EP1646353A4 - Fusionsproteine zur behandlung des zns - Google Patents

Fusionsproteine zur behandlung des zns

Info

Publication number
EP1646353A4
EP1646353A4 EP04776038A EP04776038A EP1646353A4 EP 1646353 A4 EP1646353 A4 EP 1646353A4 EP 04776038 A EP04776038 A EP 04776038A EP 04776038 A EP04776038 A EP 04776038A EP 1646353 A4 EP1646353 A4 EP 1646353A4
Authority
EP
European Patent Office
Prior art keywords
cns
treatment
fusion proteins
fusion
proteins
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
EP04776038A
Other languages
English (en)
French (fr)
Other versions
EP1646353A2 (de
Inventor
Elliott A Gruskin
Anthony O Caggiano
Jennifer Iaci
Michael P Zimber
Gargi Roy
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Acorda Therapeutics Inc
Original Assignee
Acorda Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Acorda Therapeutics Inc filed Critical Acorda Therapeutics Inc
Priority to EP10184697.0A priority Critical patent/EP2354155B1/de
Priority to EP17164945.2A priority patent/EP3210999B1/de
Priority to ES17164945T priority patent/ES2831031T3/es
Publication of EP1646353A2 publication Critical patent/EP1646353A2/de
Publication of EP1646353A4 publication Critical patent/EP1646353A4/de
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/4756—Neuregulins, i.e. p185erbB2 ligands, glial growth factor, heregulin, ARIA, neu differentiation factor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/51—Lyases (4)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/10—Fusion polypeptide containing a localisation/targetting motif containing a tag for extracellular membrane crossing, e.g. TAT or VP22

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Psychology (AREA)
  • Psychiatry (AREA)
  • Cardiology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Dermatology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
EP04776038A 2003-05-16 2004-05-17 Fusionsproteine zur behandlung des zns Ceased EP1646353A4 (de)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP10184697.0A EP2354155B1 (de) 2003-05-16 2004-05-17 Fusionsproteine zur Behandlung des ZNS
EP17164945.2A EP3210999B1 (de) 2003-05-16 2004-05-17 Fusionsproteine zur behandlung des zns
ES17164945T ES2831031T3 (es) 2003-05-16 2004-05-17 Proteínas de fusión para el tratamiento del CNS

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US47123903P 2003-05-16 2003-05-16
US47123603P 2003-05-16 2003-05-16
US47130003P 2003-05-16 2003-05-16
US47124003P 2003-05-16 2003-05-16
US47437203P 2003-05-29 2003-05-29
PCT/US2004/015661 WO2004110359A2 (en) 2003-05-16 2004-05-17 Fusion proteins for the treatment of cns

Related Child Applications (2)

Application Number Title Priority Date Filing Date
EP10184697.0A Division EP2354155B1 (de) 2003-05-16 2004-05-17 Fusionsproteine zur Behandlung des ZNS
EP17164945.2A Division EP3210999B1 (de) 2003-05-16 2004-05-17 Fusionsproteine zur behandlung des zns

Publications (2)

Publication Number Publication Date
EP1646353A2 EP1646353A2 (de) 2006-04-19
EP1646353A4 true EP1646353A4 (de) 2008-06-04

Family

ID=33556640

Family Applications (3)

Application Number Title Priority Date Filing Date
EP04776038A Ceased EP1646353A4 (de) 2003-05-16 2004-05-17 Fusionsproteine zur behandlung des zns
EP10184697.0A Expired - Lifetime EP2354155B1 (de) 2003-05-16 2004-05-17 Fusionsproteine zur Behandlung des ZNS
EP17164945.2A Expired - Lifetime EP3210999B1 (de) 2003-05-16 2004-05-17 Fusionsproteine zur behandlung des zns

Family Applications After (2)

Application Number Title Priority Date Filing Date
EP10184697.0A Expired - Lifetime EP2354155B1 (de) 2003-05-16 2004-05-17 Fusionsproteine zur Behandlung des ZNS
EP17164945.2A Expired - Lifetime EP3210999B1 (de) 2003-05-16 2004-05-17 Fusionsproteine zur behandlung des zns

Country Status (7)

