ipc code assigned before grant |
Ipc: C07K 14/47 20060101ALI20060830BHEP Ipc: C07K 16/46 20060101ALI20060830BHEP Ipc: C07K 7/08 20060101ALI20060830BHEP Ipc: C07K 7/06 20060101ALI20060830BHEP Ipc: C07K 1/00 20060101AFI20050301BHEP |
|
17Q | First examination report despatched |
Effective date: 20061129 |
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REG | Reference to a national code |
Ref country code: HK Ref legal event code: DE Ref document number: 1092479 Country of ref document: HK |
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STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
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18D | Application deemed to be withdrawn |
Effective date: 20130801 |