EP1648581B1 - Procede d'extraction faisant intervenir un micro-melangeur statique - Google Patents

Procede d'extraction faisant intervenir un micro-melangeur statique Download PDF

Info

Publication number
EP1648581B1
EP1648581B1 EP04739597A EP04739597A EP1648581B1 EP 1648581 B1 EP1648581 B1 EP 1648581B1 EP 04739597 A EP04739597 A EP 04739597A EP 04739597 A EP04739597 A EP 04739597A EP 1648581 B1 EP1648581 B1 EP 1648581B1
Authority
EP
European Patent Office
Prior art keywords
channels
plate
plates
mixing zone
sub
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Not-in-force
Application number
EP04739597A
Other languages
German (de)
English (en)
Other versions
EP1648581A1 (fr
Inventor
Gerhard Schanz
Gerhard Sendelbach
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Procter and Gamble Co
Original Assignee
Procter and Gamble Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Procter and Gamble Co filed Critical Procter and Gamble Co
Publication of EP1648581A1 publication Critical patent/EP1648581A1/fr
Application granted granted Critical
Publication of EP1648581B1 publication Critical patent/EP1648581B1/fr
Anticipated expiration legal-status Critical
Not-in-force legal-status Critical Current

Links

Images

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/30—Micromixers
    • B01F33/301—Micromixers using specific means for arranging the streams to be mixed, e.g. channel geometries or dispositions
    • B01F33/3012—Interdigital streams, e.g. lamellae
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D11/00—Solvent extraction
    • B01D11/04—Solvent extraction of solutions which are liquid
    • B01D11/0446—Juxtaposition of mixers-settlers
    • B01D11/0453—Juxtaposition of mixers-settlers with narrow passages limited by plates, walls, e.g. helically coiled tubes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D11/00—Solvent extraction
    • B01D11/04—Solvent extraction of solutions which are liquid
    • B01D11/0496—Solvent extraction of solutions which are liquid by extraction in microfluidic devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/30—Injector mixers
    • B01F25/31—Injector mixers in conduits or tubes through which the main component flows
    • B01F25/314—Injector mixers in conduits or tubes through which the main component flows wherein additional components are introduced at the circumference of the conduit
    • B01F25/3142—Injector mixers in conduits or tubes through which the main component flows wherein additional components are introduced at the circumference of the conduit the conduit having a plurality of openings in the axial direction or in the circumferential direction
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/30—Micromixers
    • B01F33/301—Micromixers using specific means for arranging the streams to be mixed, e.g. channel geometries or dispositions
    • B01F33/3017—Mixing chamber
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/30—Micromixers
    • B01F33/304—Micromixers the mixing being performed in a mixing chamber where the products are brought into contact
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/56—General build-up of the mixers
    • B01F35/561—General build-up of the mixers the mixer being built-up from a plurality of modules or stacked plates comprising complete or partial elements of the mixer
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F2215/00—Auxiliary or complementary information in relation with mixing
    • B01F2215/04—Technical information in relation with mixing
    • B01F2215/0413—Numerical information
    • B01F2215/0418—Geometrical information
    • B01F2215/0431—Numerical size values, e.g. diameter of a hole or conduit, area, volume, length, width, or ratios thereof