Country Link
EP (3) EP1646353A4 (de)
JP (5) JP5399612B2 (de)
AU (1) AU2004247025B8 (de)
CA (1) CA2525782C (de)
ES (1) ES2831031T3 (de)
MX (2) MX351062B (de)
WO (1) WO2004110359A2 (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7666852B2 (en) * 2002-04-22 2010-02-23 Agenta Biotechnologies, Inc. Wound and cutaneous injury healing with a nucleic acid encoding a proteoglycan polypeptide
US8183350B2 (en) 2002-05-04 2012-05-22 Acorda Therapeutics, Inc. Compositions and methods for promoting neuronal outgrowth
US7959914B2 (en) 2003-05-16 2011-06-14 Acorda Therapeutics, Inc. Methods of reducing extravasation of inflammatory cells
JP2007532094A (ja) 2003-05-16 2007-11-15 アコーダ セラピューティクス、インク． Ｃｎｓ治療用のプロテオグリカン分解変異体
JP4926962B2 (ja) * 2004-05-18 2012-05-09 アコーダ セラピューティクス、インク． コンドロイチン分解酵素とその安定な製剤の精製法
WO2007038548A2 (en) 2005-09-26 2007-04-05 Acorda Therapeutics, Inc. Compositions and methods of using chondroitinase abci mutants
WO2007132481A2 (en) * 2006-05-12 2007-11-22 Bharat Biotech International Limited Novel thrombolytic molecules and a process therefor
WO2007136042A1 (ja) 2006-05-19 2007-11-29 Aichi Prefecture 脳損傷改善剤
CA3086902C (en) * 2006-10-10 2021-11-09 Acorda Therapeutics, Inc. Compositions and methods of using chondroitinase abci mutants
WO2008061019A2 (en) * 2006-11-14 2008-05-22 Genentech, Inc. Modulators of neuronal regeneration
WO2008149428A1 (ja) * 2007-06-05 2008-12-11 Glycoscience Laboratories, Inc. 自己免疫疾患、炎症及び神経疾患の治療剤及び予防剤
AU2015200220A1 (en) * 2008-02-29 2015-02-12 Acorda Therapeutics, Inc. Method for achieving desired glial growth factor 2 plasma levels
ES2811127T3 (es) * 2008-02-29 2021-03-10 Acorda Therapeutics Inc Composiciones para lograr niveles plasmáticos deseados del factor 2 de crecimiento glial
EP2603221A4 (de) * 2010-08-13 2014-02-26 Univ Georgetown Ggf2 und verfahren zu seiner anwendung
US9144601B2 (en) 2011-09-15 2015-09-29 Seikagaku Corporation Skeletal muscle regeneration promoter
GB201322396D0 (en) 2013-12-18 2014-02-05 Univ Nottingham Transduction
US11396529B2 (en) 2020-11-12 2022-07-26 National Sun Yat-Sen University Isolated peptide, anti-cancer medicinal composition including the same and method of specifically reducing or inhibiting activities of cancer cells using the same

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000062067A1 (en) * 1999-02-28 2000-10-19 Washington University Novel transduction molecules and methods for using same
US6171575B1 (en) * 1998-04-06 2001-01-09 Shinichi Okuyama Method of radioisotopic assessment of the integrity and function of the nose-brain barrier
WO2002055684A2 (en) * 2001-01-09 2002-07-18 Univ Iowa Res Found Synthetic proteins containing a protein transduction domain
WO2002083179A2 (en) * 2001-04-12 2002-10-24 Bioaxone Therapeutique Inc. Fusion proteins
WO2003100031A2 (en) * 2002-05-20 2003-12-04 Board Of Regents, The University Of Texas System Methods and compositions for delivering enzymes and nucleic acid molecules to brain, bone, and other tissues
WO2004017044A2 (en) * 2002-08-15 2004-02-26 Acorda Therapeutics, Inc. Chimeric protein