Definitions

  • the invention relates to a process for the extraction of one or more substances from a fluid starting material with a suitable extraction agent using a static micromixer for mixing the starting material with the extractant.
  • the extraction uses a solvent (extractant) to separate one or more components from a mixture of substances.
  • Fluid mixtures may be liquid or gaseous.
  • Extraction is generally understood to mean the enrichment or recovery of substances from liquid mixtures by means of selectively acting immiscible solvents. However, it is also possible to extract substances from gaseous mixtures by means of suitable solvents.
  • Extraction methods play a role in particular when thermal processes such as distillation are unsuitable. Extraction methods can be used, for example, in the separation of systems with similar boiling points, for example the aromatics extraction from hydrocarbons, for example petroleum fractions; Separation of high-boiling substances from aqueous systems (eg phenols); Separation of temperature-sensitive substances, eg biological or biotechnologically derived substances (eg antibiotics from fermentation solutions); Separation of azeotropic mixtures; Extraction of organic substances from salt solutions; Extraction of salts from polymer solutions; Extraction of metal salts from ores for metal extraction or wastewater for wastewater treatment, eg extraction of copper, nickel and cobalt from aqueous salt solutions with hydroxyoximes dissolved in kerosene; Processing of nuclear fuels, eg extraction of uranium, plutonium and thorium salts by tributyl phosphate; or generally as a cleaning operation in chemical engineering.
  • nuclear fuels eg extraction of
  • the fluid extraction is based on the distribution equilibrium of the substances to be extracted between two immiscible fluid phases.
  • a component to be extracted (extract substance) is dissolved or dispersed in a fluid carrier medium.
  • a solvent which is immiscible with the carrier medium generally has the highest possible selectivity for the extractant.
  • Carrier medium and extractant are contacted with each other and ideally sets a distribution equilibrium for the distribution of the extract substance between the carrier medium and extractant. After phase separation, the raffinate formed is depleted of extract substance and the extract formed is enriched in extract substance. Frequently, a single equilibrium step is not sufficient for the desired enrichment, because the equilibrium setting was not complete or the selectivity was insufficient. It can then be worked with several, series-connected separation stages.
  • the largest possible phase boundary In order to effect a most efficient mass transfer between the immiscible fluid phases, the largest possible phase boundary must be created.
  • one of the two phases is distributed in drops, ie it a mixture of a disperse phase and a continuous phase is generated.
  • Which of the two phases is dispersed depends on several factors, eg material properties, amounts of the phases or type of extraction apparatus.
  • the phase which provides the larger surface area is dispersed; usually the phase with the larger flow rate. Distribution of the phases is particularly difficult when using high surface tension phases. On the other hand, high interfacial tension is desirable to prevent the formation of difficultly emulsifiable emulsions.
  • the object of the invention was to further improve extraction processes, in particular with regard to efficient mixing of carrier medium and extractant.
  • the micro mixers can be integrated with a separator in a mixer / separator unit, but a separator can also be connected separately.
  • the interaction or series connection of two or more integrated or separate mixer / separator units in a mixer / separator battery in a small space results in further possibilities of process optimization, in particular with regard to achieving the desired degree of enrichment or depletion.
  • the efficient formation of large boundary surfaces achievable with the static micromixers used according to the invention in particular also when mixing fluids having a high interfacial tension, supports the adjustment of the distribution equilibrium. Mixing times between 1 s and a few milliseconds can be achieved.
  • micromixers are based on diffusion-controlled mixing processes. For this purpose, alternately adjacent fluid fins of a thickness in the micrometer range are generated. The choice of geometry makes it possible to adjust the width of the fluid fins and thus the diffusion paths.
  • static micromixers are described, for example in DE 199 27 556 A1 . DE 202 06 371 U1 . WO 02/089962 .
  • the disadvantage of the micromixer based on diffusion between microscopic fluid lamellae is that a relatively low flow velocity is required for generating and maintaining laminar flow conditions. With this mixing principle, only relatively low throughputs are possible.
  • micromixers which consist of guide channels provided with through channels or grooved films which, when stacked, yield a number of channels for the various fluids to be mixed, the dimensions of the channels lying in the micrometer range.
  • the educt streams emerge as adjacent fluid lamellae from the channels into a mixing space, the mixing occurring by diffusion and / or turbulence (see in particular FIG WO 97/17130 and literature cited there as well WO 97/17133 . WO 95/30475 . WO 97/16239 . WO 00/78438 ).
  • the production of these components is relatively expensive and expensive and it can occur in the passage of the fluids to be mixed by a large number of long and very narrow channels relatively high pressure losses. This may require the use of powerful pumping systems if high throughputs are to be achieved.
  • a method according to the preamble of claim 1 is in the document WO-A-02/16017 disclosed.
  • fluid is understood to mean a gaseous or liquid substance or a mixture of such substances, which may contain one or more solid, liquid or gaseous substances dissolved or dispersed.
  • subchannels also includes splitting the fluid stream into sub-streams through microstructure installations just prior to exiting into the mixing zone.
  • the dimensions, in particular the lengths and widths of these installations can be in the range of millimeters or preferably less than 1 mm.
  • the sub-channels are preferably shortened to the flow control absolutely necessary length and therefore require for a given throughput comparable low pressures.
  • the ratio of the length to the width of the subchannels is preferably in the range from 1: 1 to 20: 1, in particular from 8: 1 to 12: 1, particularly preferably about 10: 1.
  • the microstructure internals are preferably designed such that the flow rate of the fluid stream as it exits into the mixing zone is both greater than when it enters the connecting channel and preferably also greater than the flow rate of the mixture through the mixing zone.
  • the applied on the plates connecting and sub-channels can be executed in free form. Both the panels and each individual channel contained on them can vary in height, width and thickness to promote different media and quantities.
  • the basic shape of the plates is arbitrary and can be round, for example circular or elliptical or angular, for example rectangular or square.
  • the plate shape can also be optimized in terms of the simplest possible production or in terms of the lowest possible weight and the smallest possible unused area.
  • the outputs of the subchannels may be arranged in any manner, from the straight line to any geometric shape.
  • the outlet openings may be arranged, for example, on a circular line, in particular if the mixing zone is completely enclosed by the plate plane.
  • the sub-channels may be at any angle to each other or to the line on which the outputs are in the mixing zone. It can be arranged side by side several sub-channels, each leading eg component A and in the adjacent section of the same disc several sub-channels can be arranged side by side, each leading eg component B.
  • the components can also be designed by means of additional openings and additional sub-channels in the plates so that the components A, B, etc. alternate in the same plate from sub-channel to sub-channel.
  • the sub-channels have at the mouth in the mixing zone preferably a width in the range of 1 .mu.m to 2 mm and a depth in the range of 10 .mu.m to 10 mm and more preferably a width in the range of 5 .mu.m to 250 .mu.m and a depth in the range of 250 ⁇ m to 5 mm.
  • connection channel can have a variable width.
  • the ratio of the largest width of Connecting channel and / or the width of the inlet opening to the width of the sub-channels at the outlet into the mixing zone greater than 2, more preferably greater 5.
  • the ratio of the width of the mixing zone to the width of the sub-channels is preferably greater than 2, more preferably greater than 5.
  • the plate-shaped components may have a thickness of 10 to 1000 microns.
  • the height of the channels is preferably less than 1000 microns, more preferably less than 250 microns.
  • the wall thickness of the microstructure installations and the channel bottom is preferably less than 100 ⁇ m, more preferably less than 70 ⁇ m.
  • the inlet or outlet openings or the mixing zone is completely enclosed by the plate plane.
  • the openings are then, for example, as round or square, for example, rectangular recesses.
  • the preferred shape is ellipsoidal or circular.
  • the sub-channels can be tapered in the direction of the mixing zone in the form of nozzles.
  • the sub-channels can be bent in a straight line or spirally.
  • the sub-channels may open at right angles with respect to the circumference of the mixing zone in the mixing zone or at an angle other than 90 °.
  • a non-rectangular course in the formation of a stack of a plurality of mixer plates, preferably plates with opposite deviation from the right angle are adjacent.
  • a spiral course of the subchannels in the formation of a stack of a plurality of mixer plates, in each case preferably plates with the opposite direction of rotation of the spiral are adjacent.
  • the sub-channels have a curved course in such a way that the same direction of rotation is given to the inflows into the mixing zone and a strong twist forms within the mixed stream, which has the consequence that a centrifugal effect arises.
  • the heavier of the liquid components will preferably be at the outer edge of the mixed flow passing through the mixing zone and the lighter component in the middle of the mixed flow. In this way, when the material to be extracted is in the heavier phase, a particularly intimate mixing occurs with the lighter phase, which flows in from the microchannels forming the wall of the main channel. In this way, the theoretical plate number of an extraction can be increased.
  • Such a static centrifugal extractor has advantages of a rotary extractor, without relying on its complex and error-prone mechanics.
  • the connecting channel between the openings is preferably formed by a depression.
  • the inlet and / or outlet opening or the mixing zone can also be arranged at the edge of the plate or by recesses at the edge of the plate.
  • At least two inlet openings for at least two different fluid streams are present, each inlet opening being connected by a respective connecting channel with the mixing zone.
  • the material for the components e.g. Metals, in particular corrosion-resistant metals, e.g. Stainless steel, as well as glasses, ceramics or plastic.
  • the components may be manufactured by per se known techniques for producing microstructures on surfaces, e.g. by etching or milling metals or by embossing or spraying plastics.
  • a static micromixer used according to the invention has a housing with at least 2 fluid feeds and at least one fluid outlet.
  • In the housing are at least 2 arranged in a stack plate-shaped Mikromischerbaumaschine. From any number of plates, stacks can be produced which can realize a flow corresponding to the stack height. In order to ensure the same pressure at each point of the mixer, at longer lengths, the fluid supply can take place at several points. Grooves or webs in or on the plates can serve for stackability and adjustability.
  • the plates are superimposed so that the inlet openings side channels for supplying the respective carrier and extraction fluid and the outlet openings or the mixing zones together form a main channel for discharging the fluid mixture and the main and secondary channels extend through the stack.
  • the housing wall forms a part of the secondary channel wall which closes off the respective secondary channel to the outside. If the mixing zone is arranged as a recess at the edge of the plate, the housing wall forms a part of the main channel wall which closes off the main channel to the outside.
  • the micromixer can have, for example, at least 5, 10, 100 or even more than 1000 subchannels and consists of a stack of plates each having a plurality of subchannels.
  • each partial flow of a first fluid A emerging from an outlet opening of a plate into the mixing zone is immediately adjacent to a partial flow of a second fluid B emerging from an outlet opening of an adjacent plate into the mixing zone and mixing in the mixing zone occurs through diffusion and / or turbulence , wherein mixing is preferred, which occurs at least partially or completely by turbulence.
  • the connecting channels of the plates are formed by depressions and the connecting channels are split into sub-channels before the mouth into the mixing zone by microstructure units mounted on the plates.
  • the connecting channels of the plates are formed by recesses in the plates, wherein the plates are arranged as intermediate plates between each cover and a bottom plate and the connecting channels mounted in front of the mouth in the mixing zone through at the top and / or bottom plates Microstructure units are split into subchannels.
  • heat exchangers can be integrated for heat supply or removal. As a result, due to the temperature dependence of the distribution coefficients, the separation behavior can be further optimized and it Low-temperature extractions of temperature-sensitive substances can be carried out under cooling.
  • the flow rate of the fluid flow or of the fluid flows into the mixing zone is greater than the flow velocity of the mixture within the mixing zone.
  • Particular preference is given to embodiments of the micromixer and to flow speeds at which turbulence is generated in the mixing zone and the mixture in the mixing zone is entirely or at least partially turbulent.
  • one of the phases (preferably the continuous phase) is fed through the main channel and a second phase (preferably the phase to be dispersed) via a secondary channel.
  • the number of channels in the plates can be increased or the number of plates stacked in a micromixer can be increased or several micromixers can be operated in a modular manner connected in parallel. It is also possible to operate two or more micromixers connected in series one behind the other, in particular to improve the separation efficiency.
  • separators for separating and separating the immiscible phases can either be integrated in the micromixers and / or be connected downstream of the micromixers as separate units.
  • the plates (1) each have two enclosed inlet openings (2).
  • Each inlet opening (2) is connected to one, in the plate plane formed by a depression connecting channel (3).
  • Each well channel (3) is split by a plurality of microstructure units (6) into a plurality of subchannels (7).
  • the sub-channels (7) open through the outlet openings (4) in an enclosed mixing zone (5).
  • the outlet openings (4) are arranged on a circular line around the mixing zone (5).
  • Mixing zone (5) and inlet openings (2) are formed as openings in the plates.
  • the microstructure units are formed, for example, spirally curved, wherein the spirals in Fig.1a and Fig. 1b opposite Have direction of rotation.
  • the microstructure units can also be formed in a straight line, unbent. If the plates are round, they preferably have at the edge recesses (8), which can cooperate with support elements (14) in a housing (11) to prevent twisting or slipping of the plates.
  • the plates can also be square, preferably square, for example square. Then the recesses and support elements can be omitted.
  • a micromixer preferably has a stack of a plurality of superimposed components, wherein plates according to Fig. 1a with such according to Fig.
  • FIG. 1c Another embodiment is in Fig. 1c shown.
  • the plate (1) has a single enclosed inlet opening (2), which is connected to a formed in the plane of the plate by a depression connecting channel (3).
  • the well channel (3) is split by a plurality of microstructure units (6) into a plurality of subchannels (7).
  • the sub-channels (7) open through the outlet openings (4) in the mixing zone (5).
  • the outlet openings (4) are arranged on a circular line around the mixing zone (5).
  • Mixing zone (5) and inlet opening (2) are formed as openings in the plate.
  • the microstructure units are formed by way of example spirally curved.
  • the microstructure units can also be rectilinear, unbent or formed in any other geometric shapes.
  • a micromixer preferably has a stack of several superimposed components. In the stack, the plates are superimposed so that the inlet openings form a secondary channel for supplying a fluid flow and the mixing zones form a main channel for discharging the mixture.
  • the plate stack may have a structure with an alternating layer structure, with plates lying alternately on one another, which have spiral-shaped microstructure units (6) in the opposite direction of rotation. But it can also be used only a single plate type.
  • the microstructure units are then preferably rectilinear and shaped such that the subchannels form nozzles.
  • the plate (1) has an enclosed inlet opening (2), an enclosed mixing zone (5) and an enclosed passage opening (9).
  • the inlet opening (2) is connected to a plate channel formed by a depression connecting channel (3), which is split by a plurality of microstructure units (6) in a plurality of sub-channels (7).
  • the sub-channels (7) open through the outlet openings (4) in the mixing zone (5).
  • the outlet openings (4) are arranged on a circular line around the mixing zone (5).
  • Mixing zone (5), inlet opening (2) and passage opening (9) are formed as openings in the plate.