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5670617A (en) 1989-12-21 1997-09-23 Biogen Inc Nucleic acid conjugates of tat-derived transport polypeptides
US5804604A (en) 1989-12-21 1998-09-08 Biogen, Inc. Tat-derived transport polypeptides and fusion proteins
AU697156B2 (en) * 1993-04-23 1998-10-01 American Cyanamid Company Cloning and expression of the chondroitinase I and II genes from (p. vulgaris)
WO1995013091A1 (en) * 1993-11-12 1995-05-18 International Technology Management Associates, Ltd. Methods of repairing connective tissues
JPH07316068A (ja) * 1994-05-25 1995-12-05 Canji Inc 腫瘍サプレッサー融合タンパク質
GB9622500D0 (en) * 1996-10-29 1997-01-08 Oxford Biomedica Ltd Therapeutic gene
US20010006630A1 (en) * 1997-09-02 2001-07-05 Oron Yacoby-Zeevi Introducing a biological material into a patient
AU765218B2 (en) * 1999-03-16 2003-09-11 Government of The United States of America, as represented by The Secretary Department of Health & Human Services, The National Institutes of Health, The A novel chimeric protein for prevention and treatment of HIV infection
SE9901428D0 (sv) * 1999-04-21 1999-04-21 Karolinska Innovations Ab Amphibodies
DE60019415T2 (de) * 1999-06-08 2006-03-09 Regeneron Pharmaceuticals, Inc. Modifizierte chimärische polypeptide mit verbesserten pharmakokynetischen eigenschaften
WO2001039795A2 (en) * 1999-12-02 2001-06-07 Ibex Technologies, Inc. Attenuation of fibroblast proliferation
KR20040021697A (ko) * 2001-08-13 2004-03-10 유니버시티 오브 플로리다 리서치 파운데이션, 인크. 신경 조직 복구를 증진시키는 물질 및 방법
GB0205022D0 (en) * 2002-03-04 2002-04-17 Univ Cambridge Tech Materials and methods for the treatment of cns damage

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6171575B1 (en) * 1998-04-06 2001-01-09 Shinichi Okuyama Method of radioisotopic assessment of the integrity and function of the nose-brain barrier
WO2000062067A1 (en) * 1999-02-28 2000-10-19 Washington University Novel transduction molecules and methods for using same
WO2002055684A2 (en) * 2001-01-09 2002-07-18 Univ Iowa Res Found Synthetic proteins containing a protein transduction domain
WO2002083179A2 (en) * 2001-04-12 2002-10-24 Bioaxone Therapeutique Inc. Fusion proteins
WO2003100031A2 (en) * 2002-05-20 2003-12-04 Board Of Regents, The University Of Texas System Methods and compositions for delivering enzymes and nucleic acid molecules to brain, bone, and other tissues
WO2004017044A2 (en) * 2002-08-15 2004-02-26 Acorda Therapeutics, Inc. Chimeric protein

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
"ROUTE OF ADMINISTRATION - FDA", 11 January 2006 (2006-01-11), XP055243674 *
BRADBURY E J ET AL: "Chondroitinase ABC promotes functional recovery after spinal cord injury", NATURE, NATURE PUBLISHING GROUP, LONDON, GB, vol. 416, 11 April 2002 (2002-04-11), pages 636 - 640, XP002245003, ISSN: 0028-0836 *
FROM WIKIPEDIA: "Route of administration", 5 January 2016 (2016-01-05), XP055243671 *
MCGEE A W ET AL: "The Nogo-66 receptor: focusing myelin inhibition of axon regeneration", TRENDS IN NEUROSCIENCE, ELSEVIER, AMSTERDAM, NL, vol. 26, no. 4, April 2003 (2003-04-01), pages 193 - 198, XP004418152, ISSN: 0166-2236 *

Also Published As

Publication number Publication date
JP5399612B2 (ja) 2014-01-29
WO2004110359A2 (en) 2004-12-23
MXPA05012306A (es) 2006-04-18
JP6141571B2 (ja) 2017-07-12
WO2004110359A3 (en) 2006-08-17
JP2017125035A (ja) 2017-07-20
AU2004247025A1 (en) 2004-12-23
EP3210999A1 (de) 2017-08-30
WO2004110359A9 (en) 2006-02-16
JP2014221793A (ja) 2014-11-27
EP2354155B1 (de) 2017-05-03
JP5656314B2 (ja) 2015-01-21
JP2013049677A (ja) 2013-03-14
AU2004247025B2 (en) 2011-06-23
ES2831031T3 (es) 2021-06-07
AU2004247025B8 (en) 2011-06-30
EP3210999B1 (de) 2020-08-26
EP2354155A3 (de) 2011-09-07
JP2007516229A (ja) 2007-06-21
MX351062B (es) 2017-09-29
CA2525782C (en) 2019-02-05
EP2354155A2 (de) 2011-08-10
JP6913428B2 (ja) 2021-08-04
CA2525782A1 (en) 2004-12-23
JP2020111578A (ja) 2020-07-27
EP1646353A2 (de) 2006-04-19

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Inventor name: GRUSKIN, ELLIOTT, A.

Inventor name: IACI, JENNIFER

Inventor name: ROY, GARGI

Inventor name: ZIMBER, MICHAEL, P.

Inventor name: CAGGIANO, ANTHONY, O.

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