  • the microstructure units are formed by way of example spirally curved.
  • the microstructure units can also be rectilinear, unbent or formed in any other geometric shapes.
  • the flow conditions in the connecting channel (3) can be optimized.
  • the plates are round, they preferably have at the edge recesses (8), which can cooperate with support elements (14) in a housing (11) to prevent twisting or slipping of the plates.
  • a micromixer preferably has a stack of a plurality of superimposed components, wherein plates according to Fig. 1d alternately twisted by 180 °. In this way, it is achieved that two different fluid streams can be supplied directly adjacent to one another and with one another to the mixing zone (5). In the stack, the plates are superimposed so that inlet openings (2) and passage openings (9) alternate and two secondary channels for supplying two fluid streams form and the mixing zones form a main channel for discharging the mixture.
  • the plate stack may have a structure with an alternating layer structure, with plates lying alternately on one another, which have spiral-shaped microstructure units (6) in the opposite direction of rotation. But it can also be used only a single plate type.
  • the microstructure units are then preferably rectilinear and shaped such that the subchannels form nozzles.
  • FIG. 2a to 2c Another embodiment is in Fig. 2a to 2c shown.
  • the plates (1) each have three enclosed inlet openings (2).
  • Each inlet opening (2) is connected to one, in the plate plane formed by a depression connecting channel (3).
  • Each recessed channel (3) is split by at least one microstructure unit (6) into at least two subchannels (7).
  • the sub-channels (7) open through the outlet openings (4) in the mixing zone (5).
  • the outlet openings (4) are arranged on a circular line around the mixing zone (5).
  • Mixing zone (5) and inlet openings (2) are formed as openings in the plates.
  • the microstructure units may be spirally formed with different directions of rotation or rectilinear.
  • a micromixer points Preferably, a stack of a plurality of superimposed components, wherein the different types of plates according to Fig. 2a, 2b and 2c alternate and results in a structure with alternating layer structure, eg ABCABC.
  • a structure with alternating layer structure eg ABCABC.
  • the plates are superimposed so that the inlet openings form secondary channels for supplying the respective fluid flow and the mixing zones form a main channel for discharging the mixture.
  • a fluid which forms the subsequent continuous phase of the mixture can also be supplied via the main channel.
  • FIG. 3a and Fig. 3b Another embodiment is in Fig. 3a and Fig. 3b shown.
  • the plates (1) each have two inlet openings (2) positioned at the edge of the plate.
  • Each inlet opening (2) is connected to one, in the plate plane formed by a depression connecting channel (3).
  • Each well channel (3) is split by a plurality of microstructure units (6) into a plurality of subchannels (7).
  • the sub-channels (7) open through the outlet openings (4) in an enclosed mixing zone (5).
  • the outlet openings (4) are arranged on a straight line.
  • the mixing zone (5) is exemplified as a rectangular breakthrough formed in the plates.
  • the microstructure units are exemplified obliquely to the flow direction, wherein the bevels in Fig.1a and Fig. 1b have opposite direction.
  • the microstructure units can also each be designed with the same or no bevel.
  • the plates have approximately square basic shape, However, they can also have any other basic geometric shape (angular, round, elliptical, etc.).
  • a micromixer preferably has a stack of a plurality of superimposed components, wherein plates according to Fig. 3a with such according to Fig. 3b alternate and results in a structure with alternating layer structure ABAB. In this way, it is achieved that two different fluid streams can be supplied directly adjacent to one another and with one another to the mixing zone (5).
  • the plates are superimposed so that the inlet openings together with the mixer housing at the edge of the mixer side channels for supplying the respective fluid flow and the mixing zones form a main channel in the interior of the mixer for discharging the mixture.
  • a fluid which forms the subsequent continuous phase of the mixture can also be supplied via the main channel.
  • FIG. 3c and Fig. 3d Another embodiment is in Fig. 3c and Fig. 3d shown.
  • the plates (1) each have four inlet openings (2) positioned at the edge of the plate.
  • Each inlet opening (2) is connected to one, in the plate plane formed by a depression connecting channel (3).
  • Each well channel (3) is split by several microstructure units (6) into several subchannels (7).
  • the sub-channels (7) open through the outlet openings (4) in an enclosed mixing zone (5).
  • the outlet openings (4) are arranged on a circular line.
  • the connection channels are spirally bent, the direction of rotation of the spirals in Fig. 3c and Fig. 3d are opposite.
  • the mixing zone (5) is formed as a breakthrough in the plates.
  • the microstructure units are exemplified straight, but may also be bent obliquely or spirally.
  • the plates have approximately square basic form, but can also have any other basic geometric shape (angular, round, elliptical, etc.).
  • a micromixer preferably has a stack of a plurality of superimposed components, wherein plates according to Fig. 3c with such according to Fig. 3d alternate with the opposite direction of rotation of the spiral-shaped connecting channels and results in a structure with alternating layer structure ABAB. In this way, it is achieved that two different fluid streams can be supplied directly adjacent to one another and with one another to the mixing zone (5).
  • the plates are superimposed so that the inlet openings together with the mixer housing at the edge of the mixer side channels for supplying the respective fluid flow and the mixing zones form a main channel in the interior of the mixer for discharging the mixture.
  • a fluid which forms the subsequent continuous phase of the mixture can also be supplied via the main channel.
  • FIG. 4a to 4f Other embodiments are in Fig. 4a to 4f shown.
  • the plates (1) each have an enclosed inlet opening (2) and each an enclosed passage opening (9).
  • Each inlet opening (2) is connected to one, in the plate plane formed by a depression connecting channel (3).
  • Each connection channel (3) is split by a plurality of microstructure units (6) into a plurality of subchannels (7).
  • the sub-channels (7) open at the edge of the plates arranged outlet openings (4) in a lying outside the plate surface mixing zone (5).
  • the outlet openings (4) can on straight lines ( Fig. 4e, 4f ) or on arc segments, the arc segments being convex ( Fig. 4a, 4b ) or concave ( Fig. 4c, 4d ) could be.
  • the inlet openings (2) and the passage openings (9) are formed as openings in the plates.
  • the microstructure units may be set in parallel or at different angles to the direction of flow through the connection channel. If the plates are round, they preferably have at the edge recesses (8), which can cooperate with support elements (14) in a housing (11) to prevent twisting or slipping of the plates.
  • a micromixer preferably has a stack of a plurality of superimposed components, wherein plates according to Fig. 4a with such according to Fig. 4b , or plates according to Fig. 4c with such according to Fig. 4d , or plates according to Fig. 4e with such according to Fig. 4f each alternate and results in a structure with alternating layer structure ABAB.
  • the angles of the sub-channels at the mouth into the mixing zone are different in relation to the peripheral line of the mixing zone in adjacent plates, more preferably they have opposite deviations of 90 °.
  • the plates are superimposed on one another so that inlet openings (2) and passage openings (9) alternate and form two secondary channels located inside the mixer for supplying two fluid streams.
  • the mixing zone may form with a housing a main channel for discharging the mixture.
  • the plates (1) each have an enclosed inlet opening (2) and two enclosed passage openings (9).
  • Each inlet opening (2) is connected to one, in the plate plane formed by a depression connecting channel (3).
  • Each connection channel (3) is split by a plurality of microstructure units (6) into a plurality of subchannels (7).
  • the sub-channels (7) open at the edge of the plates arranged outlet openings (4) in a lying outside the plate surface mixing zone (5).
  • the outlet openings (4) can on straight lines ( Fig. 5a ) or on arc segments ( Fig. 5b ), wherein the arc segments may be convex or concave.
  • the inlet openings (2) and the passage openings (9) are formed as openings in the plates.
  • the microstructure units may be set in parallel or at different angles to the direction of flow through the connection channel. If the plates are round, they preferably have at the edge recesses (8), which can cooperate with support elements (14) in a housing (11) to prevent twisting or slipping of the plates.
  • a micromixer preferably has a stack of a plurality of superimposed components, wherein plates of the three according to different types Fig. 5a or 5b respectively alternating and results in a structure with alternating layer structure ABCABC. In this way, it is achieved that in each case different fluid streams can be supplied directly adjacent to one another and with one another to the mixing zone (5).
  • the angles of the sub-channels at the mouth into the mixing zone are different in relation to the peripheral line of the mixing zone in adjacent plates, more preferably they have opposite deviations of 90 °.
  • the plates (1) lie over one another such that inlet openings (2) and passage openings (9) alternate and form three secondary channels located inside the mixer for feeding up to three different fluid streams.
  • the mixing zone (5) can form with a housing a main channel for discharging the mixture.
  • FIG. 6a is shown in the form of a longitudinal section of the schematic structure of an embodiment of a static micromixer.
  • a housing (11) has fluid feeds (12a).
  • a stack of several mixer plates (1) is included in the housing (11) .
  • the inlet and / or passage openings of the plates can be closed and opened by means of a locking device (13a) which is preferably movable perpendicular to the plane of the plate. With the closure device and the flow rate can be adjusted.
  • the mixture can be removed from the mixing zone within the housing via a suitable fluid removal.
  • a static mixer In Fig. 6b the cross section of a static mixer is shown.
  • a housing (11) In a housing (11) is a mixer plate (1) which is held in position by means of recesses (8) and retaining elements (14).
  • a mixer plate As a mixer plate is exemplified according to such Fig. 5a shown.
  • Fig. 7a-b and Fig. 8a-c preferred embodiments are in Fig. 7a-b and Fig. 8a-c shown.
  • the plates (1) adjacent sub-channels (7) and (13), which can be alternately flowed through by different fluid streams and so different fluid streams in a plane immediately adjacent to the mixing zone (5) can be supplied.
  • the plates (1) shown each have an enclosed inlet opening (2), an enclosed mixing zone (5) and an enclosed passage opening (9).
  • the inlet opening (2) is connected to a plate channel formed by a depression connecting channel (3), which is split by a plurality of microstructure units (6) in a plurality of sub-channels (7).
  • the sub-channels (7) open through the outlet openings (4) in the mixing zone (5).
  • the outlet openings (4) are arranged on a circular line around the mixing zone (5).
  • Mixing zone (5), inlet opening (2) and passage opening (9) are formed as openings in the plate.
  • In the microstructure units (6) deepened further sub-channels (13) are integrated, which are shielded from the connecting channel (3) and open into the mixing zone (5).
  • the sub-channels (7) and the further sub-channels (13) are arranged alternately adjacent.
  • the plates have additional openings (12), the number of openings (12) and the number of additional Partial channels (13) are the same size.
  • the apertures (12) are arranged so that when a plate (1) rotated by 180 ° on a second plate (1) is placed, each above the additional sub-channels (13) of the underlying plate.
  • a fluid stream flowing through the inlet opening (2) into the connecting channel (3) can flow through the openings (12) into an additional partial channel (13) of an underlying plate.
  • the angles of adjacent sub-channels (7) and (13) to each other and with respect to the circumferential line of the mixing zone may be different. In Fig.
  • Fig. 7a shows side by side two identical, rotated by 180 ° plates (1).
  • Fig. 7b schematically shows two 180 ° twisted plates.
  • a micromixer preferably has a stack of a plurality of superimposed components, wherein plates according to Fig. 7a alternately twisted by 180 °.
  • the plates are superimposed so that inlet openings (2) and passage openings (9) alternate and form two secondary channels for supplying two fluid streams and the mixing zones form a main channel for discharging the mixture form.
  • a fluid which forms the subsequent continuous phase of the mixture can also be supplied via the main channel.
  • the plates are superimposed so that each additional opening (12) of a plate is communicatively connected to a respective additional sub-channel (13) of an adjacent plate.
  • Fig. 8a is an embodiment similar to that of Fig. 7a shown, with the difference that the sub-channels (7) and the additional sub-channels (13) are fed in parallel at equal angles to the mixing zone (5) obliquely.
  • the left plate of the Fig. 8a differs from the right plate in that the angle of the sub-channels (7) and (13) to the peripheral line of the mixing zone (5) has an opposite deviation of 90 °.
  • a micromixer preferably comprises a stack of a plurality of superimposed components, wherein left and right plates according to Fig. 8a alternate and results in a structure with alternating layer structure ABAB. This ensures that two different fluid streams immediately adjacent to each other and the mixing zone (5) can be supplied at opposite angles.
  • Fig. 8c is an embodiment similar to that of Fig. 8a shown, with the difference that the sub-channels (7) and the additional sub-channels (13) are fed parallel and perpendicular to the mixing zone (5).
  • a micromixer preferably has a stack of a plurality of superimposed components, wherein left and right plates according to Fig. 8c alternate and results in a structure with alternating layer structure ABAB. By doing Stack the plates are superimposed so that the inlet openings (2) and passage openings (9) alternate and form two secondary channels for supplying two fluid streams and the mixing zones form a main channel for discharging the mixture.
  • each additional opening (12) of a plate is communicatively connected to a respective additional sub-channel (13) of an adjacent plate. This ensures that two different fluid streams both immediately adjacent to each other and with each other and immediately adjacent to each other the mixing zone (5) can be supplied.
  • a plate (1) has an enclosed inlet opening (2), three enclosed passage openings (9) and an enclosed mixing zone (5).
  • the inlet opening (2) is connected to a plate channel formed by a depression connecting channel (3), which is split by a plurality of microstructure units (6) in a plurality of sub-channels (7).
  • the sub-channels (7) open through the outlet openings (4) in the mixing zone (5).
  • the outlet openings (4) are arranged on a circular line around the mixing zone (5).
  • Mixing zone (5), inlet opening (2) and passage opening (9) are formed as openings in the plate.
  • In the microstructure units (6) deepened further sub-channels (13) are integrated, which are shielded from the connecting channel (3) and open into the mixing zone (5).
  • the sub-channels (7) and the further sub-channels (13) are arranged alternately adjacent.
  • the plates have additional openings (12) on, wherein the number of openings (12) and the number of additional sub-channels (13) are equal.
  • the apertures (12) are arranged so that, when a plate (1) is rotated by 90 ° on a second plate (1), each lie above the additional sub-channels (13) of the underlying plate.
  • a fluid stream flowing through the inlet opening (2) into the connecting channel (3) can flow through the openings (12) into an additional partial channel (13) of an underlying plate.
  • the angles of adjacent sub-channels (7) and (13) to each other and with respect to the circumferential line of the mixing zone may be different. In Fig.
  • angles of the sub-channels (7) with respect to the angles of the additional sub-channels (13) with respect to the peripheral line of the mixing zone (5) have a deviation opposite to 90 °.
  • the sub-channels can also run parallel at right angles or obliquely to the mixing zone.
  • a micromixer preferably has a stack of a plurality of superimposed components, wherein plates according to Fig. 8b in any order by 90 °, 180 ° or 270 ° twisted over each other.
  • the plates are superposed so that inlet openings (2) and passage openings (9) alternate and form a total of four side channels for supplying up to four fluid streams and the mixing zones a main channel for Forming the mixture.
  • a fluid which forms the subsequent continuous phase of the mixture can also be supplied via the main channel.
  • the plates are superimposed so that each additional opening (12) of a plate is communicatively connected to a respective additional sub-channel (13) of an adjacent plate.
  • a housing (11) contains a stack of components according to the invention in the form of plates (1). Illustrated is an example of a stack of several plates according to Fig. 8a , but it can also be used according to the invention other plates, where appropriate, the housing shape, number and position of Fluidzu- and discharges, etc. are adapted.
  • the plates (1) are inserted so that the recesses (8) cooperate with the support elements (14) to prevent rotation of the plates.
  • the housing has two fluid feeds (12a) for supplying the fluids.
  • the housing can be closed with a lid (15), which has a fluid outlet (16).
  • the extraction process according to the invention can be carried out according to the countercurrent principle, wherein the supply of the fluid phase with lower density takes place below the supply of the fluid phase with higher density.

Landscapes

  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dispersion Chemistry (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Extraction Or Liquid Replacement (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Claims (16)

  1. Procédé pour exécuter des extractions, dans lequel
    - au moins deux phases fluides qui ne sont pas homogènement miscibles sont mélangées l'une avec l'autre,
    - dans lequel au moins l'une des phases contient un matériau extractible avec l'autre phase,
    dans lequel le mélange résulte de l'utilisation d'au moins un micro-mélangeur statique, qui a au moins un composant sous la forme d'une plaque (1) et dans lequel la plaque (1)
    - a au moins un orifice d'entrée (2) pour l'entrée d'au moins un courant de fluide dans un canal de raccordement (3) qui se trouve dans le plan de la plaque et au moins un orifice de déchargement (4) pour l'écoulement du courant de fluide dans une zone de mélange (5) qui se trouve dans le plan de la plaque,
    - dans lequel l'orifice d'entrée (2) est joint en communication avec l'orifice de déchargement (4) au moyen du canal de raccordement (3) dans le plan de la plaque et
    - dans lequel le canal de raccordement (3) est divisé en deux ou plusieurs sous-canaux (7) au moyen d'unités de microstructure (6) à l'avant de l'ouverture dans la zone de mélange (5), dans lequel les largeurs des sous-canaux sont dans la plage du millimètre au sous-millimètre et sont inférieures à la largeur de la zone de mélange (5), et
    le micro-mélangeur a un logement (11) avec au moins 2 alimentations de fluide (12a) et au moins une évacuation de fluide (16) et le logement (11) a au moins un ou plusieurs composants en forme de plaque (1) arrangés en une pile, caractérisé en ce que plusieurs plaques (1) sont utilisées lesquelles sont superposées d'une manière telle que l'orifice d'entrée (2) forme au moins un canal latéral pour alimenter chaque phase fluide à mélanger et les zones de mélange (5) forment ensemble un canal principal pour évacuer la phase mélangée et le canal principal et l'au moins un canal latéral s'étendent à travers la pile et en ce que l'agent d'extraction est guidé à travers le canal principal dans et à travers la phase contenant le matériau à extraire à travers l'au moins un canal latéral dans le micro-mélangeur.
  2. Procédé selon l'une quelconque des revendications précédentes, caractérisé en ce que les largeurs des sous-canaux (7) des plaques (1) vont de 1 µm à 2 mm au niveau de l'orifice dans la zone de mélange (5).
  3. Procédé selon l'une quelconque des revendications précédentes, caractérisé en ce que le rapport de la plus grande largeur du canal de raccordement (3) et/ou la largeur de l'orifice d'entrée (2) sur la largeur des sous-canaux (7) des plaques (1) est supérieur à 2.
  4. Procédé selon l'une quelconque des revendications précédentes, caractérisé en ce que le rapport de la longueur sur la largeur des sous-canaux (7) des plaques (1) va de 1:1 à 20:1.
  5. Procédé selon l'une quelconque des revendications précédentes, caractérisé en ce que le rapport de la largeur de la zone de mélange (5) sur la largeur des sous-canaux (7) des plaques (1) est supérieur à 2.
  6. Procédé selon l'une quelconque des revendications précédentes, caractérisée en ce que la plaque (1) a en outre au moins une ouverture de passage (9).
  7. Procédé selon l'une quelconque des revendications précédentes, caractérisé en ce qu'au moins un des orifices d'entrée (2) ou ouvertures de passage (9) ou la zone de mélange (5) de la plaque (1) est enclavé par le plan de plaque et le canal de raccordement (3) est formé par un creux.
  8. Procédé selon l'une quelconque des revendications précédentes, caractérisé en ce qu'au moins un des orifices d'entrée (2) ou ouvertures de passage (9) ou la zone de mélange (5) de la plaque (1) est arrangé sur le bord de la plaque ou par des cavités sur le bord de la plaque.
  9. Procédé selon l'une quelconque des revendications précédentes, caractérisé en ce que la plaque (1) a au moins deux orifices d'entrée (2) pour au moins deux courants de fluide différents, dans lequel chaque orifice d'entrée (2) est relié dans chaque cas à la zone de mélange au moyen d'un canal de raccordement (3).
  10. Procédé selon l'une quelconque des revendications précédentes, caractérisé en ce que la plaque (1) a deux orifices d'entrée (2) pour deux courants de fluide différents, dans lequel chaque orifice d'entrée (2) est relié dans chaque cas à la zone de mélange (5) au moyen d'un canal de raccordement (3) et les orifices de déchargement (4) de l'un et l'autre canaux de raccordement (3) sont positionnés opposés l'un à l'autre.
  11. Procédé selon l'une quelconque des revendications précédentes, caractérisé en ce que les orifices d'évacuation (4) de la plaque (1) sont arrangés dans une ligne courbe.
  12. Procédé selon l'une quelconque des revendications précédentes, caractérisé en ce que la plaque (1) a en outre des ouvertures (12) et d'autres sous-canaux (13) intégrés dans les unités de micro-structure (6) séparées des sous-canaux (7).
  13. Procédé selon l'une quelconque des revendications précédentes, caractérisé en ce que les canaux de raccordement (3) des plaques (1) sont formés par des creux et les canaux de raccordement (3) sont divisés en sous-canaux (7) par des unités de micro-structure (6) attachées aux plaques (1) avant l'entrée dans la zone de mélange (5).
  14. Procédé selon l'une quelconque des revendications précédentes, caractérisé en ce que les canaux de raccordement (3) des plaques (1) sont formés par des cavités dans les plaques (1), dans lequel les plaques sont chacune arrangées en tant que plaques intermédiaires entre une plaque de couverture et une plaque de fond et les canaux de raccordement (3) sont divisés en sous-canaux (7) au moyen des unités de micro-structure (6) attachées aux plaques de couverture et/ou de fond avant l'entrée dans la zone de mélange (5).
  15. Procédé selon l'une quelconque des revendications précédentes, caractérisé en ce que le débit d'entrée du courant de fluide dans la zone de mélange (5) est supérieur au débit du mélange de fluide au sein de la zone de mélange.
  16. Procédé selon l'une quelconque des revendications précédentes, caractérisé en ce que, dans la zone de mélange, le mélange a lieu au moins partiellement par turbulence.
EP04739597A 2003-07-25 2004-06-04 Procede d'extraction faisant intervenir un micro-melangeur statique Not-in-force EP1648581B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10333921A DE10333921B4 (de) 2003-07-25 2003-07-25 Extraktionsverfahren unter Verwendung eines statischen Mikromischers
PCT/EP2004/006043 WO2005018772A1 (fr) 2003-07-25 2004-06-04 Procede d'extraction faisant intervenir un micro-melangeur statique

Publications (2)

Publication Number Publication Date
EP1648581A1 EP1648581A1 (fr) 2006-04-26
EP1648581B1 true EP1648581B1 (fr) 2010-09-01

Family

ID=34071901

Family Applications (1)

Application Number Title Priority Date Filing Date
EP04739597A Not-in-force EP1648581B1 (fr) 2003-07-25 2004-06-04 Procede d'extraction faisant intervenir un micro-melangeur statique

Country Status (9)

Country Link
US (1) US8057677B2 (fr)
EP (1) EP1648581B1 (fr)
JP (1) JP4958216B2 (fr)
CN (1) CN1822888B (fr)
AT (1) ATE479483T1 (fr)
DE (2) DE10333921B4 (fr)
ES (1) ES2351600T3 (fr)
MX (1) MXPA06000729A (fr)
WO (1) WO2005018772A1 (fr)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4091440B2 (ja) * 2001-05-17 2008-05-28 アマルガメイテッド リサーチ インコーポレイテッド 混合および反応に利用するフラクタル装置
DE10333922B4 (de) * 2003-07-25 2005-11-17 Wella Ag Bauteile für statische Mikromischer, daraus aufgebaute Mikromischer und deren Verwendung zum Mischen, zum Dispergieren oder zur Durchführung chemischer Reaktionen
DE102004007708A1 (de) * 2004-02-16 2005-08-25 Dynamit Nobel Gmbh Explosivstoff- Und Systemtechnik Verfahren zur Aufarbeitung von flüssigen Stoffen
US20070140042A1 (en) * 2004-06-04 2007-06-21 Gerhard Schanz Multicomponent packaging with static micromixer
DE602006003419D1 (de) * 2005-04-08 2008-12-11 Huntsman Int Llc Spiralmischerdüse und verfahren zum mischen von zwei oder mehr fluiden und verfahren zur herstellung von isocyanaten
JP5030520B2 (ja) * 2006-09-29 2012-09-19 富士フイルム株式会社 流体混合方法及びマイクロデバイス
US7520661B1 (en) * 2006-11-20 2009-04-21 Aeromed Technologies Llc Static mixer
EP1992404B1 (fr) * 2007-05-15 2011-03-23 Corning Incorporated Dispositif microfluidique et procédé pour réactions de liquides immiscibles
US9440207B2 (en) * 2007-09-18 2016-09-13 Indiana University Research And Technology Corporation Compact microfluidic structures for manipulating fluids
EP2260934B1 (fr) * 2008-03-28 2016-02-17 ARKRAY, Inc. Procédé et système d'agitation de fluide
US20100093098A1 (en) * 2008-10-14 2010-04-15 Siemens Medical Solutions Nonflow-through appratus and mehod using enhanced flow mechanisms
JP5143082B2 (ja) 2009-05-22 2013-02-13 株式会社日立製作所 液液抽出システム
US9079140B2 (en) * 2011-04-13 2015-07-14 Microfluidics International Corporation Compact interaction chamber with multiple cross micro impinging jets
JP6016706B2 (ja) * 2013-04-22 2016-10-26 株式会社神戸製鋼所 処理装置及び処理方法
JP2015201646A (ja) 2014-04-07 2015-11-12 ラム リサーチ コーポレーションＬａｍ Ｒｅｓｅａｒｃｈ Ｃｏｒｐｏｒａｔｉｏｎ 構成独立型のガス供給システム
US10557197B2 (en) 2014-10-17 2020-02-11 Lam Research Corporation Monolithic gas distribution manifold and various construction techniques and use cases therefor
US9937472B2 (en) 2015-05-07 2018-04-10 Techmetals, Inc. Assembly operable to mix or sparge a liquid
US10022689B2 (en) * 2015-07-24 2018-07-17 Lam Research Corporation Fluid mixing hub for semiconductor processing tool
US10215317B2 (en) 2016-01-15 2019-02-26 Lam Research Corporation Additively manufactured gas distribution manifold
CN107325202B (zh) * 2017-07-06 2019-09-17 淄博千汇生物科技有限公司 舒更葡萄糖钠的精制方法
CN109589643A (zh) * 2018-12-21 2019-04-09 四川大学 一种刮膜式旋转微通道强化萃取设备及其应用

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4560284A (en) * 1983-11-21 1985-12-24 Chen Hwang C Continuous type of fluid mixing and feeding device
DE4416343C2 (de) * 1994-05-09 1996-10-17 Karlsruhe Forschzent Statischer Mikro-Vermischer
DE19540292C1 (de) * 1995-10-28 1997-01-30 Karlsruhe Forschzent Statischer Mikrovermischer
DE19541266A1 (de) * 1995-11-06 1997-05-07 Bayer Ag Verfahren und Vorrichtung zur Durchführung chemischer Reaktionen mittels eines Mikrostruktur-Lamellenmischers
DE19541265A1 (de) * 1995-11-06 1997-05-07 Bayer Ag Verfahren zur Herstellung von Dispersionen und zur Durchführung chemischer Reaktionen mit disperser Phase
DE19927556C2 (de) * 1999-06-16 2003-05-08 Inst Mikrotechnik Mainz Gmbh Statischer Mikromischer und Verfahren zum statischen Mischen zweier oder mehrerer Edukte
DE19928123A1 (de) * 1999-06-19 2000-12-28 Karlsruhe Forschzent Statischer Mikrovermischer
DE19961275C2 (de) * 1999-12-18 2002-07-18 Zahnradfabrik Friedrichshafen Automatgetriebe für ein Kraftfahrzeug
DE19961257C2 (de) * 1999-12-18 2002-12-19 Inst Mikrotechnik Mainz Gmbh Mikrovermischer
DE10041823C2 (de) 2000-08-25 2002-12-19 Inst Mikrotechnik Mainz Gmbh Verfahren und statischer Mikrovermischer zum Mischen mindestens zweier Fluide
US6863867B2 (en) * 2001-05-07 2005-03-08 Uop Llc Apparatus for mixing and reacting at least two fluids
DE10123093A1 (de) * 2001-05-07 2002-11-21 Inst Mikrotechnik Mainz Gmbh Verfahren und statischer Mikrovermischer zum Mischen mindestens zweier Fluide
JP4792664B2 (ja) * 2001-06-15 2011-10-12 コニカミノルタホールディングス株式会社 混合方法、混合機構、該混合機構を備えたマイクロミキサーおよびマイクロチップ
DE20206371U1 (de) * 2002-04-23 2002-06-27 Ehrfeld Mikrotechnik Gmbh Modular aufgebauter statischer Mikrovermischer
DE10248541A1 (de) * 2002-10-17 2004-04-29 Hilti Ag Mischelement

Also Published As

Publication number Publication date
DE502004011614D1 (de) 2010-10-14
WO2005018772A1 (fr) 2005-03-03
US8057677B2 (en) 2011-11-15
CN1822888A (zh) 2006-08-23
DE10333921A1 (de) 2005-02-17
MXPA06000729A (es) 2006-04-19
JP4958216B2 (ja) 2012-06-20
US20070007204A1 (en) 2007-01-11
JP2006528542A (ja) 2006-12-21
DE10333921B4 (de) 2005-10-20
CN1822888B (zh) 2010-05-26
EP1648581A1 (fr) 2006-04-26
ES2351600T3 (es) 2011-02-08
ATE479483T1 (de) 2010-09-15

Similar Documents

Publication Publication Date Title
EP1648581B1 (fr) Procede d'extraction faisant intervenir un micro-melangeur statique
EP1658129B1 (fr) Micro-melangeur statique
EP2403633B1 (fr) Mélangeur statique compact coaxial et son utilisation
DE10041823C2 (de) Verfahren und statischer Mikrovermischer zum Mischen mindestens zweier Fluide
EP1390131B1 (fr) Procede et micromelangeur statique concu pour melanger au moins deux fluides
EP1242171B1 (fr) Micromelangeur
EP1866066B1 (fr) Système melangeur, reacteur et systéme reacteur
EP0956151B1 (fr) Procede et dispositif de fabrication d'un melange disperse
DE19917148C2 (de) Verfahren und Mikrovermischer zur Herstellung einer Dispersion
DE19604289C2 (de) Mikromischer
WO2004052518A2 (fr) Micromelangeur lamellaire statique
DE19541265A1 (de) Verfahren zur Herstellung von Dispersionen und zur Durchführung chemischer Reaktionen mit disperser Phase
DE10123092A1 (de) Verfahren und statischer Mischer zum Mischen mindestens zweier Fluide
EP2090353B1 (fr) Système de mélangeur à réaction destiné au mélange et réaction chimique d'au moins deux fluides
EP2617487A1 (fr) Microréacteur pour réactions catalytiques
EP1703969B1 (fr) Procede et dispositif pour melanger au moins deux fluides dans un microreacteur de melange
DE10218280C1 (de) Integriertes Misch- und Schaltsystem für die Mikroreaktionstechnik
DE10337097A1 (de) Vorrichtung und Verfahren zur Trennung von vorzugsweise mikrodispersen fluiden Phasen

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 20051209

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PL PT RO SE SI SK TR

DAX Request for extension of the european patent (deleted)
17Q First examination report despatched

Effective date: 20080908

GRAP Despatch of communication of intention to grant a patent

Free format text: ORIGINAL CODE: EPIDOSNIGR1

RAP1 Party data changed (applicant data changed or rights of an application transferred)

Owner name: THE PROCTER AND GAMBLE COMPANY

GRAS Grant fee paid

Free format text: ORIGINAL CODE: EPIDOSNIGR3

GRAA (expected) grant

Free format text: ORIGINAL CODE: 0009210

AK Designated contracting states

Kind code of ref document: B1

Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PL PT RO SE SI SK TR

REG Reference to a national code

Ref country code: GB

Ref legal event code: FG4D

Free format text: NOT ENGLISH

REG Reference to a national code

Ref country code: CH

Ref legal event code: EP

REG Reference to a national code

Ref country code: IE

Ref legal event code: FG4D

Free format text: LANGUAGE OF EP DOCUMENT: GERMAN

REF Corresponds to:

Ref document number: 502004011614

Country of ref document: DE

Date of ref document: 20101014

Kind code of ref document: P

REG Reference to a national code

Ref country code: SE

Ref legal event code: TRGR

REG Reference to a national code

Ref country code: NL

Ref legal event code: VDEP

Effective date: 20100901

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: FI

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20100901

REG Reference to a national code

Ref country code: ES

Ref legal event code: FG2A

Effective date: 20110127

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: SI

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20100901

Ref country code: PL

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20100901

Ref country code: CY

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20100901

REG Reference to a national code

Ref country code: IE

Ref legal event code: FD4D

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: NL

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20100901

Ref country code: GR

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20101202

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: IE

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20100901

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: EE

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20100901

Ref country code: CZ

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20100901

Ref country code: SK

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20100901

Ref country code: RO

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20100901

Ref country code: PT

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20110103

PLBE No opposition filed within time limit

Free format text: ORIGINAL CODE: 0009261

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: NO OPPOSITION FILED WITHIN TIME LIMIT

26N No opposition filed

Effective date: 20110606

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: DK

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20100901

REG Reference to a national code

Ref country code: DE

Ref legal event code: R097

Ref document number: 502004011614

Country of ref document: DE

Effective date: 20110606

BERE Be: lapsed

Owner name: THE PROCTER AND GAMBLE CY

Effective date: 20110630

REG Reference to a national code

Ref country code: CH

Ref legal event code: PL

REG Reference to a national code

Ref country code: ES

Ref legal event code: PC2A

Owner name: WELLA GMBH

Effective date: 20120503

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: BE

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20110630

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: CH

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20110630

Ref country code: LI

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20110630

REG Reference to a national code

Ref country code: DE

Ref legal event code: R081

Ref document number: 502004011614

Country of ref document: DE

Owner name: WELLA GMBH, DE

Free format text: FORMER OWNER: THE PROCTER & GAMBLE COMPANY, CINCINNATI, OHIO, US

Effective date: 20120525

REG Reference to a national code

Ref country code: GB

Ref legal event code: 732E

Free format text: REGISTERED BETWEEN 20121101 AND 20121107

REG Reference to a national code

Ref country code: AT

Ref legal event code: MM01

Ref document number: 479483

Country of ref document: AT

Kind code of ref document: T

Effective date: 20110604

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: AT

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20110604

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: MC

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20110630

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: LU

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20110604

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: TR

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20100901

Ref country code: BG

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20101201

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: HU

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20100901

REG Reference to a national code

Ref country code: FR

Ref legal event code: PLFP

Year of fee payment: 13

REG Reference to a national code

Ref country code: FR

Ref legal event code: PLFP

Year of fee payment: 14

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: GB

Payment date: 20170731

Year of fee payment: 14

Ref country code: FR

Payment date: 20170807

Year of fee payment: 14

Ref country code: ES

Payment date: 20170725

Year of fee payment: 14

Ref country code: IT

Payment date: 20170725

Year of fee payment: 14

Ref country code: DE

Payment date: 20170727

Year of fee payment: 14

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: SE

Payment date: 20170728

Year of fee payment: 14

REG Reference to a national code

Ref country code: DE

Ref legal event code: R119

Ref document number: 502004011614

Country of ref document: DE

REG Reference to a national code

Ref country code: SE

Ref legal event code: EUG

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: SE

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20180605

GBPC Gb: european patent ceased through non-payment of renewal fee

Effective date: 20180604

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: GB

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20180604

Ref country code: FR

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20180630

Ref country code: IT

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20180604

Ref country code: DE

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20190101

REG Reference to a national code

Ref country code: ES

Ref legal event code: FD2A

Effective date: 20190916

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: ES

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20180605